Charting, navigating, and populating natural product chemical space for drug discovery

Journal of Medicinal Chemistry

Volumn 55, Issue 13, 2012, Pages 5989-6001

  Lachance, Hugo ^a   Wetzel, Stefan ^a,b   Kumar, Kamal ^a,b   Waldmann, Herbert ^a,b  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b TU DORTMUND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; 11BETA HYDROXYSTEROID DEHYDROGENASE 2 INHIBITOR; 4 PYRONE DERIVATIVE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; BENZOMORPHANE DERIVATIVE; BETA CARBOLINE DERIVATIVE; CHOLINESTERASE INHIBITOR; CODEINE; DIAMORPHINE; ETORPHINE; HETEROCYCLIC COMPOUND; LIPOXYGENASE INHIBITOR; METHADONE; MONOAMINE OXIDASE INHIBITOR; MORPHINANE DERIVATIVE; MORPHINE; MORPHINE DERIVATIVE; NATURAL PRODUCT; OXIDOREDUCTASE INHIBITOR; OXYCODONE; PHOSPHOPROTEIN PHOSPHATASE CDC25A INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PIPERIDINE DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR; QUINOLIZIDINE DERIVATIVE; QUINOLIZINE DERIVATIVE; SPIROTYPROSTATIN B; TETRAHYDROINDOLO[2,3 A]QUINOLIZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CHEMICAL REACTION; COMPUTER MODEL; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MOLECULAR LIBRARY; PRINCIPAL COMPONENT ANALYSIS; REVIEW; SOLID PHASE SYNTHESIS; STEREOCHEMISTRY;

BIOLOGICAL AGENTS; DATABASES, FACTUAL; DRUG DESIGN; DRUG DISCOVERY; DRUG INDUSTRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PRINCIPAL COMPONENT ANALYSIS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863825873     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300288g     Document Type: Review

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