Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1

Experimental Eye Research

Volumn 84, Issue 4, 2007, Pages 737-744

  Peterson, Lynda J ^a   Wittchen, Erika S ^b   Geisen, Pete ^a   Burridge, Keith ^b   Hartnett, M Elizabeth ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

age related macular degeneration; cell migration; choroidal endothelial cell; endothelial; GTPase signaling; PI 3 kinase; Rac1

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; RAC1 PROTEIN;

ARTICLE; CELL INTERACTION; CELL MIGRATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENETIC LINKAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR MODEL; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL MOVEMENT; CELLS, CULTURED; CHOROID; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; EYE PROTEINS; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT AGENTS; MACULAR DEGENERATION; PIGMENT EPITHELIUM OF EYE; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 33947189597     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2006.12.012     Document Type: Article

References (42)

1. Ackah E., Yu J., Zoellner S., Iwakiri Y., Skurk C., Shibata R., Ouchi N., Easton R.M., Galasso G., Birnbaum M.J., Walsh K., and Sessa W.C. Akt1/protein kinase B{alpha} is critical for ischemic and VEGF-mediated angiogenesis. J. Clin. Investig. 115 (2005) 2119-2127
2. Arefieva T.I., Kuktina N.B., Antonova O.A., and Krasnikova T.L. MCP-1 stimulated chemotaxis of monocytic and endothelial cells is dependent on activation of different signaling cascades. Cytokine (2005) 439-446
3. Burridge K., and Wennerberg K. Rho and Rac take center stage. Cell 116 (2004) 167-179
4. Cheng H.L., Steinway M.L., Russell J.W., and Feldman E.L. GTPases and phosphatidylinositol 3-kinase are critical for insulin-like growth factor-1-mediated Schwann cell motility. J. Biol. Chem. 275 (2000) 27197-27204
5. Cho S.Y., and Klemke R.L. Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J. Cell Biol. 156 (2002) 725-736
6. Chopdar A., Chakravarth U., and Verma D. Age related macular degeneration. BMJ 326 (2003) 485-488
7. Datta S.R., Burnet A., and Greenberg M.E. Cellular survival: a play in three Akts. Genes Dev. 13 (1999) 2905-2927
8. Friedlander M., Theesfeld C.L., Sugita M., Fruttiger M., Thomas M.A., Chang S., and Cheresh D.A. Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 9764-9769
9. Garcia C.M., Darland D.C., Massingham L.J., and D'Amore P.A. Endothelial cell-astrocyte interactions and TGF beta are required for induction of blood-neural barrier properties. Brain Res. Dev. Brain Res. 152 (2004) 25-38
10. Gardiner E.M., Pestonjamasp K.N., Bohl B.P., Chamberlain C., Hahn K.M., and Bokoch G.M. Spatial and temporal Rac activation during live neutrophil chemotaxis. Curr. Biol. 12 (2002) 2029-2034
11. Geisen P., McColm J.R., and Hartnett M.E. Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor. Exp. Eye Res. 82 (2006) 608-619
12. Geisen P., McColm J.R., King B.M., and Hartnett M.E. Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture. Curr. Eye Res. 31 9 (2006) 739-748
13. Gille H., Kowalski J., Yu L., Chen H., Pisabarro M.T., Davis-Smyth T., and Ferrara N. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3-kinase activation and endothelial cell migration. EMBO J. 19 (2000) 4064-4073
14. Gonzalez E., Kou R., and Michel T. Rac1 Modulates Sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. J. Biol. Chem. 281 (2006) 3210-3216
15. Hartnett M.E., Lappas A., Darland D., McColm J.R., Lovejoy S., and D'Amore P.A. Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism. Exp. Eye Res. 77 (2003) 593-599
16. Hemmings B.A. Akt signaling: linking membrane events to life and death decisions. Science 275 (1997) 628-630
17. Hooshmand-Rad R., Claesson-Wesh L., Wennstrom S., Yokoto K., Siegbahn A., and Heldin C.H. Involvement of phosphatidyliositide 3′-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis. Exp. Cell Res. 234 (1997) 434-441
18. Isakson B.E., and Duling B.R. Heterocellular contact at the myoendothelial junction influences gap junction organization. Circ. Res. 97 (2005) 44-51
19. Kotani K., Hara K., Kotani K., Yonezawa K., and Kasuga M. Phosphoinositide 3-kinase as an upstream regulator of the small GTP-binding protein Rac in the insulin signaling of membrane ruffling. Biochem. Biophys. Res. Commun. 208 (1995) 985-990
20. Kotani K., Yonezawa K., Hara K., Ueda H., Kitamura Y., Sakaue H., Ando A., Chavanieu A., Calas B., Grigorescu F., et al. Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induce membrane ruffling. EMBO J. 13 (1994) 2313-2321
21. Kulkarni A.D., and Kupperman B.D. Wet age-related macular degeneration. Adv. Drug Deliv. Rev. 57 (2005) 1994-2009
22. Lauffenburger D.A., and Horwitz A.F. Cell migration: a physically integrated molecular process. Cell 84 (1996) 359-369
23. Lee H.T., and Kay E.P. FGF-2 induced reorganization and disruption of actin cytoskeleton through PI 3-kinase, Rho, and Cdc42 in corneal endothelial cells. Mol. Vis. 9 (2003) 624-634
24. Liu B.P., and Burridge K. Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. Mol. Cell. Biol. 20 (2000) 7160-7169
25. Montiel M., de la Blanca E.P., and Jimenez E. Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 327 (2005) 971-978
26. Nobes C., and Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81 (1995) 53-62
27. Posern G., Saffrich R., Ansorge W., and Feller S.M. Rapid lamellipodia formation in nerve growth factor-stimulated PC12 cells is dependent on Rac and PI3K activity. J. Cell. Physiol. 83 (2000) 416-424
28. Reif K., Nobes C.D., Thomas J., Hall A., and Cantrell D.A. Phosphatidylinositide 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6 (1996) 1445-1455
29. Resnikoff S., Pascolini D., Etya'ale D., Kocur I., Ramachandra P., Pokharei G.P., and Mariotti S.P. Global data on visual impairment in the year 2002. Bull. World Health Organ. 82 (2004) 844-851
30. Sakamoto T., Sakamoto H., Murphy T.L., Spee C., Soriano D., Ishibashi T., Hinton D.R., and Ryan S.J. Vessel formation by choroidal endothelial cells in vitro is modulated by retinal pigment epithelial cells. Arch. Ophthalmol. 113 (1995) 512-520
31. Sato Y., Okada F., Abe M., Seguchi T., Kuwano M., Sat S., Furuya A., Hanai N., and Tamaoki T. The mechanism for the activation of latent TGF-beta during coculture of endothelial cells and smooth muscle cells: cell-type specific targeting of latent TGF-beta to smooth muscle cells. J. Cell Biol. 123 (1993) 1249-1254
32. Sato Y., and Rifkin D.B. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during coculture. J. Cell Biol. 109 (1989) 309-315
33. Saunders K.B., and D'Amore P.A. An in vitro model for cell-cell interactions. In Vitro Cell. Dev. Biol. Anim. 28A (1992) 521-528
34. Sheetz M.P., Flesenfeld D., Galbraith C.G., and Choquet D. Cell migration as a five-step cycle. Biochem. Soc. Symp. 65 (1999) 233-263
35. Srinivasan S., Wang F., Galvas S., Ott A., Hofmann F., Aktories K., Kalman D., and Bourne H.R. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J. Cell Biol. 160 (2003) 375-385
36. Steinle J.J., and Granger H.J. Nerve growth factor regulates human choroidal, but not retinal, endothelial cell migration and proliferation. Auton. Neurosci. 108 (2003) 57-62
37. Steinle J.J., Zamora D.O., Rosenbaum J.T., and Granger H.J. [beta]3-Adrenergic receptors mediate choroidal endothelial cell invasion, proliferation, and cell elongation. Exp. Eye Res. 80 (2005) 83-91
38. Stevens T.S., Bressler N.M., Maguire M.G., Bressler S.B., Fine S.L., Alexander J., Phillips D.A., Margherio R.R., Muphy P.L., and Schachat A.P. Occult choroidal neovascularization in age-related macular degeneration: a natural history study. Arch. Ophthalmol. 115 (1997) 345-350
39. Vlahos C.J., Matter W.F., Hui K.Y., and Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269 (1994) 5241-5248
40. Wang F., Herzmark P., Weiner O.D., Srinicasan S., Servant G., and Bourne H.R. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat. Cell Biol. 4 (2002) 513-518
41. Weiner O.D., Neilsen P.O., Prestwich G.D., Kirshner M.W., Cantley L.C., and Bourne H.R. A Ptd lnsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat. Cell Biol. 4 (2002) E171-E172
42. Wennerberg K., Ellerbroek S.M., Liu R.Y., Karnoub A.E., Burridge K., and Der C.J. RhoG signals in parallel with Rac1 and Cdc42. J. Biol. Chem. 277 (2002) 47810-47817