Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 21, 2003, Pages 12171-12176

  Trushina, Eugenia ^a   Heldebrant, Michael P ^a   Perez Terzic, Carmen M ^a   Bortolon, Ryan ^a   Kovtun, Irina V ^a   Badger II, John D ^a   Terzic, Andre ^a   Estévez, Alvaro ^b   Windebank, Anthony J ^a   Dyer, Roy B ^a   Yao, Janet ^a   McMurray, Cynthia T ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; MUTANT PROTEIN; PACLITAXEL;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DOWNSTREAM PROCESSING; GENETIC TRANSCRIPTION; HUNTINGTON CHOREA; MICROTUBULE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; THEORY; TIME; TOXICITY;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; CYTOPLASM; HUMANS; HUNTINGTON DISEASE; MICROTUBULES; MUTATION; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PACLITAXEL;

ANIMALIA;

EID: 0142123112     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2034961100     Document Type: Article

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