Decorin inhibits angiogenic potential of choroid-retinal endothelial cells by downregulating hypoxia-induced Met, Rac1, HIF-1α and VEGF expression in cocultured retinal pigment epithelial cells

Experimental Eye Research

Volumn 116, Issue , 2013, Pages 151-160

  Du, Shanshan ^a   Wang, Shuai ^a   Wu, Qiang ^a   Hu, Jianyan ^a   Li, Tingting ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Choroidal neovascularization; Decorin; Hypoxia; Met; Retinal pigment epithelial cells; Vascular endothelial growth factor

Indexed keywords

ANGIOGENESIS INHIBITOR; CHOLECYSTOKININ OCTAPEPTIDE; DECORIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LENTIVIRUS VECTOR; RAC1 PROTEIN; SCATTER FACTOR RECEPTOR; SMALL INTERFERING RNA; VASCULOTROPIN;

ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL ASSAY; CELL COUNT; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CHOROID RETINAL ENDOTHELIAL CELL; COCULTURE; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RECOMBINANT PLASMID; RHESUS MONKEY; RNA INTERFERENCE; UPREGULATION; WESTERN BLOTTING;

CHOROIDAL NEOVASCULARIZATION; DECORIN; HYPOXIA; MET; RETINAL PIGMENT EPITHELIAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

ANOXIA; BLOTTING, WESTERN; CELLS, CULTURED; CHOROID; CHOROIDAL NEOVASCULARIZATION; DECORIN; DOWN-REGULATION; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; PROTO-ONCOGENE PROTEINS C-MET; RAC1 GTP-BINDING PROTEIN; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL PIGMENT EPITHELIUM; RNA; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84884397754     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2013.08.019     Document Type: Article

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