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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4431-4436

Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series

(22) McGowan, David a Vendeville, Sandrine a Lin, Tse I a Tahri, Abdellah a Hu, Lili a Cummings, Maxwell D a Amssoms, Katie a Berke, Jan Martin a Canard, Maxime a Cleiren, Erna a Dehertogh, Pascale a Last, Stefaan a Fransen, Els a Van Der Helm, Elisabeth a Van Den Steen, Iris a Vijgen, Leen a Rouan, Marie Claude a Fanning, Gregory a Nyanguile, Origène a Van Emelen, Kristof a more..

a JANSSEN RESEARCH FOUNDATION (Belgium)

Author keywords

Allosteric inhibitor; Hepatitis C virus; Macrocycle; NS5b polymerase

Indexed keywords

1,6 MACROCYCLIC INDOLE; 2,6 MACROCYCLIC INDOLE; ACYLSULFAMIDE ACID; ANTIVIRUS AGENT; INDOLE DERIVATIVE; NITROGEN; NONSTRUCTURAL PROTEIN 5B; SULFAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; HEPATITIS C VIRUS; NONHUMAN;

ALLOSTERIC REGULATION; ANIMALS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HEPACIVIRUS; HUMANS; INDOLES; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 84862221637 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.03.097 Document Type: Article

Times cited : (17)

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