DNA adducts of the tobacco carcinogens 2-amino-9 H -pyrido[2,3- b ]indole and 4-aminobiphenyl are formed at environmental exposure levels and persist in human hepatocytes

Chemical Research in Toxicology

Volumn 26, Issue 9, 2013, Pages 1367-1377

  Nauwelaërs, Gwendoline ^a,b   Bellamri, Medjda ^a,b   Fessard, Valérie ^b   Turesky, Robert J ^c,d   Langouët, Sophie ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b Unit of Contaminants Toxicology ANSES Laboratory of Fougères   (France)

^c WADSWORTH CENTER   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; 2 AMINO ALPHA CARBOLINE; 4 BIPHENYLAMINE; AROMATIC AMINE; CARCINOGEN; CELL ENZYME; CYTOCHROME P450 1A2; FURAFYLLINE; TOBACCO SMOKE; UNCLASSIFIED DRUG; 2-AMINO-9H-PYRIDO(2,3-B)INDOLE; 4-BIPHENYLAMINE; AMINOBIPHENYL DERIVATIVE; CARBOLINE DERIVATIVE; CYTOCHROME P450 1A2 INHIBITOR; DNA ADDUCT;

ARTICLE; CELL CULTURE; CELL ISOLATION; CHEMICAL STRUCTURE; COMBUSTION; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; HUMAN; HUMAN CELL; KINETICS; LIVER CANCER; LIVER CELL; SMOKING; TOBACCO; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

NICOTIANA TABACUM; RODENTIA;

AMINOBIPHENYL COMPOUNDS; CARBOLINES; CARCINOGENS; CELLS, CULTURED; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP1A2 INHIBITORS; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; HEPATOCYTES; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TOBACCO;

EID: 84884227087     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx4002226     Document Type: Article

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