Mitochondrial function and dysfunction in the cell: Its relevance to aging and aging-related disease

International Journal of Biochemistry and Cell Biology

Volumn 34, Issue 11, 2002, Pages 1372-1381

  Nicholls, David G ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Calcium; Glutathione; Membrane potential; Mitochondria; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; GLUTATHIONE; PROTON; REACTIVE OXYGEN METABOLITE;

AGING; ANIMAL CELL; BIOENERGY; CELL DAMAGE; CELL FUNCTION; CELL ORGANELLE; CYTOPLASM; ELECTROCHEMISTRY; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOLECULAR INTERACTION; NERVE DEGENERATION; NONHUMAN; REVIEW;

EID: 0036830474     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(02)00077-8     Document Type: Short Survey

References (66)

1. Novelli A., Reilly J.A., Lysko P.G., Henneberry R.C. Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res. 451:1988;205-212.
2. Beal M.F., Hyman B.T., Koroshetz W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci. 16:1993;125-131.
3. Nicholls D.G., Budd S.L. Mitochondria and neuronal survival. Physiol. Rev. 80:2000;315-360.
4. Cadenas E., Davies K.J.A. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 29:2000;222-230.
5. Nicholls D.G., Åkerman K.E.O. Mitochondrial calcium transport. Biochim. Biophys. Acta. 683:1982;57-88.
6. Liu X., Kim C.N., Yang J., Jemmerson R., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 86:1996;147-157.
7. D.G. Nicholls, S.J. Ferguson, Bioenergetics 3, Academic Press, London, 2002.
8. Hoek J.B., Rydstrom J. Physiological roles of nicotinamide nucleotide transhydrogenase. Biochem. J. 254:1988;1-10.
9. Han D., Williams E., Cadenas E. Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space. Biochem. J. 353:2001;411-416.
10. Barja G., Herrero A. Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon. J. Bioenerg. Biomembr. 30:1998;235-243.
11. Cohen G., Kesler N. Monoamine oxidase and mitochondrial respiration. J. Neurochem. 73:1999;2310-2315.
12. Scott I.D., Nicholls D.G. Energy transduction in intact synaptosomes: influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ. Biochem. J. 186:1980;21-33.
13. Stuart J.A., Brindle K.M., Harper J.A., Brand M.D. Mitochondrial proton leak and the uncoupling proteins. J. Bioenerg. Biomembr. 31:1999;517-525.
14. Hafner R.P., Brown G.C., Brand M.D. Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the 'top-down' approach of metabolic control theory. Eur. J. Biochem. 188:1990;313-319.
15. Davey G.P., Canevari L., Clark J.B. Threshold effects in synaptosomal and nonsynaptic mitochondria from hippocampal CA1 and paramedian neocortex brain regions. J. Neurochem. 69:1997;2564-2570.
16. Kavanagh N.I., Ainscow E.K., Brand M.D. Calcium regulation of oxidative phosphorylation in rat skeletal muscle mitochondria. Biochim. Biophys. Acta Bioenerg. 1457:2000;57-70.
17. Barrientos A., Moraes C.T. Titrating the effects of mitochondrial complex I impairment in the cell physiology. J. Biol. Chem. 274:1999;16188-16197.
18. Barja G. Mitochondrial oxygen radical generation and leak: sites of production in state 4 and 3, organ specificity, and relation to aging and longevity. J. Bioenerg. Biomembr. 31:1999;347-366.
19. Cooper J.M., Schapira A.H.V. Mitochondrial dysfunction in neurodegeneration. J. Bioenerg. Biomembr. 29:1997;175-183.
20. Cohen G. Oxidative stress, mitochondrial respiration, and Parkinson's disease. Ann. N. Y. Acad. Sci. 899:2000;112-120.
21. Jha N., Jurma O., Lalli G., Liu Y., Pettus E.H., Greenamyre J.T., Liu R.M., Forman H.J., Andersen J.K. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity - implications for Parkinson's disease. J. Biol. Chem. 275:2000;26096-26101.
22. Korshunov S.S., Skulachev V.P., Starkov A.A. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 416:1997;15-18.
23. Nicholls D.G. The effective proton conductances of the inner membrane of mitochondria from brown adipose tissue: dependency on proton electrochemical gradient. Eur. J. Biochem. 77:1977;349-356.
24. Chinopoulos C., Adam-Vizi V. Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease. J. Neurochem. 76:2001;302-306.
25. Bautista J., Corpas R., Ramos R., Cremades O., Gutiérrez J.F., Alegre S. Brain mitochondrial complex I inactivation by oxidative modification. Biochem. Biophys. Res. Commun. 275:2000;890-894.
26. Riobó N.A., Clementi E., Melani M., Boveris A., Cadenas E., Moncada S., Poderoso J.J. Nitric oxide inhibits mitochondrial NADH: ubiquinone reductase activity through peroxynitrite formation. Biochem. J. 359:2001;139-145.
27. Sriram K., Shankar S.K., Boyd M.R., Ravindranath V. Thiol oxidation and loss of mitochondrial complex I precede excitatory amino acid-mediated neurodegeneration. J. Neurosci. 18:1998;10287-10296.
28. Balijepalli S., Annepu J., Boyd M.R., Ravindranath V. Effect of thiol modification on brain mitochondrial complex I activity. Neurosci. Lett. 272:1999;203-206.
29. Davey G.P., Peuchen S., Clark J.B. Energy thresholds in brain mitochondria - potential involvement in neurodegeneration. J. Biol. Chem. 273:1998;12753-12757.
30. Banaclocha M.M. N-acetylcysteine elicited increase in complex I activity in synaptic mitochondria from aged mice: implications for treatment of Parkinson's disease. Brain Res. 859:2000;173-175.
31. Betarbet R., Sherer T.B., MacKenzie G., Garcia-Osuna M., Panov A.V., Greenamyre J.T. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3:2000;1301-1306.
32. Langston J.W., Ballard P., Tetrud J.W., Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science. 219:1983;979-980.
33. J.T. Greenamyre, G. MacKenzie, T.-I. Peng, S.E. Stephans, Mitochondrial dysfunction in Parkinson's disease, in: G.C. Brown, D.G. Nicholls, C. Cooper (Eds.), Mitochondria and Cell Death, Portland Press, London, 1999, pp. 85-98.
34. Brown M.D., Trounce I.A., Jun A.S., Allen J.C., Wallace D.C. Functional analysis of lymphoblast and cybrid mitochondria containing the 3460, 11,778 or 14,484 Leber's hereditary optic neuropathy mitochondrial DNA mutation. J. Biol. Chem. 275:2000;39831-39836.
35. Schapira A.H.V. Human complex I defects in neurodegenerative diseases. Biochim. Biophys. Acta Bioenerg. 1364:1998;261-270.
36. Jun A.S., Trounce I.A., Brown M.D., Shoffner J.M., Wallace D.C. Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14,459 that causes Leber hereditary optic neuropathy and dystonia. Mol. Cell. Biol. 16:1996;771-777.
37. Howell N. Leber hereditary optic neuropathy: how do mitochondrial DNA mutations cause degeneration of the optic nerve? J. Bioenerg. Biomembr. 29:1997;165-173.
38. Romano C., Price M.T., Olney J.W. Delayed excitotoxic neurodegeneration induced by excitatory amino acid agonists in isolated retina. J. Neurochem. 65:1995;59-67.
39. Rego A.C., Santos M.S., Oliveira C.R. Adenosine triphosphate degradation products after oxidative stress and metabolic dysfunction in cultured retinal cells. J. Neurochem. 69:1997;1228-1235.
40. Du Y.S., Dodel R.C., Bales K.R., Jemmerson R., Hamilton-Byrd E., Paul S.M. Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons. J. Neurochem. 69:1997;1382-1388.
41. Yan L.J., Levine R.L., Sohal R.S. Oxidative damage during aging targets mitochondrial aconitase. Proc. Natl. Acad. Sci. U.S.A. 94:1997;11168-11172.
42. Gibson G.E., Park L.C., Sheu K.F., Blass J.P., Calingasan N.Y. The α-ketoglutarate dehydrogenase complex in neurodegeneration. Neurochem. Int. 36:2000;97-112.
43. Lucas D.T., Szweda L.I. Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of α-ketoglutarate dehydrogenase. Proc. Natl. Acad. Sci. U.S.A. 96:1999;6689-6693.
44. Tretter L., Adam-Vizi V. Inhibition of Krebs cycle enzymes by hydrogen peroxide: a key role of α-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. J. Neurosci. 20:2000;8972-8979.
45. Beal M.F., Brouillet E., Jenkins B., Henshaw R., Rosen B., Hyman B.T. Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. J. Neurochem. 61:1993;1147-1150.
46. Greene J.G., Sheu S.S., Gross R.A., Greenamyre J.T. 3-Nitropropionic acid exacerbates N-methyl-D-aspartate toxicity in striatal culture by multiple mechanisms. Neuroscience. 84:1998;503-510.
47. S.J. Tabrizi, A.H.V. Schapira, Secondary abnormalities of mitochondrial DNA associated with neurodegeneration, in: G.C. Brown, D.G. Nicholls, C. Cooper (Eds.), Mitochondria in the Life and Death of the Cell, Portland Press, London, 1999, pp. 99-110.
48. Senoo-Matsuda N., Yasuda K., Tsuda M., Ohkubo T., Yoshimura S., Nakazawa H., Hartman P.S., Ishii N. A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans. J. Biol. Chem. 276:2001;41553-41558.
49. Cadenas E., Boveris A. Enhancement of hydrogen peroxide formation by protophores and ionophores in antimycin-supplemented mitochondria. Biochem. J. 188:1980;31-37.
50. Jurma O.P., Hom D.G., Andersen J.K. Decreased glutathione results in calcium-mediated cell death in PC12. Free Radic. Biol. Med. 23:1997;1055-1066.
51. Schafer F.Q., Buettner G.R. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic. Biol. Med. 30:2001;1191-1212.
52. Nicholls D.G. The influence of respiration and ATP hydrolysis on the proton electrochemical potential gradient across the inner membrane of rat liver mitochondria as determined by ion distribution. Eur. J. Biochem. 50:1974;305-315.
53. Ricquier D., Bouillaud F. Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance. J. Physiol. (London). 529:2000;3-10.
54. Nicholls D.G. The regulation of extra-mitochondrial free Ca by rat liver mitochondria. Biochem. J. 176:1978;463-474.
55. Nicholls D.G., Scott I.D. The regulation of brain mitochondrial calcium-ion transport: the role of ATP in the discrimination between kinetic and membrane-potential-dependent Ca efflux mechanisms. Biochem. J. 186:1980;833-839.
56. Thayer S.A., Miller R.J. Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro. J. Physiol. (London). 425:1990;85-115.
57. Ward M.W., Rego A.C., Frenguelli B.G., Nicholls D.G. Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. J. Neurosci. 20:2000;7208-7219.
58. Budd S.L., Nicholls D.G. Mitochondrial calcium regulation and acute glutamate excitotoxicity in cultured cerebellar granule cells. J. Neurochem. 67:1996;2282-2291.
59. Castilho R.F., Hansson O., Ward M.W., Budd S.L., Nicholls D.G. Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells. J. Neurosci. 18:1998;10277-10286.
60. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341:1999;233-249.
61. Lemasters J.J., Nieminen A.L., Qian T., Trost L.C., Elmore S.P., Nishimura Y., Crowe R.A., Cascio W.E., Bradham C.A., Brenner D.A., Herman B. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim. Biophys. Acta Bioenerg. 1366:1998;177-196.
62. Marchetti P., Castedo M., Susin S.A., Zamzami N., Hirsch T., Macho A., Haeffner A., Hirsch F., Geuskens M., Kroemer G. Mitochondrial permeability transition is a central coordinating event in apoptosis. J. Exp. Med. 184:1996;1155-1160.
63. Rottenberg H., Wu S.L. Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells. Biochim. Biophys. Acta. 1404:1998;393-404.
64. Finucane D.M., Waterhouse N.J., Amarante-Mendes G.P., Cotter T.G., Green D.R. Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells. Exp. Cell Res. 251:1999;166-174.
65. Krohn A.J., Wahlbrink T., Prehn J.H.M. Mitochondrial depolarization is not required for neuronal apoptosis. J. Neurosci. 19:1999;7394-7404.
66. Adrain C., Creagh E.M., Martin S.J. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J. 20:2001;6627-6636.