메뉴 건너뛰기




Volumn 17, Issue 6 PART B, 2012, Pages 1133-1146

HCV's days are numbered: Next-generation direct-acting antivirals and host-targeting agents

Author keywords

[No Author keywords available]

Indexed keywords

ALISPORIVIR; ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; ASUNAPREVIR; BI 207127; BOCEPREVIR; DACLATASVIR; DANOPREVIR; ENZYME INHIBITOR; FALDAPREVIR; FILIBUVIR; LOMIBUVIR; MERICITABINE; MIRAVIRSEN; MK 5172; NONSTRUCTURAL PROTEIN 5B POLYMERASE INHIBITOR; PEGINTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON LAMBDA; PROTEINASE INHIBITOR; PSI 938; R 7218; RIBAVIRIN; RITONAVIR; SIMEPREVIR; SOFOSBUVIR; TELAPREVIR; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

EID: 84867266290     PISSN: 13596535     EISSN: 20402058     Source Type: Journal    
DOI: 10.3851/IMP2425     Document Type: Review
Times cited : (5)

References (128)
  • 1
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • Medline doi:10.1056/NEJM200107053450107
    • Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001; 345: 41-52. Medline doi:10.1056/NEJM200107053450107
    • (2001) N Engl J Med , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 2
    • 0033584440 scopus 로고    scopus 로고
    • The prevalence of hepatitis C virus infection in the United States, 1988 through 1994
    • Medline doi:10.1056/NEJM199908193410802
    • Alter MJ, Kruszon-Moran D, Nainan OV, et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med 1999; 341: 556-562. Medline doi:10.1056/NEJM199908193410802
    • (1999) N Engl J Med , vol.341 , pp. 556-562
    • Alter, M.J.1    Kruszon-Moran, D.2    Nainan, O.V.3
  • 3
    • 7044272630 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
    • Medline doi:10.1053/j.gastro.2004.09.014
    • Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004; 127 Suppl 1: S35-S50. Medline doi:10.1053/j.gastro.2004.09.014
    • (2004) Gastroenterology , vol.127 , Issue.SUPPL. 1
    • Fattovich, G.1    Stroffolini, T.2    Zagni, I.3    Donato, F.4
  • 4
    • 23944480609 scopus 로고    scopus 로고
    • Hepatitis C and liver transplantation
    • Medline doi:10.1038/nature04083
    • Brown RS. Hepatitis C and liver transplantation. Nature 2005; 436: 973-978. Medline doi:10.1038/nature04083
    • (2005) Nature , vol.436 , pp. 973-978
    • Brown, R.S.1
  • 5
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • Medline doi:10.1016/S0140-6736(01)06102-5
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358: 958-965. Medline doi:10.1016/S0140-6736(01)06102-5
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 6
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Medline doi:10.1056/NEJMoa020047
    • Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347: 975-982. Medline doi:10.1056/NEJMoa020047
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 7
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • Medline doi:10.1056/NEJMoa1010494
    • Poordad F, McCone J, Bacon BR, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011; 364: 1195-1206. Medline doi:10.1056/NEJMoa1010494
    • (2011) N Engl J Med , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone, J.2    Bacon, B.R.3
  • 8
    • 78650820415 scopus 로고    scopus 로고
    • Telaprevir in combination with peginterferon and ribavirin in genotype 1 HCV treatment-naive patients: Final results of phase 3 ADVANCE study
    • Jacobson I. Telaprevir in combination with peginterferon and ribavirin in genotype 1 HCV treatment-naive patients: final results of phase 3 ADVANCE study. Hepatology 2010; 52 Suppl 1: 427A.
    • (2010) Hepatology , vol.52 , Issue.SUPPL. 1
    • Jacobson, I.1
  • 9
    • 80052826527 scopus 로고    scopus 로고
    • Response-guided telaprevir combination treatment for hepatitis C virus infection
    • Medline doi:10.1056/NEJMoa1014463
    • Sherman KE, Flamm SL, Afdhal NH, et al. Response-guided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med 2011; 365: 1014-1024. Medline doi:10.1056/NEJMoa1014463
    • (2011) N Engl J Med , vol.365 , pp. 1014-1024
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3
  • 10
    • 79751513059 scopus 로고    scopus 로고
    • Hepatitis in 2010: The dawn of a new era in HCV therapy
    • Medline doi:10.1038/nrgastro.2010.219
    • Ciesek S, Manns MP. Hepatitis in 2010: the dawn of a new era in HCV therapy. Nat Rev Gastroenterol Hepatol 2011; 8: 69-71. Medline doi:10.1038/nrgastro.2010.219
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 69-71
    • Ciesek, S.1    Manns, M.P.2
  • 11
    • 34548693442 scopus 로고    scopus 로고
    • Cryo-electron microscopy and three-dimensional reconstructions of hepatitis C virus particles
    • Medline doi:10.1016/j.virol.2007.05.038
    • Yu X, Qiao M, Atanasov I, et al. Cryo-electron microscopy and three-dimensional reconstructions of hepatitis C virus particles. Virology 2007; 367: 126-134. Medline doi:10.1016/j.virol.2007.05.038
    • (2007) Virology , vol.367 , pp. 126-134
    • Yu, X.1    Qiao, M.2    Atanasov, I.3
  • 12
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • Medline doi:10.1038/nm1268
    • Wakita T, Pietschmann T, Kato T, et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005; 11: 791-796. Medline doi:10.1038/nm1268
    • (2005) Nat Med , vol.11 , pp. 791-796
    • Wakita, T.1    Pietschmann, T.2    Kato, T.3
  • 13
    • 0026794059 scopus 로고
    • p26 protein and 33-nm particle associated with nucleocapsid of hepatitis C virus recovered from the circulation of infected hosts
    • Medline doi:10.1016/0042-6822(92)90204-3
    • Takahashi K, Kishimoto S, Yoshizawa H, Okamoto H, Yoshikawa A, Mishiro S. p26 protein and 33-nm particle associated with nucleocapsid of hepatitis C virus recovered from the circulation of infected hosts. Virology 1992; 191: 431-434. Medline doi:10.1016/0042-6822(92)90204-3
    • (1992) Virology , vol.191 , pp. 431-434
    • Takahashi, K.1    Kishimoto, S.2    Yoshizawa, H.3    Okamoto, H.4    Yoshikawa, A.5    Mishiro, S.6
  • 15
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
    • Medline doi:10.1126/science.282.5386.103
    • Neumann AU, Lam NP, Dahari H, et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 1998; 282: 103-107. Medline doi:10.1126/science.282.5386.103
    • (1998) Science , vol.282 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3
  • 16
    • 58149388300 scopus 로고    scopus 로고
    • Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients
    • Medline doi:10.1002/hep.22549
    • Kuntzen T, Timm J, Berical A, et al. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients. Hepatology 2008; 48: 1769-1778. Medline doi:10.1002/hep.22549
    • (2008) Hepatology , vol.48 , pp. 1769-1778
    • Kuntzen, T.1    Timm, J.2    Berical, A.3
  • 17
    • 65449157987 scopus 로고    scopus 로고
    • Hepatitis C virus drug resistance and immune-driven adaptations: Relevance to new antiviral therapy
    • Medline doi:10.1002/hep.22773
    • Gaudieri S, Rauch A, Pfafferott K, et al. Hepatitis C virus drug resistance and immune-driven adaptations: relevance to new antiviral therapy. Hepatology 2009; 49: 1069-1082. Medline doi:10.1002/hep.22773
    • (2009) Hepatology , vol.49 , pp. 1069-1082
    • Gaudieri, S.1    Rauch, A.2    Pfafferott, K.3
  • 18
    • 59149097207 scopus 로고    scopus 로고
    • Expert opinion on the treatment of patients with chronic hepatitis C
    • Medline doi:10.1111/j.1365-2893.2008.01012.x
    • Zeuzem S, Berg T, Moeller B, et al. Expert opinion on the treatment of patients with chronic hepatitis C. J Viral Hepat 2009; 16: 75-90. Medline doi:10.1111/j.1365-2893.2008.01012.x
    • (2009) J Viral Hepat , vol.16 , pp. 75-90
    • Zeuzem, S.1    Berg, T.2    Moeller, B.3
  • 19
    • 68249154875 scopus 로고    scopus 로고
    • Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection
    • Medline doi:10.1056/NEJMoa0808010
    • McHutchison JG, Lawitz EJ, Shiffman ML, et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med 2009; 361: 580-593. Medline doi:10.1056/NEJMoa0808010
    • (2009) N Engl J Med , vol.361 , pp. 580-593
    • McHutchison, J.G.1    Lawitz, E.J.2    Shiffman, M.L.3
  • 20
    • 33846356749 scopus 로고    scopus 로고
    • Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C
    • Medline doi:10.1053/j.gastro.2006.11.011
    • Shiffman ML, Ghany MG, Morgan TR, et al. Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C. Gastroenterology 2007; 132: 103-112. Medline doi:10.1053/j.gastro. 2006.11.011
    • (2007) Gastroenterology , vol.132 , pp. 103-112
    • Shiffman, M.L.1    Ghany, M.G.2    Morgan, T.R.3
  • 21
    • 40949117600 scopus 로고    scopus 로고
    • The cyclophilin inhibitor debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus
    • Medline doi:10.1002/hep.22131
    • Flisiak R, Horban A, Gallay P, et al. The cyclophilin inhibitor debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus. Hepatology 2008; 47: 817-826. Medline doi:10.1002/hep.22131
    • (2008) Hepatology , vol.47 , pp. 817-826
    • Flisiak, R.1    Horban, A.2    Gallay, P.3
  • 22
    • 80051916510 scopus 로고    scopus 로고
    • Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN α-2a/RBV in hepatitis C patients
    • Medline doi:10.1016/j.jhep.2011.01.046
    • Gane EJ, Rouzier R, Stedman C, et al. Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN α-2a/RBV in hepatitis C patients. J Hepatol 2011; 55: 972-979. Medline doi:10.1016/j.jhep. 2011.01.046
    • (2011) J Hepatol , vol.55 , pp. 972-979
    • Gane, E.J.1    Rouzier, R.2    Stedman, C.3
  • 23
    • 84856293564 scopus 로고    scopus 로고
    • Virologic response to an interferon-free regimen of BI 201335 and BI 207127, with and without ribavirin, in treatment-naive patients with chronic genotype-1 HCV infection: Week 12 interim results of the SOUND-C2 study
    • Zeuzem S, Soriano V, Asselah T, et al. Virologic response to an interferon-free regimen of BI 201335 and BI 207127, with and without ribavirin, in treatment-naive patients with chronic genotype-1 HCV infection: week 12 interim results of the SOUND-C2 study. Hepatology 2011; 54 Suppl 1: 1436A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Zeuzem, S.1    Soriano, V.2    Asselah, T.3
  • 24
    • 0028290579 scopus 로고
    • Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins
    • Failla C, Tomei L, De Francesco R. Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J Virol 1994; 68: 3753-3760. Medline (Pubitemid 24177400)
    • (1994) Journal of Virology , vol.68 , Issue.6 , pp. 3753-3760
    • Failla, C.1    Tomei, L.2    De Francesco, R.3
  • 25
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Medline doi:10.1126/science.1082604
    • Foy E, Li K, Wang C, et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003; 300: 1145-1148. Medline doi:10.1126/science.1082604
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3
  • 26
    • 14544280209 scopus 로고    scopus 로고
    • Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
    • Medline doi:10.1073/pnas.0408824102
    • Li K, Foy E, Ferreon JC, et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A 2005; 102: 2992-2997. Medline doi:10.1073/pnas.0408824102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2992-2997
    • Li, K.1    Foy, E.2    Ferreon, J.C.3
  • 27
    • 0028817781 scopus 로고
    • C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity
    • Medline doi:10.1006/bbrc.1995.2447
    • Kim DW, Gwack Y, Han JH, Choe J. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun 1995; 215: 160-166. Medline doi:10.1006/bbrc.1995.2447
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 160-166
    • Kim, D.W.1    Gwack, Y.2    Han, J.H.3    Choe, J.4
  • 28
    • 0027287798 scopus 로고
    • Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions
    • Bartenschlager R, Ahlborn-Laake L, Mous J, Jacobsen H. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol 1993; 67: 3835-3844. Medline (Pubitemid 23180705)
    • (1993) Journal of Virology , vol.67 , Issue.7 , pp. 3835-3844
    • Bartenschlager, R.1    Ahlborn-Laake, L.2    Mous, J.3    Jacobsen, H.4
  • 29
    • 16044364658 scopus 로고    scopus 로고
    • Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide
    • Medline doi:10.1016/S0092-8674(00)81351-3
    • Kim JL, Morgenstern KA, Lin C, et al. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell 1996; 87: 343-355. Medline doi:10.1016/S0092-8674(00)81351-3
    • (1996) Cell , vol.87 , pp. 343-355
    • Kim, J.L.1    Morgenstern, K.A.2    Lin, C.3
  • 30
    • 34547927078 scopus 로고    scopus 로고
    • Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: Sensitivity to telaprevir (VX-950) and interferon alpha
    • Medline doi:10.1074/jbc.M610207200
    • Zhou Y, Müh U, Hanzelka BL, et al. Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha. J Biol Chem 2007; 282: 22619-22628. Medline doi:10.1074/jbc.M610207200
    • (2007) J Biol Chem , vol.282 , pp. 22619-22628
    • Zhou, Y.1    Müh, U.2    Hanzelka, B.L.3
  • 31
    • 37849032050 scopus 로고    scopus 로고
    • Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease
    • Medline doi:10.1128/AAC.00863-07
    • Zhou Y, Bartels DJ, Hanzelka BL, et al. Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease. Antimicrob Agents Chemother 2008; 52: 110-120. Medline doi:10.1128/AAC.00863-07
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 110-120
    • Zhou, Y.1    Bartels, D.J.2    Hanzelka, B.L.3
  • 32
    • 77951210464 scopus 로고    scopus 로고
    • In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435
    • Medline doi:10.1128/AAC.01452-09
    • Lenz O, Verbinnen T, Lin TI, et al. In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435. Antimicrob Agents Chemother 2010; 54: 1878-1887. Medline doi:10.1128/AAC.01452-09
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1878-1887
    • Lenz, O.1    Verbinnen, T.2    Lin, T.I.3
  • 33
    • 84865563661 scopus 로고    scopus 로고
    • Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-naive patients with chronic hepatitis C: A randomized Phase II study
    • doi:10.1002/hep.25743. Medline doi:10.1002/hep.25743
    • Manns MP, Gane E, Rodriguez-Torres M, et al. Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-naive patients with chronic hepatitis C: a randomized Phase II study. Hepatology 2012; doi:10.1002/hep. 25743. Medline doi:10.1002/hep.25743
    • (2012) Hepatology
    • Manns, M.P.1    Gane, E.2    Rodriguez-Torres, M.3
  • 35
    • 79960860112 scopus 로고    scopus 로고
    • Antiviral activity of danoprevir (ITMN-191/RG7227) in combination with pegylated interferon α-2a and ribavirin in patients with hepatitis C
    • Medline doi:10.1093/infdis/jir315
    • Forestier N, Larrey D, Marcellin P, et al. Antiviral activity of danoprevir (ITMN-191/RG7227) in combination with pegylated interferon α-2a and ribavirin in patients with hepatitis C. J Infect Dis 2011; 204: 601-608. Medline doi:10.1093/infdis/jir315
    • (2011) J Infect Dis , vol.204 , pp. 601-608
    • Forestier, N.1    Larrey, D.2    Marcellin, P.3
  • 36
    • 84863524062 scopus 로고    scopus 로고
    • High sustained virologic response (SVR24) rates with response-guided danoprevir (DNV; RG7227) plus pegIFN α-2a (40kd) and ribavirin (P/R) in treatment naive HCV genotype 1(G1) patients: Results from the ATLAS study
    • Terrault NA. High sustained virologic response (SVR24) rates with response-guided danoprevir (DNV; RG7227) plus pegIFN α-2a (40kd) and ribavirin (P/R) in treatment naive HCV genotype 1(G1) patients: results from the ATLAS study. Hepatology 2011; 54 Suppl 1: 398A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Terrault, N.A.1
  • 37
    • 78049527728 scopus 로고    scopus 로고
    • Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebo-controlled, dose-escalation trial
    • Medline doi:10.1016/S0140-6736(10)61384-0
    • Gane EJ, Roberts SK, Stedman CAM, et al. Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 2010; 376: 1467-1475. Medline doi:10.1016/S0140-6736(10)61384-0
    • (2010) Lancet , vol.376 , pp. 1467-1475
    • Gane, E.J.1    Roberts, S.K.2    Stedman, C.A.M.3
  • 38
    • 80055076797 scopus 로고    scopus 로고
    • Rapid viral response of once-daily TMC435 plus pegylated interferon/ribavirin in hepatitis C genotype-1 patients: A randomized trial
    • Medline doi:10.3851/IMP1894
    • Manns M, Reesink H, Berg T, et al. Rapid viral response of once-daily TMC435 plus pegylated interferon/ribavirin in hepatitis C genotype-1 patients: a randomized trial. Antivir Ther 2011; 16: 1021-1033. Medline doi:10.3851/IMP1894
    • (2011) Antivir Ther , vol.16 , pp. 1021-1033
    • Manns, M.1    Reesink, H.2    Berg, T.3
  • 39
    • 77449158033 scopus 로고    scopus 로고
    • Rapid HCV-RNA decline with once daily TMC435: A Phase i study in healthy volunteers and hepatitis C patients
    • Medline doi:10.1053/j.gastro.2009.10.033
    • Reesink HW, Fanning GC, Farha KA, et al. Rapid HCV-RNA decline with once daily TMC435: a Phase I study in healthy volunteers and hepatitis C patients. Gastroenterology 2010; 138: 913-921. Medline doi:10.1053/j.gastro.2009.10.033
    • (2010) Gastroenterology , vol.138 , pp. 913-921
    • Reesink, H.W.1    Fanning, G.C.2    Farha, K.A.3
  • 40
    • 64849085631 scopus 로고    scopus 로고
    • Inhibitory activity of TMC435350 on HCV NS3/4A proteases from genotypes 1 to 6
    • Lin T, Devogerlare B, Lenz O, et al. Inhibitory activity of TMC435350 on HCV NS3/4A proteases from genotypes 1 to 6. Hepatology 2008; 48 Suppl 1: 1166A.
    • (2008) Hepatology , vol.48 , Issue.SUPPL. 1
    • Lin, T.1    Devogerlare, B.2    Lenz, O.3
  • 41
    • 65749112245 scopus 로고    scopus 로고
    • In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor
    • Medline doi:10.1128/AAC.01058-08
    • Lin T-I, Lenz O, Fanning G, et al. In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor. Antimicrob Agents Chemother 2009; 53: 1377-1385. Medline doi:10.1128/AAC.01058-08
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 1377-1385
    • Lin, T.-I.1    Lenz, O.2    Fanning, G.3
  • 42
    • 84856906043 scopus 로고    scopus 로고
    • TMC435 in combination with peginterferon and ribavirin in treatment-naive HCV genotype 1 patients
    • Fried MW, Buti M, Dore GJ, et al. TMC435 in combination with peginterferon and ribavirin in treatment-naive HCV genotype 1 patients. Hepatology 2011; 54 Suppl 1: 1429A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Fried, M.W.1    Buti, M.2    Dore, G.J.3
  • 44
    • 78049316315 scopus 로고    scopus 로고
    • Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease
    • Medline doi:10.1128/AAC.00787-10
    • White PW, Llinàs-Brunet M, Amad M, et al. Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease. Antimicrob Agents Chemother 2010; 54: 4611-4618. Medline doi:10.1128/AAC.00787-10
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 4611-4618
    • White, P.W.1    Llinàs-Brunet, M.2    Amad, M.3
  • 45
    • 79953224799 scopus 로고    scopus 로고
    • Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection
    • Medline doi:10.1016/j.jhep.2010.08.040
    • Manns MP, Bourlière M, Benhamou Y, et al. Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection. J Hepatol 2011; 54: 1114-1122. Medline doi:10.1016/j.jhep.2010.08.040
    • (2011) J Hepatol , vol.54 , pp. 1114-1122
    • Manns, M.P.1    Bourlière, M.2    Benhamou, Y.3
  • 46
    • 84858244296 scopus 로고    scopus 로고
    • Virological response and safety of BI 201335 protease inhibitor, peginterferon alfa 2a and ribavirin treatment of HCV genotype-1 patients with compensated liver cirrhosis and non-response to previous peginterferon/ribavirin
    • Pol S, Berg T, Bonacini M, et al. Virological response and safety of BI 201335 protease inhibitor, peginterferon alfa 2a and ribavirin treatment of HCV genotype-1 patients with compensated liver cirrhosis and non-response to previous peginterferon/ribavirin. Hepatology 2009; 50 Suppl 4: 228A.
    • (2009) Hepatology , vol.50 , Issue.SUPPL. 4
    • Pol, S.1    Berg, T.2    Bonacini, M.3
  • 47
    • 81855228070 scopus 로고    scopus 로고
    • Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection
    • Medline doi:10.1053/j.gastro.2011.08.051
    • Zeuzem S, Asselah T, Angus P, et al. Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection. Gastroenterology 2011; 141: 2047-2055. Medline doi:10.1053/j.gastro.2011.08.051
    • (2011) Gastroenterology , vol.141 , pp. 2047-2055
    • Zeuzem, S.1    Asselah, T.2    Angus, P.3
  • 48
    • 84863676547 scopus 로고    scopus 로고
    • Safety and antiviral activity of MK-5172, a next generation HCV NS3/4a protease inhibitor with a broad HCV genotipic activity spectrum and potent activity against known resistance mutants, in genotype 1 and 3 HCV-infected patients
    • Petry AS. Safety and antiviral activity of MK-5172, a next generation HCV NS3/4a protease inhibitor with a broad HCV genotipic activity spectrum and potent activity against known resistance mutants, in genotype 1 and 3 HCV-infected patients. Hepatology 2011; 54 Suppl 1: 531A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Petry, A.S.1
  • 49
    • 84867267637 scopus 로고    scopus 로고
    • 39 MK-5172: A novel HCV NS3/4A protease inhibitor with potent activity against known resistance mutants
    • doi:10.1016/S0168-8278(10)60041-4
    • Carroll S, McCauley J, Ludmerer S, et al. 39 MK-5172: a novel HCV NS3/4A protease inhibitor with potent activity against known resistance mutants. J Hepatol 2010; 52 Suppl 1: S17. doi:10.1016/S0168-8278(10)60041-4
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Carroll, S.1    McCauley, J.2    Ludmerer, S.3
  • 50
    • 84867277295 scopus 로고    scopus 로고
    • MK-5172, a second generation HCV NS3/4a protease inhibitor is active against common resistance associated variants (RAVs) and exhibits gross-genotype activity
    • Graham D. MK-5172, a second generation HCV NS3/4a protease inhibitor is active against common resistance associated variants (RAVs) and exhibits gross-genotype activity. Hepatology 2011; 54 Suppl 1: 543A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Graham, D.1
  • 51
    • 84867241116 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship for MK-5172, a novel hepatitis c virus (HCV) NS3/4a protease inhibitor, in genotype 1 and genotype 3 HCV-infected patients
    • Caro L. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship for MK-5172, a novel hepatitis c virus (HCV) NS3/4a protease inhibitor, in genotype 1 and genotype 3 HCV-infected patients. Hepatology 2011; 54 Suppl 1: 1005A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Caro, L.1
  • 52
    • 52449124695 scopus 로고    scopus 로고
    • NS5A - From obscurity to new target for HCV therapy
    • Medline doi:10.2174/157489108784746597
    • Schmitz U, Tan S-L. NS5A - from obscurity to new target for HCV therapy. Recent Pat Antiinfect Drug Discov 2008; 3: 77-92. Medline doi:10.2174/ 157489108784746597
    • (2008) Recent Pat Antiinfect Drug Discov , vol.3 , pp. 77-92
    • Schmitz, U.1    Tan, S.-L.2
  • 53
    • 42949145532 scopus 로고    scopus 로고
    • Regulation of hepatitis C virion production via phosphorylation of the NS5A protein
    • Medline doi:10.1371/journal.ppat.1000032
    • Tellinghuisen TL, Foss KL, Treadaway J. Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. PLoS Pathog 2008; 4: e1000032. Medline doi:10.1371/journal.ppat.1000032
    • (2008) PLoS Pathog , vol.4
    • Tellinghuisen, T.L.1    Foss, K.L.2    Treadaway, J.3
  • 54
    • 4544336360 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A: Tales of a promiscuous protein
    • Medline doi:10.1099/vir.0.80204-0
    • Macdonald A, Harris M. Hepatitis C virus NS5A: tales of a promiscuous protein. J Gen Virol 2004; 85: 2485-2502. Medline doi:10.1099/vir.0.80204-0
    • (2004) J Gen Virol , vol.85 , pp. 2485-2502
    • Macdonald, A.1    Harris, M.2
  • 56
    • 82955200702 scopus 로고    scopus 로고
    • 1212 ACH-2928: A novel highly potent HCV NS5A inhibitor with favorable preclinical characteristics
    • doi:10.1016/S0168-8278(11)61214-2
    • Huang M, Yang G, Patel D, et al. 1212 ACH-2928: a novel highly potent HCV NS5A inhibitor with favorable preclinical characteristics. J Hepatol 2011; 54 Suppl 1: S479. doi:10.1016/S0168-8278(11)61214-2
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Huang, M.1    Yang, G.2    Patel, D.3
  • 57
    • 72849113547 scopus 로고    scopus 로고
    • Identification of hepatitis C virus NS5A inhibitors
    • Medline doi:10.1128/JVI.01360-09
    • Lemm JA, O'Boyle D, Liu M, et al. Identification of hepatitis C virus NS5A inhibitors. J Virol 2010; 84: 482-491. Medline doi:10.1128/JVI.01360-09
    • (2010) J Virol , vol.84 , pp. 482-491
    • Lemm, J.A.1    O'Boyle, D.2    Liu, M.3
  • 58
    • 77952035218 scopus 로고    scopus 로고
    • Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
    • Medline doi:10.1038/nature08960
    • Gao M, Nettles RE, Belema M, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 2010; 465: 96-100. Medline doi:10.1038/nature08960
    • (2010) Nature , vol.465 , pp. 96-100
    • Gao, M.1    Nettles, R.E.2    Belema, M.3
  • 59
    • 77956116880 scopus 로고    scopus 로고
    • Resistance analysis of the hepatitis C Virus NS5A inhibitor BMS-790052 in an in vitro replicon system
    • Medline doi:10.1128/AAC.00556-10
    • Fridell RA, Qiu D, Wang C, Valera L, Gao M. Resistance analysis of the hepatitis C Virus NS5A inhibitor BMS-790052 in an in vitro replicon system. Antimicrob Agents Chemother 2010; 54: 3641-3650. Medline doi:10.1128/AAC.00556- 10
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3641-3650
    • Fridell, R.A.1    Qiu, D.2    Wang, C.3    Valera, L.4    Gao, M.5
  • 60
    • 84856159009 scopus 로고    scopus 로고
    • Preliminary study of two antiviral agents for hepatitis C genotype 1
    • Medline doi:10.1056/NEJMoa1104430
    • Lok AS, Gardiner DF, Lawitz E, et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med 2012; 366: 216-224. Medline doi:10.1056/NEJMoa1104430
    • (2012) N Engl J Med , vol.366 , pp. 216-224
    • Lok, A.S.1    Gardiner, D.F.2    Lawitz, E.3
  • 61
    • 33845247515 scopus 로고    scopus 로고
    • General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2′-modified nucleotide analogues
    • Medline doi:10.1128/AAC.00433-06
    • Dutartre H, Bussetta C, Boretto J, Canard B. General catalytic deficiency of hepatitis C virus RNA polymerase with an S282T mutation and mutually exclusive resistance towards 2′-modified nucleotide analogues. Antimicrob Agents Chemother 2006; 50: 4161-4169. Medline doi:10.1128/AAC.00433-06
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 4161-4169
    • Dutartre, H.1    Bussetta, C.2    Boretto, J.3    Canard, B.4
  • 62
    • 16644390339 scopus 로고    scopus 로고
    • Antivirals against DNA viruses (hepatitis B and the herpes viruses)
    • Medline doi:10.1016/j.coph.2004.06.004
    • Hewlett G, Hallenberger S, Rübsamen-Waigmann H. Antivirals against DNA viruses (hepatitis B and the herpes viruses). Curr Opin Pharmacol 2004; 4: 453-464. Medline doi:10.1016/j.coph.2004.06.004
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 453-464
    • Hewlett, G.1    Hallenberger, S.2    Rübsamen-Waigmann, H.3
  • 63
    • 30844469498 scopus 로고    scopus 로고
    • Nucleoside and nucleotide inhibitors of HIV-1 replication
    • Medline doi:10.1007/s00018-005-5367-x
    • Vivet-Boudou V, Didierjean J, Isel C, Marquet R. Nucleoside and nucleotide inhibitors of HIV-1 replication. Cell Mol Life Sci 2006; 63: 163-186. Medline doi:10.1007/s00018-005-5367-x
    • (2006) Cell Mol Life Sci , vol.63 , pp. 163-186
    • Vivet-Boudou, V.1    Didierjean, J.2    Isel, C.3    Marquet, R.4
  • 64
    • 79955103901 scopus 로고    scopus 로고
    • Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus
    • Medline doi:10.1002/hep.24262
    • Pawlotsky JM. Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus. Hepatology 2011; 53: 1742-1751. Medline doi:10.1002/hep.24262
    • (2011) Hepatology , vol.53 , pp. 1742-1751
    • Pawlotsky, J.M.1
  • 65
    • 77954727003 scopus 로고    scopus 로고
    • New NS5B polymerase inhibitors for hepatitis C
    • Medline doi:10.1517/13543784.2010.500285
    • Legrand-Abravanel F, Nicot F, Izopet J. New NS5B polymerase inhibitors for hepatitis C. Expert Opin Investig Drugs 2010; 19: 963-975. Medline doi:10.1517/13543784.2010.500285
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 963-975
    • Legrand-Abravanel, F.1    Nicot, F.2    Izopet, J.3
  • 66
    • 35648968189 scopus 로고    scopus 로고
    • Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-d-2′-deoxy-2′-fluoro-2′-C- methylcytidine (PSI-6130) and identification of a novel active 5′-triphosphate species
    • Medline doi:10.1074/jbc.M705274200
    • Ma H, Jiang W-R, Robledo N, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-d-2′-deoxy- 2′-fluoro-2′-C-methylcytidine (PSI-6130) and identification of a novel active 5′-triphosphate species. J Biol Chem 2007; 282: 29812-29820. Medline doi:10.1074/jbc.M705274200
    • (2007) J Biol Chem , vol.282 , pp. 29812-29820
    • Ma, H.1    Jiang, W.-R.2    Robledo, N.3
  • 67
    • 84863396230 scopus 로고    scopus 로고
    • Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128)
    • Medline doi:10.1002/hep.24788
    • Guedj J, Dahari H, Tafoya E, Smith P, Perelson AS. Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128). Hepatology 2012; 55: 1030-1037. Medline doi:10.1002/hep.24788
    • (2012) Hepatology , vol.55 , pp. 1030-1037
    • Guedj, J.1    Dahari, H.2    Tafoya, E.3    Smith, P.4    Perelson, A.S.5
  • 68
    • 41349083638 scopus 로고    scopus 로고
    • Antiviral activity, pharmacokinetics, safety, and tolerability of R7128, a novel nucleoside HCV RNA polymerase inhibitor, following multiple, ascending, oral doses in patients with HCV genotype 1 infection who have failed prior interferon therapy
    • Reddy R, Rodriguez-Torres M, Gane E, et al. Antiviral activity, pharmacokinetics, safety, and tolerability of R7128, a novel nucleoside HCV RNA polymerase inhibitor, following multiple, ascending, oral doses in patients with HCV genotype 1 infection who have failed prior interferon therapy. Hepatology 2007; 46 Suppl 1: 862A.
    • (2007) Hepatology , vol.46 , Issue.SUPPL. 1
    • Reddy, R.1    Rodriguez-Torres, M.2    Gane, E.3
  • 69
    • 67650571603 scopus 로고    scopus 로고
    • Potent antiviral response to the HCV nucleoside polymerase inhibitor R7128 for 28 days with peg-IFN and ribavirin: Subanalysis by race/ethnicity, weight, and HCV genotype
    • Rodriguez-Torres M, Lalezari J, Gane E, et al. Potent antiviral response to the HCV nucleoside polymerase inhibitor R7128 for 28 days with peg-IFN and ribavirin: subanalysis by race/ethnicity, weight, and HCV genotype. Hepatology 2008; 48: 1160A.
    • (2008) Hepatology , vol.48
    • Rodriguez-Torres, M.1    Lalezari, J.2    Gane, E.3
  • 70
    • 59149098021 scopus 로고    scopus 로고
    • Antiviral activity of the HCV nucleoside polymerase inhibitor R7128 in HCV genotype 2 and 3 prior non-responders: Interim results of R7128 1500mg BID with PEG-IFN and ribavirin for 28 days
    • Gane E, Rodriguez-Torres M, Nelson DR, et al. Antiviral activity of the HCV nucleoside polymerase inhibitor R7128 in HCV genotype 2 and 3 prior non-responders: interim results of R7128 1500mg BID with PEG-IFN and ribavirin for 28 days. Hepatology 2008; 48: 1024A.
    • (2008) Hepatology , vol.48
    • Gane, E.1    Rodriguez-Torres, M.2    Nelson, D.R.3
  • 71
    • 78349268362 scopus 로고    scopus 로고
    • RG7128 alone or in combination with pegylated interferon-α2a and ribavirin prevents hepatitis C virus (HCV) replication and selection of resistant variants in HCV-infected patients
    • Medline doi:10.1086/656774
    • Le Pogam S, Seshaadri A, Ewing A, et al. RG7128 alone or in combination with pegylated interferon-α2a and ribavirin prevents hepatitis C virus (HCV) replication and selection of resistant variants in HCV-infected patients. J Infect Dis 2010; 202: 1510-1519. Medline doi:10.1086/656774
    • (2010) J Infect Dis , vol.202 , pp. 1510-1519
    • Le Pogam, S.1    Seshaadri, A.2    Ewing, A.3
  • 72
    • 33744910421 scopus 로고    scopus 로고
    • In vitro selected Con1 subgenomic replicons resistant to 2′-C-methyl-cytidine or to R1479 show lack of cross resistance
    • Medline doi:10.1016/j.virol.2006.03.045
    • Le Pogam S, Jiang W-R, Leveque V, et al. In vitro selected Con1 subgenomic replicons resistant to 2′-C-methyl-cytidine or to R1479 show lack of cross resistance. Virology 2006; 351: 349-359. Medline doi:10.1016/j.virol.2006.03.045
    • (2006) Virology , vol.351 , pp. 349-359
    • Le Pogam, S.1    Jiang, W.-R.2    Leveque, V.3
  • 73
    • 84867278904 scopus 로고    scopus 로고
    • No detection of variants bearing NS5B S282T mericitabine (MCB) resistance mutation in DAA treatment-naive HCV genotype 1 infected patients using ultra-deep pyrosequencing (UDPS)
    • Margeridon S, Le Pogam S, Liu TF, et al. No detection of variants bearing NS5B S282T mericitabine (MCB) resistance mutation in DAA treatment-naive HCV genotype 1 infected patients using ultra-deep pyrosequencing (UDPS). Hepatology 2011; 54 Suppl 1: 532A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Margeridon, S.1    Le Pogam, S.2    Liu, T.F.3
  • 74
    • 78751634051 scopus 로고    scopus 로고
    • High rates of early viral response, promising safety profile and lack of resistance-related breakthrough in HCV Gt1/4 patients treated with RG7128 plus pegIFN alfa-2a (40kD)/RBV: Planned week 12 interim analysis from the propel study
    • Jensen D, Wedemeyer H, Herring PF, et al. High rates of early viral response, promising safety profile and lack of resistance-related breakthrough in HCV Gt1/4 patients treated with RG7128 plus pegIFN alfa-2a (40kD)/RBV: planned week 12 interim analysis from the propel study. Hepatology 2010; 52 Suppl 1: 360A.
    • (2010) Hepatology , vol.52 , Issue.SUPPL. 1
    • Jensen, D.1    Wedemeyer, H.2    Herring, P.F.3
  • 75
    • 79960453114 scopus 로고    scopus 로고
    • 1359 First SVR data with the nucleoside analogue polymerase inhibitor mericitabine (RG7128) combined with pefinterferon/ribavirin in treatment-naive HCV G1/4 patients: Interim analysis from the JUMP-C trial
    • doi:10.1016/S0168-8278(11)61361-5
    • Pockros P, Jensen D, Tsai N, et al. 1359 First SVR data with the nucleoside analogue polymerase inhibitor mericitabine (RG7128) combined with pefinterferon/ribavirin in treatment-naive HCV G1/4 patients: interim analysis from the JUMP-C trial. J Hepatol 2011; 54 Suppl 1: S538. doi:10.1016/S0168- 8278(11)61361-5
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Pockros, P.1    Jensen, D.2    Tsai, N.3
  • 77
    • 78049375232 scopus 로고    scopus 로고
    • Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977
    • Medline doi:10.1074/jbc.M110.161802
    • Murakami E, Tolstykh T, Bao H, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem 2010; 285: 34337-34347. Medline doi:10.1074/jbc.M110.161802
    • (2010) J Biol Chem , vol.285 , pp. 34337-34347
    • Murakami, E.1    Tolstykh, T.2    Bao, H.3
  • 78
    • 77951296579 scopus 로고    scopus 로고
    • Antiviral activity, pharmacokinetics, safety, and tolerability of PSI-7851, a novel nucleotide polymerase inhibitor for HCV, following single and 3 day multiple ascending oral doses in healthy volunteers and patients with chronic HCV infection
    • Rodriguez-Torres M, Lawitz E, Flach S, et al. Antiviral activity, pharmacokinetics, safety, and tolerability of PSI-7851, a novel nucleotide polymerase inhibitor for HCV, following single and 3 day multiple ascending oral doses in healthy volunteers and patients with chronic HCV infection. Hepatology 2009; 50 Suppl 4: 228A.
    • (2009) Hepatology , vol.50 , Issue.SUPPL. 4
    • Rodriguez-Torres, M.1    Lawitz, E.2    Flach, S.3
  • 79
    • 79960443316 scopus 로고    scopus 로고
    • 1372 Once daily PSI-7977 plus PEG-IFN/RBV in HCV GT1: 98% rapid virologic response, complete early virologic response: The Proton study
    • doi:10.1016/S0168-8278(11)61374-3
    • Nelson DR, Lalezari J, Lawitz E, et al. 1372 Once daily PSI-7977 plus PEG-IFN/RBV in HCV GT1: 98% rapid virologic response, complete early virologic response: the Proton study. J Hepatol 2011; 54 Suppl 1: S544. doi:10.1016/S0168-8278(11)61374-3
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Nelson, D.R.1    Lalezari, J.2    Lawitz, E.3
  • 80
    • 79960471533 scopus 로고    scopus 로고
    • 61 Once daily PSI-7977 plus pegIFN/RBV in a phase 2B trial: Rapid virologic suppression in treatment-naive patients with HCV GT2/GT3
    • doi:10.1016/S0168-8278(11)60063-9
    • Lalezari J, Lawitz E, Rodriguez-Torres M, et al. 61 Once daily PSI-7977 plus pegIFN/RBV in a phase 2B trial: rapid virologic suppression in treatment-naive patients with HCV GT2/GT3. J Hepatol 2011; 54 Suppl 1: S28. doi:10.1016/S0168-8278(11)60063-9
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Lalezari, J.1    Lawitz, E.2    Rodriguez-Torres, M.3
  • 81
    • 84855248040 scopus 로고    scopus 로고
    • Once-daily PSI-7977 plus RBV: Pegylated interferon-alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3
    • Gane E, Stedman C, Hyland R, et al. Once-daily PSI-7977 plus RBV: pegylated interferon-alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3. Hepatology 2011; 54 Suppl 1: 377A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Gane, E.1    Stedman, C.2    Hyland, R.3
  • 82
    • 79960471175 scopus 로고    scopus 로고
    • 1370 once daily dual-nucleotide combination of PSI-938 and PSI-7977 provides 94% HCVRNA
    • doi:10.1016/S0168-8278(11)61372-X
    • Lawitz E, Rodriguez-Torres M, Denning J, et al. 1370 once daily dual-nucleotide combination of PSI-938 and PSI-7977 provides 94% HCVRNA
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Lawitz, E.1    Rodriguez-Torres, M.2    Denning, J.3
  • 83
    • 84860313573 scopus 로고    scopus 로고
    • Will interferon-free regimens prevail?
    • Medline doi:10.1053/j.gastro.2011.12.062
    • Welsch C, Zeuzem S. Will interferon-free regimens prevail? Gastroenterology 2012; 142: 1352-1355. Medline doi:10.1053/j.gastro.2011.12.062
    • (2012) Gastroenterology , vol.142 , pp. 1352-1355
    • Welsch, C.1    Zeuzem, S.2
  • 84
    • 83555163165 scopus 로고    scopus 로고
    • 35 Genotypic characterisation of filibuvir (PF-00868554) resistance in patients receiving four weeks co-administration of filibuvir with pegIFN/RBV (12 week analysis)
    • doi:10.1016/S0168-8278(10)60037-2
    • Mori J, Hammond JL, Srinivasan S, Jagannatha S, van der Ryst E. 35 Genotypic characterisation of filibuvir (PF-00868554) resistance in patients receiving four weeks co-administration of filibuvir with pegIFN/RBV (12 week analysis). J Hepatol 2010; 52 Suppl 1: S15. doi:10.1016/S0168-8278(10)60037-2
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Mori, J.1    Hammond, J.L.2    Srinivasan, S.3    Jagannatha, S.4    Van Der Ryst, E.5
  • 85
    • 84857186976 scopus 로고    scopus 로고
    • Characterization of resistance to the non-nucleoside NS5B inhibitor filibuvir in hepatitis C infected patients
    • Medline doi:10.1128/AAC.05611-11
    • Troke PJF, Lewis M, Simpson P, et al. Characterization of resistance to the non-nucleoside NS5B inhibitor filibuvir in hepatitis C infected patients. Antimicrob Agents Chemother 2011; 56: 1331-1341. Medline doi:10.1128/AAC.05611- 11
    • (2011) Antimicrob Agents Chemother , vol.56 , pp. 1331-1341
    • Troke, P.J.F.1    Lewis, M.2    Simpson, P.3
  • 86
    • 77954745283 scopus 로고    scopus 로고
    • 31 Safety and antiviral activity of the HCV non-nucleoside polymerase inhibitor VX-222 in treatment-naive genotype 1 HCV-infected patients
    • doi:10.1016/S0168-8278(10)60033-5
    • Rodriguez-Torres M, Lawitz E, Conway B, et al. 31 Safety and antiviral activity of the HCV non-nucleoside polymerase inhibitor VX-222 in treatment-naive genotype 1 HCV-infected patients. J Hepatol 2010; 52 Suppl 1: S14. doi:10.1016/S0168-8278(10)60033-5
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Rodriguez-Torres, M.1    Lawitz, E.2    Conway, B.3
  • 87
    • 84863020256 scopus 로고    scopus 로고
    • 939 Preclinical pharmacokinetic and adme characterization of VCH-222, a novel NS5B polymerase inhibitor
    • doi:10.1016/S0168-8278(09)60941-7
    • Chauret N, Chagnon-Labelle C, Diallo M, et al. 939 Preclinical pharmacokinetic and adme characterization of VCH-222, a novel NS5B polymerase inhibitor. J Hepatol 2009; 50 Suppl 1: S341-S342. doi:10.1016/S0168-8278(09) 60941-7
    • (2009) J Hepatol , vol.50 , Issue.SUPPL. 1
    • Chauret, N.1    Chagnon-Labelle, C.2    Diallo, M.3
  • 88
    • 67650556130 scopus 로고    scopus 로고
    • 940 Safety, tolerability and pharmacokinetics of the HCV polymerase inhibitor VCH-222 following single doses administration in healthy volunteers and antiviral activity in HCV-infected individuals
    • doi:10.1016/S0168-8278(09)60942-9
    • Cooper C, Larouche R, Bourgault B, Chauret N, Proulx L. 940 Safety, tolerability and pharmacokinetics of the HCV polymerase inhibitor VCH-222 following single doses administration in healthy volunteers and antiviral activity in HCV-infected individuals. J Hepatol 2009; 50 Suppl 1: S342. doi:10.1016/S0168-8278(09)60942-9
    • (2009) J Hepatol , vol.50 , Issue.SUPPL. 1
    • Cooper, C.1    Larouche, R.2    Bourgault, B.3    Chauret, N.4    Proulx, L.5
  • 89
    • 80051915933 scopus 로고    scopus 로고
    • 1363 VX-222 with TVR alone or in combination with peginterferon alfa-2a and ribavirin in treatment-naive patients with chronic hepatitis C: Zenith study interim results
    • doi:10.1016/S0168-8278(11)61365-2
    • Di Bisceglie AM, Nelson DR, Gane E, et al. 1363 VX-222 with TVR alone or in combination with peginterferon alfa-2a and ribavirin in treatment-naive patients with chronic hepatitis C: Zenith study interim results. J Hepatol 2011; 54 Suppl 1: S540. doi:10.1016/S0168-8278(11)61365-2
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Di Bisceglie, A.M.1    Nelson, D.R.2    Gane, E.3
  • 90
    • 4043129511 scopus 로고    scopus 로고
    • Function-dependent clustering of orthologues and paralogues of cyclophilins
    • Medline doi:10.1002/prot.20156
    • Galat A. Function-dependent clustering of orthologues and paralogues of cyclophilins. Proteins 2004; 56: 808-820. Medline doi:10.1002/prot.20156
    • (2004) Proteins , vol.56 , pp. 808-820
    • Galat, A.1
  • 91
    • 77951046665 scopus 로고    scopus 로고
    • HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors
    • Medline doi:10.1016/j.jhep.2010.01.041
    • Chatterji U, Lim P, Bobardt MD, et al. HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. J Hepatol 2010; 53: 50-56. Medline doi:10.1016/j.jhep. 2010.01.041
    • (2010) J Hepatol , vol.53 , pp. 50-56
    • Chatterji, U.1    Lim, P.2    Bobardt, M.D.3
  • 92
    • 43949123575 scopus 로고    scopus 로고
    • Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro
    • Medline doi:10.1128/JVI.02614-07
    • Yang F, Robotham JM, Nelson HB, Irsigler A, Kenworthy R, Tang H. Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro. J Virol 2008; 82: 5269-5278. Medline doi:10.1128/JVI.02614-07
    • (2008) J Virol , vol.82 , pp. 5269-5278
    • Yang, F.1    Robotham, J.M.2    Nelson, H.B.3    Irsigler, A.4    Kenworthy, R.5    Tang, H.6
  • 93
    • 67449093865 scopus 로고    scopus 로고
    • Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex
    • Medline doi:10.1128/JVI.02550-08
    • Liu Z, Yang F, Robotham JM, Tang H. Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex. J Virol 2009; 83: 6554-6565. Medline doi:10.1128/JVI.02550-08
    • (2009) J Virol , vol.83 , pp. 6554-6565
    • Liu, Z.1    Yang, F.2    Robotham, J.M.3    Tang, H.4
  • 94
    • 67651171774 scopus 로고    scopus 로고
    • Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A
    • Medline doi:10.1002/hep.22987
    • Liu Z, Robida JM, Chinnaswamy S, et al. Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A. Hepatology 2009; 50: 25-33. Medline doi:10.1002/hep.22987
    • (2009) Hepatology , vol.50 , pp. 25-33
    • Liu, Z.1    Robida, J.M.2    Chinnaswamy, S.3
  • 95
    • 0142182744 scopus 로고    scopus 로고
    • Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
    • Medline doi:10.1053/jhep.2003.50449
    • Watashi K, Hijikata M, Hosaka M, Yamaji M, Shimotohno K. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology 2003; 38: 1282-1288. Medline doi:10.1053/jhep.2003.50449
    • (2003) Hepatology , vol.38 , pp. 1282-1288
    • Watashi, K.1    Hijikata, M.2    Hosaka, M.3    Yamaji, M.4    Shimotohno, K.5
  • 96
    • 10744223246 scopus 로고    scopus 로고
    • Specific inhibition of hepatitis C virus replication by cyclosporin A
    • Medline doi:10.1016/j.bbrc.2003.11.080
    • Nakagawa M, Sakamoto N, Enomoto N, et al. Specific inhibition of hepatitis C virus replication by cyclosporin A. Biochem Biophys Res Commun 2004; 313: 42-47. Medline doi:10.1016/j.bbrc.2003.11.080
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 42-47
    • Nakagawa, M.1    Sakamoto, N.2    Enomoto, N.3
  • 97
    • 78149434641 scopus 로고    scopus 로고
    • DEB025 (alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A
    • Medline doi:10.1371/journal.pone.0013687
    • Coelmont L, Hanoulle X, Chatterji U, et al. DEB025 (alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS ONE 2010; 5: e13687. Medline doi:10.1371/journal.pone.0013687
    • (2010) PLoS ONE , vol.5
    • Coelmont, L.1    Hanoulle, X.2    Chatterji, U.3
  • 98
    • 66149129922 scopus 로고    scopus 로고
    • The cyclophilin inhibitor debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients
    • Medline doi:10.1002/hep.22835
    • Flisiak R, Feinman SV, Jablkowski M, et al. The cyclophilin inhibitor debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients. Hepatology 2009; 49: 1460-1468. Medline doi:10.1002/hep.22835
    • (2009) Hepatology , vol.49 , pp. 1460-1468
    • Flisiak, R.1    Feinman, S.V.2    Jablkowski, M.3
  • 99
    • 77954999006 scopus 로고    scopus 로고
    • Cyclophilin inhibitors for the treatment of HCV infection
    • Medline
    • Fischer G, Gallay P, Hopkins S. Cyclophilin inhibitors for the treatment of HCV infection. Curr Opin Investig Drugs 2010; 11: 911-918. Medline
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 911-918
    • Fischer, G.1    Gallay, P.2    Hopkins, S.3
  • 100
    • 33646015668 scopus 로고    scopus 로고
    • The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro
    • Medline doi:10.1002/hep.21102
    • Paeshuyse J, Kaul A, De Clercq E, et al. The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro. Hepatology 2006; 43: 761-770. Medline doi:10.1002/hep.21102
    • (2006) Hepatology , vol.43 , pp. 761-770
    • Paeshuyse, J.1    Kaul, A.2    De Clercq, E.3
  • 101
    • 79960446187 scopus 로고    scopus 로고
    • 4 Once daily alisporivir (DEB025) plus pegifnalfa2a/ribavirin results in superior sustained virologic response (SVR24) in chronic hepatitis C genotype 1 treatment naive patients
    • doi:10.1016/S0168-8278(11)60006-8
    • Flisiak R, Pawlotsky JM, Crabbe R, et al. 4 Once daily alisporivir (DEB025) plus pegifnalfa2a/ribavirin results in superior sustained virologic response (SVR24) in chronic hepatitis C genotype 1 treatment naive patients. J Hepatol 2011; 54 Suppl 1: S2. doi:10.1016/S0168-8278(11)60006-8
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Flisiak, R.1    Pawlotsky, J.M.2    Crabbe, R.3
  • 102
    • 84855223336 scopus 로고    scopus 로고
    • Once daily alisporivir interferon (IFN)-free regimens achieve high rates of early HCV clearance in previously untreated patients with hcv genotype (G) 2 or 3
    • Pawlotsky J, Flisiak R, Rasenack J, et al. Once daily alisporivir interferon (IFN)-free regimens achieve high rates of early HCV clearance in previously untreated patients with hcv genotype (G) 2 or 3. Hepatology 2011; 54 Suppl 1: 1433A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Pawlotsky, J.1    Flisiak, R.2    Rasenack, J.3
  • 103
    • 77951224110 scopus 로고    scopus 로고
    • Mechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors
    • Medline doi:10.1128/AAC.01236-09
    • Puyang X, Poulin DL, Mathy JE, et al. Mechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors. Antimicrob Agents Chemother 2010; 54: 1981-1987. Medline doi:10.1128/AAC.01236- 09
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1981-1987
    • Puyang, X.1    Poulin, D.L.2    Mathy, J.E.3
  • 104
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Medline doi:10.1016/S0092-8674(04)00045-5
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297. Medline doi:10.1016/S0092-8674(04)00045-5
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 105
    • 23844523406 scopus 로고    scopus 로고
    • miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1
    • Medline doi:10.4161/rna.1.2.1066
    • Chang J, Nicolas E, Marks D, et al. miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1. RNA Biol 2004; 1: 106-113. Medline doi:10.4161/rna.1.2.1066
    • (2004) RNA Biol , vol.1 , pp. 106-113
    • Chang, J.1    Nicolas, E.2    Marks, D.3
  • 106
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA
    • Medline doi:10.1126/science.1113329
    • Jopling CL, Yi M, Lancaster AM, Lemon SM, Sarnow P. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science 2005; 309: 1577-1581. Medline doi:10.1126/science.1113329
    • (2005) Science , vol.309 , pp. 1577-1581
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarnow, P.5
  • 107
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • Medline doi:10.1126/science.1178178
    • Lanford RE, Hildebrandt-Eriksen ES, Petri A, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010; 327: 198-201. Medline doi:10.1126/science.1178178
    • (2010) Science , vol.327 , pp. 198-201
    • Lanford, R.E.1    Hildebrandt-Eriksen, E.S.2    Petri, A.3
  • 108
    • 84861537600 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo (PLB) controlled safety and anti-viral proof of concept study of Miravirsen (MIR), an oligonucleotide targeting miR-122, in treatment naive patients with genotype 1 (Gt1) chronic HCV infection
    • Janssen HLA, Reesink HW, Zeuzem S, et al. A randomized, double-blind, placebo (PLB) controlled safety and anti-viral proof of concept study of Miravirsen (MIR), an oligonucleotide targeting miR-122, in treatment naive patients with genotype 1 (Gt1) chronic HCV infection. Hepatology 2011; 54 Suppl 1: 1430A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Janssen, H.L.A.1    Reesink, H.W.2    Zeuzem, S.3
  • 109
    • 79953201904 scopus 로고    scopus 로고
    • MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5′ UTR
    • Medline doi:10.1073/pnas.1016606108
    • Li YP, Gottwein JM, Scheel TK, Jensen TB, Bukh J. MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5′ UTR. Proc Natl Acad Sci U S A 2011; 108: 4991. Medline doi:10.1073/pnas.1016606108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4991
    • Li, Y.P.1    Gottwein, J.M.2    Scheel, T.K.3    Jensen, T.B.4    Bukh, J.5
  • 110
    • 3242711262 scopus 로고    scopus 로고
    • Innate sensing of viruses by Toll-like receptors
    • Medline doi:10.1128/JVI.78.15.7867-7873.2004
    • Boehme KW, Compton T. Innate sensing of viruses by Toll-like receptors. J Virol 2004; 78: 7867-7873. Medline doi:10.1128/JVI.78.15.7867-7873.2004
    • (2004) J Virol , vol.78 , pp. 7867-7873
    • Boehme, K.W.1    Compton, T.2
  • 111
    • 4344689650 scopus 로고    scopus 로고
    • Toll-like receptors involved in the response to microbial pathogens: Development of agonists for toll-like receptor 9
    • Schetter C, Vollmer J. Toll-like receptors involved in the response to microbial pathogens: development of agonists for toll-like receptor 9. Curr Opin Drug Discov Devel 2004; 7: 204-210. Medline (Pubitemid 44111952)
    • (2004) Current Opinion in Drug Discovery and Development , vol.7 , Issue.2 , pp. 204-210
    • Schetter, C.1    Vollmer, J.2
  • 112
    • 23944482649 scopus 로고    scopus 로고
    • Challenges and successes in developing new therapies for hepatitis C
    • Medline doi:10.1038/nature04080
    • De Francesco R, Migliaccio G. Challenges and successes in developing new therapies for hepatitis C. Nature 2005; 436: 953-960. Medline doi:10.1038/nature04080
    • (2005) Nature , vol.436 , pp. 953-960
    • De Francesco, R.1    Migliaccio, G.2
  • 113
    • 79960554471 scopus 로고    scopus 로고
    • Randomised clinical trial: Anti-viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV
    • Medline doi:10.1111/j.1365-2036.2011.04745.x
    • Bergmann JF, de Bruijne J, Hotho DM, et al. Randomised clinical trial: anti-viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV. Aliment Pharmacol Ther 2011; 34: 443-453. Medline doi:10.1111/j.1365-2036.2011.04745.x
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 443-453
    • Bergmann, J.F.1    De Bruijne, J.2    Hotho, D.M.3
  • 114
    • 78650965673 scopus 로고    scopus 로고
    • 32 A Phase 1, multi-center, randomized, placebo-controlled, dose-escalation study of IMO-2125, a TLR9 agonist, in hepatitis C-nonresponders
    • doi:10.1016/S0168-8278(10)60034-7
    • Muir A, Ghalib R, Lawitz E, et al. 32 A Phase 1, multi-center, randomized, placebo-controlled, dose-escalation study of IMO-2125, a TLR9 agonist, in hepatitis C-nonresponders. J Hepatol 2010; 52 Suppl 1: S14. doi:10.1016/S0168-8278(10)60034-7
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Muir, A.1    Ghalib, R.2    Lawitz, E.3
  • 115
    • 0033795196 scopus 로고    scopus 로고
    • Interferons: Cell signalling, immune modulation, antiviral response and virus countermeasures
    • Medline
    • Goodbourn S, Didcock L, Randall RE. Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J Gen Virol 2000; 81: 2341-2364. Medline
    • (2000) J Gen Virol , vol.81 , pp. 2341-2364
    • Goodbourn, S.1    Didcock, L.2    Randall, R.E.3
  • 116
    • 0037243222 scopus 로고    scopus 로고
    • IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex
    • Medline doi:10.1038/ni875
    • Kotenko SV, Gallagher G, Baurin VV, et al. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol 2003; 4: 69-77. Medline doi:10.1038/ni875
    • (2003) Nat Immunol , vol.4 , pp. 69-77
    • Kotenko, S.V.1    Gallagher, G.2    Baurin, V.V.3
  • 117
    • 42949160129 scopus 로고    scopus 로고
    • IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo
    • Medline doi:10.1371/journal.ppat.1000017
    • Sommereyns C, Paul S, Staeheli P, Michiels T. IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog 2008; 4: e1000017. Medline doi:10.1371/journal.ppat.1000017
    • (2008) PLoS Pathog , vol.4
    • Sommereyns, C.1    Paul, S.2    Staeheli, P.3    Michiels, T.4
  • 118
    • 77955873433 scopus 로고    scopus 로고
    • Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection
    • Medline doi:10.1002/hep.23743
    • Muir AJ, Shiffman ML, Zaman A, et al. Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection. Hepatology 2010; 52: 822-832. Medline doi:10.1002/hep.23743
    • (2010) Hepatology , vol.52 , pp. 822-832
    • Muir, A.J.1    Shiffman, M.L.2    Zaman, A.3
  • 119
    • 79960443884 scopus 로고    scopus 로고
    • Pegylated interferon-lambda (PegIFN-λ) shows superior viral response with improved safety and tolerability versus PegIFN-α-2a in HCV patients (G1/2/3/4): EMERGE Phase IIb through week 12
    • doi:10.1016/S0168-8278(11)61362-7
    • Zeuzem S, Arora S, Box T, et al. Pegylated interferon-lambda (PegIFN-λ) shows superior viral response with improved safety and tolerability versus PegIFN-α-2a in HCV patients (G1/2/3/4): EMERGE Phase IIb through week 12. J Hepatol 2011; 54 Suppl 1: S538-S539. doi:10.1016/S0168- 8278(11)61362-7
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Zeuzem, S.1    Arora, S.2    Box, T.3
  • 120
    • 84863712408 scopus 로고    scopus 로고
    • Safety and efficacy of Pegylated interferon lambda (peg-lambda) compared to pegylated interferon-α-2a (peg-alfa) in HCV-infected patients (G1/2/3) with compensated cirrhosis: EMERGE phase IIb efficacy and safety results through week 12
    • Rodriguez-Torres M, Hillson JL, Bacon BR, et al. Safety and efficacy of Pegylated interferon lambda (peg-lambda) compared to pegylated interferon-α-2a (peg-alfa) in HCV-infected patients (G1/2/3) with compensated cirrhosis: EMERGE phase IIb efficacy and safety results through week 12. Hepatology 2011; 54 Suppl 1: 994A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Rodriguez-Torres, M.1    Hillson, J.L.2    Bacon, B.R.3
  • 121
    • 84857868101 scopus 로고    scopus 로고
    • Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the protease inhibitor BMS-650032 achieved 90% sustained virologic response (SVR12) in HCV genotype 1b-infected null responders
    • Chayama K. Dual oral combination therapy with the NS5A inhibitor BMS-790052 and the protease inhibitor BMS-650032 achieved 90% sustained virologic response (SVR12) in HCV genotype 1b-infected null responders. Hepatology 2011; 54 Suppl 1: 1428A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Chayama, K.1
  • 122
    • 42149127046 scopus 로고    scopus 로고
    • Ribavirin considerations in treatment optimization
    • Dusheiko G, Nelson D, Reddy KR. Ribavirin considerations in treatment optimization. Antivir Ther 2008; 13 Suppl 1: 23-30. Medline (Pubitemid 351542495)
    • (2008) Antiviral Therapy , vol.13 , Issue.SUPPL. 1 , pp. 23-30
    • Dusheiko, G.1    Nelson, D.2    Reddy, K.R.3
  • 124
    • 0028832632 scopus 로고
    • The NS2 protein of hepatitis C virus is a transmembrane polypeptide
    • Medline
    • Santolini E, Pacini L, Fipaldini C, Migliaccio G, Monica N. The NS2 protein of hepatitis C virus is a transmembrane polypeptide. J Virol 1995; 69: 7461-7471. Medline
    • (1995) J Virol , vol.69 , pp. 7461-7471
    • Santolini, E.1    Pacini, L.2    Fipaldini, C.3    Migliaccio, G.4    Monica, N.5
  • 125
    • 34547734952 scopus 로고    scopus 로고
    • Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
    • Medline doi:10.1128/JVI.00690-07
    • Jones CT, Murray CL, Eastman DK, Tassello J, Rice CM. Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J Virol 2007; 81: 8374-8383. Medline doi:10.1128/JVI.00690-07
    • (2007) J Virol , vol.81 , pp. 8374-8383
    • Jones, C.T.1    Murray, C.L.2    Eastman, D.K.3    Tassello, J.4    Rice, C.M.5
  • 126
    • 0028884176 scopus 로고
    • Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase
    • Medline doi:10.1006/abbi.1995.0008
    • Jin L, Peterson DL. Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase. Arch Biochem Biophys 1995; 323: 47-53. Medline doi:10.1006/abbi.1995.0008
    • (1995) Arch Biochem Biophys , vol.323 , pp. 47-53
    • Jin, L.1    Peterson, D.L.2
  • 127
    • 0242456017 scopus 로고    scopus 로고
    • Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines
    • Medline doi:10.1128/JVI.74.5.2293-2304.2000
    • Wölk B, Sansonno D, Kräusslich HG, et al. Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines. J Virol 2000; 74: 2293-2304. Medline doi:10.1128/JVI.74.5.2293-2304.2000
    • (2000) J Virol , vol.74 , pp. 2293-2304
    • Wölk, B.1    Sansonno, D.2    Kräusslich, H.G.3
  • 128
    • 79955647061 scopus 로고    scopus 로고
    • New opportunities in anti-hepatitis C virus drug discovery: Targeting NS4B
    • Medline doi:10.1016/j.antiviral.2011.01.009
    • Rai R, Deval J. New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B. Antiviral Res 2011; 90: 93-101. Medline doi:10.1016/j.antiviral.2011.01.009
    • (2011) Antiviral Res , vol.90 , pp. 93-101
    • Rai, R.1    Deval, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.