Correlation of DNA adduct levels with tumor incidence: Carcinogenic potency of DNA adducts

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 424, Issue 1-2, 1999, Pages 237-247

  Otteneder, Michael ^a   Lutz, Werner K ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cancer risk; Carcinogen; DNA adduct; Dose response relationship; Neoplasm

Indexed keywords

2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; 2 NITROFLUORENE; 2,4 DIAMINOTOLUENE; 4 BIPHENYLAMINE; AFLATOXIN B1; BENZO[A]PYRENE; BENZO[K]FLUORANTHENE; CYPROTERONE ACETATE; DIMETHYLNITROSAMINE; ETHYLENE OXIDE; FLUORANTHENE; N (2 FLUORENYL)ACETAMIDE; QUINOLINE DERIVATIVE; STYRENE; TAMOXIFEN; TOREMIFENE;

ANIMAL EXPERIMENT; ARTICLE; CANCER INCIDENCE; CANCER RISK; CONTROLLED STUDY; DNA ADDUCT; DOSE RESPONSE; FEMALE; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; CARCINOGENS; DNA ADDUCTS; DNA, NEOPLASM; HUMANS; MICE; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; RATS; RISK FACTORS;

EID: 0033535379     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(99)00022-6     Document Type: Article

References (38)

1. R.C. Gupta, W.K. Lutz, Background DNA damage from endogenous and unavoidable exogenous exposure to genotoxic carcinogens, Mutat. Res. (1999), in press.
2. Haseman J.K., Huff J., Boorman G.A. Use of historical control data in carcinogenicity studies in rodents. Toxicol. Pathol. 12:1984;126-135.
3. Lutz W.K. In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis. Mutat. Res. 65:1979;289-356.
4. Li D., Dragan Y., Jordan V.C., Wang M., Pitot H.C. Effects of chronic administration of tamoxifen and toremifene on DNA adducts in rat liver, kidney, and uterus. Cancer Res. 57:1997;1438-1441.
5. L.S. Gold, E. Zeiger, Handbook of Carcinogenic Potency and Genotoxicity Database, CRC Press, Boca Raton, FL 1997.
6. 6-position of guanine, Submitted to Chem. Res. Toxicol. 12 (1999) 93-99.
7. Hofer T., Möller L. Reduction of oxidation during the preparation of DNA and analysis of 8-hydroxy-2′-deoxyguanosine. Chem. Res. Toxicol. 11:1998;882-887.
8. Poirier M.C., Beland F.A. DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment. Chem. Res. Toxicol. 5:1992;749-755.
9. Fischer W., Lutz W.K. Correlation of individual papilloma latency time with DNA adducts, 8-hydroxy-2′-deoxyguanosine, and the rate of DNA synthesis in the epidermis of mice treated with 7,12-dimethylbenz[a]anthracene. Proc. Natl. Acad. Sci. U.S.A. 92:1995;5900-5904.
10. Ohgaki H., Ludeke B.I., Meier I., Kleihues P., Lutz W.K., Schlatter C. DNA methylation in the digestive tract of F344 rats during chronic exposure to N-methyl-N-nitrosourea. J. Cancer Res. Clin. Oncol. 117:1991;13-18.
11. Zaidi N.H., Potten C.S., Margison G.P., Cooper D.P., O'Connor P.J. Tissue and cell specific methylation, repair and synthesis of DNA in the upper gastrointestinal tract of Wistar rats treated with N-methyl-N′-nitro-N-nitrosoguanidine via the drinking water. Carcinogenesis. 14:1993;1991-2001.
12. Belinsky S.A., White C.M., Devereux T.R., Swenberg J.A., Anderson M.W. Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 47:1987;1143-1148.
13. Belinsky S.A., White C.M., Boucheron J.A., Richardson F.C., Swenberg J.A., Anderson M. Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 46:1986;1280-1284.
14. 6-methyldeoxyguanosine in DNA methylated by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone using a biotin-avidin enzyme-linked immunosorbent assay. Carcinogenesis. 6:1985;989-993.
15. 6-methylguanine in rat DNA after low-dose, chronic exposure to N-nitrosodimethylamine (NDMA). Implications for the mechanism of NDMA hepatocarcinogenesis. Carcinogenesis. 16:1995;2381-2387.
16. 6-methylguanine-DNA methyltransferase activity in hepatocytes of rats and mice continuously exposed to dimethylnitrosamine. Cancer Res. 44:1984;196-200.
17. 6-alkylguanine-DNA alkyltransferase in rat tissues. Carcinogenesis. 15:1994;1681-1688.
18. 6-methylguanine in humans and rodents treated with dacarbazine. Carcinogenesis. 17:1996;725-732.
19. Lewis J.G., Swenberg J.A. The kinetics of DNA alkylation, repair and replication in hepatocytes, Kupffer cells, and sinusoidal endothelial cells in rat liver during continuous exposure to 1,2-dimethylhydrazine. Carcinogenesis. 4:1983;529-536.
20. 4-ethyldeoxythymidine in rats continuously exposed to diethylnitrosamine. Cancer Res. 47:1987;1577-1581.
21. Walker V.E., Fennell T.R., Upton P.B., Skopek T.R., Prevost V., Shuker D.E., Swenberg J.A. Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice. Cancer Res. 52:1992;4328-4334.
22. Buss P., Caviezel M., Lutz W.K. Linear dose-response relationship for DNA adducts in rat liver from chronic exposure to aflatoxin B1. Carcinogenesis. 11:1990;2133-2135.
23. Wild C.P., Garner R.C., Montesano R., Tursi F. Aflatoxin B1 binding to plasma albumin and liver DNA upon chronic administration to rats. Carcinogenesis. 7:1986;853-858.
24. Poirier M.C., Fullerton N.F., Smith B.A., Beland F.A. DNA adduct formation and tumorigenesis in mice during the chronic administration of 4-aminobiphenyl at multiple dose levels. Carcinogenesis. 16:1995;2917-2921.
25. Frantz C.E., Bangerter C., Fultz E., Mayer K.M., Vogel J.S., Turteltaub K.W. Dose-response studies of MeIQx in rat liver and liver DNA at low doses. Carcinogenesis. 16:1995;367-373.
26. Yamashita K., Adachi M., Kato S., Nakagama H., Ochiai M., Wakabayashi K., Sato S., Nagao M., Sugimura T. DNA adducts formed by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat liver: dose-response on chronic administration. Jpn. J. Cancer Res. 81:1990;470-476.
27. Schut H.A., Herzog C.R., Cummings D.A. Accumulation of DNA adducts of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) in tissues and white blood cells of the Fischer-344 rat after multiple oral dosing. Carcinogenesis. 15:1994;1467-1470.
28. Davis C.D., Schut H.A., Snyderwine E.G. Adduction of the heterocyclic amine food mutagens IQ and PhIP to mitochondrial and nuclear DNA in the liver of Fischer-344 rats. Carcinogenesis. 15:1994;641-645.
29. La D.K., Froines J.R. Formation and removal of DNA adducts in Fischer-344 rats exposed to 2,4-diaminotoluene. Arch. Toxicol. 69:1994;8-13.
30. Poirier M.C., Beland F.A., Deal F.H., Swenberg J.A. DNA adduct formation and removal in specific liver cell populations during chronic dietary administration of 2-acetylaminofluorene. Carcinogenesis. 10:1989;1143-1145.
31. Poirier M.C., True B., Laishes B.A. Formation and removal of (guan-8-yl)-DNA-2-acetylaminofluorene adducts in liver and kidney of male rats given dietary 2-acetylaminofluorene. Cancer Res. 42:1982;1317-1321.
32. Poirier M.C., Fullerton N.F., Kinouchi T., Smith B.A., Beland F.A. Comparison between DNA adduct formation and tumorigenesis in livers and bladders of mice chronically fed 2-acetylaminofluorene. Carcinogenesis. 12:1991;895-900.
33. Gupta R.C., Earley K., Fullerton N.F., Beland F.A. Formation and removal of DNA adducts in target and nontarget tissues of rats administered multiple doses of 2-acetylaminophenanthrene. Carcinogenesis. 10:1989;2025-2033.
34. Tullis D.L., Dooley K.L., Miller D.W., Baetcke K.P., Kadlubar F.F. Characterization and properties of the DNA adducts formed from N-methyl-4-aminoazobenzene in rats during a carcinogenic treatment regimen. Carcinogenesis. 8:1987;577-583.
35. Cui X.S., Torndal U.B., Eriksson L.C., Möller L. Early formation of DNA adducts compared with tumor formation in a long-term tumor study in rats after administration of 2-nitrofluorene. Carcinogenesis. 16:1995;2135-2141.
36. Arif J.M., Gupta R.C. Detection of DNA-reactive metabolites in serum and their tissue distribution in mice exposed to multiple doses of carcinogen mixtures: role in human biomonitoring. Carcinogenesis. 17:1996;2213-2219.
37. Gorelick N.J., Hutchins D.A., Tannenbaum S.R., Wogan G.N. Formation of DNA and hemoglobin adducts of fluoranthene after single and multiple exposures. Carcinogenesis. 10:1989;1579-1587.
38. Werner S., Topinka J., Wolff T., Schwarz L.R. Accumulation and persistence of DNA adducts of the synthetic steroid cyproterone acetate in rat liver. Carcinogenesis. 16:1995;2369-2372.