nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge

Frontiers in Physiology

Volumn 4 MAY, Issue , 2013, Pages

  Canzoniero, Lorella M T ^a   Granzotto, Alberto ^b   Turetsky, Dorothy M ^c   Choi, Dennis W ^d   Dugan, Laura L ^e,f   Sensi, Stefano L ^b,g  

^a UNIVERSITY OF SANNIO   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c OKLAHOMA STATE UNIVERSITY   (United States)

^d STONY BROOK UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Excitotoxicity; Huntington's disease; NADPH diaphorase; Nitric oxide synthase; Reactive oxygen species

Indexed keywords

AMPA RECEPTOR; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEURONAL NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CELL SUBPOPULATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORPUS STRIATUM; EXCITOTOXICITY; FETUS; HUNTINGTON CHOREA; INTERNEURON; MITOCHONDRION; MOUSE; NERVE CELL; NONHUMAN; PATCH CLAMP; PHOTOOXIDATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TISSUE CULTURE;

EID: 84883800480     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2013.00112     Document Type: Article

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