A novel antiviral agent which inhibits the endonuclease of influenza viruses

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 5, 1996, Pages 1189-1193

  Tomassini, J E ^a   Davies, M E ^a   Hastings, J C ^a   Lingham, R ^a   Mojena, M ^b   Raghoobar, S L ^a   Singh, S B ^a   Tkacz, J S ^a   Goetz, M A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Medical affairs Merck sharp and Dohme ltd   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ENDONUCLEASE; FLUTIMIDE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL DIVISION; CYTOTOXICITY; DRUG STRUCTURE; ENZYME INHIBITION; INFLUENZA; INFLUENZA VIRUS; INFLUENZA VIRUS A; PRIORITY JOURNAL; RNA SYNTHESIS; RNA TRANSCRIPTION; VIRUS REPLICATION;

EID: 0029990093     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.5.1189     Document Type: Article

References (27)

1. Braam, J., I. Ulmanen, and R. Krug. 1983. Molecular model of a eukaryotic transcription complex. functions and movements of influenza P protein during capped RNA-primed transcription. Cell 34:609-618.
2. De la Luna, S., C. Martinez, and J. Ortin. 1989 Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domains. Virus Res. 13: 143-155.
3. Douglas, R. G., Jr. Prophylaxis and treatment of influenza. N Engl. J Med. 322:443-450.
4. Hastings, J., H. Selnick, B. Wolanski, and J. Tomassini. 1996. Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acids. Antimicrob. Agents Chemother. 40:1304-1307
5. Hayden, F. G., and A. J. Hay. 1992 Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine. Curr Top. Microbiol. Immunol. 176:119-130.
6. Hensens, O. D., M. A. Goetz, J. M. Liesch, D. L. Zink, S. L. Raghoobar, G. L. Helms, and S. B. Singh. 1995. Isolation and structure of flutimide. a novel endonuclease inhibitor of influenza virus. Tetrahedron Lett. 36:2005-2008
7. Jin, H., and R. M. Elliott. 1993. Characterization of Bunyamwcra virus S RNA that is transcribed and replicated by the L protein expressed from recombinant vaccinia virus. J. Virol 67:1396-1404.
8. Kilbourne, E. D. 1987. Influenza. Plenum Press, New York
9. Krug, R. M., F. V. Alonso-Caplan, I. Julkunen, and M. G. Katze. 1989. Expression and replication of the influenza virus genome, p. 89-152. In R. M. Krug (ed.), The influenza viruses. Plenum Press, New York.
10. Nakagawa, Y., N. Kimura, T. Toyoda, K. Mizumoto, A. Ishihama, K. Oda, and S. Nakada. 1995. The RNA polymerase PB2 subunit is not required for replication of the influenza virus genome but is involved in capped mRNA synthesis. J. Virol. 69:728-733.
11. Oxford, J. S., and D. D. Perrin. 1977. Influenza RNA transcriptase inhibitors: studies in vitro and in vivo. Ann. N. Y. Acad. Sci. 284:613-623.
12. Patterson, J. L., B. Holloway, and D. Kolakofsky. 1984. La Cross virions contain a primer-stimulated RNA polymerase and a methylated cap-dependent endonuclease. J. Virol. 52:215-222.
13. Pelaez, F., J. D. Polishook, M. Valldosera, and J. Guarro. 1994. A new species of Delitschia from west Africa. Mycotaxon 50:115-122.
14. Plotch, S. J., M. Bouloy, I. Ulmanen, and R. M. Krug. 1981. A unique cap (m7GpppXm)-dependent influenza vinon endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription. Cell 23: 847-858.
15. Rossier, C. J., J. L. Patterson, and D. Kolakofsky. 1986. La Crosse virus small genome mRNA is made in the cytoplasm. J. Virol. 58:647-650.
16. Rychlik, W., L. L. Domier, P. R. Gardner, G. M. Hellmann, and R. E. Rhoads. 1987. Amino acid sequence of the mRNA cap-binding protein from human tissue. Proc. Natl. Acad. Sci. USA 84:945-949.
17. Sakagami, H., Y. Kawazoe, N. Komatsu, A. Simpson, M. Nonoyama, K. Konno, T. Yoshida, Y. Kuroiwa, and S. Tanuma. 1991. Antitumor, antiviral and immunopotentiating activities of pine cone extracts: potential medicinal efficacy of natural and synthetic lignin-related materials. Anticancer Res. 11: 881-888.
18. Sakagami, H., K. Nagata, A. Ishihama, T. Oh-hara, and Y. Kawazoe. 1990. Anti-influenza virus activity of synthetically polymerized phenylpropenoids. Biochem. Biophys. Res. Commun. 172:1267-1272.
19. Schwartz, R. E., R. A. Giacobbe, J. A. Bland, and R. L. Monaghan. 1989. L-671,329, a new antifungal agent. I. Fermentation and isolation. J. Antibiot. 42:163-167
20. Shi, L., D. F. Summers, Q. Peng, and J. M. Galarza. 1995. Influenza A virus RNA polymerase subunit PB2 is the endonuclease which cleaves host cell mRNA and functions only as the trimeric enzyme. Virology 208:38-47.
21. Singh, S. B. 1995. Total synthesis of flutimide, a novel endonuclease inhibitor of influenza virus. Tetrahedron Lett. 36:2009-2012.
22. Strid, S., C. Ekström, and R. Datema. 1989. Comparison of foscarnet and foscarnet esters as anti-influenza virus agents. Chemotherapy (Basel) 35: 69-76.
23. Tisdale, M., G. Appleyard, J. V. Tuttle, D. J. Nelson, S. Nusinoff-Lehrman, W. Al Nakib, J. N. Stables, D. J. M. Purifoy, K. L. Powell, and G. Darby. 1993. Inhibition of influenza A and B viruses by 2′-deoxy-2′-fluororibosides. Antiviral Chem. Chemother. 4:281-287.
24. 0. J. Ind. Microbiol. 11:95-103
25. Tomassini, J., H. Selnick, M. E. Davies, M. E. Armstrong, J. Baldwin, M. Bourgeois, J. Hastings, D. Hazuda, J. Lewis, W. McClements, G. Ponticello, E. Radzilowski, G. Smith, A. Tebben, and A. Wolfe. 1994 Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. Antimicrob. Agents Chemother. 38: 2827-2837.
26. Ulmanen, I., B. A. Broni, and R. M. Krug. 1981 Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription. Proc. Natl. Acad. Sci. USA 78: 7355-7359.
27. Yamashita, M., M. Krystal, and P. Palese. 1989 Comparison of the three large polymerase proteins of influenza A, B, and C viruses. Virology 171: 458-466.