Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors

Molecules

Volumn 13, Issue 10, 2008, Pages 2442-2461

  Sechi, Mario ^a   Azzena, Ugo ^a   Delussu, Maria Paola ^a   Dallocchio, Roberto ^b   Dessì, Alessandro ^b   Cosseddu, Alessia ^c   Pala, Nicolino ^a   Neamati, Nouri ^d  

^a UNIVERSITY OF SASSARI   (Italy)

^b CNR Consiglio Nazionale delle Ricerche   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Bis amides; Docking studies; HIV 1; HIV 1 integrase; Hydrazides; Malonic acid

Indexed keywords

AMIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; AZIDE; INTEGRASE INHIBITOR; MALONIC ACID; MALONIC ACID DERIVATIVE;

ARTICLE; CHEMISTRY; COMPUTER SIMULATION; DRUG DESIGN; ENZYME ACTIVE SITE; HUMAN; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDES; ANTI-HIV AGENTS; AZIDES; CATALYTIC DOMAIN; COMPUTER SIMULATION; DRUG DESIGN; HIV INTEGRASE INHIBITORS; HUMANS; MALONATES; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55249107993     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules13102442     Document Type: Article

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