Bidentate ligands on osmium(VI) nitrido complexes control intracellular targeting and cell death pathways

Journal of the American Chemical Society

Volumn 135, Issue 38, 2013, Pages 14060-14063

  Suntharalingam, Kogularamanan ^a   Johnstone, Timothy C ^a   Bruno, Peter M ^a   Lin, Wei ^a   Hemann, Michael T ^a   Lippard, Stephen J ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ,10-PHENANTHROLINE; APOPTOTIC CELL DEATH; BIDENTATE LIGANDS; CELL-CYCLE ARREST; CELL-DEATH PATHWAYS; ENDOPLASMIC RETICULUM STRESS; INTRACELLULAR TARGETING; UNFOLDED PROTEIN RESPONSE;

CELL DEATH; CELL MEMBRANES; LIGANDS; OSMIUM; OSMIUM COMPOUNDS; PROTEINS;

CHLORINE COMPOUNDS;

1,10 PHENANTHROLINE; 2,2' BIPYRIDINE; 3,4,7,8 TETRAMETHYL 1,10 PHENANTHROLINE; BATHOPHENANTHROLINE; BIDENTATE LIGAND; CASPASE; CISPLATIN; COORDINATION COMPOUND; ERBIUM; LIGAND; OSMIUM DERIVATIVE; OSMIUM NITRIDO COMPLEX; PROTEIN P53; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; TARGET CELL; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

2,2'-DIPYRIDYL; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; COORDINATION COMPLEXES; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOPLASMIC RETICULUM STRESS; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; LIGANDS; M PHASE CELL CYCLE CHECKPOINTS; OSMIUM; PHENANTHROLINES; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84884871292     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja4075375     Document Type: Article

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