UDP-glucuronosyltransferase-mediated metabolic activation of the tobacco carcinogen 2-amino-9H-pyrido[2,3-b]indole

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 14960-14972

  Tang, Yijin ^a   LeMaster, David M ^a   Nauwelaërs, Gwendoline ^b,c   Gu, Dan ^a   Langouët, Sophie ^b   Turesky, Robert J ^a  

^a WADSWORTH CENTER   (United States)

^b UNIVERSITÉ DE RENNES 1   (France)

^c FRENCH AGENCY FOR FOOD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE GROUPS; BIOACTIVATION; CALF THYMUS DNA; GENOTOXIC METABOLITES; GLUCURONIDATION; GLUCURONIDES; HETEROCYCLIC AROMATIC AMINES; HUMAN HEPATOCYTES; HUMAN LIVER MICROSOMES; ISOFORMS; METABOLIC ACTIVATION; METABOLIC PRODUCTS; MINOR PRODUCTS; O-LINKED; REACTIVE METABOLITES; TOBACCO SMOKE;

BIOMOLECULES; MASS SPECTROMETRY; METABOLISM; METABOLITES; PROTEINS;

ENZYMES;

2 FLUORENYLAMINE; 2 HYDROXYAMINO 9H PYRIDO[2,3 B]INDOLE; 4 BIPHENYLAMINE; CYTOCHROME P450; DNA; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A4; INDOLE DERIVATIVE; TOBACCO SMOKE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENICITY; CHEMICAL STRUCTURE; COVALENT BOND; DETOXIFICATION; ENZYME ACTIVATION; ENZYME KINETICS; ENZYME METABOLISM; GENOTOXICITY; GLUCURONIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; LIVER CELL; LIVER MICROSOME; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEADY STATE;

CARBOLINES; CARCINOGENS; FEMALE; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MICROSOMES, LIVER; RECOMBINANT PROTEINS; TOBACCO;

NICOTIANA TABACUM;

EID: 84860372546     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.320093     Document Type: Article

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