Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase η selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site

Journal of Biological Chemistry

Volumn 281, Issue 35, 2006, Pages 25297-25306

  Choi, Jeong Yun ^a,b,c   Stover, James S ^a,b   Angel, Karen C ^a,b   Chowdhury, Goutam ^a,b   Rizzo, Carmelo J ^a,b   Guengerich, F Peter ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BIOCHEMISTRY; DNA; ENZYMES; GENES; MASS SPECTROMETRY;

CHEMICAL ADDUCTS; GENOTOXICITY; HETEROCYCLIC ARYLAMINES; HUMAN DNA POLYMERASE;

MUTAGENS;

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; AROMATIC AMINE; DNA POLYMERASE; MUTAGENIC AGENT;

ARTICLE; CHEMICAL ANALYSIS; DNA ADDUCT; FRAMESHIFT MUTATION; GENE DELETION; GENOTOXICITY; MASS SPECTROMETRY; MUTAGENIC ACTIVITY; PRIORITY JOURNAL; STEADY STATE;

BIOCHEMISTRY; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; DNA PRIMERS; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; GENE DELETION; HUMANS; KINETICS; MODELS, CHEMICAL; QUINOLINES; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

ANIMALIA;

EID: 33748746680     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605699200     Document Type: Article

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