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Volumn , Issue , 2010, Pages 217-238

Structure-Function Characteristics of Aromatic Amine-DNA Adducts

Author keywords

Aromatic amine; Carcinogenesis; Conformational motif; DNA adduct; DNA duplex; Nucleotide excision repair

Indexed keywords


EID: 78649295926     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527630110.ch10     Document Type: Chapter
Times cited : (33)

References (92)
  • 1
    • 33947311640 scopus 로고    scopus 로고
    • Aromatic amines in experimental cancer research: tissue-specific effects, an old problem and new solutions
    • Neumann, H.G. (2007) Aromatic amines in experimental cancer research: tissue-specific effects, an old problem and new solutions. Crit. Rev. Toxicol., 37, 211-236.
    • (2007) Crit. Rev. Toxicol. , vol.37 , pp. 211-236
    • Neumann, H.G.1
  • 2
    • 13444273224 scopus 로고    scopus 로고
    • Nature and nurture-lessons from chemical carcinogenesis
    • Luch, A. (2005) Nature and nurture-lessons from chemical carcinogenesis. Nat. Rev. Cancer, 5, 113-125.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 113-125
    • Luch, A.1
  • 3
    • 0033841374 scopus 로고    scopus 로고
    • Mutagenicity of nitroaromatic compounds
    • Purohit, V. and Basu, A.K. (2000) Mutagenicity of nitroaromatic compounds. Chem. Res. Toxicol., 13, 673-692.
    • (2000) Chem. Res. Toxicol. , vol.13 , pp. 673-692
    • Purohit, V.1    Basu, A.K.2
  • 4
    • 0036041273 scopus 로고    scopus 로고
    • Heterocyclic aromatic amine metabolism, DNA adduct formation, mutagenesis, and carcinogenesis
    • Turesky, R.J. (2002) Heterocyclic aromatic amine metabolism, DNA adduct formation, mutagenesis, and carcinogenesis. Drug Metab. Rev., 34, 625-650.
    • (2002) Drug Metab. Rev. , vol.34 , pp. 625-650
    • Turesky, R.J.1
  • 5
    • 0033034183 scopus 로고    scopus 로고
    • DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis
    • Schut, H.A. and Snyderwine, E.G. (1999) DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis. Carcinogenesis, 20, 353-368.
    • (1999) Carcinogenesis , vol.20 , pp. 353-368
    • Schut, H.A.1    Snyderwine, E.G.2
  • 6
    • 0345254979 scopus 로고    scopus 로고
    • An overview of the mechanisms of mutagenesis and carcinogenesis
    • Sarasin, A. (2003) An overview of the mechanisms of mutagenesis and carcinogenesis. Mutat. Res., 544, 99-106.
    • (2003) Mutat. Res. , vol.544 , pp. 99-106
    • Sarasin, A.1
  • 7
    • 0030995727 scopus 로고    scopus 로고
    • Relationship between adduct formation, rates of excision repair and the cytotoxic and mutagenic effects of structurally-related polycyclic aromatic carcinogens
    • McGregor, W.G., Wei, D., Chen, R.H., Maher, V.M., and McCormick, J.J. (1997) Relationship between adduct formation, rates of excision repair and the cytotoxic and mutagenic effects of structurally-related polycyclic aromatic carcinogens. Mutat. Res., 376, 143-152.
    • (1997) Mutat. Res. , vol.376 , pp. 143-152
    • McGregor, W.G.1    Wei, D.2    Chen, R.H.3    Maher, V.M.4    McCormick, J.J.5
  • 8
    • 0037604848 scopus 로고    scopus 로고
    • Aromatic amines and human urinary bladder cancer: exposure sources and epidemiology
    • Takaska, G. (2003) Aromatic amines and human urinary bladder cancer: exposure sources and epidemiology. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev., 21, 29-43.
    • (2003) J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. , vol.21 , pp. 29-43
    • Takaska, G.1
  • 9
    • 0036797382 scopus 로고    scopus 로고
    • 4-Aminobiphenyl is a major etiologi cal agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene
    • Feng, Z., Hu, W., Rom, W.N., Beland, F.A., and Tang, M.S. (2002) 4-Aminobiphenyl is a major etiologi cal agent of human bladder cancer: evidence from its DNA binding spectrum in human p53 gene. Carcinogenesis, 23, 1721-1727.
    • (2002) Carcinogenesis , vol.23 , pp. 1721-1727
    • Feng, Z.1    Hu, W.2    Rom, W.N.3    Beland, F.A.4    Tang, M.S.5
  • 10
    • 0034131114 scopus 로고    scopus 로고
    • Nucleic acid sequence and repair: role of adduct, neighbor bases and enzyme specificity
    • Singer, B. and Hang, B. (2000) Nucleic acid sequence and repair: role of adduct, neighbor bases and enzyme specificity. Carcinogenesis, 21, 1071-1078.
    • (2000) Carcinogenesis , vol.21 , pp. 1071-1078
    • Singer, B.1    Hang, B.2
  • 11
    • 34249946978 scopus 로고    scopus 로고
    • Interplay of replication checkpoints and repair proteins at stalled replication forks
    • Branzei, D. and Foiani, M. (2007) Interplay of replication checkpoints and repair proteins at stalled replication forks. DNA Repair, 6, 994-1003.
    • (2007) DNA Repair , vol.6 , pp. 994-1003
    • Branzei, D.1    Foiani, M.2
  • 12
    • 32644450616 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian global genome nucleotide excision repair
    • Gillet, L.C.J. and Scharer, O.D. (2006) Molecular mechanisms of mammalian global genome nucleotide excision repair. Chem. Rev., 106, 253-276.
    • (2006) Chem. Rev. , vol.106 , pp. 253-276
    • Gillet, L.C.J.1    Scharer, O.D.2
  • 13
    • 10044226288 scopus 로고    scopus 로고
    • Nucleotide excision repair in E. coli and man
    • Sancar, A. and Reardon, J.T. (2004) Nucleotide excision repair in E. coli and man. Adv. Protein Chem., 69, 43-71.
    • (2004) Adv. Protein Chem. , vol.69 , pp. 43-71
    • Sancar, A.1    Reardon, J.T.2
  • 14
    • 19444383801 scopus 로고    scopus 로고
    • Trading places: how do DNA polymerases switch during translesion DNA synthesis?
    • Friedberg, E.C., Lehmann, A.R., and Fuchs, R.P. (2005) Trading places: how do DNA polymerases switch during translesion DNA synthesis? Mol. Cell, 18, 11205-11215.
    • (2005) Mol. Cell , vol.18 , pp. 11205-11215
    • Friedberg, E.C.1    Lehmann, A.R.2    Fuchs, R.P.3
  • 16
    • 49449091485 scopus 로고    scopus 로고
    • DNA polymerases as therapeutic targets
    • Berdis, A.J. (2008) DNA polymerases as therapeutic targets. Biochemistry, 47, 8253-8260.
    • (2008) Biochemistry , vol.47 , pp. 8253-8260
    • Berdis, A.J.1
  • 17
    • 47849098199 scopus 로고    scopus 로고
    • Mutat. Res.
    • Use of DNA adducts to identify human health risk from exposure to hazardous environmental pollutants: the increasing role of mass spectrometry in assessing biologically effective doses of genotoxic carcinogens
    • Farmer, P.B. and Singh, R. (2008) Use of DNA adducts to identify human health risk from exposure to hazardous environmental pollutants: the increasing role of mass spectrometry in assessing biologically effective doses of genotoxic carcinogens. Mutat. Res., 659, 68-76.
    • (2008) , vol.659 , pp. 68-76
    • Farmer, P.B.1    Singh, R.2
  • 18
    • 0000037422 scopus 로고
    • in Handbook of Experimental Pharmacology (eds C.S. Cooper and P.L. Grover), Springer, Heidelberg
    • Beland, F.A. and Kadlubar, F.F. (1990) in Handbook of Experimental Pharmacology (eds C.S. Cooper and P.L. Grover), Springer, Heidelberg, pp. 267-325.
    • (1990) , pp. 267-325
    • Beland, F.A.1    Kadlubar, F.F.2
  • 19
    • 0027975141 scopus 로고
    • Mutations induced by aromatic amine DNA adducts in pBR322
    • Melchior, W.B., Jr., Marques, M.M., and Beland, F.A. (1994) Mutations induced by aromatic amine DNA adducts in pBR322. C arcinogenesis, 15, 889-899.
    • (1994) C arcinogenesis , vol.15 , pp. 889-899
    • Melchior Jr, W.B.1    Marques, M.M.2    Beland, F.A.3
  • 20
    • 0027935994 scopus 로고
    • Genetic toxicity of 2-acetylaminofl uorene, 2-aminofl uorene and some of their metabolites and model metabolites
    • Heflich, R.H. and Neft, R.E. (1994) Genetic toxicity of 2-acetylaminofl uorene, 2-aminofl uorene and some of their metabolites and model metabolites. Mutat. Res., 318, 73-114.
    • (1994) Mutat. Res. , vol.318 , pp. 73-114
    • Heflich, R.H.1    Neft, R.E.2
  • 21
    • 0028946536 scopus 로고
    • DNA adducts of chemical carcinogens
    • Dipple, A. (1995) DNA adducts of chemical carcinogens. Carcinogenesis, 16, 437-441.
    • (1995) Carcinogenesis , vol.16 , pp. 437-441
    • Dipple, A.1
  • 22
    • 0031041812 scopus 로고    scopus 로고
    • NMR solution structures of stereoisometric covalent polycyclicaromatic carcinogen-DNA adduct: principles, patterns, and diversity
    • Geacintov, N.E., Cosman, M., Hingerty, B.E., Amin, S., Broyde, S., and Patel, D.J. (1997) NMR solution structures of stereoisometric covalent polycyclicaromatic carcinogen-DNA adduct: principles, patterns, and diversity. Chem. Res. Toxicol., 10, 111-146.
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 111-146
    • Geacintov, N.E.1    Cosman, M.2    Hingerty, B.E.3    Amin, S.4    Broyde, S.5    Patel, D.J.6
  • 23
    • 0031910204 scopus 로고
    • DNA adduct formation by polycyclic aromatic hydrocarbon dihydrodiol epoxides
    • Szeliga, J. and Dipple, A. (1995) DNA adduct formation by polycyclic aromatic hydrocarbon dihydrodiol epoxides. Chem. Res. Toxicol., 11, 1-11.
    • (1995) Chem. Res. Toxicol. , vol.11 , pp. 1-11
    • Szeliga, J.1    Dipple, A.2
  • 24
    • 33644634327 scopus 로고    scopus 로고
    • Interactions of carcinogen-bound DNA with individual DNA polymerases
    • Guengerich, F.P. (2006) Interactions of carcinogen-bound DNA with individual DNA polymerases. Chem. Rev., 106, 420-452.
    • (2006) Chem. Rev. , vol.106 , pp. 420-452
    • Guengerich, F.P.1
  • 25
    • 0001207626 scopus 로고
    • Covalent carcinogenic guanine-modified DNA lesions solution structures of adducts and crosslinks
    • Patel, D.J. (1992) Covalent carcinogenic guanine-modified DNA lesions solution structures of adducts and crosslinks. Curr. Opin. Struct. Biol., 2, 345-353.
    • (1992) Curr. Opin. Struct. Biol. , vol.2 , pp. 345-353
    • Patel, D.J.1
  • 26
    • 0031800438 scopus 로고    scopus 로고
    • Nuclear magnetic resonance solution structures of covalent aromatic amine-DNA adducts and their mutagenic relevance
    • Patel, D.J., Mao, B., Gu, Z., Hingerty, B.E., Gorin, A., Basu, A.K., and Broyde, S. (1998) Nuclear magnetic resonance solution structures of covalent aromatic amine-DNA adducts and their mutagenic relevance. Chem. Res. Toxicol., 11, 391-407.
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 391-407
    • Patel, D.J.1    Mao, B.2    Gu, Z.3    Hingerty, B.E.4    Gorin, A.5    Basu, A.K.6    Broyde, S.7
  • 27
    • 9644265249 scopus 로고    scopus 로고
    • Dynamic conformational heterogeneities of carcinogen-DNA adducts and their mutagenic relevance
    • Cho, B.P. (2004) Dynamic conformational heterogeneities of carcinogen-DNA adducts and their mutagenic relevance. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev., 22, 57-90.
    • (2004) J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. , vol.22 , pp. 57-90
    • Cho, B.P.1
  • 28
    • 33644626078 scopus 로고    scopus 로고
    • NMR structures of damaged DNA
    • Lukin, M. and De Los Santos, C. (2006) NMR structures of damaged DNA. Chem. Rev., 106, 607-686.
    • (2006) Chem. Rev. , vol.106 , pp. 607-686
    • Lukin, M.1    De Los, S.C.2
  • 29
    • 9644276853 scopus 로고    scopus 로고
    • Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase
    • Hsu, G.W., Kiefer, J.R., Burnouf, D., Becherel, O.J., Fuchs, R.P., and Beese, L.S. (2004) Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase. J. Biol. Chem., 279, 50280-50285.
    • (2004) J. Biol. Chem. , vol.279 , pp. 50280-50285
    • Hsu, G.W.1    Kiefer, J.R.2    Burnouf, D.3    Becherel, O.J.4    Fuchs, R.P.5    Beese, L.S.6
  • 30
    • 9244229513 scopus 로고    scopus 로고
    • Crystal structures of 2-acetylaminofl uorene and 2-aminofl uorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis
    • Dutta, S., Li, Y., Johnson, D., Dzantiev, J., Richardson, C.C., Romano, L.J., and Ellenberger, T. (2004) Crystal structures of 2-acetylaminofl uorene and 2-aminofl uorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis. Proc. Natl. Acad. Sci. USA, 101, 16186-16191.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16186-16191
    • Dutta, S.1    Li, Y.2    Johnson, D.3    Dzantiev, J.4    Richardson, C.C.5    Romano, L.J.6    Ellenberger, T.7
  • 31
    • 0026795019 scopus 로고
    • NMR structural studies of a 15-mer DNA sequence from a ras protooncogene, modified at the first base of codon 61 with the carcinogen 4-aminobiphenyl
    • Cho, B.P., Beland, F.A., and Marques, M.M. (1992) NMR structural studies of a 15-mer DNA sequence from a ras protooncogene, modified at the first base of codon 61 with the carcinogen 4-aminobiphenyl. Biochemistry, 31, 9587-9602.
    • (1992) Biochemistry , vol.31 , pp. 9587-9602
    • Cho, B.P.1    Beland, F.A.2    Marques, M.M.3
  • 32
    • 0029817865 scopus 로고    scopus 로고
    • Solution conformation of the N-(deoxyguanosin-8-yl)-1-aminopyrene ([AP]dG) adduct opposite dC in a DNA duplex
    • Mao, B., Vyas, R.R., Hingerty, B.E., Broyde, S., Basu, A.K., and Patel, D.J. (1996) Solution conformation of the N-(deoxyguanosin-8-yl)-1-aminopyrene ([AP]dG) adduct opposite dC in a DNA duplex. Biochemistry, 35, 12659-12670.
    • (1996) Biochemistry , vol.35 , pp. 12659-12670
    • Mao, B.1    Vyas, R.R.2    Hingerty, B.E.3    Broyde, S.4    Basu, A.K.5    Patel, D.J.6
  • 33
    • 33745318167 scopus 로고    scopus 로고
    • Structure and stability of duplex DNA containing the 3-(deoxyguanosin-N 2-yl)-2-acetylaminofl uorene (dG(N 2)-AAF) lesion: a bulky adduct that persists in cellular DNA
    • Zaliznyak, T., Bonala, R., Johnson, F., and de los Santos, C. (2006) Structure and stability of duplex DNA containing the 3-(deoxyguanosin-N 2-yl)-2-acetylaminofl uorene (dG(N 2)-AAF) lesion: a bulky adduct that persists in cellular DNA. Chem. Res. Toxicol., 19, 745-752.
    • (2006) Chem. Res. Toxicol. , vol.19 , pp. 745-752
    • Zaliznyak, T.1    Bonala, R.2    Johnson, F.3    De Los, S.C.4
  • 34
    • 33746874095 scopus 로고    scopus 로고
    • Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f ]-quinoline in the recognition sequence of the Nar I restriction enzyme, a hotspot for-2 bp deletions
    • Wang, F., DeMuro, N.E., Elmquist, C.E., Stover, J.S., Rizzo, C.J., and Stone, M.P. (2006) Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f ]-quinoline in the recognition sequence of the Nar I restriction enzyme, a hotspot for-2 bp deletions. J. Am. Chem. Soc., 128, 10085-10095.
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 10085-10095
    • Wang, F.1    DeMuro, N.E.2    Elmquist, C.E.3    Stover, J.S.4    Rizzo, C.J.5    Stone, M.P.6
  • 35
    • 34047251295 scopus 로고    scopus 로고
    • Conformational differences of the C8-deoxyguanosine adduct of 2-amino-3-methylimidazo[4,5-f ]quinoline (IQ) within the Nar I recognition sequence
    • Elmquist, C.E., Wang, F., Stover, J.S., Stone, M.P., and Rizzo, C.J. (2007) Conformational differences of the C8-deoxyguanosine adduct of 2-amino-3-methylimidazo[4,5-f ]quinoline (IQ) within the Nar I recognition sequence. Chem. Res. Toxicol., 20, 445-454.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 445-454
    • Elmquist, C.E.1    Wang, F.2    Stover, J.S.3    Stone, M.P.4    Rizzo, C.J.5
  • 36
    • 34547092924 scopus 로고    scopus 로고
    • DNA sequence modulates the confor mation of the food mutagen 2-amino-3- methylimidazo[4,5-f ]quinoline in the recognition sequence of the Nar I restriction enzyme
    • Wang, F., Elmquist, C.E., Stover, J.S., Rizzo, C.J., and Stone, M.P. (2007) DNA sequence modulates the confor mation of the food mutagen 2-amino-3- methylimidazo[4,5-f ]quinoline in the recognition sequence of the Nar I restriction enzyme. Biochemistry, 46, 8498-8516.
    • (2007) Biochemistry , vol.46 , pp. 8498-8516
    • Wang, F.1    Elmquist, C.E.2    Stover, J.S.3    Rizzo, C.J.4    Stone, M.P.5
  • 37
    • 0039547559 scopus 로고
    • Single adduct mutagenesis: strong effect of the position of a single acetylaminofl uorene adduct within a mutation hot spot
    • Burnouf, D., Koehl, P., and Fuchs, R.P.P. (1989) Single adduct mutagenesis: strong effect of the position of a single acetylaminofl uorene adduct within a mutation hot spot. Proc. Natl. Acad. Sci. USA, 86, 4147-4151.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 4147-4151
    • Burnouf, D.1    Koehl, P.2    Fuchs, R.P.P.3
  • 38
    • 34249942974 scopus 로고    scopus 로고
    • Translesion synthesis in Escherichia coli : lessons from the Nar I mutation hot spot. DNA Repair
    • Amst.
    • Fuchs, R.P.P. and Fujii, S. (2007) Translesion synthesis in Escherichia coli : lessons from the Nar I mutation hot spot. DNA Repair (Amst.), 6, 1032-1041.
    • (2007) , vol.6 , pp. 1032-1041
    • Fuchs, R.P.P.1    Fujii, S.2
  • 39
    • 0024428898 scopus 로고
    • NMR and com putational characterization of the N-(deoxyguanosin-8-yl)aminofl uorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[ syn ] · A[ anti ] pair formation and its pH dependence
    • Norman, D., Abuaf, P., Hingerty, B.E., Live, D., Grunberger, D., Broyde, S., and Patel, D.J. (1989) NMR and com putational characterization of the N-(deoxyguanosin-8-yl)aminofl uorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[ syn ] · A[ anti ] pair formation and its pH dependence. Biochemistry, 28, 7462-7476.
    • (1989) Biochemistry , vol.28 , pp. 7462-7476
    • Norman, D.1    Abuaf, P.2    Hingerty, B.E.3    Live, D.4    Grunberger, D.5    Broyde, S.6    Patel, D.J.7
  • 40
    • 0035957238 scopus 로고    scopus 로고
    • Infl uence of fl anking sequence context on the mutagenicity of acetylaminofl uorene-derived DNA adducts in mammalian cells
    • Shibutani, S., Suzuki, N., Tan, X., Johnson, F., and Grollman, A.P. (2001) Infl uence of fl anking sequence context on the mutagenicity of acetylaminofl uorene-derived DNA adducts in mammalian cells. Biochemistry, 27, 3717-3722.
    • (2001) Biochemistry , vol.27 , pp. 3717-3722
    • Shibutani, S.1    Suzuki, N.2    Tan, X.3    Johnson, F.4    Grollman, A.P.5
  • 41
    • 84888663071 scopus 로고    scopus 로고
    • Enhancing the " A-rule " of tran slesion DNA synthesis: promutagenic DNA synthesis using modified nucleoside triphosphates
    • Devadoss, B., Lee, I., and Berdis, A.J. (2008) Enhancing the " A-rule " of tran slesion DNA synthesis: promutagenic DNA synthesis using modified nucleoside triphosphates. Biochemistry, 47, 8253-8260.
    • (2008) Biochemistry , vol.47 , pp. 8253-8260
    • Devadoss, B.1    Lee, I.2    Berdis, A.J.3
  • 42
    • 0028901297 scopus 로고
    • Chem. Res. Toxicol.
    • Solution conformation of the N-(deoxyguanosin-8-yl)aminofl uorene adduct opposite deoxyinosine and deoxyguanosine in DNA by NMR and computational characterization
    • Abuaf, P., Hingerty, B.E., Broyde, S., and Grunberger, D. (1995) Solution conformation of the N-(deoxyguanosin-8-yl)aminofl uorene adduct opposite deoxyinosine and deoxyguanosine in DNA by NMR and computational characterization. Chem. Res. Toxicol., 8,369-378.
    • (1995) , vol.8 , pp. 369-378
    • Abuaf, P.1    Hingerty, B.E.2    Broyde, S.3    Grunberger, D.4
  • 43
    • 0028323638 scopus 로고
    • NMR structural studies of a 15-mer DNA duplex from a ras protooncogene modified with the carcinogen 2-aminofl uorene: conformational heterogeneity
    • Cho, B.P., Beland, F.A., and Marques, M.M. (1994) NMR structural studies of a 15-mer DNA duplex from a ras protooncogene modified with the carcinogen 2-aminofl uorene: conformational heterogeneity. Biochemistry, 33,1373-1384.
    • (1994) Biochemistry , vol.33 , pp. 1373-1384
    • Cho, B.P.1    Beland, F.A.2    Marques, M.M.3
  • 44
    • 0028382509 scopus 로고
    • 2-Aminofl uorene modified DNA duplex exists in two interchangeable conformations
    • Eckel, L.M. and Krugh, T.R. (1994) 2-Aminofl uorene modified DNA duplex exists in two interchangeable conformations. Nat. Struct. Biol., 1, 89-94.
    • (1994) Nat. Struct. Biol. , vol.1 , pp. 89-94
    • Eckel, L.M.1    Krugh, T.R.2
  • 45
    • 0028033727 scopus 로고
    • Biochemistry
    • Structural characterization of two interchangeable conformations of a 2-aminofl uorene-modified DNA oligomer by NMR and energy minimization
    • Eckel, L.M. and Krugh, T.R. (1994) Structural characterization of two interchangeable conformations of a 2-aminofl uorene-modified DNA oligomer by NMR and energy minimization.Biochemistry, 33, 13611-13624.
    • (1994) , vol.33 , pp. 13611-13624
    • Eckel, L.M.1    Krugh, T.R.2
  • 46
    • 0032488634 scopus 로고    scopus 로고
    • Solution structure of the aminofl uorene [AF]-intercalated conformer of the anti [AF]-C 8-dG adduct opposite dC in a DNA duplex
    • Mao, B., Gu, Z., Hingerty, B.E., Broyde, S., and Patel, D.J. (1998) Solution structure of the aminofl uorene [AF]-intercalated conformer of the anti [AF]-C 8-dG adduct opposite dC in a DNA duplex. Biochemistry, 37, 81-94.
    • (1998) Biochemistry , vol.37 , pp. 81-94
    • Mao, B.1    Gu, Z.2    Hingerty, B.E.3    Broyde, S.4    Patel, D.J.5
  • 47
    • 0032488597 scopus 로고    scopus 로고
    • Biochemistry
    • Solution structure of the aminofl uorene [AF]- external conformer of the anti [AF]-C 8-dG adduct opposite dC in a DNA duplex
    • Mao, B., Gu, Z., Hingerty, B.E., Broyde, S., and Patel, D.J. (1998) Solution structure of the aminofl uorene [AF]- external conformer of the anti [AF]-C 8-dG adduct opposite dC in a DNA duplex.Biochemistry, 37, 95-106.
    • (1998) , vol.37 , pp. 95-106
    • Mao, B.1    Gu, Z.2    Hingerty, B.E.3    Broyde, S.4    Patel, D.J.5
  • 49
    • 0027457947 scopus 로고
    • Structural characterization of an N-acetyl-2-aminofl uorene (AAF) modified DNA oligomer by NMR, energy minimization, and molecular dynamics
    • O'Handley, S.F., Sanford, D.G., Xu, R., Lester, C.C., Hingerty, B.E., Broyde, S., and Krugh, T.R. (1993) Structural characterization of an N-acetyl-2-aminofl uorene (AAF) modified DNA oligomer by NMR, energy minimization, and molecular dynamics. Biochemistry, 32, 2481-2497.
    • (1993) Biochemistry , vol.32 , pp. 2481-2497
    • O'Handley, S.F.1    Sanford, D.G.2    Xu, R.3    Lester, C.C.4    Hingerty, B.E.5    Broyde, S.6    Krugh, T.R.7
  • 50
    • 0028148841 scopus 로고
    • NMR evidence of the stabilisation by the carcinogen N-2-acetylaminofl uorene of a frameshift mutagenesis intermediate
    • Milhe, C., Dhalluin, C., Fuchs, R.P., and Lefevre, J.F. (1994) NMR evidence of the stabilisation by the carcinogen N-2-acetylaminofl uorene of a frameshift mutagenesis intermediate. Nucleic Acids Res., 22, 4646-4652.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4646-4652
    • Milhe, C.1    Dhalluin, C.2    Fuchs, R.P.3    Lefevre, J.F.4
  • 51
    • 0030029120 scopus 로고    scopus 로고
    • NMR data show that the carcinogen N-2-acetylaminofl uorene stabilises an intermediate of-2 frameshift mutagenesis in a region of high mutation frequency
    • Milhe, C., Fuchs, R.P., and Lefevre, J.F. (1996) NMR data show that the carcinogen N-2-acetylaminofl uorene stabilises an intermediate of-2 frameshift mutagenesis in a region of high mutation frequency. Eur. J. Biochem., 235, 120-127.
    • (1996) Eur. J. Biochem. , vol.235 , pp. 120-127
    • Milhe, C.1    Fuchs, R.P.2    Lefevre, J.F.3
  • 52
    • 0033535926 scopus 로고    scopus 로고
    • Probing the conformational heterogeneity of the acetylaminofl uorene-modified 2 ′-Deoxyguanosine and DNA by 19 F NMR spectroscopy
    • Cho, B.P. and Zhou, L. (1999) Probing the conformational heterogeneity of the acetylaminofl uorene-modified 2 ′-Deoxyguanosine and DNA by 19 F NMR spectroscopy. Biochemistry, 38, 7572-7583.
    • (1999) Biochemistry , vol.38 , pp. 7572-7583
    • Cho, B.P.1    Zhou, L.2
  • 53
    • 0028039973 scopus 로고
    • Use of single-turnover kinetics to study bulky adduct bypass by T7 DNA polymerase
    • Lindsley, J.E. and Fuchs, R.P. (1994) Use of single-turnover kinetics to study bulky adduct bypass by T7 DNA polymerase. Biochemistry, 33, 764-772.
    • (1994) Biochemistry , vol.33 , pp. 764-772
    • Lindsley, J.E.1    Fuchs, R.P.2
  • 54
    • 0031923292 scopus 로고    scopus 로고
    • Effect of ring size on conformations of aromatic amine-DNA adducts: the aniline-C8 guanine adduct resides in the B-DNA major groove
    • Shapiro, R., Ellis, S., Hingerty, B.E., and Broyde, S. (1998) Effect of ring size on conformations of aromatic amine-DNA adducts: the aniline-C8 guanine adduct resides in the B-DNA major groove. Chem. Res. Toxicol., 11, 335-341.
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 335-341
    • Shapiro, R.1    Ellis, S.2    Hingerty, B.E.3    Broyde, S.4
  • 55
    • 35048822835 scopus 로고    scopus 로고
    • Spectroscopic and theoretical insights into sequence effects of aminofl uorene-induced conformational heterogeneity and nucleotide excision repair
    • Meneni, S.R., Shell, S.M., Gao, L., Jurecka, P., Lee, W., Sponer, J., Zou, Y., Chiarelli, M.P., and Cho, B.P. (2007) Spectroscopic and theoretical insights into sequence effects of aminofl uorene-induced conformational heterogeneity and nucleotide excision repair. Biochemistry, 46, 11263-11278.
    • (2007) Biochemistry , vol.46 , pp. 11263-11278
    • Meneni, S.R.1    Shell, S.M.2    Gao, L.3    Jurecka, P.4    Lee, W.5    Sponer, J.6    Zou, Y.7    Chiarelli, M.P.8    Cho, B.P.9
  • 56
    • 33846818707 scopus 로고    scopus 로고
    • Examination of the long-range effects of aminofl uorene-induced conformational heterogeneity and its relevance to the mechanisms of translesion DNA synthesis
    • Meneni, S.R., Liang, F., and Cho, B.P. (2007) Examination of the long-range effects of aminofl uorene-induced conformational heterogeneity and its relevance to the mechanisms of translesion DNA synthesis. J. Mol. Biol., 366, 1387-1400.
    • (2007) J. Mol. Biol. , vol.366 , pp. 1387-1400
    • Meneni, S.R.1    Liang, F.2    Cho, B.P.3
  • 57
    • 0030757459 scopus 로고    scopus 로고
    • Conformational heterogeneity of arylamine-modified DNA: 19 F NMR evidence
    • Zhou, L., Rajabzadeh, G., Traficante, D.D., and Cho, B.P. (1997) Conformational heterogeneity of arylamine-modified DNA: 19 F NMR evidence. J. Am. Chem. Soc., 119, 5384-5389.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 5384-5389
    • Zhou, L.1    Rajabzadeh, G.2    Traficante, D.D.3    Cho, B.P.4
  • 58
    • 41649110883 scopus 로고    scopus 로고
    • Fluorescence probing of aminofl uorene- induced conformational heterogeneity in DNA duplexes
    • Jain, N., Reshetnyak, Y.K., Gao, L., Chiarelli, M.P., and Cho, B.P. (2008) Fluorescence probing of aminofl uorene- induced conformational heterogeneity in DNA duplexes. Chem. Res. Toxicol., 21, 445-452.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 445-452
    • Jain, N.1    Reshetnyak, Y.K.2    Gao, L.3    Chiarelli, M.P.4    Cho, B.P.5
  • 59
    • 32644440758 scopus 로고    scopus 로고
    • Sequence effects of aminofl uorene-modified DNA duplexes: thermodynamic and circular dichroism properties
    • Meneni, S.R., D'Mello, R., Norigian, G., Baker, G., Gao, L., Chiarelli, M.P., and Cho, B.P. (2006) Sequence effects of aminofl uorene-modified DNA duplexes: thermodynamic and circular dichroism properties. N ucleic Acids Res., 34, 755-763.
    • (2006) N ucleic Acids Res. , vol.34 , pp. 755-763
    • Meneni, S.R.1    D'Mello, R.2    Norigian, G.3    Baker, G.4    Gao, L.5    Chiarelli, M.P.6    Cho, B.P.7
  • 61
    • 0033804390 scopus 로고    scopus 로고
    • Factors that infl uence the mutagenic patterns of DNA adducts from chemical carcinogens
    • Seo, K.Y., Jelinsky, S.A., and Loechler, E.L. (2000) Factors that infl uence the mutagenic patterns of DNA adducts from chemical carcinogens. Mutat. Res.,463, 215-246.
    • (2000) Mutat. Res. , vol.463 , pp. 215-246
    • Seo, K.Y.1    Jelinsky, S.A.2    Loechler, E.L.3
  • 62
    • 0032512437 scopus 로고    scopus 로고
    • Rate of incision of N-acetyl-2-aminofl uorene and N-2-aminofl uorene adducts by UvrABC nuclease is adduct-and sequence-specific: comparison of the rates of UvrABC nuclease incision and protein-DNA complex formation
    • Mekhovich, O., Tang, M., and Romano, L.J. (1998) Rate of incision of N-acetyl-2-aminofl uorene and N-2-aminofl uorene adducts by UvrABC nuclease is adduct-and sequence-specific: comparison of the rates of UvrABC nuclease incision and protein-DNA complex formation. Biochemistry, 37, 571-579.
    • (1998) Biochemistry , vol.37 , pp. 571-579
    • Mekhovich, O.1    Tang, M.2    Romano, L.J.3
  • 63
    • 0242318377 scopus 로고    scopus 로고
    • Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease
    • Zou, Y., Shell, S.M., Utzat, C.D., Luo, C., Yang, Z., Geacintov, N.E., and Basu, A.K. (2003) Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease. Biochemistry, 42, 12654-12661.
    • (2003) Biochemistry , vol.42 , pp. 12654-12661
    • Zou, Y.1    Shell, S.M.2    Utzat, C.D.3    Luo, C.4    Yang, Z.5    Geacintov, N.E.6    Basu, A.K.7
  • 64
    • 34250177258 scopus 로고    scopus 로고
    • Sequence context-and temperature-dependent nucleotide excision repair of a benzo[ a ] pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins
    • Ruan, Q., Liu, T., Kolbanovskiy, A., Liu, Y., Ren, J., Skovraga, M., Zou, Y., Lader, J., Malkani, B., Amin, S., Van Houten, B., and Geacintov, N.E. (2007) Sequence context-and temperature-dependent nucleotide excision repair of a benzo[ a ] pyrene diol epoxide-guanine DNA adduct catalyzed by thermophilic UvrABC proteins. Biochemistry, 46, 7006-7015.
    • (2007) Biochemistry , vol.46 , pp. 7006-7015
    • Ruan, Q.1    Liu, T.2    Kolbanovskiy, A.3    Liu, Y.4    Ren, J.5    Skovraga, M.6    Zou, Y.7    Lader, J.8    Malkani, B.9    Amin, S.10    Van Houten, B.11    Geacintov, N.E.12
  • 65
    • 33646839960 scopus 로고    scopus 로고
    • Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells
    • Kalam, M.A., Haraguchi, K., Chandani, S., Loechler, E.L., Moriya, M., Greenberg, M.M., and Basu, A.K. (2006) Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells. Nucleic Acids Res., 34, 2305-2315.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 2305-2315
    • Kalam, M.A.1    Haraguchi, K.2    Chandani, S.3    Loechler, E.L.4    Moriya, M.5    Greenberg, M.M.6    Basu, A.K.7
  • 66
    • 23844463175 scopus 로고    scopus 로고
    • Mutagenesis of 8-oxoguanine adjacent to an abasic site in simian kidney cells: tandem mutations and enhancement of G-T transversions
    • Kalam, M.A. and Basu, A.K. (2005) Mutagenesis of 8-oxoguanine adjacent to an abasic site in simian kidney cells: tandem mutations and enhancement of G-T transversions. Chem. Res. Toxicol., 18, 1187-1192.
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 1187-1192
    • Kalam, M.A.1    Basu, A.K.2
  • 68
    • 0032742715 scopus 로고    scopus 로고
    • DNA damage recognition during nucleotide excision repair in mammalian cells
    • Wood, R.D. (1999) DNA damage recognition during nucleotide excision repair in mammalian cells. Biochemistry, 81, 39-44.
    • (1999) Biochemistry , vol.81 , pp. 39-44
    • Wood, R.D.1
  • 69
    • 0141753120 scopus 로고    scopus 로고
    • The comings and goings of nucleotide excision repair factors on damaged DNA
    • Riedl, T., Hanaoka, F., and Egly, J.M. (2003) The comings and goings of nucleotide excision repair factors on damaged DNA. EMBO J., 22, 5293-5303.
    • (2003) EMBO J. , vol.22 , pp. 5293-5303
    • Riedl, T.1    Hanaoka, F.2    Egly, J.M.3
  • 70
    • 34948892722 scopus 로고    scopus 로고
    • Recognition of DNA damage by the Rad4 nucleotide excision repair protein
    • Min, J.H. and Pavletich, N.P. (2007) Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature, 449, 570-575.
    • (2007) Nature , vol.449 , pp. 570-575
    • Min, J.H.1    Pavletich, N.P.2
  • 71
    • 35348954826 scopus 로고    scopus 로고
    • Achieving broad substrate specificity in damage recognition by binding accessible nondamaged DNA
    • Sharer, O.D. (2007) Achieving broad substrate specificity in damage recognition by binding accessible nondamaged DNA. Mol. Cell, 28, 184-186.
    • (2007) Mol. Cell , vol.28 , pp. 184-186
    • Sharer, O.D.1
  • 72
    • 0037027367 scopus 로고    scopus 로고
    • Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery
    • Geacintov, N.E., Broyde, S., Buterin, T., Naegeli, H., Wu, M., Yan, S., and Patel, D.J. (2002) Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery. Biopolymers, 65, 202-210.
    • (2002) Biopolymers , vol.65 , pp. 202-210
    • Geacintov, N.E.1    Broyde, S.2    Buterin, T.3    Naegeli, H.4    Wu, M.5    Yan, S.6    Patel, D.J.7
  • 73
    • 43149102700 scopus 로고    scopus 로고
    • Versatile protection from mutagenic DNA lesions conferred by bipartite recognition in nucleotide excision repair
    • Maillard, O., Camenisch, U., Blagoev, K.B., and Naegeli, H. (2008) Versatile protection from mutagenic DNA lesions conferred by bipartite recognition in nucleotide excision repair. Mutat. Res., 658, 271-286.
    • (2008) Mutat. Res. , vol.658 , pp. 271-286
    • Maillard, O.1    Camenisch, U.2    Blagoev, K.B.3    Naegeli, H.4
  • 74
    • 1842785956 scopus 로고    scopus 로고
    • A model for initial DNA lesion recognition by NER and MMR based on local conformational fl exibility
    • Isaacs, R.J. and Spielmann, H.P. (2004) A model for initial DNA lesion recognition by NER and MMR based on local conformational fl exibility. DNA Repair, 4, 455-464.
    • (2004) DNA Repair , vol.4 , pp. 455-464
    • Isaacs, R.J.1    Spielmann, H.P.2
  • 75
    • 4544242205 scopus 로고    scopus 로고
    • Mechanisms of DNA damage recognition and strand discrimination inhuman nucleotide excision repair
    • Dip, R., Camenisch, U., and Naegeli, H. (2004) Mechanisms of DNA damage recognition and strand discrimination inhuman nucleotide excision repair. DNA Repair, 2, 1409-1423.
    • (2004) DNA Repair , vol.2 , pp. 1409-1423
    • Dip, R.1    Camenisch, U.2    Naegeli, H.3
  • 76
    • 0034029834 scopus 로고    scopus 로고
    • Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots
    • Buterin, T., Hess, M.T., Luneva, N., Geacintov, N.E., Amin, S., Kroth, H., Seidel, A., and Naegeli, H. (2000) Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots. Cancer Res., 60, 1849-1856.
    • (2000) Cancer Res. , vol.60 , pp. 1849-1856
    • Buterin, T.1    Hess, M.T.2    Luneva, N.3    Geacintov, N.E.4    Amin, S.5    Kroth, H.6    Seidel, A.7    Naegeli, H.8
  • 77
    • 63249108233 scopus 로고    scopus 로고
    • Infl uence of fl anking sequence context on the conformational fl exibility of aminofl uorene-modified dG adduct in dA mismatch DNA duplexes
    • Jain, N., Meneni, S., and Cho, B.P. (2009) Infl uence of fl anking sequence context on the conformational fl exibility of aminofl uorene-modified dG adduct in dA mismatch DNA duplexes. Nucleic Acids Res., 37, 1628-1637.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1628-1637
    • Jain, N.1    Meneni, S.2    Cho, B.P.3
  • 78
    • 35548986675 scopus 로고    scopus 로고
    • Dynamics of a benzo[ a ] pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: enhanced mobility in TGT explains conformational heterogeneity, fl exible bending, and greater susceptibility to nucleotide excision repair
    • Cai, Y., Patel, D.J., Geacintov, N.E., and Broyde, S. (2007) Dynamics of a benzo[ a ] pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: enhanced mobility in TGT explains conformational heterogeneity, fl exible bending, and greater susceptibility to nucleotide excision repair. J. Mol. Biol., 374, 292-305.
    • (2007) J. Mol. Biol. , vol.374 , pp. 292-305
    • Cai, Y.1    Patel, D.J.2    Geacintov, N.E.3    Broyde, S.4
  • 79
    • 35048853499 scopus 로고    scopus 로고
    • Probing the thermodynamics of aminofl uorene-induced trans-lesion DNA synthesis by differential scanning calorimetry
    • Liang, F. and Cho, B.P. (2007) Probing the thermodynamics of aminofl uorene-induced trans-lesion DNA synthesis by differential scanning calorimetry. J. Am. Chem. Soc., 129, 12108-12109.
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 12108-12109
    • Liang, F.1    Cho, B.P.2
  • 80
    • 33748668675 scopus 로고    scopus 로고
    • Induced circular dichroism characteristics as conformational probes for carcinogenic aminofl uorene-DNA adducts
    • Liang, F., Meneni, S.R., and Cho, B.P. (2006) Induced circular dichroism characteristics as conformational probes for carcinogenic aminofl uorene-DNA adducts. Chem. Res. Toxicol., 19, 1040-1043.
    • (2006) Chem. Res. Toxicol. , vol.19 , pp. 1040-1043
    • Liang, F.1    Meneni, S.R.2    Cho, B.P.3
  • 81
    • 0030693128 scopus 로고    scopus 로고
    • Kinetics of DNA polymerase I (Klenow fragment exo-) activity on damaged DNA templates: effect of proximal and distal template damage on DNA synthesis
    • Miller, H. and Grollman, A.P. (1997) Kinetics of DNA polymerase I (Klenow fragment exo-) activity on damaged DNA templates: effect of proximal and distal template damage on DNA synthesis. Biochemistry, 36, 15336-15342.
    • (1997) Biochemistry , vol.36 , pp. 15336-15342
    • Miller, H.1    Grollman, A.P.2
  • 83
    • 0032168923 scopus 로고    scopus 로고
    • Mutagenic specificity of (acetylamino)-fl uorene-derived DNA adducts in mammalian cells
    • Shibutani, S., Suzuki, N., and Grollman, A.P. (1998) Mutagenic specificity of (acetylamino)-fl uorene-derived DNA adducts in mammalian cells. Biochemistry, 37, 12034-12041.
    • (1998) Biochemistry , vol.37 , pp. 12034-12041
    • Shibutani, S.1    Suzuki, N.2    Grollman, A.P.3
  • 84
    • 0037015986 scopus 로고    scopus 로고
    • Mutagenic events in Escherichia coli and mamma lian cells generated in response to acetylaminofl uorene-derived DNA adducts positioned in the Nar I restriction enzyme site
    • Tan, X., Suzuki, N., Grollman, A.P., and Shibutani, S. (2002) Mutagenic events in Escherichia coli and mamma lian cells generated in response to acetylaminofl uorene-derived DNA adducts positioned in the Nar I restriction enzyme site. Biochemistry, 41, 14255-14262.
    • (2002) Biochemistry , vol.41 , pp. 14255-14262
    • Tan, X.1    Suzuki, N.2    Grollman, A.P.3    Shibutani, S.4
  • 85
    • 0033597348 scopus 로고    scopus 로고
    • Sequence-dependent modulation of frameshift mutagenesis at the Nar I-derived mutation hot spots
    • Broschard, T.H., Koffel-chwartz, N., and Fuchs, R.P.P. (1999) Sequence-dependent modulation of frameshift mutagenesis at the Nar I-derived mutation hot spots. J. Mol. Biol., 288, 191-199.
    • (1999) J. Mol. Biol. , vol.288 , pp. 191-199
    • Broschard, T.H.1    Koffel-schwartz, N.2    Fuchs, R.P.P.3
  • 86
    • 36248931510 scopus 로고    scopus 로고
    • Probing the sequence effects on Nar I-induced-2 frameshift mutagenesis by dynamic 19 F NMR, UV and CD spectroscopy
    • Jain, N., Li, Y., Zhang, L., Meneni, S., and Cho, B.P. (2007) Probing the sequence effects on Nar I-induced-2 frameshift mutagenesis by dynamic 19 F NMR, UV and CD spectroscopy. Biochemistry, 46, 13310-13321.
    • (2007) Biochemistry , vol.46 , pp. 13310-13321
    • Jain, N.1    Li, Y.2    Zhang, L.3    Meneni, S.4    Cho, B.P.5
  • 87
    • 27944479681 scopus 로고    scopus 로고
    • Mechanism for N-acetyl-2-aminofl uorene -induced frameshift mutagenesis by Escherichia coli DNA polymerase I
    • Klenow fragment
    • Gill, J.P. and Romano, L.J. (2005) Mechanism for N-acetyl-2-aminofl uorene -induced frameshift mutagenesis by Escherichia coli DNA polymerase I (Klenow fragment). Biochemistry, 44,15387-15395.
    • (2005) Biochemistry , vol.44 , pp. 15387-15395
    • Gill, J.P.1    Romano, L.J.2
  • 88
    • 33845270444 scopus 로고    scopus 로고
    • Translesion synthesis past the C8-and N 2-deoxyguanosine adducts of the dietary mutagen 2-amino-3-methylimidazo[4,5-f ] quinoline in the Nar I recognition sequence by prokaryotic DNA polymerases
    • Stover, J.S., Chowdhury, G., Zang, H., Guengerich, F.P., and Rizzo, C.J. (2006) Translesion synthesis past the C8-and N 2-deoxyguanosine adducts of the dietary mutagen 2-amino-3-methylimidazo[4,5-f ] quinoline in the Nar I recognition sequence by prokaryotic DNA polymerases. Chem. Res. Toxicol., 19, 1506-1517.
    • (2006) Chem. Res. Toxicol. , vol.19 , pp. 1506-1517
    • Stover, J.S.1    Chowdhury, G.2    Zang, H.3    Guengerich, F.P.4    Rizzo, C.J.5
  • 90
    • 38949092032 scopus 로고    scopus 로고
    • DNA adduct structure-function relationships: comparing solution with polymerase structures
    • Broyde, S., Wang, L., Zhang, L., Rechkoblit, O., Geacintov, N.E., and Patel, D.J. (2008) DNA adduct structure-function relationships: comparing solution with polymerase structures. Chem. Res. Toxicol., 21, 45-52.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 45-52
    • Broyde, S.1    Wang, L.2    Zhang, L.3    Rechkoblit, O.4    Geacintov, N.E.5    Patel, D.J.6
  • 92
    • 45549102966 scopus 로고    scopus 로고
    • Cancers exhibit a mutator phenotype: clinical implications
    • Loeb, L.A., Bielas, J.H., and Beckman, R.A. (2008) Cancers exhibit a mutator phenotype: clinical implications. Cancer Res., 68, 3551-3557.
    • (2008) Cancer Res. , vol.68 , pp. 3551-3557
    • Loeb, L.A.1    Bielas, J.H.2    Beckman, R.A.3


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