메뉴 건너뛰기




Volumn 17, Issue 10, 1996, Pages 2259-2265

Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and amino(α)carboline

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; CARBOLINE DERIVATIVE; HETEROCYCLIC AMINE; MUTAGENIC AGENT;

EID: 0343762013     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.10.2259     Document Type: Article
Times cited : (72)

References (48)
  • 1
    • 0020582085 scopus 로고
    • Mutagens-carcinogens in foods
    • Sugimura, T. and Sato, S. (1983) Mutagens-carcinogens in foods. Cancer Res., 43, 2415s-2421s.
    • (1983) Cancer Res. , vol.43
    • Sugimura, T.1    Sato, S.2
  • 2
    • 0025802760 scopus 로고
    • Carcinogenicities of heterocyclic amines in cooked food
    • Ohgaki, H., Takayama, S. and Sugimura, T. (1991) Carcinogenicities of heterocyclic amines in cooked food. Mutat. Res., 259, 399-410.
    • (1991) Mutat. Res. , vol.259 , pp. 399-410
    • Ohgaki, H.1    Takayama, S.2    Sugimura, T.3
  • 3
    • 0019413789 scopus 로고
    • Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolysate
    • Matsukura, N., Kawachi, T., Morino, K., Ohgaki, H., Sugimura, T. and Takayama, S. (1981) Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolysate. Science, 213, 346-347.
    • (1981) Science , vol.213 , pp. 346-347
    • Matsukura, N.1    Kawachi, T.2    Morino, K.3    Ohgaki, H.4    Sugimura, T.5    Takayama, S.6
  • 6
    • 0025758143 scopus 로고
    • Occurrence, identification, and potential mutagenicity of heterocyclic amines in cooked food
    • Felton, J.S. and Knize, M.G. (1991) Occurrence, identification, and potential mutagenicity of heterocyclic amines in cooked food. Mutat. Res., 259, 205-217.
    • (1991) Mutat. Res. , vol.259 , pp. 205-217
    • Felton, J.S.1    Knize, M.G.2
  • 8
    • 0028835983 scopus 로고
    • Cancer risk of heterocyclic amines in cooked foods: An analysis and implications for research
    • Layton, D.W., Bogen, K.T., Knize, M.G., Hatch, F.T., Johnson, M. and Felton, J.S. (1995) Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. Carcinogenesis, 16, 30-52.
    • (1995) Carcinogenesis , vol.16 , pp. 30-52
    • Layton, D.W.1    Bogen, K.T.2    Knize, M.G.3    Hatch, F.T.4    Johnson, M.5    Felton, J.S.6
  • 9
    • 0023017251 scopus 로고
    • The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-] pyridine (PhIP)
    • Felton, J.S., Knize, M.G., Shen, N.H., Lewis, P.R., Andresen, B.D., Happe, J. and Hatch, F.T. (1986) The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-] pyridine (PhIP). Carcinogenesis, 7, 1081-1086.
    • (1986) Carcinogenesis , vol.7 , pp. 1081-1086
    • Felton, J.S.1    Knize, M.G.2    Shen, N.H.3    Lewis, P.R.4    Andresen, B.D.5    Happe, J.6    Hatch, F.T.7
  • 10
    • 0000918297 scopus 로고
    • Heterocyclic-amine mutagens/ carcinogens in foods
    • Cooper, C.S. and Grover, P.L. (eds), Spring-Verlag, Berlin, Germany
    • Felton, J.S. and Knize, M.G. (1990) Heterocyclic-amine mutagens/ carcinogens in foods. In Cooper, C.S. and Grover, P.L. (eds), Handbook of Experimental Pharmacology. Spring-Verlag, Berlin, Germany, vol. 94/I, pp. 471-502.
    • (1990) Handbook of Experimental Pharmacology , vol.94 , Issue.1 , pp. 471-502
    • Felton, J.S.1    Knize, M.G.2
  • 12
    • 0027096844 scopus 로고
    • Formation of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in male F344 rats
    • Schut, H.A.J. and Herzog, C.R. (1992) Formation of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in male F344 rats. Cancer Lett., 67, 117-124.
    • (1992) Cancer Lett. , vol.67 , pp. 117-124
    • Schut, H.A.J.1    Herzog, C.R.2
  • 13
    • 0030052806 scopus 로고    scopus 로고
    • Cytogenetic analysis of mice chronically fed the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5b] pyridine (PhIP)
    • Director, A., Nath, J., Ramsey, M.J., Swiger, R.R. and Tucker, J.D. (1996) Cytogenetic analysis of mice chronically fed the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5b] pyridine (PhIP). Mutat. Res., 359, 53-61.
    • (1996) Mutat. Res. , vol.359 , pp. 53-61
    • Director, A.1    Nath, J.2    Ramsey, M.J.3    Swiger, R.R.4    Tucker, J.D.5
  • 14
    • 0024854930 scopus 로고
    • Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
    • Esumi, H., Ohgaki, H., Kohzen, E., Takayama, S. and Sugimura, T. (1989) Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J. Cancer Res., 80, 1176-1178.
    • (1989) Jpn J. Cancer Res. , vol.80 , pp. 1176-1178
    • Esumi, H.1    Ohgaki, H.2    Kohzen, E.3    Takayama, S.4    Sugimura, T.5
  • 15
    • 0025768966 scopus 로고
    • A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    • Ito, N., Hasegawa, R., Sano, M., Tamano, S., Esumi, H., Takayama, S. and Sugimura, T. (1991) A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis, 12, 1503-1506.
    • (1991) Carcinogenesis , vol.12 , pp. 1503-1506
    • Ito, N.1    Hasegawa, R.2    Sano, M.3    Tamano, S.4    Esumi, H.5    Takayama, S.6    Sugimura, T.7
  • 16
    • 0025800944 scopus 로고
    • Induction of intestinal adenocarcinoma by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats
    • Ochiai, M., Ogawa, K., Wakabayashi, K., Sugimura, T., Nagase, S., Esumi, H. and Nagao, M. (1991) Induction of intestinal adenocarcinoma by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats. Jpn J. Cancer Res., 82, 363-366.
    • (1991) Jpn J. Cancer Res. , vol.82 , pp. 363-366
    • Ochiai, M.1    Ogawa, K.2    Wakabayashi, K.3    Sugimura, T.4    Nagase, S.5    Esumi, H.6    Nagao, M.7
  • 17
  • 18
    • 0024458424 scopus 로고
    • The food mutagens 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) initiate enzyme altered foci in the 'resistant hepatocyte' model
    • Kleman, N., Overvik, E., Blanck, A. and Gustafsson, J.A. (1989) The food mutagens 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) initiate enzyme altered foci in the 'resistant hepatocyte' model. Carcinogenesis, 9, 1696-1700.
    • (1989) Carcinogenesis , vol.9 , pp. 1696-1700
    • Kleman, N.1    Overvik, E.2    Blanck, A.3    Gustafsson, J.A.4
  • 20
    • 0019313002 scopus 로고
    • Amino-α-carbolines as mutagenic agents in cigarette smoke condensate
    • Yoshida, D. and Matsumoto, T. (1980) Amino-α-carbolines as mutagenic agents in cigarette smoke condensate. Cancer Lett., 10, 14-140.
    • (1980) Cancer Lett. , vol.10 , pp. 14-140
    • Yoshida, D.1    Matsumoto, T.2
  • 21
    • 0027215566 scopus 로고
    • Detection of the carcinogen 2-amino-1-memyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in beer and wine
    • Manabe, S., Suzuki, H., Wada, O. and Ueki, A. (1993) Detection of the carcinogen 2-amino-1-memyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in beer and wine. Carcinogenesis, 14, 899-901.
    • (1993) Carcinogenesis , vol.14 , pp. 899-901
    • Manabe, S.1    Suzuki, H.2    Wada, O.3    Ueki, A.4
  • 22
    • 0028087921 scopus 로고
    • Effect of cooking time and temperature on the heterocyclic amine content of fried beef
    • Knize, M.G., Dolbeare, F.A., Carroll, K.L., Moore, D.H. II and Felton, J.S. (1994) Effect of cooking time and temperature on the heterocyclic amine content of fried beef. Food Chem. Toxicol., 7, 595-603.
    • (1994) Food Chem. Toxicol. , vol.7 , pp. 595-603
    • Knize, M.G.1    Dolbeare, F.A.2    Carroll, K.L.3    Moore II, D.H.4    Felton, J.S.5
  • 23
  • 26
    • 0011980193 scopus 로고
    • The φX174 bacteriophage shuttle vector for the study of mutagenesis
    • Burkhard, J.G., Winn, R.N., VanBeneden, R. and Malling, H.V. (1992) The φX174 bacteriophage shuttle vector for the study of mutagenesis. Environ. Mol. Mutagen., 19 (Suppl. 20), 8.
    • (1992) Environ. Mol. Mutagen. , vol.19 , Issue.20 SUPPL. , pp. 8
    • Burkhard, J.G.1    Winn, R.N.2    VanBeneden, R.3    Malling, H.V.4
  • 27
  • 28
    • 0021857850 scopus 로고
    • A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes
    • Jones, I.M., Burkhart-Shultz, K. and Carrano, A.V. (1985) A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes. Mutat. Res., 147, 97-105.
    • (1985) Mutat. Res. , vol.147 , pp. 97-105
    • Jones, I.M.1    Burkhart-Shultz, K.2    Carrano, A.V.3
  • 29
    • 0017666705 scopus 로고
    • Detection of chemically induced somatic mutation in Chinese hamsters
    • Dean, B.J. and Senner, K.R. (1977) Detection of chemically induced somatic mutation in Chinese hamsters. Mutat. Res., 46, 403-407.
    • (1977) Mutat. Res. , vol.46 , pp. 403-407
    • Dean, B.J.1    Senner, K.R.2
  • 30
    • 0020980090 scopus 로고
    • The granuloma pouch assay
    • de Serres, F.J. (ed.), Plenum Press, New York
    • Maier, P. (1983) The granuloma pouch assay. In de Serres, F.J. (ed.), Chemical Mutagens: Principles and Methods for their Detection. Plenum Press, New York, vol. 8, pp. 233-260.
    • (1983) Chemical Mutagens: Principles and Methods for Their Detection , vol.8 , pp. 233-260
    • Maier, P.1
  • 31
    • 0023894101 scopus 로고
    • A clonal marker induced by mutation in mouse intestinal epithelium
    • Winton, D.J., Blount, M.A. and Ponder, B.A.J. (1988) A clonal marker induced by mutation in mouse intestinal epithelium. Nature, 333, 463-466.
    • (1988) Nature , vol.333 , pp. 463-466
    • Winton, D.J.1    Blount, M.A.2    Ponder, B.A.J.3
  • 32
    • 0025309553 scopus 로고
    • Development of a short-term, in vivo mutagenesis assay: The effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice
    • Kohler, S.W., Provost, G.S., Kretz, P.L., Dycaico, M.J., Sorge, J.A. and Short, J.M. (1990) Development of a short-term, in vivo mutagenesis assay: the effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice. Nucleic Acids Res., 18, 3007-3013.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 3007-3013
    • Kohler, S.W.1    Provost, G.S.2    Kretz, P.L.3    Dycaico, M.J.4    Sorge, J.A.5    Short, J.M.6
  • 33
    • 0027421332 scopus 로고
    • Comparison of somatic mutation in a transgenic versus host locus
    • Tao, K.S., Urlando, C. and Heddle, J.A. (1993) Comparison of somatic mutation in a transgenic versus host locus. Proc. Natl Acad. Sci. USA, 90, 10681-10685.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 10681-10685
    • Tao, K.S.1    Urlando, C.2    Heddle, J.A.3
  • 34
    • 0028991066 scopus 로고
    • Relative sensitivity of the endogenous hprt gene and the lacI transgene in ENU-treated Big Blue™ B6C3F1 mice
    • Skopek, T.R., Kort, K.L. and Marino, D.R. (1995) Relative sensitivity of the endogenous hprt gene and the lacI transgene in ENU-treated Big Blue™ B6C3F1 mice. Environ. Mol. Mutagen., 26, 9-15.
    • (1995) Environ. Mol. Mutagen. , vol.26 , pp. 9-15
    • Skopek, T.R.1    Kort, K.L.2    Marino, D.R.3
  • 35
    • 0028004439 scopus 로고
    • Organization of heterologous DNA inserts on the mouse meiotic chromosome core
    • Heng, H.H.Q., Tsui, L.-C. and Moens, P.B. (1994) Organization of heterologous DNA inserts on the mouse meiotic chromosome core. Chromosoma, 103, 401-407.
    • (1994) Chromosoma , vol.103 , pp. 401-407
    • Heng, H.H.Q.1    Tsui, L.-C.2    Moens, P.B.3
  • 36
    • 0028973217 scopus 로고
    • The transmission rate of the lacI transgene from the Big Blue™ mouse
    • Heddle, J.A., Tao, K., Swiger, R.R. and Tucker, J.D. (1995) The transmission rate of the lacI transgene from the Big Blue™ mouse. Mutat. Res., 348, 63-66.
    • (1995) Mutat. Res. , vol.348 , pp. 63-66
    • Heddle, J.A.1    Tao, K.2    Swiger, R.R.3    Tucker, J.D.4
  • 37
    • 0029612230 scopus 로고
    • Enhanced somatic mutation rales induced in stem cells of mice by low chronic exposures to ethylnitrosourea
    • Shaver-Walker, P.M., Urlando, C., Tao, K.S., Zhang, X.B. and Heddle, J.A. (1995) Enhanced somatic mutation rales induced in stem cells of mice by low chronic exposures to ethylnitrosourea. Proc. Natl Acad. Sci. USA, 92, 11470-11474.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 11470-11474
    • Shaver-Walker, P.M.1    Urlando, C.2    Tao, K.S.3    Zhang, X.B.4    Heddle, J.A.5
  • 38
    • 0028177266 scopus 로고
    • The accumulation and persistence of somatic mutations
    • Tao, K.S. and Heddle, J.A. (1994) The accumulation and persistence of somatic mutations. Mutagenesis, 9, 187-191.
    • (1994) Mutagenesis , vol.9 , pp. 187-191
    • Tao, K.S.1    Heddle, J.A.2
  • 39
    • 0025168006 scopus 로고
    • Concurrent detection of gene mutations and chromosomal aberrations induced in vivo in somatic cells
    • Heddle, J.A., Bouch, A., Khan, M.A. and Gingerich, J.D. (1990) Concurrent detection of gene mutations and chromosomal aberrations induced in vivo in somatic cells. Mutagenesis, 5, 179-184.
    • (1990) Mutagenesis , vol.5 , pp. 179-184
    • Heddle, J.A.1    Bouch, A.2    Khan, M.A.3    Gingerich, J.D.4
  • 40
    • 0029133857 scopus 로고
    • Factors affecting somatic mutation frequencies in vivo
    • Zhang, X.B., Urlando, C., Tao, K.S. and Heddle, J.A. (1995) Factors affecting somatic mutation frequencies in vivo. Mutat. Res., 338, 189-201.
    • (1995) Mutat. Res. , vol.338 , pp. 189-201
    • Zhang, X.B.1    Urlando, C.2    Tao, K.S.3    Heddle, J.A.4
  • 41
    • 0028348705 scopus 로고
    • The lacI transgenic mouse mutagenicity assay: Quantitative evaluation in comparison to tests for carcinogenicity and cytogenetic damage in vivo
    • Shephard, S.E., Lutz, W.K. and Schlatter, C. (1994) The lacI transgenic mouse mutagenicity assay: quantitative evaluation in comparison to tests for carcinogenicity and cytogenetic damage in vivo. Mutat. Res., 306, 119-128.
    • (1994) Mutat. Res. , vol.306 , pp. 119-128
    • Shephard, S.E.1    Lutz, W.K.2    Schlatter, C.3
  • 42
    • 0028871774 scopus 로고
    • Treatment protocols for transgenic mutation assays in vivo
    • Heddle, J.A., Shaver-Walker, P., Tao, K.S. and Zhang, X.B. (1995) Treatment protocols for transgenic mutation assays in vivo. Mutagenesis, 10, 467-480.
    • (1995) Mutagenesis , vol.10 , pp. 467-480
    • Heddle, J.A.1    Shaver-Walker, P.2    Tao, K.S.3    Zhang, X.B.4
  • 43
    • 0021255812 scopus 로고
    • Site-specific induction of nuclear anomalies (apoptotic bodies and micronuclei) by carcinogens
    • Ronen, A. and Heddle, J.A. (1984) Site-specific induction of nuclear anomalies (apoptotic bodies and micronuclei) by carcinogens. Cancer Res., 44, 1536-1540.
    • (1984) Cancer Res. , vol.44 , pp. 1536-1540
    • Ronen, A.1    Heddle, J.A.2
  • 45
    • 0028092975 scopus 로고
    • Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes and formation of two distinct N-glucuronides of N-OH-PhIP in vivo and in vitro in the rat and dog
    • Kaderlik, K.R., Mulder, G.J., Turesky, R.J., Lang, N.P. and Kadluber, F.F. (1994) Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes and formation of two distinct N-glucuronides of N-OH-PhIP in vivo and in vitro in the rat and dog. Cardnogenesis, 15, 1695-1701.
    • (1994) Cardnogenesis , vol.15 , pp. 1695-1701
    • Kaderlik, K.R.1    Mulder, G.J.2    Turesky, R.J.3    Lang, N.P.4    Kadluber, F.F.5
  • 46
    • 0028878974 scopus 로고
    • Specific 5′-GGGA-3′→5′-GGA-3′ mutation of the Apc gene in rat colon tumours induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
    • Kakiuchi, H., Watenabe, M., Ushijima, J., Toyota, M., Imai, K., Weisburger, J.H., Sugimura, T. and Nagao, M. (1995) Specific 5′-GGGA-3′→5′-GGA-3′ mutation of the Apc gene in rat colon tumours induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Proc. Natl Acad. Sci. USA, 92, 910-914.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 910-914
    • Kakiuchi, H.1    Watenabe, M.2    Ushijima, J.3    Toyota, M.4    Imai, K.5    Weisburger, J.H.6    Sugimura, T.7    Nagao, M.8
  • 47
    • 0027288461 scopus 로고
    • Rare frequency of activation of the Ki-ras gene in rat colon tumours induced by heterocyclic amines: Possible alternative mechanisms of human colon carcinogenesis
    • Kakiuchi, H., Ushijima, T., Ochiai, M., Imai, K., Ito, N., Yachi, A., Sugimura, T. and Nagao, M. (1993) Rare frequency of activation of the Ki-ras gene in rat colon tumours induced by heterocyclic amines: possible alternative mechanisms of human colon carcinogenesis. Mol. Carcinogen., 8, 44-48.
    • (1993) Mol. Carcinogen. , vol.8 , pp. 44-48
    • Kakiuchi, H.1    Ushijima, T.2    Ochiai, M.3    Imai, K.4    Ito, N.5    Yachi, A.6    Sugimura, T.7    Nagao, M.8
  • 48
    • 0030250608 scopus 로고    scopus 로고
    • Risk estimation from somatic mutation assays
    • in press
    • Heddle, J.A. and Swiger, R R. (1996) Risk estimation from somatic mutation assays. Mutat. Res., in press.
    • (1996) Mutat. Res.
    • Heddle, J.A.1    Swiger, R.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.