Retinoic acid: Metabolism, developmental functions, and evolution

Vitamin-Binding Proteins: Functional Consequences

Volumn , Issue , 2013, Pages 1-30

  Carvalho, João E ^a   Schubert, Michael ^a  

^a Villefranche sur Mer Oceanographic Laboratory   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84884906890     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b15313     Document Type: Chapter

References (206)

1. Abu-Abed, S., P. Dollé, D. Metzger, et al. 2001. The Retinoic Acid-Metabolizing Enzyme, Cyp26a1, Is Essential for Normal Hindbrain Patterning, Vertebral Identity, and Development of Posterior Structures. Genes Dev 15, no 2: 226-40.
2. Aggarwal, S., S. W. Kim, K. Cheon, et al. 2006. Nonclassical Action of Retinoic Acid on the Activation of the Camp Response Element-Binding Protein in Normal Human Bronchial Epithelial Cells. Mol Biol Cell 17, no 2: 566-75.
3. Albalat, R., F. Brunet, V. Laudet, and M. Schubert. 2011. Evolution of Retinoid and Steroid Signaling: Vertebrate Diversification from an Amphioxus Perspective. Genome Biol Evol 3: 985-1005.
4. Albalat, R., and C. Cañestro. 2009. Identification of Aldh1a, Cyp26 and Rar Orthologs in Protostomes Pushes Back the Retinoic Acid Genetic Machinery in Evolutionary Time to the Bilaterian Ancestor. Chem-Biol Interact 178, no 1-3: 188-96.
5. Avantaggiato, V., D. Acampora, F. Tuorto, and A. Simeone. 1996. Retinoic Acid Induces Stage-Specific Repatterning of the Rostral Central Nervous System. Dev Biol 175, no 2: 347-57.
6. Balmer, J. E., and R. Blomhoff. 2005. A Robust Characterization of Retinoic Acid Response Elements Based on a Comparison of Sites in Three Species. J Steroid Biochem 96, no 5: 347-54.
7. Barron, M., D. McAllister, S. M. Smith, and J. Lough. 1998. Expression of Retinol Binding Protein and Transthyretin During Early Embryogenesis. Dev Dynam 212, no 3: 413-22.
8. Bayha, E., M. C. Jørgensen, P. Serup, and A. Grapin-Botton. 2009. Retinoic Acid Signaling Organizes Endodermal Organ Specification Along the Entire Antero-Posterior Axis. Plos One 4, no 6: e5845.
9. Begemann, G., T. F. Schilling, G. J. Rauch, R. Geisler, and P. W. Ingham. 2001. The Zebrafish Neckless Mutation Reveals a Requirement for Raldh2 in Mesodermal Signals That Pattern the Hindbrain. Development 128, no 16: 3081-94.
10. Bempong, D. K., I. L. Honigberg, and N. M. Meltzer. 1995. Normal-Phase Lc-Ms Determination of Retinoic Acid Degradation Products. J Pharmaceut Biomed 13, no 3: 285-91.
11. Berry, D. C., and N. Noy. 2009. All-trans-Retinoic Acid Represses Obesity and Insulin Resistance by Activating Both Peroxisome Proliferation-Activated Receptor β/δ and Retinoic Acid Receptor. Mol Cell Biol 29, no 12: 3286-96.
12. Berry, D. C., and N. Noy. 2012. Signaling by Vitamin A and Retinol-Binding Protein in Regulation of Insulin Responses and Lipid Homeostasis. Biochim Biophys Acta 1821, no 1: 168-76.
13. Blomhoff, R., and H. K. Blomhoff. 2006. Overview of Retinoid Metabolism and Function. J Neurobiol 66, no 7: 606-30.
14. Bollig, F., B. Perner, B. Besenbeck, et al. 2009. A Highly Conserved Retinoic Acid Responsive Element Controls Wt1a Expression in the Zebrafish Pronephros. Development 136, no 17: 2883-92.
15. Brent, A. E., and C. J. Tabin. 2002. Developmental Regulation of Somite Derivatives: Muscle, Cartilage and Tendon. Curr Opin Genet Dev 12, no 5: 548-57.
16. Cai, A. Q., K. Radtke, A. Linville, et al. 2012. Cellular Retinoic Acid-Binding Proteins Are Essential for Hindbrain Patterning and Signal Robustness in Zebrafish. Development 139, no 12: 2150-55.
17. Campo-Paysaa, F., F. Marlétaz, V. Laudet, and M. Schubert. 2008. Retinoic Acid Signaling in Development: Tissue-Specific Functions and Evolutionary Origins. Genesis 46, no 11: 640-56.
18. Cañestro, C., L. Godoy, R. Gonzàlez-Duarte, and R. Albalat. 2003. Comparative Expression Analysis of Adh3 During Arthropod, Urochordate, Cephalochordate, and Vertebrate Development Challenges Its Predicted Housekeeping Role. Evol Dev 5, no 2: 157-62.
19. Cañestro, C., L. Hjelmqvist, R. Albalat, et al. 2000. Amphioxus Alcohol Dehydrogenase Is a Class 3 Form of Single Type and of Structural Conservation but with Unique Developmental Expression. Eur J Biochem 267, no 22: 6511-18.
20. Cañestro, C., and J. H. Postlethwait. 2007. Development of a Chordate Anterior-Posterior Axis without Classical Retinoic Acid Signaling. Dev Biol 305, no 2: 522-38.
21. Cañestro, C., J. H. Postlethwait, R. Gonzàlez-Duarte, and R. Albalat. 2006. Is Retinoic Acid Genetic Machinery a Chordate Innovation? Evol Dev 8, no 5: 394-406.
22. Cañestro, C., H. Yokoi, and J. H. Postlethwait. 2007. Evolutionary Developmental Biology and Genomics. Nat Rev Genet 8, no 12: 932-42.
23. Carter, C. J., N. Farrar, R. L. Carlone, and G. E. Spencer. 2010. Developmental Expression of a Molluscan Rxr and Evidence for Its Novel, Nongenomic Role in Growth Cone Guidance. Dev Biol 343, no 1-2: 124-37.
24. Cartry, J., M. Nichane, V. Ribes, et al. 2006. Retinoic Acid Signalling Is Required for Specification of Pronephric Cell Fate. Dev Biol 299, no 1: 35-51.
25. Chambers, D., L. Wilson, M. Maden, and A. Lumsden. 2007. Raldh-Independent Generation of Retinoic Acid During Vertebrate Embryogenesis by Cyp1b1. Development 134, no 7: 1369-83.
26. Chambon, P. 1996. A Decade of Molecular Biology of Retinoic Acid Receptors. Faseb J 10, no 9: 940-54.
27. Chazaud, C., P. Chambon, and P. Dollé. 1999. Retinoic Acid Is Required in the Mouse Embryo for Left-Right Asymmetry Determination and Heart Morphogenesis. Development 126, no 12: 2589-96.
28. Chen, Y. L., N. Pollet, C. Niehrs, and T. Pieler. 2001. Increased Xraldh2 Activity Has a Posteriorizing Effect on the Central Nervous System of Xenopus Embryos. Mech Develop 101, no 1-2: 91-103.
29. Collins, M. D., and G. E. Mao. 1999. Teratology of Retinoids. Annu Rev Pharmacol 39: 399-430.
30. Corcoran, J., B. Shroot, J. Pizzey, and M. Maden. 2000. The Role of Retinoic Acid Receptors in Neurite Outgrowth from Different Populations of Embryonic Mouse Dorsal Root Ganglia. J Cell Sci 113: 2567-74.
31. Créton, R., G. Zwaan, and R. Dohmen. 1993. Specific Developmental Defects in Mollusks after Treatment with Retinoic Acid During Gastrulation. Dev Growth Differ 35, no 3: 357-64.
32. Dalfó, D., N. Marqués, and R. Albalat. 2007. Analysis of the Nadh-Dependent Retinaldehyde Reductase Activity of Amphioxus Retinol Dehydrogenase Enzymes Enhances Our Understanding of the Evolution of the Retinol Dehydrogenase Family. Febs J 274, no 14: 3739-52.
33. D’Ambrosio, D. N., R. D. Clugston, and W. S. Blaner. 2011. Vitamin A Metabolism: An Update. Nutrients 3, no 1: 63-103.
34. De Bernardi, F., C. Sotgia, and G. Ortolani. 1994. Retinoic Acid Treatment of Ascidian Embryos: Effects on Larvae and Metamorphosis. Anim Dev 3: 75-81.
35. del Corral, R. D., and K. G. Storey. 2004. Opposing Fgf and Retinoid Pathways: A Signalling Switch That Controls Differentiation and Patterning Onset in the Extending Vertebrate Body Axis. Bioessays 26, no 8: 857-69.
36. Dong, D., S. E. Ruuska, D. J. Levinthal, and N. Noy. 1999. Distinct Roles for Cellular Retinoic Acid-Binding Proteins I and Ii in Regulating Signaling by Retinoic Acid. J Biol Chem 274, no 34: 23695-98.
37. Dubrulle, J., and O. Pourquié. 2004. Coupling Segmentation to Axis Formation. Development 131, no 23: 5783-93.
38. Duester, G. 2007. Retinoic Acid Regulation of the Somitogenesis Clock. Birth Defects Res C Embryo Today 81, no 2: 84-92.
39. Duester, G. 2008. Retinoic Acid Synthesis and Signaling During Early Organogenesis. Cell 134, no 6: 921-31.
40. Duester, G., F. A. Mic, and A. Molotkov. 2003. Cytosolic Retinoid Dehydrogenases Govern Ubiquitous Metabolism of Retinol to Retinaldehyde Followed by Tissue-Specific Metabolism to Retinoic Acid. Chem-Biol Interact 143: 201-10.
41. Duong, V., and C. Rochette-Egly. 2011. The Molecular Physiology of Nuclear Retinoic Acid Receptors. From Health to Disease. Biochem Biophys Acta 1812, no 8: 1023-31.
42. Dupé, V., N. B. Ghyselinck, O. Wendling, P. Chambon, and M. Mark. 1999. Key Roles of Retinoic Acid Receptors Alpha and Beta in the Patterning of the Caudal Hindbrain, Pharyngeal Arches and Otocyst in the Mouse. Development 126, no 22: 5051-59.
43. Durston, A. J., J. P. M. Timmermans, W. J. Hage, et al. 1989. Retinoic Acid Causes an Anteroposterior Transformation in the Developing Central Nervous System. Nature 340, no 6229: 140-44.
44. Engberg, N., M. Kahn, D. R. Petersen, M. Hansson, and P. Serup. 2010. Retinoic Acid Synthesis Promotes Development of Neural Progenitors from Mouse Embryonic Stem Cells by Suppressing Endogenous, Wnt-Dependent Nodal Signaling. Stem Cells 28, no 9: 1498-509.
45. Escriva, H., S. Bertrand, P. Germain, et al. 2006. Neofunctionalization in Vertebrates: The Example of Retinoic Acid Receptors. Plos Genet 2, no 7: 955-65.
46. Escriva, H., N. D. Holland, H. Gronemeyer, C. Laudet, and L. Z. Holland. 2002. The Retinoic Acid Signaling Pathway Regulates Anterior/Posterior Patterning in the Nerve Cord and Pharynx of Amphioxus, a Chordate Lacking Neural Crest. Development 129, no 12: 2905-16.
47. Estephane, D., and M. Anctil. 2010. Retinoic Acid and Nitric Oxide Promote Cell Proliferation and Differentially Induce Neuronal Differentiation in vitro in the Cnidarian Renilla koellikeri. Dev Neurobiol 70, no 12: 842-52.
48. Farjo, K. M., G. Moiseyev, O. Nikolaeva, et al. 2011. Rdh10 Is the Primary Enzyme Responsible for the First Step of Embryonic Vitamin A Metabolism and Retinoic Acid Synthesis. Dev Biol 357, no 2: 347-55.
49. Farrar, N. R., J. M. Dmetrichuk, R. L. Carlone, and G. E. Spencer. 2009. A Novel, Nongenomic Mechanism Underlies Retinoic Acid-Induced Growth Cone Turning. J Neurosci 29, no 45: 14136-42.
50. Feng, L., R. E. Hernandez, J. S. Waxman, D. Yelon, and C. B. Moens. 2010. Dhrs3a Regulates Retinoic Acid Biosynthesis through a Feedback Inhibition Mechanism. Dev Biol 338, no 1: 1-14.
51. Fraser, P. D., and P. M. Bramley. 2004. The Biosynthesis and Nutritional Uses of Carotenoids. Prog Lipid Res 43, no 3: 228-65.
52. Ghyselinck, N. B., C. Båvik, V. Sapin, et al. 1999. Cellular Retinol-Binding Protein I Is Essential for Vitamin A Homeostasis. Embo J 18, no 18: 4903-14.
53. Gibbs, M. A., and R. G. Northcutt. 2004. Retinoic Acid Repatterns Axolotl Lateral Line Receptors. Int J Dev Biol 48, no 1: 63-6.
54. Gibert, Y., A. Gajewski, A. Meyer, and G. Begemann. 2006. Induction and Prepatterning of the Zebrafish Pectoral Fin Bud Requires Axial Retinoic Acid Signaling. Development 133, no 14: 2649-59.
55. Giguere, V., E. S. Ong, P. Segui, and R. M. Evans. 1987. Identification of a Receptor for the Morphogen Retinoic Acid. Nature 330, no 6149: 624-29.
56. Glover, J. C., J. S. Renaud, and F. M. Rijli. 2006. Retinoic Acid and Hindbrain Patterning. J Neurobiol 66, no 7: 705-25.
57. Grandel, H., and M. Brand. 2011. Zebrafish Limb Development Is Triggered by a Retinoic Acid Signal During Gastrulation. Dev Dynam 240, no 5: 1116-26.
58. Gronemeyer, H., J. A. Gustafsson, and V. Laudet. 2004. Principles for Modulation of the Nuclear Receptor Superfamily. Nat Rev Drug Discov 3, no 11: 950-64.
59. Gutierrez-Mazariegos, J., M. Theodosiou, F. Campo-Paysaa, and M. Schubert. 2011. Vitamin A: A Multifunctional Tool for Development. Semin Cell Dev Biol 22, no 6: 603-10.
60. Hale, F. 1933. Pigs Born Without Eye Balls. J Heredity 24, no 3: 105-06.
61. Hall, B. K. 2009. The Neural Crest and Neural Crest Cells on Vertebrate Development and Evolution. 2nd ed. ed: Springer.
62. Hall, J. A., J. R. Grainger, S. P. Spencer, and Y. Belkaid. 2011. The Role of Retinoic Acid in Tolerance and Immunity. Immunity 35, no 1: 13-22.
63. Halme, A., M. Cheng, and I. K. Hariharan. 2010. Retinoids Regulate a Developmental Checkpoint for Tissue Regeneration in Drosophila. Curr Biol 20, no 5: 458-63.
64. Hernandez, R. E., A. P. Putzke, J. P. Myers, L. Margaretha, and C. B. Moens. 2007. Cyp26 Enzymes Generate the Retinoic Acid Response Pattern Necessary for Hindbrain Development. Development 134, no 1: 177-87.
65. Hessel, S., A. Eichinger, A. Isken, et al. 2007. Cmo1 Deficiency Abolishes Vitamin A Production from β-Carotene and Alters Lipid Metabolism in Mice. J Biol Chem 282, no 46: 33553-61.
66. Hinman, V. F., and B. M. Degnan. 1998. Retinoic Acid Disrupts Anterior Ectodermal and Endodermal Development in Ascidian Larvae and Postlarvae. Dev Genes Evol 208, no 6: 336-45.
67. Hinman, V. F., and B. M. Degnan. 2000. Retinoic Acid Perturbs Otx Gene Expression in the Ascidian Pharynx. Dev Genes Evol 210, no 3: 129-39.
68. Hochgreb, T., V. L. Linhares, D. C. Menezes, et al. 2003. A Caudorostral Wave of Raldh2 Conveys Anteroposterior Information to the Cardiac Field. Development 130, no 22: 5363-74.
69. Holland, L. Z., R. Albalat, K. Azumi, et al. 2008. The Amphioxus Genome Illuminates Vertebrate Origins and Cephalochordate Biology. Genome Res 18, no 7: 1100-11.
70. Holland, L. Z., and N. D. Holland. 1996. Expression of Amphihox-1 and Amphipax-1 in Amphioxus Embryos Treated with Retinoic Acid: Insights into Evolution and Patterning of the Chordate Nerve Cord and Pharynx. Development 122, no 6: 1829-38.
71. Hopkins, P. M. 2001. Limb Regeneration in the Fiddler Crab, Uca pugilator: Hormonal and Growth Factor Control. Am Zool 41, no 3: 389-98.
72. Ikuta, T., N. Satoh, and H. Saiga. 2010. Limited Functions of Hox Genes in the Larval Development of the Ascidian Ciona intestinalis. Development 137, no 9: 1505-13.
73. Ikuta, T., N. Yoshida, N. Satoh, and H. Saiga. 2004. Ciona intestinalis Hox Gene Cluster: Its Dispersed Structure and Residual Colinear Expression in Development. P Natl Acad Sci USA 101, no 42: 15118-23.
74. Irving, C., and I. Mason. 2000. Signalling by Fgf8 from the Isthmus Patterns Anterior Hindbrain and Establishes the Anterior Limit of Hox Gene Expression. Development 127, no 1: 177-86.
75. Jackman, W. R., J. M. Mougey, G. D. Panopoulou, and C. B. Kimmel. 2004. Crabp and Maf Highlight the Novelty of the Amphioxus Club-Shaped Gland. Acta Zool-Stockholm 85, no 2: 91-99.
76. Kam, R. K., Y. Deng, Y. Chen, and H. Zhao. 2012. Retinoic Acid Synthesis and Functions in Early Embryonic Development. Cell Biosci 2, no 1: 11.
77. Kanda, M., H. Wada, and S. Fujiwara. 2009. Epidermal Expression of Hox1 Is Directly Activated by Retinoic Acid in the Ciona intestinalis Embryo. Dev Biol 335, no 2: 454-63.
78. Kane, M. A. 2012. Analysis, Occurrence, and Function of 9-cis-Retinoic Acid. Biochem Biophys Acta 1821, no 1: 10-20.
79. Katsuyama, Y., and H. Saiga. 1998. Retinoic Acid Affects Patterning Along the Anterior-Posterior Axis of the Ascidian Embryo. Dev Growth Differ 40, no 4: 413-22.
80. Katsuyama, Y., S. Wada, S. Yasugi, and H. Saiga. 1995. Expression of the Labial Group Hox Gene Hrhox-1 and Its Alteration Induced by Retinoic Acid in Development of the Ascidian Halocynthia roretzi. Development 121, no 10: 3197-205.
81. Kawaguchi, R., J. M. Yu, J. Honda, et al. 2007. A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A. Science 315, no 5813: 820-25.
82. Kiefer, C., S. Hessel, J. M. Lampert, et al. 2001. Identification and Characterization of a Mammalian Enzyme Catalyzing the Asymmetric Oxidative Cleavage of Provitamin A. J Biol Chem 276, no 17: 14110-16.
83. Kim, Y. K., L. Wassef, S. Chung, et al. 2011. β-Carotene and Its Cleavage Enzyme β-Carotene-15,15′-Oxygenase (CmoI) Affect Retinoid Metabolism in Developing Tissues. Faseb J 25, no 5: 1641-52.
84. Koop, D., and L. Z. Holland. 2008. The Basal Chordate Amphioxus as a Simple Model for Elucidating Developmental Mechanisms in Vertebrates. Birth Defects Res C Embryo Today 84, no 3: 175-87.
85. Koop, D., L. Z. Holland, D. Setiamarga, M. Schubert, and N. D. Holland. 2011. Tail Regression Induced by Elevated Retinoic Acid Signaling in Amphioxus Larvae Occurs by Tissue Remodeling, Not Cell Death. Evol Dev 13, no 5: 427-35.
86. Koop, D., N. D. Holland, M. Sémon, et al. 2010. Retinoic Acid Signaling Targets Hox Genes During the Amphioxus Gastrula Stage: Insights into Early Anterior-Posterior Patterning of the Chordate Body Plan. Dev Biol 338, no 1: 98-106.
87. Kopinke, D., J. Sasine, J. Swift, W. Z. Stephens, and T. Piotrowski. 2006. Retinoic Acid Is Required for Endodermal Pouch Morphogenesis and Not for Pharyngeal Endoderm Specification. Dev Dynam 235, no 10: 2695-709.
88. -/-Mutant Mice Are Viable. P Natl Acad Sci USA 93, no 17: 9010-4.
89. Krispin, S., E. Nitzan, Y. Kassem, and C. Kalcheim. 2010. Evidence for a Dynamic Spatiotemporal Fate Map and Early Fate Restrictions of Premigratory Avian Neural Crest. Development 137, no 4: 585-95.
90. Kruse, S. W., K. Suino-Powell, X. E. Zhou, et al. 2008. Identification of Coup-Tfii Orphan Nuclear Receptor as a Retinoic Acid-Activated Receptor. Plos Biol 6, no 9: 2002-15.
91. Lampert, J. M., J. Holzschuh, S. Hessel, et al. 2003. Provitamin A Conversion to Retinal Via the β,β-Carotene-15,15′-Oxygenase (Bcox) Is Essential for Pattern Formation and Differentiation During Zebrafish Embryogenesis. Development 130, no 10: 2173-86.
92. Lee, S. J., S. Kim, S. C. Choi, and J. K. Han. 2010. Xpteg (Xenopus Proximal Tubules-Expressed Gene) Is Essential for Pronephric Mesoderm Specification and Tubulogenesis. Mech Develop 127, no 1-2: 49-61.
93. Li, Z., V. Korzh, and Z. Y. Gong. 2007. Localized Rbp4 Expression in the Yolk Syncytial Layer Plays a Role in Yolk Cell Extension and Early Liver Development. Bmc Dev Biol 7: 117.
94. Lin, M., M. Zhang, M. Abraham, S. M. Smith, and J. L. Napoli. 2003. Mouse Retinal Dehydrogenase 4 (Raldh4), Molecular Cloning, Cellular Expression, and Activity in 9-cis-Retinoic Acid Biosynthesis in Intact Cells. J Biol Chem 278, no 11: 9856-61.
95. Lin, S. C., P. Dollé, L. Ryckebusch, et al. 2010. Endogenous Retinoic Acid Regulates Cardiac Progenitor Differentiation. P Natl Acad Sci USA 107, no 20: 9234-39.
96. Linney, E., S. Donerly, L. Mackey, and B. Dobbs-McAuliffe. 2011. The Negative Side of Retinoic Acid Receptors. Neurotoxicol Teratol 33, no 6: 631-40.
97. Liu, J. P., E. Laufer, and T. M. Jessell. 2001. Assigning the Positional Identity of Spinal Motor Neurons: Rostrocaudal Patterning of Hox-C Expression by Fgfs, Gdf11, and Retinoids. Neuron 32, no 6: 997-1012.
98. Lobo, G. P., J. Amengual, G. Palczewski, D. Babino, and J. von Lintig. 2012. Mammalian Carotenoid-Oxygenases: Key Players for Carotenoid Function and Homeostasis. Biochem Biophys Acta 1821, no 1: 78-87.
99. López-Carballo, G., L. Moreno, S. Masiá, P. Pérez, and D. Barettino. 2002. Activation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Retinoic Acid Is Required for Neural Differentiation of Sh-Sy5y Human Neuroblastoma Cells. J Biol Chem 277, no 28: 25297-304.
100. MacLean, G., H. Li, D. Metzger, P. Chambon, and M. Petkovich. 2007. Apoptotic Extinction of Germ Cells in Testes of Cyp26b1 Knockout Mice. Endocrinology 148, no 10: 4560-67.
101. Maden, M. 2002. Retinoid Signalling in the Development of the Central Nervous System. Nat Rev Neurosci 3, no 11: 843-53.
102. Mark, M., N. B. Ghyselinck, and P. Chambon. 2006. Function of Retinoid Nuclear Receptors. Lessons from Genetic and Pharmacological Dissections of the Retinoic Acid Signaling Pathway During Mouse Embryogenesis. Annu Rev Pharmacol 46: 451-80.
103. Mark, M., N. B. Ghyselinck, and P. Chambon. 2009. Function of Retinoic Acid Receptors During Embryonic Development. Nucl Recept Signal 7: e002.
104. Marletaz, F., L. Z. Holland, V. Laudet, and M. Schubert. 2006. Retinoic Acid Signaling and the Evolution of Chordates. Int J Biol Sci 2, no 2: 38-47.
105. Marshall, H., A. Morrison, M. Studer, H. Pöpperl, and R. Krumlauf. 1996. Retinoids and Hox Genes. Faseb J 10, no 9: 969-78.
106. Martínez-Morales, P. L., R. D. del Corral, I. Olivera-Martínez, et al. 2011. Fgf and Retinoic Acid Activity Gradients Control the Timing of Neural Crest Cell Emigration in the Trunk. J Cell Biol 194, no 3: 489-503.
107. Matt, N., V. Dupé, J. M. Garnier, et al. 2005. Retinoic Acid-Dependent Eye Morphogenesis Is Orchestrated by Neural Crest Cells. Development 132, no 21: 4789-800.
108. Matt, N., N. B. Ghyselinck, O. Wendling, P. Chambon, and M. Mark. 2003. Retinoic Acid-Induced Developmental Defects Are Mediated by Rarβ/Rxr Heterodimers in the Pharyngeal Endoderm. Development 130, no 10: 2083-93.
109. Matt, N., C. K. Schmidt, V. Dupé, et al. 2005. Contribution of Cellular Retinol-Binding Protein Type 1 to Retinol Metabolism During Mouse Development. Dev Dynam 233, no 1: 167-76.
110. McCaffery, P., E. Wagner, J. O’Neil, M. Petkovich, and U. C. Dräger. 1999. Dorsal and Ventral Retinal Territories Defined by Retinoic Acid Synthesis, Break-Down and Nuclear Receptor Expression. Mech Develop 82, no 1-2: 119-30.
111. McNamara, P., S. B. Seo, R. D. Rudic, et al. 2001. Regulation of Clock and Mop4 by Nuclear Hormone Receptors in the Vasculature: A Humoral Mechanism to Reset a Peripheral Clock. Cell 105, no 7: 877-89.
112. Mic, F. A., R. J. Haselbeck, A. E. Cuenca, and G. Duester. 2002. Novel Retinoic Acid Generating Activities in the Neural Tube and Heart Identified by Conditional Rescue of Raldh2 Null Mutant Mice. Development 129, no 9: 2271-82.
113. Mic, F. A., A. Molotkov, D. M. Benbrook, and G. Duester. 2003. Retinoid Activation of Retinoic Acid Receptor but Not Retinoid X Receptor Is Sufficient to Rescue Lethal Defect in Retinoic Acid Synthesis. P Natl Acad Sci USA 100, no 12: 7135-40.
114. Minoux, M., and F. M. Rijli. 2010. Molecular Mechanisms of Cranial Neural Crest Cell Migration and Patterning in Craniofacial Development. Development 137, no 16: 2605-21.
115. Molotkov, A., N. Molotkova, and G. Duester. 2005. Retinoic Acid Generated by Raldh2 in Mesoderm Is Required for Mouse Dorsal Endodermal Pancreas Development. Dev Dynam 232, no 4: 950-57.
116. Molotkova, N., A. Molotkov, I. O. Sirbu, and G. Duester. 2005. Requirement of Mesodermal Retinoic Acid Generated by Raldh2 for Posterior Neural Transformation. Mech Develop 122, no 2: 145-55.
117. Moreno, T. A., and C. Kintner. 2004. Regulation of Segmental Patterning by Retinoic Acid Signaling During Xenopus Somitogenesis. Dev Cell 6, no 2: 205-18.
118. Müller, W. A. 1984. Retinoids and Pattern Formation in a Hydroid. J Embryol Exp Morph 81, no Jun: 253-71.
119. Müller, W. E. G., M. Binder, J. von Lintig, et al. 2011. Interaction of the Retinoic Acid Signaling Pathway with Spicule Formation in the Marine Sponge Suberites domuncula Through Activation of Bone Morphogenetic Protein-1. Biochem Biophys Acta 1810, no 12: 1178-94.
120. Nagatomo, K., and S. Fujiwara. 2003. Expression of Raldh2, Cyp26 and Hox-1 in Normal and Retinoic Acid-Treated Ciona intestinalis Embryos. Gene Expr Patterns 3, no 3: 273-77.
121. Nagatomo, K., T. Ishibashi, Y. Satou, N. Satoh, and S. Fujiwara. 2003. Retinoic Acid Affects Gene Expression and Morphogenesis Without Upregulating the Retinoic Acid Receptor in the Ascidian Ciona intestinalis. Mech Develop 120, no 3: 363-72.
122. Nagl, F., K. Schönhofer, B. Seidler, et al. 2009. Retinoic Acid-Induced Nnos Expression Depends on a Novel Pi3k/Akt/Dax1 Pathway in Human Tgw-Nu-I Neuroblastoma Cells. Am J Physiol Cell Physiol 297, no 5: C1146-56.
123. Napoli, J. L. 1999. Interactions of Retinoid Binding Proteins and Enzymes in Retinoid Metabolism. Biochem Biophys Acta 1440, no 2-3: 139-62.
124. Napoli, J. L. 2000. A Gene Knockout Corroborates the Integral Function of Cellular Retinol-Binding Protein in Retinoid Metabolism. Nutr Rev 58, no 8: 230-6.
125. Natale, A., C. Sims, M. L. Chiusano, et al. 2011. Evolution of Anterior Hox Regulatory Elements among Chordates. Bmc Evol Biol 11: 330.
126. Niederreither, K., and P. Dollé. 2008. Retinoic Acid in Development: Towards an Integrated View. Nat Rev Genet 9, no 7: 541-53.
127. Niederreither, K., V. Subbarayan, P. Dollé, and P. Chambon. 1999. Embryonic Retinoic Acid Synthesis Is Essential for Early Mouse Post-Implantation Development. Nat Genet 21, no 4: 444-48.
128. Niederreither, K., J. Vermot, I. Le Roux, et al. 2003. The Regional Pattern of Retinoic Acid Synthesis by Raldh2 Is Essential for the Development of Posterior Pharyngeal Arches and the Enteric Nervous System. Development 130, no 11: 2525-34.
129. Novitch, B. G., H. Wichterle, T. M. Jessell, and S. Sockanathan. 2003. A Requirement for Retinoic Acid-Mediated Transcriptional Activation in Ventral Neural Patterning and Motor Neuron Specification. Neuron 40, no 1: 81-95.
130. Noy, N. 2000. Retinoid-Binding Proteins: Mediators of Retinoid Action. Biochem J 348: 481-95.
131. Noy, N. 2010. Between Death and Survival: Retinoic Acid in Regulation of Apoptosis. Annu Rev Nutr 30: 201-17.
132. Ochoa, W. F., A. Torrecillas, I. Fita, et al. 2003. Retinoic Acid Binds to the C2-Domain of Protein Kinase Cα. Biochemistry 42, no 29: 8774-79.
133. Ogasawara, M., H. Wada, H. Peters, and N. Satoh. 1999. Developmental Expression of Pax1/9 Genes in Urochordate and Hemichordate Gills: Insight into Function and Evolution of the Pharyngeal Epithelium. Development 126, no 11: 2539-50.
134. Osborne, P. W., G. Benoit, V. Laudet, M. Schubert, and D. E. K. Ferrier. 2009. Differential Regulation of Parahox Genes by Retinoic Acid in the Invertebrate Chordate Amphioxus (Branchiostoma floridae). Dev Biol 327, no 1: 252-62.
135. Parés, X., J. Farrés, N. Kedishvili, and G. Duester. 2008. Medium-Chain and Short-Chain Dehydrogenases/Reductases in Retinoid Metabolism. Cell Mol Life Sci 65, no 24: 3936-49.
136. Petkovich, M., N. J. Brand, A. Krust, and P. Chambon. 1987. A Human Retinoic Acid Receptor Which Belongs to the Family of Nuclear Receptors. Nature 330, no 6147: 444-50.
137. Piskunov, A., and C. Rochette-Egly. 2011. A Retinoic Acid Receptor Rarα Pool Present in Membrane Lipid Rafts Forms Complexes with G Protein Αq to Activate P38mapk. Oncogene 31, no 28: 3333-45.
138. Plant, M. R., M. E. MacDonald, L. I. Grad, S. J. Ritchie, and J. M. Richman. 2000. Locally Released Retinoic Acid Repatterns the First Branchial Arch Cartilages in vivo. Dev Biol 222, no 1: 12-26.
139. Pourquié, O. 2003. The Segmentation Clock: Converting Embryonic Time into Spatial Pattern. Science 301, no 5631: 328-30.
140. Quadro, L., L. Hamberger, M. E. Gottesman, et al. 2004. Transplacental Delivery of Retinoid: The Role of Retinol-Binding Protein and Lipoprotein Retinyl Ester. Am J Physiol-Endoc M 286, no 5: E844-E51.
141. Quadro, L., L. Hamberger, M. E. Gottesman, et al. 2005. Pathways of Vitamin A Delivery to the Embryo: Insights from a New Tunable Model of Embryonic Vitamin A Deficiency. Endocrinology 146, no 10: 4479-90.
142. Reijntjes, S., E. Gale, and M. Maden. 2004. Generating Gradients of Retinoic Acid in the Chick Embryo: Cyp26c1 Expression and a Comparative Analysis of the Cyp26 Enzymes. Dev Dynam 230, no 3: 509-17.
143. Rhinn, M., and P. Dollé. 2012. Retinoic Acid Signalling During Development. Development 139, no 5: 843-58.
144. Ribes, V., I. Le Roux, M. Rhinn, B. Schuhbaur, and P. Dollé. 2009. Early Mouse Caudal Development Relies on Crosstalk Between Retinoic Acid, Shh and Fgf Signalling Pathways. Development 136, no 4: 665-76.
145. Richardson, S. J. 2009. Evolutionary Changes to Transthyretin: Evolution of Transthyretin Biosynthesis. Febs J 276, no 19: 5342-56.
146. Rijli, F. M., A. Gavalas, and P. Chambon. 1998. Segmentation and Specification in the Branchial Region of the Head: The Role of the Hox Selector Genes. Int J Dev Biol 42, no 3: 393-401.
147. Rosenthal, N., and J. Xavier-Neto. 2000. From the Bottom of the Heart: Anteroposterior Decisions in Cardiac Muscle Differentiation. Curr Opin Cell Biol 12, no 6: 742-46.
148. Ross, A. C. 2003. Retinoid Production and Catabolism: Role of Diet in Regulating Retinol Esterification and Retinoic Acid Oxidation. J Nutr 133, no 1: 291s-96s.
149. Ross, A. C., and R. Zolfaghari. 2011. Cytochrome P450s in the Regulation of Cellular Retinoic Acid Metabolism. Annu Rev Nutr 31, no 1: 65-87.
150. Ross, S. A., P. J. McCaffery, U. C. Drager, and L. M. De Luca. 2000. Retinoids in Embryonal Development. Physiol Rev 80, no 3: 1021-54.
151. Rosselot, C., L. Spraggon, I. Chia, et al. 2010. Non-Cell-Autonomous Retinoid Signaling Is Crucial for Renal Development. Development 137, no 2: 283-92.
152. Samarut, E., and C. Rochette-Egly. 2012. Nuclear Retinoic Acid Receptors: Conductors of the Retinoic Acid Symphony During Development. Mol Cell Endocrinol 348, no 2: 348-60.
153. Sandell, L. L., B. W. Sanderson, G. Moiseyev, et al. 2007. Rdh10 Is Essential for Synthesis of Embryonic Retinoic Acid and Is Required for Limb, Craniofacial, and Organ Development. Genes Dev 21, no 9: 1113-24.
154. Sasakura, Y., M. Kanda, T. Ikeda, et al. 2012. Retinoic Acid-Driven Hox1 Is Required in the Epidermis for Forming the Otic/Atrial Placodes During Ascidian Metamorphosis. Development 139, no 12: 2156-60.
155. Schlosser, G. 2010. Making Senses: Development of Vertebrate Cranial Placodes. Int Rev Cell Mol Biol 283: 129-234.
156. Schubert, M., H. Escriva, J. Xavier-Neto, and V. Laudet. 2006. Amphioxus and Tunicates as Evolutionary Model Systems. Trends Ecol Evol 21, no 5: 269-77.
157. Schubert, M., N. D. Holland, H. Escriva, L. Z. Holland, and V. Laudet. 2004. Retinoic Acid Influences Anteroposterior Positioning of Epidermal Sensory Neurons and Their Gene Expression in a Developing Chordate (Amphioxus). P Natl Acad Sci USA 101, no 28: 10320-25.
158. Schubert, M., N. D. Holland, V. Laudet, and L. Z. Holland. 2006. A Retinoic Acid-Hox Hierarchy Controls Both Anterior/Posterior Patterning and Neuronal Specification in the Developing Central Nervous System of the Cephalochordate Amphioxus. Dev Biol 296, no 1: 190-202.
159. Schubert, M., J. K. Yu, N. D. Holland, et al. 2005. Retinoic Acid Signaling Acts Via Hox1 to Establish the Posterior Limit of the Pharynx in the Chordate Amphioxus. Development 132, no 1: 61-73.
160. Schug, T. T., D. C. Berry, N. S. Shaw, S. N. Travis, and N. Noy. 2007. Opposing Effects of Retinoic Acid on Cell Growth Result from Alternate Activation of Two Different Nuclear Receptors. Cell 129, no 4: 723-33.
161. Seo, H. C., R. B. Edvardsen, A. D. Maeland, et al. 2004. Hox Cluster Disintegration with Persistent Anteroposterior Order of Expression in Oikopleura dioica. Nature 431, no 7004: 67-71.
162. Serluca, F. C., and M. C. Fishman. 2001. Pre-Pattern in the Pronephric Kidney Field of Zebrafish. Development 128, no 12: 2233-41.
163. Shaw, N., M. Elholm, and N. Noy. 2003. Retinoic Acid Is a High Affinity Selective Ligand for the Peroxisome Proliferator-Activated Receptor β/δ. J Biol Chem 278, no 43: 41589-92.
164. Sheng, N. Y., Z. H. Xie, C. Wang, et al. 2010. Retinoic Acid Regulates Bone Morphogenic Protein Signal Duration by Promoting the Degradation of Phosphorylated Smad1. P Natl Acad Sci USA 107, no 44: 18886-91.
165. Shirai, H., K. Oishi, and N. Ishida. 2006. Bidirectional Clock/Bmal1-Dependent Circadian Gene Regulation by Retinoic Acid in vitro. Biochem Bioph Res Co 351, no 2: 387-91.
166. Simões-Costa, M. S., A. P. Azambuja, and J. Xavier-Neto. 2008. The Search for Non-Chordate Retinoic Acid Signaling: Lessons from Chordates. J Exp Zool Part B 310B, no 1: 54-72.
167. Sirbu, I. O., and G. Duester. 2006. Retinoic-Acid Signalling in Node Ectoderm and Posterior Neural Plate Directs Left-Right Patterning of Somitic Mesoderm. Nat Cell Biol 8, no 3: 271-77.
168. Sirbu, I. O., L. Gresh, J. Barra, and G. Duester. 2005. Shifting Boundaries of Retinoic Acid Activity Control Hindbrain Segmental Gene Expression. Development 132, no 11: 2611-22.
169. Sirbu, I. O., X. L. Zhao, and G. Duester. 2008. Retinoic Acid Controls Heart Anteroposterior Patterning by Down-Regulating Isl1 Through the Fgf8 Pathway. Dev Dynam 237, no 6: 1627-35.
170. Sobreira, T. J. P., F. Marlétaz, M. Simões-Costa, et al. 2011. Structural Shifts of Aldehyde Dehydrogenase Enzymes Were Instrumental for the Early Evolution of Retinoid-Dependent Axial Patterning in Metazoans. P Natl Acad Sci USA 108, no 1: 226-31.
171. Song, Y., J. N. Hui, K. K. Fu, and J. M. Richman. 2004. Control of Retinoic Acid Synthesis and Fgf Expression in the Nasal Pit Is Required to Pattern the Craniofacial Skeleton. Dev Biol 276, no 2: 313-29.
172. Spiegler, E., Y. K. Kim, L. Wassef, V. Shete, and L. Quadro. 2012. Maternal-Fetal Transfer and Metabolism of Vitamin A and Its Precursor β-Carotene in the Developing Tissues. Biochem Biophys Acta 1821, no 1: 88-98.
173. Stafford, D., A. Hornbruch, P. R. Mueller, and V. E. Prince. 2004. A Conserved Role for Retinoid Signaling in Vertebrate Pancreas Development. Dev Genes Evol 214, no 9: 432-41.
174. Stainier, D. Y. R., and M. C. Fishman. 1992. Patterning the Zebrafish Heart Tube: Acquisition of Anteroposterior Polarity. Dev Biol 153, no 1: 91-101.
175. Stehlin-Gaon, C., D. Willmann, D. Zeyer, et al. 2003. All-trans Retinoic Acid Is a Ligand for the Orphan Nuclear Receptor Rorβ. Nat Struct Biol 10, no 10: 820-25.
176. Sun, H. 2012. Membrane Receptors and Transporters Involved in the Function and Transport of Vitamin A and Its Derivatives. Biochem Biophys Acta 1821, no 1: 99-112.
177. Suruga, K., T. Goda, M. Igarashi, et al. 1997. Cloning of Chick Cellular Retinol-Binding Protein, Type II and Comparison to That of Some Mammals: Expression of the Gene at Different Developmental Stages, and Possible Involvement of Rxrs and Ppar. Comp Biochem Physiol A Physiol 118, no 3: 859-69.
178. Tan, N. S., N. S. Shaw, N. Vinckenbosch, et al. 2002. Selective Cooperation Between Fatty Acid Binding Proteins and Peroxisome Proliferator-Activated Receptors in Regulating Transcription. Mol Cell Biol 22, no 14: 5114-27.
179. Tanaka, Y., Y. Okada, and N. Hirokawa. 2005. Fgf-Induced Vesicular Release of Sonic Hedgehog and Retinoic Acid in Leftward Nodal Flow Is Critical for Left-Right Determination. Nature 435, no 7039: 172-77.
180. Theodosiou, M., V. Laudet, and M. Schubert. 2010. From Carrot to Clinic: An Overview of the Retinoic Acid Signaling Pathway. Cell Mol Life Sci 67, no 9: 1423-45.
181. Tickle, C., B. Alberts, L. Wolpert, and J. Lee. 1982. Local Application of Retinoic Acid to the Limb Bond Mimics the Action of the Polarizing Region. Nature 296, no 5857: 564-66.
182. Trainor, P. A., and R. Krumlauf. 2001. Hox Genes, Neural Crest Cells and Branchial Arch Patterning. Curr Opin Cell Biol 13, no 6: 698-705.
183. Uehara, M., K. Yashiro, S. Mamiya, et al. 2007. Cyp26a1 and Cyp26c1 Cooperatively Regulate Anterior-Posterior Patterning of the Developing Brain and the Production of Migratory Cranial Neural Crest Cells in the Mouse. Dev Biol 302, no 2: 399-411.
184. Van de Peer, Y., S. Maere, and A. Meyer. 2009. The Evolutionary Significance of Ancient Genome Duplications. Nat Rev Genet 10, no 10: 725-32.
185. Vermot, J., and O. Pourquié. 2005. Retinoic Acid Coordinates Somitogenesis and Left-Right Patterning in Vertebrate Embryos. Nature 435, no 7039: 215-20.
186. Vilhais-Neto, G. C., and O. Pourquié. 2008. Retinoic Acid. Curr Biol 18, no 7: 550-52.
187. von Lintig, J., S. Hessel, A. Isken, et al. 2005. Towards a Better Understanding of Carotenoid Metabolism in Animals. Biochem Biophys Acta 1740, no 2: 122-31.
188. Wada, H., H. Escriva, S. C. Zhang, and V. Laudet. 2006. Conserved Rare Localization in Amphioxus Hox Clusters and Implications for Hox Code Evolution in the Vertebrate Neural Crest. Dev Dynam 235, no 6: 1522-31.
189. Wang, Z. X., P. Dollé, W. V. Cardoso, and K. Niederreither. 2006. Retinoic Acid Regulates Morphogenesis and Patterning of Posterior Foregut Derivatives. Dev Biol 297, no 2: 433-45.
190. Wasiak, S., and D. Lohnes. 1999. Retinoic Acid Affects Left-Right Patterning. Dev Biol 215, no 2: 332-42.
191. Waxman, J. S., and D. Yelon. 2007. Comparison of the Expression Patterns of Newly Identified Zebrafish Retinoic Acid and Retinoid X Receptors. Dev Dynam 236, no 2: 587-95.
192. White, J. C., M. Highland, M. Kaiser, and M. Clagett-Dame. 2000. Vitamin A Deficiency Results in the Dose-Dependent Acquisition of Anterior Character and Shortening of the Caudal Hindbrain of the Rat Embryo. Dev Biol 220, no 2: 263-84.
193. White, R. J., and T. F. Schilling. 2008. How Degrading: Cyp26s in Hindbrain Development. Dev Dynam 237, no 10: 2775-90.
194. Wiens, M., R. Batel, M. Korzhev, and W. E. G. Müller. 2003. Retinoid X Receptor and Retinoic Acid Response in the Marine Sponge Suberites domuncula. J Exp Biol 206, no 18: 3261-71.
195. Wilson, J. G., C. B. Roth, and J. Warkany. 1953. An Analysis of the Syndrome of Malformations Induced by Maternal Vitamin A Deficiency. Effects of Restoration of Vitamin A at Various Times During Gestation. Am J Anat 92, no 2: 189-217.
196. Wilson, J. G., and J. Warkany. 1949. Aortic-Arch and Cardiac Anomalies in the Offspring of Vitamin A Deficient Rats. Am J Anat 85, no 1: 113-55.
197. Wingert, R. A., R. Selleck, J. Yu, et al. 2007. The Cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros. Plos Genet 3, no 10: 1922-38.
198. Xavier-Neto, J., N. Rosenthal, F. A. Silva, et al. 2001. Retinoid Signaling and Cardiac Anteroposterior Segmentation. Genesis 31, no 3: 97-104.
199. Yamauchi, K., and A. Ishihara. 2009. Evolutionary Changes to Transthyretin: Developmentally Regulated and Tissue-Specific Gene Expression. Febs J 276, no 19: 5357-66.
200. Yashiro, K., X. L. Zhao, M. Uehara, et al. 2004. Regulation of Retinoic Acid Distribution Is Required for Proximodistal Patterning and Outgrowth of the Developing Mouse Limb. Dev Cell 6, no 3: 411-22.
201. Yasuda, Y., N. Nishi, J. A. Takahashi, et al. 1992. Induction of Avascular Yolk Sac Due to Reduction of Basic Fibroblast Growth Factor by Retinoic Acid in Mice. Dev Biol 150, no 2: 397-413.
202. Zanotto-Filho, A., M. Cammarota, D. P. Gelain, et al. 2008. Retinoic Acid Induces Apoptosis by a Non-Classical Mechanism of Erk1/2 Activation. Toxicol in vitro 22, no 5: 1205-12.
203. Zhang, Z. Y., J. E. Balmer, A. Lovlie, S. H. Fromm, and R. Blomhoff. 1996. Specific Teratogenic Effects of Different Retinoic Acid Isomers and Analogs in the Developing Anterior Central Nervous System of Zebrafish. Dev Dynam 206, no 1: 73-86.
204. Zhao, X. L., T. Brade, T. J. Cunningham, and G. Duester. 2010. Retinoic Acid Controls Expression of Tissue Remodeling Genes Hmgn1 and Fgf18 at the Digit-Interdigit Junction. Dev Dynam 239, no 2: 665-71.
205. Zhao, X. L., I. O. Sirbu, F. A. Mlc, et al. 2009. Retinoic Acid Promotes Limb Induction Through Effects on Body Axis Extension but Is Unnecessary for Limb Patterning. Curr Biol 19, no 12: 1050-57.
206. Zhou, X. E., K. M. Suino-Powell, Y. Xu, et al. 2011. The Orphan Nuclear Receptor Tr4 Is a Vitamin A-Activated Nuclear Receptor. J Biol Chem 286, no 4: 2877-85.