The metabolism and disposition of a potent inhibitor of hepatitis C virus NS3/4A protease

Xenobiotica

Volumn 40, Issue 12, 2010, Pages 826-839

  Monteagudo, E ^a   Fonsi, M ^a   Chu, X ^b   Bleasby, K ^b   Evers, R ^b   Pucci, V ^a   Orsale, M V ^a   Cianetti, S ^a   Ferrara, M ^a   Harper, S ^a   Laufer, R ^a   Rowley, M ^a   Summa, V ^a  

^a IRBM   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

antivirals; genotype 1,2,3 macrocycle inhibitor; Hepatitis C virus; NS3 4A protease

Indexed keywords

COMPOUND A; CYTOCHROME P450 3A; GLUTATHIONE; MONTIRELIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; BILE FLOW; DRUG BIOAVAILABILITY; FIRST PASS EFFECT; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; LIVER CELL; LIVER METABOLISM; LIVER MICROSOME; MALE; MEMBRANE PERMEABILITY; NONHUMAN; RAT; VIRUS INHIBITION;

ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL TRANSPORT; DOGS; HEPACIVIRUS; HUMANS; INJECTIONS, INTRAVENOUS; LIVER; MEMBRANE TRANSPORT PROTEINS; METABOLIC NETWORKS AND PATHWAYS; MICROSOMES, LIVER; PROTEASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; TIME FACTORS; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS; RATTUS;

EID: 78249266936     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2010.519061     Document Type: Article

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