Synthetic Macrocycles in Small-Molecule Drug Discovery

Annual Reports in Medicinal Chemistry

Volumn 48, Issue , 2013, Pages 371-386

  Vendeville, Sandrine ^a   Cummings, Maxwell D ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Drug likeness; Ghrelin agonist; HCV NS3 4A protease inhibitor; Kinase inhibitor; Macrocycle; Natural product; NS5b polymerase inhibitor; Protein protein interaction; Stapled peptide

Indexed keywords

ADENOSINE TRIPHOSPHATE COMPETITIVE KINASE INHIBITOR; ANALPLASTIC LYMPHOMA KINASE INHIBITOR; ANAMORELIN; BIM PROTEIN; BOSUTINIB; CD135 ANTIGEN; CILUPREVIR; CRIZOTINIB; CYCLIN DEPENDENT KINASE 2; DASATINIB; G PROTEIN COUPLED RECEPTOR; GHRELIN; IBUTAMOREN; INSULIN RECEPTOR KINASE; MACROCYCLIC COMPOUND; MACROCYCLIC DIAMINOPYRIMIDINE; MK 3281; PACRITINIB; PROTEIN BCL 2; PROTEIN KINASE TYK2; PROTEIN MDM2; PROTEIN P53; PROTEINASE INHIBITOR; SB 1317; SB 1578; SIMEPREVIR; SULOTROBAN; TOFACITINIB; ULIMORELIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANIPREVIR;

ANTIVIRAL ACTIVITY; ARTICLE; CARDIOTOXICITY; CRYSTALLOGRAPHY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG RESEARCH; DRUG SAFETY; HEPATITIS C VIRUS; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 84884149846     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-417150-3.00023-5     Document Type: Chapter

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