Incorporation of basic side chains into cryptolepine scaffold: Structure-antimalarial activity relationships and mechanistic studies

Journal of Medicinal Chemistry

Volumn 54, Issue 3, 2011, Pages 734-750

  Lavrado, João ^a   Cabal, Ghislain G ^b   Prudêncio, Miguel ^b   Mota, Maria M ^b   Gut, Jiri ^c   Rosenthal, Philip J ^c   Díaz, Cecília ^d   Guedes, Rita C ^a   Dos Santos, Daniel J V A ^a   Bichenkovß, Elena ^e   Douglaŝ, Kenneth T ^e   Moreira, Rui ^a   Paulo, Alexandra ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSITY OF LISBON   (Portugal)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; BUTANE; CHLOROQUINE; CRYPTOLEPINE; HEMATIN; PROPANE;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DNA DRUG COMPLEX; DRUG ACCUMULATION; DRUG ACTIVITY; DRUG BINDING; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MALARIA; NONHUMAN; PARASITE; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; ANTIMALARIALS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; CHLOROQUINE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DNA; DRUG RESISTANCE; ERYTHROCYTES; HEMIN; HUMANS; INDOLE ALKALOIDS; MEFLOQUINE; OLIGONUCLEOTIDES; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 79851504683     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101383f     Document Type: Article

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