Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus

Antiviral Research

Volumn 94, Issue 1, 2012, Pages 35-43

  Meneghesso, Silvia ^a   Vanderlinden, Evelien ^b   Stevaert, Annelies ^b   McGuigan, Christopher ^a   Balzarini, Jan ^b   Naesens, Lieve ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Carboxypeptidase Y; ProTide; RNA polymerase; Uridine based nucleoside analogues

Indexed keywords

1 NAPHTHYL(BENZOXY LEVO ALANINYL)PHOSPHOROCHLORIDATE; 2' DEOXY 2' FLUOROURIDINE 5' O NAPHTHYL(BENZOXY LEVO ALANINYL)PHOSPHATE; 2',3' O,O CYCLOPENTYLIDENE 5 BROMOURIDINE 5' O NAPHTHYL(BENZOXY LEVO ALANINYL)PHOSPHATE; 2',3' O,O CYCLOPENTYLIDENE 5 IODOURIDINE 5' O NAPHTHYL(BENZOXY LEVO ALANINYL)PHOSPHATE; 5 BROMO 2' DEOXYURIDINE 5' O PHENYL(BENZOXY LEVO ALANINYL)PHOSPHATE; 5 BROMOURIDINE 5' O NAPHTHYL(BENZOXY LEVO ALANINYL)PHOSPHATE; 5 IODOURIDINE 5' O NAPHTHYL(BENZOXY LEVO ALANINYL)PHOSPHATE; 5 METHYL URIDINE 5' O NAPHTHYL(BENZOXY LEVO ALANINYL)PHOSPHATE; CARBOXYPEPTIDASE C; PHENYL(BENZOXY LEVO ALANINYL)PHOSPHOROCHLORIDATE; PRODRUG; PYRIMIDINE NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CELL LYSATE; CELL METABOLISM; CELL STRAIN; CHEMICAL REACTION; DRUG SYNTHESIS; IC 50; INFLUENZA VIRUS; LIMIT OF DETECTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DNA-DIRECTED RNA POLYMERASES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INFLUENZA, HUMAN; ORTHOMYXOVIRIDAE; PRODRUGS; PYRIMIDINE NUCLEOSIDES; VIRAL PROTEINS;

ORTHOMYXOVIRIDAE;

EID: 84857988723     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2012.01.007     Document Type: Article

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