Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degeneration

American Journal of Ophthalmology

Volumn 129, Issue 2, 2000, Pages 205-214

  Russell, Stephen R ^a   Mullins, Robert F ^a   Schneider, Bobbie L ^a   Hageman, Gregory S ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLUTININ; AMYLOID P COMPONENT; APOLIPOPROTEIN E; COLLAGEN TYPE 4; COMPLEMENT COMPONENT C5; FIBRINOGEN; HLA DR ANTIGEN; LAMININ; MEMBRANE PROTEIN; PREALBUMIN; PROTEOHEPARAN SULFATE; VITRONECTIN;

AGING; ARTICLE; CELL ULTRASTRUCTURE; CLINICAL ARTICLE; DRUSEN; ELECTRON MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PHENOTYPE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RETINA MACULA AGE RELATED DEGENERATION;

AGING; BIOLOGICAL MARKERS; BRUCH MEMBRANE; EYE PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLYCOCONJUGATES; HUMANS; IMMUNOENZYME TECHNIQUES; MACULAR DEGENERATION; PIGMENT EPITHELIUM OF EYE; RETINAL DRUSEN;

EID: 0033968180     PISSN: 00029394     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9394(99)00345-1     Document Type: Article

References (18)

1. Gass J.D.M. Stereoscopic atlas of macular diseases diagnosis and treatment. (2nd ed):1977;Mosby, St Louis.
2. Gass J.D.M., Jallow S., Davis B. Adult vitelliform macular detachment occurring in patients with basal laminar drusen. Am J Ophthalmol. 99:1985;445-459.
3. Kenyon K.R., Maumenee A.E., Ryan S.J., Whitmore P.V., Green W.R. Diffuse drusen and associated complications. Am J Ophthalmol. 100:1985;119-128.
4. Farkas T.G., Krill A.E., Sylvester V.M., Archer D. Familial and secondary drusen histologic and functional correlations. Trans Am Acad Ophthalmol Otolaryngol. 75:1971;333-343.
5. Sarks S.H., Arnold J.J., Killingsworth M.C., Sarks J.P. Early drusen formation in the normal and aging eye and their relation to age related maculopathy a clinicopathological study. Br J Ophthalmol. 83:1999;358-368.
6. Lerche W. Pigmentepithelieländerungen bei Drusen im Maculaberiech. Ber Dtch Ophthalmol Ges. 73:1973;439-446.
7. Gass J.D.M. Stereoscopic atlas of macular diseases diagnosis and treatment. (4th ed):1997;Mosby, St Louis.
8. Cohen S.Y., Meunier I., Soubrane G., Glacet-Bernard A., Coscas G.J. Visual function and course of basal laminar drusen combined with vitelliform macular detachment. Br J of Ophthalmol. 78:1994;437-440.
9. Holz F.G., Owens S.L., Marks J., Haimovici R., Bird A.C. Ultrastructural findings in autosomal dominant drusen. Arch Ophthalmol. 115:1997;788-792.
10. Pauleikhoff D., Zuels S., Sheraidah G.S., Marshall J., Wessing A., Bird A.C. Correlation between biochemical composition and fluorescein binding of deposits in Bruch’s membrane. Ophthalmology. 99:1992;1548-1553.
11. Hageman G.S., Mullins R.F., Russell S.R., Johnson L.V., Anderson D.H. Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells. FASEB J. 13:1999;477-484.
12. Mullins R.F., Johnson L.V., Anderson D.H., Hageman G.S. Characterization of drusen-associated glycoconjugates. Ophthalmology. 104:1997;288-294.
13. Mullins RF, Russell SR, Anderson DH, Hageman GS. Drusen associated with aging and age-related macular degeneration contain molecular constituents common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. Forthcoming.
14. Hageman G.S., Mullins R.F. Molecular composition of drusen as related to substructural phenotype. Molecular Vision. 5:1999;28.
15. Mullins R.F., Hageman G.S. Histochemical comparison of ocular "drusen" in monkey and human. LaVail M., Hollyfield J.C., Anderson R.E. Degenerative retinal diseases. 1997;1-10 Plenum Press, New York.
16. Mullins R.F., Hageman G.S. Human ocular drusen possess novel core domains with a distinct carbohydrate composition. J Histochem Cytochem. 47:1999;1533-1539.
17. Curcio C.A., Millican C.L. Basal linear deposits and large drusen are specific for early age-related maculopathy. Arch Ophthalmol. 117:1999;329-339.
18. Evans K., Gregory C.Y., Wijesuriya S.D., et al. Assessment of the phenotypic range seen in Doyne honeycomb retinal dystrophy. Arch Ophthalmol. 115:1997;904-910.