Relationship between content and activity of cytochrome P450 and induction of heterocyclic amine DNA adducts in human liver samples in vivo and in vitro

Cancer Epidemiology Biomarkers and Prevention

Volumn 13, Issue 6, 2004, Pages 1071-1078

  Baranczewski, Pawel ^a   Möller, Lennart ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; DNA; ELLIPTICINE; FURAFYLLINE; HETEROCYCLIC AMINE; INDOLE DERIVATIVE; PHOSPHORUS 32; TROLEANDOMYCIN;

ADULT; ARTICLE; CLINICAL ARTICLE; COLON CANCER; CONTROLLED STUDY; DNA ADDUCT; ENZYME ACTIVATION; ENZYME INDUCTION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER; LIVER MICROSOME; MALE; PHENOTYPE; PRIORITY JOURNAL;

ADULT; AMINES; ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL MARKERS; CARBOLINES; CATTLE; CELL CULTURE TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; ENZYME INHIBITORS; FEMALE; HETEROCYCLIC COMPOUNDS; HUMANS; IMIDAZOLES; LIVER; MALE; MICROSOMES, LIVER; MIDDLE AGED; PYRIDINES; SMOKING; THYMUS GLAND;

EID: 2942642014     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Lang NP, Butler MA, Massengill J, et al. Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-bome heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol Biomarkers & Prev 1994;3:675-82.
2. Johansson MAE, Jägerstad M. Occurrence of mutagenic/carcinogenic heterocyclic amines in meat and fish products, including pan residues, prepared under domestic conditions. Carcinogenesis 1994;15:1511-8.
3. Felton JS, Jagerstad M, Knize MG, Skog K, Wakabayashi K. Contents in foods, beverages and tobacco. In: Nagao M, Sugimura T, editors. Food borne carcinogens heterocyclic amine. West Sussex: John Wiley & Sons Ltd.; 2000. p. 31-71.
4. 32P-post-labeling. Chem Res Toxicol 1994;7:733-9.
5. 2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues. Carcinogenesis 1996;17:1029-34.
6. Turteltaub K, Mauthe RJ, Dingey KH, et al. MeIQx-DNA adduct formation in rodent and human tissues at low doses. Mutat Res 1997;376:243-52.
7. Cui X-S, Tomdal U-B, Eriksson LC, Möller L. Early formation of DNA adducts compared with tumor formation in a long-term tumor study in rats after administration of 2-nitrofluorene. Carcinogenesis 1995;16:2135-41.
8. Turesky RJ. Heterocyclic aromatic amine metabolism, DNA adduct formation, mutagenesis, and carcinogenesis. Drug Metab Rev 2002;34:625-50.
9. Boobis AR, Lynch AM, Murray S, et al. CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans. Cancer Res 1994;54:89-94.
10. King RS, Teitel CH, Kadlubar FF. In vitro bioactivation of N-hydroxy-2-amino-α-carboline. Carcinogenesis 2000;21:1347-54.
11. Shimada T, Hayes CL, Yamazaki H, et al. Activation of chemically diverse procarcinogens by human cytochrome P450 1B1. Cancer Res 1996;56:2979-84.
12. Josephy PD, Batty SM, Boverhof DR. Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains. Environ Mol Mutagen 2001;38:12-8.
13. Raza H, King RS, Squires RB, et al. Metabolism of 2-amino-α carboline a food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2. Drug Metab Dispos 1996;24:395-400.
14. Frandsen H, Grivas S, Andersson R, Dragsted L, Larsen JC. Reaction of the N2-acetoxy derivative of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) with 2′-deoxyguanosine and DNA. Synthesis and identification of N-(2′-deoxyguanosin-8-yl)-PhIP. Carcinogenesis 1992;13:629-35.
15. Pfau W, Schulze, Ch, Shirai T, Hasegawa R, Brockstedt U. Identification of the major hepatic DNA adduct formed by the food mutagen 2-amino-9H-pyrido[2,3-b]indole (AαC). Chem Res Toxicol 1997;10:1192-7.
16. 32P-HPLC analysis of DNA adducts formed in vitro and in vivo by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,4,8-trimethyl-3H-imi-dazo[4,5-f]quinoxaline, utilizing an improved adduct enrichment procedure. Chem Res Toxicol 1996;9:1050-6.
17. Pearce RE, McIntyre ChJ, Madan A, et al. Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity. Arch Biochem Biophys 1996;331:145-69.
18. 32P-postlabeled DNA adducts. Carcinogenesis 1993;7:1343-8.
19. Hemminki K. DNA adducts, mutations and cancer. Carcinogenesis 1993;14:2007-12.
20. Miller EC, Miller JA. Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules. Cancer 1981;47:2327-45.
21. Perera FP. Environmental and cancer: who are susceptible. Science 1997;278:1068-73.
22. Crofts FG, Strickland PT, Hayes CL, Sutter TR. Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1. Carcinogenesis, 1997;18:1793-8.
23. Guengerich FP. Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene. Chem Res Toxicol 1990;3:363-71.