Lengthening the intersubunit linker of procaspase 3 leads to constitutive activation

Biochemistry

Volumn 52, Issue 36, 2013, Pages 6219-6231

  MacKenzie, Sarah H ^a   Schipper, Joshua L ^a   England, Erika J ^a   Thomas III, Melvin E ^a   Blackburn, Kevin ^a   Swartz, Paul ^a   Clark, A Clay ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE SITES; CONFORMATIONAL ENSEMBLE; CONSTITUTIVELY ACTIVES; DIMER INTERFACE; HYDROPHOBIC CLUSTERS; INCREASED FLEXIBILITY; SPECIFIC CONTACT; SUBSTANTIAL ENERGY;

AMINO ACIDS; CELL DEATH; INDUSTRIAL PLANTS; MASS SPECTROMETRY;

PROTEINS;

ALANINE; PROCASPASE 3;

APOPTOSIS; ARTICLE; CHEMICAL INTERACTION; ENZYME ACTIVATION; ENZYME ACTIVITY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REGULATORY MECHANISM; WESTERN BLOTTING;

APOPTOSIS; CASPASE 3; CASPASE INHIBITORS; CATALYTIC DOMAIN; ENZYME ACTIVATION; ENZYME PRECURSORS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION;

EID: 84884276799     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400793s     Document Type: Article

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