Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 12, 2005, Pages 3114-3118

  Dodo, Kosuke ^a,b   Katoh, Miho ^a,c   Shimizu, Tadashi ^a   Takahashi, Masahiro ^a   Sodeoka, Mikiko ^a,b,c  

^a TOHOKU UNIVERSITY   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

Author keywords

Apoptosis; Cell death; Indolylmaleimide; Necrosis

Indexed keywords

2 (1H INDOL 3 YL) 3 PENTYLAMINOMALEIMIDE; ACETYLCYSTEINE; APOPTOSIS INHIBITOR; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BISINDOLYLMALEIMIDE; CASPASE INHIBITOR; ETOPOSIDE; HYDROGEN PEROXIDE; IM 54; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NECROSIS;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL DEATH; ENZYME INHIBITORS; ETOPOSIDE; HL-60 CELLS; HUMANS; HYDROGEN PEROXIDE; INDOLES; MALEIMIDES; MOLECULAR STRUCTURE; NECROSIS; OXIDANTS; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 19944417921     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.04.016     Document Type: Article

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