Vitamin A: A multifunctional tool for development

Seminars in Cell and Developmental Biology

Volumn 22, Issue 6, 2011, Pages 603-610

  Gutierrez Mazariegos, Juliana ^a,b   Theodosiou, Maria ^a,b   Campo Paysaa, Florent ^a,b   Schubert, Michael ^a,b  

^a UNIVERSITÉ DE LYON   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Embryo and fetus; Regulatory crosstalk; Retinoic acid signaling; Retinoid teratology; Vitamin a metabolism

Indexed keywords

ETRETIN; ETRETINATE; ISOTRETINOIN; RETINOIC ACID; RETINOL; RETINOL DERIVATIVE;

CARDIOVASCULAR DISEASE; CLEFT PALATE; CRANIOFACIAL MALFORMATION; EMBRYO; EMBRYO DEVELOPMENT; FACE DYSMORPHIA; HUMAN; HUMAN DEVELOPMENT; HYDROCEPHALUS; MENINGOMYELOCELE; MICROTIA; MOLECULAR GENETICS; NONHUMAN; PREGNANCY; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TERATOLOGY; VITAMIN METABOLISM;

ANIMALIA; MUS;

EID: 80054762730     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2011.06.001     Document Type: Review

References (112)

1. Allen L.H., Haskell M. Estimating the potential for vitamin A toxicity in women and young children. J Nutr 2002, 132:2907S-2919S.
2. Hale F. Pigs born without eye balls. J Hered 1933, 24:105-106.
3. Hale F. The relation of vitamin A to the eye development in the pig. J Anim Sci 1935, 126-128.
4. Wilson J.G., Warkany J. Cardiac and aortic arch anomalies in the offspring of vitamin A deficient rats correlated with similar human anomalies. Pediatrics 1950, 5:708-725.
5. Cohlan S.Q. Excessive intake of vitamin A as a cause of congenital anomalies in the rat. Science 1953, 117:535-536.
6. Cohlan S.Q. Congenital anomalies in the rat produced by excessive intake of vitamin A during pregnancy. Pediatrics 1954, 13:556-567.
7. Shenefelt R.E. Morphogenesis of malformations in hamsters caused by retinoic acid: relation to dose and stage at treatment. Teratology 1972, 5:103-118.
8. Hathcock J.N., Hattan D.G., Jenkins M.Y., McDonald J.T., Sundaresan P.R., Wilkening V.L. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990, 52:183-202.
9. Parkinson C.E., Tan J.C., Gal I. Vitamin A concentration in amniotic fluid and maternal serum related to neural-tube defects. Br J Obstet Gynaecol 1982, 89:935-939.
10. Venkatachalam P.S., Belavady B., Gopalan C. Studies on vitamin A nutritional status of mothers and infants in poor communities of India. J Pediatr 1962, 61:262-268.
11. Godel J.C., Basu T.K., Pabst H.F., Hodges R.S., Hodges P.E., Ng M.L. Perinatal vitamin A (retinol) status of northern Canadian mothers and their infants. Biol Neonate 1996, 69:133-139.
12. Underwood B.A. Maternal vitamin A status and its importance in infancy and early childhood. Am J Clin Nutr 1994, 59:517S-524S.
13. Ortega R.M., Andrés P.P., Martínez R.M., López-Sobaler A.M. Vitamin A status during the third trimester of pregnancy in Spanish women: influence on concentrations of vitamin A in breast milk. Am J Clin Nutr 1997, 66:564-568.
14. Schulz C., Engel U., Kreienberg R., Biesalski H.K. Vitamin A and β-carotene supply of women with gemini or short birth intervals: a pilot study. Eur J Nutr 2007, 46:12-20.
15. Ross D.A. Recommendations for vitamin A supplementation. J Nutr 2002, 132:2902S-2906S.
16. US Teratology Society Vitamin A during pregnancy. Teratology 1987, 35:267-268.
17. Rothman K.J., Moore L.L., Singer M.R., Nguyen U.S., Mannino S., Milunsky A. Teratogenicity of high vitamin A intake. N Engl J Med 1995, 333:1369-1373.
18. Rosa F.W. Retinoid embryopathy in humans. Retinoids in clinical practice 1993, 77-109. Informa Healthcare, New York. G. Koren (Ed.).
19. Schardein J.L., Macina O.T. Human developmental toxicants: aspects of toxicology and chemistry 2006, Informa Healthcare, New York.
20. Christian M.S., Mitala J.J., Powers W.J., McKenzie B.E., Latriano L. A developmental toxicity study of tretinoin emollient cream (Renova) applied topically to New Zealand white rabbits. J Am Acad Dermatol 1997, 36:S67-76.
21. Rosa F.W. Teratogenicity of isotretinoin. Lancet 1983, 2:513.
22. Geelen J.A. Hypervitaminosis A induced teratogenesis. Crit Rev Toxicol 1979, 6:351-375.
23. Kamm J.J. Toxicology, carcinogenicity, and teratogenicity of some orally administered retinoids. J Am Acad Dermatol 1982, 6:652-659.
24. Benke P.J. The isotretinoin teratogen syndrome. J Am Med Assoc 1984, 251:3267-3269.
25. Stern R.S., Rosa F., Baum C. Isotretinoin and pregnancy. J Am Acad Dermatol 1984, 10:851-854.
26. Hersh J.H., Danhauer D.E., Hand M.E., Weisskopf B. Retinoic acid embryopathy: timing of exposure and effects on fetal development. J Am Med Assoc 1985, 254:909-910.
27. Lammer E.J., Chen D.T., Hoar R.M., Agnish N.D., Benke P.J., Braun J.T., et al. Retinoic acid embryopathy. N Engl J Med 1985, 313:837-841.
28. Adams J., Lammer E.J. Neurobehavioral teratology of isotretinoin. Reprod Toxicol 1993, 7:175-177.
29. Lynberg M.C., Khoury M.J., Lammer E.J., Waller K.O., Cordero J.F., Erickson J.D. Sensitivity, specificity, and positive predictive value of multiple malformations in isotretinoin embryopathy surveillance. Teratology 1990, 42:513-519.
30. Brazzell R.K., Vane F.M., Ehmann C.W., Colburn W.A. Pharmacokinetics of isotretinoin during repetitive dosing to patients. Eur J Clin Pharmacol 1983, 24:695-702.
31. Colburn W.A., Vane F.M., Shorter H.J. Pharmacokinetics of isotretinoin and its major blood metabolite following a single oral dose to man. Eur J Clin Pharmacol 1983, 24:689-694.
32. Schaefer H., Zesch A. Penetration of vitamin A acid into human skin. Acta Derm Venereol 1975, 74:50-55.
33. Franz T.J., Lehman P.A., Franz S.F. Topical use of retinoic acid gel is not teratogenic. J Invest Dermatol 1993, 100:490.
34. Camera G., Pregliasco P. Ear malformation in baby born to mother using tretinoin cream. Lancet 1992, 339:687.
35. Lipson A.H., Collins F., Webster W.S. Multiple congenital defects associated with maternal use of topical tretinoin. Lancet 1993, 341:1352-1353.
36. Navarre-Belhassen C., Blanchet P., Hillaire-Buys D., Sarda P., Blayac J.P. Multiple congenital malformations associated with topical tretinoin. Ann Pharmacother 1998, 32:505-506.
37. Selcen D., Seidman S., Nigro M.A. Otocerebral anomalies associated with topical tretinoin use. Brain Dev 2000, 22:218-220.
38. Willhite C.C., Sharma R.P., Allen P.V., Berry D.L. Percutaneous retinoid absorption and embryotoxicity. J Invest Dermatol 1990, 95:523-529.
39. Seegmiller R.E., Carter M.W., Ford W.H., White R.D. Induction of maternal toxicity in the rat by dermal application of retinoic acid and its effect on fetal outcome. Reprod Toxicol 1990, 4:277-281.
40. Jick S.S., Terris B.Z., Jick H. First trimester topical tretinoin and congenital disorders. Lancet 1993, 341:1181-1182.
41. Seegmiller R.E., Ford W.H., Carter M.W., Mitala J.J., Powers W.J. A developmental toxicity study of tretinoin administered topically and orally to pregnant Wistar rats. J Am Acad Dermatol 1997, 36:S60-S66.
42. Shapiro L., Pastuszak A., Curto G., Koren G. Safety of first-trimester exposure to topical tretinoin: prospective cohort study. Lancet 1997, 350:1143-1144.
43. Loureiro K.D., Kao K.K., Jones K.L., Alvarado S., Chavez C., Dick L., et al. Minor malformations characteristic of the retinoic acid embryopathy and other birth outcomes in children of women exposed to topical tretinoin during early pregnancy. Am J Med Genet 2005, 136A:117-121.
44. Martinez-Frias M.L., Rodriguez-Pinilla E. First-trimester exposure to topical tretinoin: its safety is not warranted. Teratology 1999, 60:5.
45. Vahlquist A., Rollman O. Etretinate and the risk for teratogenicity: drug monitoring in a pregnant woman for 9 months after stopping treatment. Br J Dermatol 1990, 123:131.
46. Maradit H., Geiger J.M. Potential risk of birth defects after acitretin discontinuation. Dermatology 1999, 198:3-4.
47. Katz W.I., Waalen J., Leach J.J. Acitretin in psoriasis: an overview of adverse effects. J Am Acad Dermatol 1999, 41:S7-S12.
48. Gronhoj Larsen F., Steinkjer B., Jakobsen P., Hjorter A., Brockhoff P.B., Nielsen-Kudsk F. Acitretin is converted to etretinate only during concomitant alcohol intake. Br J Dermatol 2000, 143:1164-1169.
49. Van Dorp D.A., Arens J.F. Biological activity of vitamin A acid. Nature 1946, 158:60.
50. Fujiwara S. Retinoids and nonvertebrate chordate development. J Neurobiol 2006, 66:645-652.
51. Campo-Paysaa F., Marlétaz F., Laudet V., Schubert M. Retinoic acid signaling in development: tissue-specific functions and evolutionary origins. Genesis 2008, 46:640-656.
52. Duester G. Retinoic acid synthesis and signaling during early organogenesis. Cell 2008, 134:921-931.
53. Niederreither K., Subbarayan V., Dollé P., Chambon P. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet 1999, 21:444-448.
54. Durston A.J., Timmermans J.P., Hage W.J., Hendriks H.F., de Vries N.J., Heideveld M., et al. Retinoic acid causes an anteroposterior transformation in the developing central nervous system. Nature 1989, 340:140-144.
55. Sive H.L., Draper B.W., Harland R.M., Weintraub H. Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis. Genes Dev 1990, 4:932-942.
56. Koop D., Holland N.D., Sémon M., Alvarez S., de Lera A.R., Laudet V., et al. Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: insights into early anterior-posterior patterning of the chordate body plan. Dev Biol 2010, 338:98-106.
57. Alexa K., Choe S.K., Hirsch N., Etheridge L., Laver E., Sagerström C.G. Maternal and zygotic aldh1a2 activity is required for pancreas development in zebrafish. PLoS ONE 2009, 4:e8261.
58. Zhao X., Brade T., Cunningham T.J., Duester G. Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction. Dev Dyn 2010, 239:665-671.
59. Bok J., Raft S., Kong K.A., Koo S.K., Dräger U.C., Wu D.K. Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear. Proc Natl Acad Sci USA 2011, 108:161-166.
60. Xavier-Neto J., Rosenthal N., Silva F.A., Matos T.G., Hochgreb T., Linhares V.L. Retinoid signaling and cardiac anteroposterior segmentation. Genesis 2001, 31:97-104.
61. Rosenthal N., Xavier-Neto J. From the bottom of the heart: anteroposterior decisions in cardiac muscle differentiation. Curr Opin Cell Biol 2000, 12:742-746.
62. Lin S.C., Dollé P., Ryckebüsch L., Noseda M., Zaffran S., Schneider M.D., et al. Endogenous retinoic acid regulates cardiac progenitor differentiation. Proc Natl Acad Sci USA 2010, 107:9234-9239.
63. Li P., Pashmforoush M., Sucov H.M. Retinoic acid regulates differentiation of the secondary heart field and TGFβ-mediated outflow tract septation. Dev Cell 2010, 18:480-485.
64. Chazaud C., Chambon P., Dollé P. Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis. Development 1999, 126:2589-2596.
65. Dupé V., Pellerin I. Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells. Dev Dyn 2009, 238:2701-2711.
66. Bowles J., Koopman P. Retinoic acid, meiosis and germ cell fate in mammals. Development 2007, 134:3401-3411.
67. Blomhoff R., Blomhoff H.K. Overview of retinoid metabolism and function. J Neurobiol 2006, 66:606-630.
68. Corcoran J., Shroot B., Pizzey J., Maden M. The role of retinoic acid receptors in neurite outgrowth from different populations of embryonic mouse dorsal root ganglia. J Cell Sci 2000, 113:2567-2574.
69. Fu M., Sato Y., Lyons-Warren A., Zhang B., Kane M.A., Napoli J.L., et al. Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation. Development 2010, 137:631-640.
70. Novitch B.G., Wichterle H., Jessell T.M., Sockanathan S. A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron 2003, 40:81-95.
71. Kaneko N., Katsuyama Y., Kawamura K., Fujiwara S. Regeneration of the gut requires retinoic acid in the budding ascidian Polyandrocarpa misakiensis. Dev Growth Differ 2010, 52:457-468.
72. Peterson P.A. Studies on the interaction between prealbumin, retinol-binding protein, and vitamin A. J Biol Chem 1971, 246:44-49.
73. Kawaguchi R., Yu J., Honda J., Hu J., Whitelegge J., Ping P., et al. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science 2007, 315:820-825.
74. Wu B.X., Moiseyev G., Chen Y., Rohrer B., Crouch R.K., Ma J.X. Identification of RDH10, an all-trans retinol dehydrogenase, in retinal Müller cells. Invest Ophthalmol Vis Sci 2004, 45:3857-3862.
75. Sandell L.L., Sanderson B.W., Moiseyev G., Johnson T., Mushegian A., Young K., et al. RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev 2007, 21:1113-1124.
76. Strate I., Min T.H., Iliev D., Pera E.M. Retinol dehydrogenase 10 is a feedback regulator of retinoic acid signalling during axis formation and patterning of the central nervous system. Development 2009, 136:461-472.
77. Theodosiou M., Laudet V., Schubert M. From carrot to clinic: an overview of the retinoic acid signaling pathway. Cell Mol Life Sci 2010, 67:1423-1445.
78. Niederreither K., Abu-Abed S., Schuhbaur B., Petkovich M., Chambon P., Dollé P. Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Nat Genet 2002, 31:84-88.
79. Reijntjes S., Blentic A., Gale E., Maden M. The control of morphogen signalling: regulation of the synthesis and catabolism of retinoic acid in the developing embryo. Dev Biol 2005, 285:224-237.
80. Feng L., Hernandez R.E., Waxman J.S., Yelon D., Moens C.B. Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Dev Biol 2010, 338:1-14.
81. Napoli J.L. Retinoic acid biosynthesis and metabolism. FASEB J 1996, 10:993-1001.
82. Levin M.S. Cellular retinol-binding proteins are determinants of retinol uptake and metabolism in stably transfected caco-2 cells. J Biol Chem 1993, 268:8267-8276.
83. Delva L., Bastie J.N., Rochette-Egly C., Kraïba R., Balitrand N., Despouy G., et al. Physical and functional interactions between cellular retinoic acid binding protein II and the retinoic acid-dependent nuclear complex. Mol Cell Biol 1999, 19:7158-7167.
84. Gronemeyer H., Gustafsson J.A., Laudet V. Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov 2004, 3:950-964.
85. Mic F.A., Molotkov A., Benbrook D.M., Duester G. Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis. Proc Natl Acad Sci USA 2003, 100:7135-7140.
86. Calléja C., Messaddeq N., Chapellier B., Yang H., Krezel W., Li M., et al. Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes. Genes Dev 2006, 20:1525-1538.
87. Balmer J.E., Blomhoff R. A robust characterization of retinoic acid response elements based on a comparison of sites in three species. J Steroid Biochem Mol Biol 2005, 96:347-354.
88. Balmer J.E., Blomhoff R. Gene expression regulation by retinoic acid. J Lipid Res 2002, 43:1773-1808.
89. Wang Y., Zolfaghari R., Ross A.C. Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Arch Biochem Biophys 2002, 401:235-243.
90. Niederreither K., McCaffery P., Dräger U.C., Chambon P., Dollé P. Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development. Mech Dev 1997, 62:67-78.
91. Dollé P. Developmental expression of retinoic acid receptors (RARs). Nucl Recept Signal 2009, 7:e006.
92. McCaffery P., Wagner E., O'Neil J., Petkovich M., Dräger U.C. Dorsal and ventral retinal territories defined by retinoic acid synthesis, break-down and nuclear receptor expression. Mech Dev 1999, 82:119-130.
93. White R.J., Nie Q., Lander A.D., Schilling T.F. Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo. PLoS Biol 2007, 5:e304.
94. Yasuda Y., Nishi N., Takahashi J.A., Konishi H., Ohara I., Fujita H., et al. Induction of avascular yolk sac due to reduction of basic fibroblast growth factor by retinoic acid in mice. Dev Biol 1992, 150:397-413.
95. Ribes V., Le Roux I., Rhinn M., Schuhbaur B., Dollé P. Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways. Development 2009, 136:665-676.
96. Engberg N., Kahn M., Petersen D.R., Hansson M., Serup P. Retinoic acid synthesis promotes development of neural progenitors from mouse embryonic stem cells by suppressing endogenous, Wnt-dependent nodal signaling. Stem Cells 2010, 28:1498-1509.
97. Sheng N., Xie Z., Wang C., Bai G., Zhang K., Zhu Q., et al. Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1. Proc Natl Acad Sci USA 2010, 107:18886-18891.
98. Duester G. Retinoic acid regulation of the somitogenesis clock. Birth Defects Res C: Embryo Today 2007, 81:84-92.
99. Gavalas A., Krumlauf R. Retinoid signalling and hindbrain patterning. Curr Opin Genet Dev 2000, 10:380-386.
100. Kumar S., Duester G. Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2. Dev Biol 2010, 340:67-74.
101. Lewandoski M., Mackem S. Limb development: the rise and fall of retinoic acid. Curr Biol 2009, 19:R558-R561.
102. Birkholz D.A., Olesnicky Killian E.C., George K.M., Artinger K.B. Prdm1a is necessary for posterior pharyngeal arch development in zebrafish. Dev Dyn 2009, 238:2575-2587.
103. Kennedy K.A., Porter T., Mehta V., Ryan S.D., Price F., Peshdary V., et al. Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative β-catenin. BMC Biol 2009, 7:67.
104. Alfano G., Conte I., Caramico T., Avellino R., Arnò B., Pizzo M.T., et al. Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye. Development 2011, 138:261-271.
105. Gonzalez-Quevedo R., Lee Y., Poss K.D., Wilkinson D.G. Neuronal regulation of the spatial patterning of neurogenesis. Dev Cell 2010, 18:136-147.
106. Numayama-Tsuruta K., Arai Y., Takahashi M., Sasaki-Hoshino M., Funatsu N., Nakamura S., et al. Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain. BMC Dev Biol 2010, 10:6.
107. Lohnes D., Mark M., Mendelsohn C., Dollé P., Dierich A., Gorry P., et al. Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants. Development 1994, 120:2723-2748.
108. Partanen J., Schwartz L., Rossant J. Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev 1998, 12:2332-2344.
109. Lohnes D. The Cdx1 homeodomain protein: an integrator of posterior signaling in the mouse. Bioessays 2003, 25:971-980.
110. Ikeya M., Takada S. Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. Mech Dev 2001, 103:27-33.
111. Houle M., Prinos P., Iulianella A., Bouchard N., Lohnes D. Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification. Mol Cell Biol 2000, 20:6579-6586.
112. Keenan I.D., Sharrard R.M., Isaacs H.V. FGF signal transduction and the regulation of Cdx gene expression. Dev Biol 2006, 299:478-488.