-
1
-
-
29344457845
-
Transformation-associated gene regulation by ATF6alpha during hepatocarcinogenesis
-
doi: 10.1016/j.febslet.2005.11.072
-
Arai, M., Kondoh, N., Imazeki, N., Hada, A., Hatsuse, K., Kimura, F., et al. (2006). Transformation-associated gene regulation by ATF6alpha during hepatocarcinogenesis. FEBS Lett. 580, 184-190. doi: 10.1016/j.febslet.2005.11.072
-
(2006)
FEBS Lett.
, vol.580
, pp. 184-190
-
-
Arai, M.1
Kondoh, N.2
Imazeki, N.3
Hada, A.4
Hatsuse, K.5
Kimura, F.6
-
2
-
-
77955486614
-
XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments
-
doi: 10.1182/blood-2010-01-263236
-
Bagratuni, T., Wu, P., Gonzalez de Castro, D., Davenport, E. L., Dickens, N. J., Walker, B. A., et al. (2010). XBP1s levels are implicated in the biology and outcome of myeloma mediating different clinical outcomes to thalidomide-based treatments. Blood 116, 250-253. doi: 10.1182/blood-2010-01-263236
-
(2010)
Blood
, vol.116
, pp. 250-253
-
-
Bagratuni, T.1
Wu, P.2
Gonzalez de Castro, D.3
Davenport, E.L.4
Dickens, N.J.5
Walker, B.A.6
-
3
-
-
0026443494
-
Plasma cell dyscrasias
-
doi: 10.1001/jama.1992.03490200198025
-
Barlogie, B., Alexanian, R., and Jagannath, S. (1992). Plasma cell dyscrasias. JAMA 268, 2946-2951.doi: 10.1001/jama.1992.03490200198025
-
(1992)
JAMA
, vol.268
, pp. 2946-2951
-
-
Barlogie, B.1
Alexanian, R.2
Jagannath, S.3
-
4
-
-
27144458505
-
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
-
doi: 10.1038/sj.emboj.7600777
-
Bi, M., Naczki, C., Koritzinsky, M., Fels, D., Blais, J., Hu, N., et al. (2005). ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J. 24, 3470-3481. doi: 10.1038/sj.emboj.7600777
-
(2005)
EMBO J.
, vol.24
, pp. 3470-3481
-
-
Bi, M.1
Naczki, C.2
Koritzinsky, M.3
Fels, D.4
Blais, J.5
Hu, N.6
-
5
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
doi: 10.1038/415092a
-
Calfon, M., Zeng, H., Urano, F., Till, J. H., Hubbard, S. R., Harding, H. P., et al. (2002). IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415, 92-96. doi: 10.1038/415092a
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
-
6
-
-
34047136169
-
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis
-
doi: 10.1016/j.ccr.2007.02.015
-
Carrasco, D. R., Sukhdeo, K., Protopopova, M., Sinha, R., Enos, M., Carrasco, D. E., et al. (2007). The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 11, 349-360. doi: 10.1016/j.ccr.2007.02.015
-
(2007)
Cancer Cell
, vol.11
, pp. 349-360
-
-
Carrasco, D.R.1
Sukhdeo, K.2
Protopopova, M.3
Sinha, R.4
Enos, M.5
Carrasco, D.E.6
-
7
-
-
0037066741
-
The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi
-
doi: 10.1074/jbc.M110636200
-
Chen, X., Shen, J., and Prywes, R. (2002). The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J. Biol. Chem. 277, 13045-13052. doi: 10.1074/jbc.M110636200
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13045-13052
-
-
Chen, X.1
Shen, J.2
Prywes, R.3
-
8
-
-
0027324844
-
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
-
doi: 10.1016/0092-8674(93)90648-A
-
Cox, J. S., Shamu, C. E., and Walter, P. (1993). Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73, 1197-1206. doi: 10.1016/0092-8674(93)90648-A
-
(1993)
Cell
, vol.73
, pp. 1197-1206
-
-
Cox, J.S.1
Shamu, C.E.2
Walter, P.3
-
9
-
-
34948890040
-
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
-
doi: 10.1182/blood-2006-11-053728
-
Davenport, E. L., Moore, H. E., Dunlop, A. S., Sharp, S. Y., Workman, P., Morgan, G. J., et al. (2007). Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood 110, 2641-2649. doi: 10.1182/blood-2006-11-053728
-
(2007)
Blood
, vol.110
, pp. 2641-2649
-
-
Davenport, E.L.1
Moore, H.E.2
Dunlop, A.S.3
Sharp, S.Y.4
Workman, P.5
Morgan, G.J.6
-
10
-
-
80052691722
-
Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas?
-
doi: 10.1093/neuonc/nor053
-
Emdad, L., Qadeer, Z. A., Bederson, L. B., Kothari, H. P., Uzzaman, M., and Germano, I. M. (2011). Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas? Neuro-oncology 13, 725-735. doi: 10.1093/neuonc/nor053
-
(2011)
Neuro-oncology
, vol.13
, pp. 725-735
-
-
Emdad, L.1
Qadeer, Z.A.2
Bederson, L.B.3
Kothari, H.P.4
Uzzaman, M.5
Germano, I.M.6
-
11
-
-
80054758767
-
Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response
-
doi: 10.1177/1087057111414893
-
Fribley, A. M., Cruz, P. G., Miller, J. R., Callaghan, M. U., Cai, P., Narula, N., et al. (2011). Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. J. Biomol. Screen. 16, 825-835. doi: 10.1177/1087057111414893
-
(2011)
J. Biomol. Screen.
, vol.16
, pp. 825-835
-
-
Fribley, A.M.1
Cruz, P.G.2
Miller, J.R.3
Callaghan, M.U.4
Cai, P.5
Narula, N.6
-
12
-
-
0036268259
-
Phosphorylation of initiation factor-2 alpha is required for activation of internal translation initiation during cell differentiation
-
doi: 10.1046/j.1432-1033.2002.02974.x
-
Gerlitz, G., Jagus, R., and Elroy-Stein, O. (2002). Phosphorylation of initiation factor-2 alpha is required for activation of internal translation initiation during cell differentiation. Eur. J. Biochem. 269, 2810-2819. doi: 10.1046/j.1432-1033.2002.02974.x
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 2810-2819
-
-
Gerlitz, G.1
Jagus, R.2
Elroy-Stein, O.3
-
13
-
-
13244261152
-
Induction of C/EBP beta and GADD153 expression by dopamine in human neuroblastoma cells
-
doi: 10.1016/j.brainresbull.2004.11.008
-
Gomez-Santos, C., Barrachina, M., Gimenez-Xavier, P., Dalfo, E., Ferrer, I., and Ambrosio, S. (2005). Induction of C/EBP beta and GADD153 expression by dopamine in human neuroblastoma cells. Relationship with alpha-synuclein increase and cell damage. Brain Res. Bull. 65, 87-95. doi: 10.1016/j.brainresbull.2004.11.008
-
(2005)
Relationship with alpha-synuclein increase and cell damage. Brain Res. Bull.
, vol.65
, pp. 87-95
-
-
Gomez-Santos, C.1
Barrachina, M.2
Gimenez-Xavier, P.3
Dalfo, E.4
Ferrer, I.5
Ambrosio, S.6
-
14
-
-
0033634641
-
Perk is essential for translational regulation and cell survival during the unfolded protein response
-
doi: 10.1016/S1097-2765(00)80330-5
-
Harding, H. P., Zhang, Y., Bertolotti, A., Zeng, H., and Ron, D. (2000). Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell 5, 897-904. doi: 10.1016/S1097-2765(00)80330-5
-
(2000)
Mol. Cell
, vol.5
, pp. 897-904
-
-
Harding, H.P.1
Zhang, Y.2
Bertolotti, A.3
Zeng, H.4
Ron, D.5
-
15
-
-
0037353039
-
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
-
doi: 10.1016/S1097-2765(03)00105-9
-
Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M., et al. (2003). An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell. 11, 619-633. doi: 10.1016/S1097-2765(03)00105-9
-
(2003)
Mol. Cell.
, vol.11
, pp. 619-633
-
-
Harding, H.P.1
Zhang, Y.2
Zeng, H.3
Novoa, I.4
Lu, P.D.5
Calfon, M.6
-
16
-
-
84870546460
-
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth
-
doi: 10.1172/JCI62973
-
Hart, L. S., Cunningham, J. T., Datta, T., Dey, S., Tameire, F., Lehman, S. L., et al. (2012). ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth. J. Clin. Invest. 122, 4621-4634. doi: 10.1172/JCI62973
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 4621-4634
-
-
Hart, L.S.1
Cunningham, J.T.2
Datta, T.3
Dey, S.4
Tameire, F.5
Lehman, S.L.6
-
17
-
-
0037385313
-
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
-
doi: 10.1038/ni907
-
Iwakoshi, N. N., Lee, A. H., Vallabhajosyula, P., Otipoby, K. L., Rajewsky, K., and Glimcher, L. H. (2003). Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat. Immunol. 4, 321-329.doi: 10.1038/ni907
-
(2003)
Nat. Immunol.
, vol.4
, pp. 321-329
-
-
Iwakoshi, N.N.1
Lee, A.H.2
Vallabhajosyula, P.3
Otipoby, K.L.4
Rajewsky, K.5
Glimcher, L.H.6
-
18
-
-
77958590030
-
IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level
-
doi: 10.1371/journal.pone.0013052
-
Iwawaki, T., Akai, R., and Kohno, K. (2010). IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level. PLoS ONE 5, e13052. doi: 10.1371/journal.pone.0013052
-
(2010)
PLoS ONE
, vol.5
-
-
Iwawaki, T.1
Akai, R.2
Kohno, K.3
-
19
-
-
0035504022
-
Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR
-
doi: 10.1093/nar/29.21.4341
-
Jousse, C., Bruhat, A., Carraro, V., Urano, F., Ferrara, M., Ron, D., et al. (2001). Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR. Nucleic Acids Res. 29, 4341-4351.doi: 10.1093/nar/29.21.4341
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 4341-4351
-
-
Jousse, C.1
Bruhat, A.2
Carraro, V.3
Urano, F.4
Ferrara, M.5
Ron, D.6
-
20
-
-
73949147271
-
Activation of the unfolded protein response contributes toward the antitumor activity of vorinostat
-
Kahali, S., Sarcar, B., Fang, B., Williams, E. S., Koomen, J. M., Tofilon, P. J., et al. (2010). Activation of the unfolded protein response contributes toward the antitumor activity of vorinostat. Neoplasia 12, 80-86.
-
(2010)
Neoplasia
, vol.12
, pp. 80-86
-
-
Kahali, S.1
Sarcar, B.2
Fang, B.3
Williams, E.S.4
Koomen, J.M.5
Tofilon, P.J.6
-
21
-
-
84864886676
-
Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells
-
doi: 10.1038/cddis.2012.87
-
Kawabata, S., Gills, J. J., Mercado-Matos, J. R., Lopiccolo, J., Wilson, W., III, Hollander, M. C., et al. (2012). Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells. Cell Death Dis. 3, e353.doi: 10.1038/cddis.2012.87
-
(2012)
Cell Death Dis.
, vol.3
-
-
Kawabata, S.1
Gills, J.J.2
Mercado-Matos, J.R.3
Lopiccolo, J.4
Wilson, W.5
Hollander, M.C.6
-
22
-
-
72049124015
-
ATF4-dependent transcription mediates signaling of amino acid limitation
-
doi: 10.1016/j.tem.2009.05.008
-
Kilberg, M. S., Shan, J., and Su, N. (2009). ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol. Metab. 20, 436-443. doi: 10.1016/j.tem.2009.05.008
-
(2009)
Trends Endocrinol. Metab.
, vol.20
, pp. 436-443
-
-
Kilberg, M.S.1
Shan, J.2
Su, N.3
-
23
-
-
31444449462
-
Role of the unfolded protein response in cell death
-
doi: 10.1007/s10495-005-3088-0
-
Kim, R., Emi, M., Tanabe, K., and Murakami, S. (2006). Role of the unfolded protein response in cell death. Apoptosis 11, 5-13.doi: 10.1007/s10495-005-3088-0
-
(2006)
Apoptosis
, vol.11
, pp. 5-13
-
-
Kim, R.1
Emi, M.2
Tanabe, K.3
Murakami, S.4
-
24
-
-
8444250981
-
A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1
-
doi: 10.1083/jcb.200405153
-
Kimata, Y., Oikawa, D., Shimizu, Y., Ishiwata-Kimata, Y., and Kohno, K. (2004). A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1. J. Cell Biol. 167, 445-456.doi: 10.1083/jcb.200405153
-
(2004)
J. Cell Biol.
, vol.167
, pp. 445-456
-
-
Kimata, Y.1
Oikawa, D.2
Shimizu, Y.3
Ishiwata-Kimata, Y.4
Kohno, K.5
-
25
-
-
51049124323
-
Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis
-
doi: 10.1158/1535-7163.MCT-07-2375
-
Kraus, M., Malenke, E., Gogel, J., Muller, H., Ruckrich, T., Overkleeft, H., et al. (2008). Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis. Mol. Cancer Ther. 7, 1940-1948.doi: 10.1158/1535-7163.MCT-07-2375
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 1940-1948
-
-
Kraus, M.1
Malenke, E.2
Gogel, J.3
Muller, H.4
Ruckrich, T.5
Overkleeft, H.6
-
26
-
-
42649146188
-
The PERK/eIF2 alpha signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells
-
doi: 10.1016/j.yexcr.2008.02.002
-
Lai, W. L., and Wong, N. S. (2008). The PERK/eIF2 alpha signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells. Exp. Cell Res. 314, 1667-1682.doi: 10.1016/j.yexcr.2008.02.002
-
(2008)
Exp. Cell Res.
, vol.314
, pp. 1667-1682
-
-
Lai, W.L.1
Wong, N.S.2
-
27
-
-
18144431710
-
Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of Velcade (PS-341/bortezomib) cytotoxicity in myeloma cell lines
-
doi: 10.1158/0008-5472.CAN-04-3684
-
Landowski, T. H., Megli, C. J., Nullmeyer, K. D., Lynch, R. M., and Dorr, R. T. (2005). Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of Velcade (PS-341/bortezomib) cytotoxicity in myeloma cell lines. Cancer Res. 65, 3828-3836.doi: 10.1158/0008-5472.CAN-04-3684
-
(2005)
Cancer Res.
, vol.65
, pp. 3828-3836
-
-
Landowski, T.H.1
Megli, C.J.2
Nullmeyer, K.D.3
Lynch, R.M.4
Dorr, R.T.5
-
28
-
-
0142059951
-
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
-
doi: 10.1128/MCB.23.21.7448-7459.2003
-
Lee, A. H., Iwakoshi, N. N., and Glimcher, L. H. (2003). XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol. Cell. Biol. 23, 7448-7459.doi: 10.1128/MCB.23.21.7448-7459.2003
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 7448-7459
-
-
Lee, A.H.1
Iwakoshi, N.N.2
Glimcher, L.H.3
-
29
-
-
15944366885
-
The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress
-
doi: 10.1016/j.ymeth.2004.10.010
-
Lee, A. S. (2005). The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods 35, 373-381.doi: 10.1016/j.ymeth.2004.10.010
-
(2005)
Methods
, vol.35
, pp. 373-381
-
-
Lee, A.S.1
-
30
-
-
80455124076
-
Transgenic zebrafish model to study translational control mediated by upstream open reading frame of human chop gene
-
doi: 10.1093/nar/gkr645
-
Lee, H. C., Chen, Y. J., Liu, Y. W., Lin, K. Y., Chen, S. W., Lin, C. Y., et al. (2011). Transgenic zebrafish model to study translational control mediated by upstream open reading frame of human chop gene. Nucleic Acids Res. 39, e139.doi: 10.1093/nar/gkr645
-
(2011)
Nucleic Acids Res.
, vol.39
-
-
Lee, H.C.1
Chen, Y.J.2
Liu, Y.W.3
Lin, K.Y.4
Chen, S.W.5
Lin, C.Y.6
-
31
-
-
0037083755
-
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
-
doi: 10.1101/gad.964702
-
Lee, K., Tirasophon, W., Shen, X., Michalak, M., Prywes, R., Okada, T., et al. (2002). IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16, 452-466.doi: 10.1101/gad.964702
-
(2002)
Genes Dev.
, vol.16
, pp. 452-466
-
-
Lee, K.1
Tirasophon, W.2
Shen, X.3
Michalak, M.4
Prywes, R.5
Okada, T.6
-
32
-
-
57649221592
-
Hypoxic reactive oxygen species regulate the integrated stress response and cell survival
-
doi: 10.1074/jbc.M805056200
-
Liu, L., Wise, D. R., Diehl, J. A., and Simon, M. C. (2008). Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J. Biol. Chem. 283, 31153-31162.doi: 10.1074/jbc.M805056200
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 31153-31162
-
-
Liu, L.1
Wise, D.R.2
Diehl, J.A.3
Simon, M.C.4
-
33
-
-
84876032962
-
New directions in ER stress-induced cell death
-
doi: 10.1007/s10495-013-0818-6
-
Logue, S. E., Cleary, P., Saveljeva, S., and Samali, A. (2013). New directions in ER stress-induced cell death. Apoptosis 18, 537-546.doi: 10.1007/s10495-013-0818-6
-
(2013)
Apoptosis
, vol.18
, pp. 537-546
-
-
Logue, S.E.1
Cleary, P.2
Saveljeva, S.3
Samali, A.4
-
34
-
-
5444264022
-
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
-
doi: 10.1083/jcb.200408003
-
Lu, P. D., Harding, H. P., and Ron, D. (2004). Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J. Cell Biol. 167, 27-33. doi: 10.1083/jcb.200408003
-
(2004)
J. Cell Biol.
, vol.167
, pp. 27-33
-
-
Lu, P.D.1
Harding, H.P.2
Ron, D.3
-
35
-
-
71949101502
-
Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia
-
Lust, S., Vanhoecke, B., Van Gele, M., Boelens, J., Van Melckebeke, H., Kaileh, M., et al. (2009). Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia. Anticancer. Res. 29, 3797-3805.
-
(2009)
Anticancer. Res.
, vol.29
, pp. 3797-3805
-
-
Lust, S.1
Vanhoecke, B.2
Van Gele, M.3
Boelens, J.4
Van Melckebeke, H.5
Kaileh, M.6
-
36
-
-
0037166237
-
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
-
doi: 10.1074/jbc.M200903200
-
Ma, K., Vattem, K. M., and Wek, R. C. (2002). Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress. J. Biol. Chem. 277, 18728-18735. doi: 10.1074/jbc.M200903200
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18728-18735
-
-
Ma, K.1
Vattem, K.M.2
Wek, R.C.3
-
37
-
-
77951252041
-
Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response
-
doi: 10.1007/s12192-009-0142-9
-
Ma, Y., Shimizu, Y., Mann, M. J., Jin, Y., and Hendershot, L. M. (2010). Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response. Cell Stress Chaperones 15, 281-293.doi: 10.1007/s12192-009-0142-9
-
(2010)
Cell Stress Chaperones
, vol.15
, pp. 281-293
-
-
Ma, Y.1
Shimizu, Y.2
Mann, M.J.3
Jin, Y.4
Hendershot, L.M.5
-
38
-
-
36248949141
-
The endoplasmic reticulum and the unfolded protein response
-
doi: 10.1016/j.semcdb.2007.09.003
-
Malhotra, J. D., and Kaufman, R. J. (2007). The endoplasmic reticulum and the unfolded protein response. Semin. Cell Dev. Biol. 18, 716-731.doi: 10.1016/j.semcdb.2007.09.003
-
(2007)
Semin. Cell Dev. Biol.
, vol.18
, pp. 716-731
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
39
-
-
10644233167
-
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
-
doi: 10.1101/gad.1250704
-
Marciniak, S. J., Yun, C. Y., Oyadomari, S., Novoa, I., Zhang, Y., Jungreis, R., et al. (2004). CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 18, 3066-3077.doi: 10.1101/gad.1250704
-
(2004)
Genes Dev.
, vol.18
, pp. 3066-3077
-
-
Marciniak, S.J.1
Yun, C.Y.2
Oyadomari, S.3
Novoa, I.4
Zhang, Y.5
Jungreis, R.6
-
40
-
-
0030597160
-
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells
-
doi: 10.1016/0014-5793(96)01016-2
-
Matsumoto, M., Minami, M., Takeda, K., Sakao, Y., and Akira, S. (1996). Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett. 395, 143-147. doi: 10.1016/0014-5793(96)01016-2
-
(1996)
FEBS Lett.
, vol.395
, pp. 143-147
-
-
Matsumoto, M.1
Minami, M.2
Takeda, K.3
Sakao, Y.4
Akira, S.5
-
41
-
-
33847714599
-
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition
-
doi: 10.1158/0008-5472.CAN-06-2258
-
Meister, S., Schubert, U., Neubert, K., Herrmann, K., Burger, R., Gramatzki, M., et al. (2007). Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition. Cancer Res. 67, 1783-1792. doi: 10.1158/0008-5472.CAN-06-2258
-
(2007)
Cancer Res.
, vol.67
, pp. 1783-1792
-
-
Meister, S.1
Schubert, U.2
Neubert, K.3
Herrmann, K.4
Burger, R.5
Gramatzki, M.6
-
42
-
-
80054750084
-
Compromising the unfolded protein response induces autophagy-mediated cell death in multiple myeloma cells
-
doi: 10.1371/journal.pone.0025820
-
Michallet, A. S., Mondiere, P., Taillardet, M., Leverrier, Y., Genestier, L., and Defrance, T. (2011). Compromising the unfolded protein response induces autophagy-mediated cell death in multiple myeloma cells. PLoS ONE 6, e25820. doi: 10.1371/journal.pone.0025820
-
(2011)
PLoS ONE
, vol.6
-
-
Michallet, A.S.1
Mondiere, P.2
Taillardet, M.3
Leverrier, Y.4
Genestier, L.5
Defrance, T.6
-
43
-
-
84862501186
-
Blockade of XBP1 splicing by inhibition of IRE1alpha is a promising therapeutic option in multiple myeloma
-
doi: 10.1182/blood-2011-07-366633
-
Mimura, N., Fulciniti, M., Gorgun, G., Tai, Y. T., Cirstea, D., Santo, L., et al. (2012). Blockade of XBP1 splicing by inhibition of IRE1alpha is a promising therapeutic option in multiple myeloma. Blood 119, 5772-5781. doi: 10.1182/blood-2011-07-366633
-
(2012)
Blood
, vol.119
, pp. 5772-5781
-
-
Mimura, N.1
Fulciniti, M.2
Gorgun, G.3
Tai, Y.T.4
Cirstea, D.5
Santo, L.6
-
44
-
-
84862693704
-
The future of therapy for relapsed/refractory multiple myeloma: emerging agents and novel treatment strategies
-
doi: 10.1053/j.seminhematol.2012.05.004
-
Moreau, P. (2012). The future of therapy for relapsed/refractory multiple myeloma: emerging agents and novel treatment strategies. Semin. Hematol. 49(Suppl. 1), S33-S46.doi: 10.1053/j.seminhematol.2012.05.004
-
(2012)
Semin. Hematol.
, vol.49
, Issue.SUPPL. 1
-
-
Moreau, P.1
-
46
-
-
33744539521
-
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
-
doi: 10.1182/blood-2005-08-3531
-
Obeng, E. A., Carlson, L. M., Gutman, D. M., Harrington, W. J. Jr., Lee, K. P., and Boise, L. H. (2006). Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 107, 4907-4916. doi: 10.1182/blood-2005-08-3531
-
(2006)
Blood
, vol.107
, pp. 4907-4916
-
-
Obeng, E.A.1
Carlson, L.M.2
Gutman, D.M.3
Harrington Jr., W.J.4
Lee, K.P.5
Boise, L.H.6
-
47
-
-
0036713724
-
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
-
doi: 10.1042/BJ20020391
-
Okada, T., Yoshida, H., Akazawa, R., Negishi, M., and Mori, K. (2002). Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem. J. 366, 585-594. doi: 10.1042/BJ20020391
-
(2002)
Biochem. J.
, vol.366
, pp. 585-594
-
-
Okada, T.1
Yoshida, H.2
Akazawa, R.3
Negishi, M.4
Mori, K.5
-
48
-
-
84870294008
-
Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines
-
doi: 10.1016/j.taap.2012.08.034
-
Pan, M. Y., Shen, Y. C., Lu, C. H., Yang, S. Y., Ho, T. F., Peng, Y. T., et al. (2012). Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines. Toxicol. Appl. Pharmacol. 265, 325-334. doi: 10.1016/j.taap.2012.08.034
-
(2012)
Toxicol. Appl. Pharmacol.
, vol.265
, pp. 325-334
-
-
Pan, M.Y.1
Shen, Y.C.2
Lu, C.H.3
Yang, S.Y.4
Ho, T.F.5
Peng, Y.T.6
-
49
-
-
79251589342
-
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
-
doi: 10.1182/blood-2010-08-303099
-
Papandreou, I., Denko, N. C., Olson, M., Van Melckebeke, H., Lust, S., Tam, A., et al. (2011). Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 117, 1311-1314. doi: 10.1182/blood-2010-08-303099
-
(2011)
Blood
, vol.117
, pp. 1311-1314
-
-
Papandreou, I.1
Denko, N.C.2
Olson, M.3
Van Melckebeke, H.4
Lust, S.5
Tam, A.6
-
50
-
-
0035370949
-
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals
-
doi: 10.1016/S0955-0674(00)00219-2
-
Patil, C., and Walter, P. (2001). Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell Biol 13, 349-355. doi: 10.1016/S0955-0674(00)00219-2
-
(2001)
Curr. Opin. Cell Biol
, vol.13
, pp. 349-355
-
-
Patil, C.1
Walter, P.2
-
51
-
-
41049105321
-
IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells
-
doi: 10.1007/s00280-007-0546-0
-
Patterson, J., Palombella, V. J., Fritz, C., and Normant, E. (2008). IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells. Cancer Chemother. Pharmacol. 61, 923-932. doi: 10.1007/s00280-007-0546-0
-
(2008)
Cancer Chemother. Pharmacol.
, vol.61
, pp. 923-932
-
-
Patterson, J.1
Palombella, V.J.2
Fritz, C.3
Normant, E.4
-
52
-
-
84868102038
-
D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis
-
doi: 10.1007/s10495-012-0746-x
-
Qiao, S., Cabello, C. M., Lamore, S. D., Lesson, J. L., and Wondrak, G. T. (2012). D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis 17, 1079-1094. doi: 10.1007/s10495-012-0746-x
-
(2012)
Apoptosis
, vol.17
, pp. 1079-1094
-
-
Qiao, S.1
Cabello, C.M.2
Lamore, S.D.3
Lesson, J.L.4
Wondrak, G.T.5
-
53
-
-
0035913294
-
Plasma cell differentiation requires the transcription factor XBP-1
-
doi: 10.1038/35085509
-
Reimold, A. M., Iwakoshi, N. N., Manis, J., Vallabhajosyula, P., Szomolanyi-Tsuda, E., Gravallese, E. M., et al. (2001). Plasma cell differentiation requires the transcription factor XBP-1. Nature 412, 300-307. doi: 10.1038/35085509
-
(2001)
Nature
, vol.412
, pp. 300-307
-
-
Reimold, A.M.1
Iwakoshi, N.N.2
Manis, J.3
Vallabhajosyula, P.4
Szomolanyi-Tsuda, E.5
Gravallese, E.M.6
-
54
-
-
84866001506
-
Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing
-
doi: 10.1038/bcj.2012.26
-
Ri, M., Tashiro, E., Oikawa, D., Shinjo, S., Tokuda, M., Yokouchi, Y., et al. (2012). Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J. 2, e79. doi: 10.1038/bcj.2012.26
-
(2012)
Blood Cancer J.
, vol.2
-
-
Ri, M.1
Tashiro, E.2
Oikawa, D.3
Shinjo, S.4
Tokuda, M.5
Yokouchi, Y.6
-
55
-
-
84873658356
-
The secreted protein acidic and rich in cysteine (SPARC) induces endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma
-
doi: 10.3892/ijo.2012.1678
-
Sailaja, G. S., Bhoopathi, P., Gorantla, B., Chetty, C., Gogineni, V. R., Velpula, K. K., et al. (2013). The secreted protein acidic and rich in cysteine (SPARC) induces endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma. Int. J. Oncol. 42, 188-196.doi: 10.3892/ijo.2012.1678
-
(2013)
Int. J. Oncol.
, vol.42
, pp. 188-196
-
-
Sailaja, G.S.1
Bhoopathi, P.2
Gorantla, B.3
Chetty, C.4
Gogineni, V.R.5
Velpula, K.K.6
-
56
-
-
60549106248
-
Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy
-
doi: 10.1158/0008-5472.CAN-08-3858
-
Schewe, D. M., and Aguirre-Ghiso, J. A. (2009). Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. Cancer Res. 69, 1545-1552. doi: 10.1158/0008-5472.CAN-08-3858
-
(2009)
Cancer Res.
, vol.69
, pp. 1545-1552
-
-
Schewe, D.M.1
Aguirre-Ghiso, J.A.2
-
57
-
-
84873409612
-
Pharmacological targeting of endoplasmic reticulum stress signaling in cancer
-
doi: 10.1016/j.bcp.2012.09.012
-
Schonthal, A. H. (2013). Pharmacological targeting of endoplasmic reticulum stress signaling in cancer. Biochem. Pharmacol. 85, 653-666. doi: 10.1016/j.bcp.2012.09.012
-
(2013)
Biochem. Pharmacol.
, vol.85
, pp. 653-666
-
-
Schonthal, A.H.1
-
58
-
-
3142658576
-
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
-
doi: 10.1016/j.immuni.2004.06.010
-
Shaffer, A. L., Shapiro-Shelef, M., Iwakoshi, N. N., Lee, A. H., Qian, S. B., Zhao, H., et al. (2004). XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21, 81-93. doi: 10.1016/j.immuni.2004.06.010
-
(2004)
Immunity
, vol.21
, pp. 81-93
-
-
Shaffer, A.L.1
Shapiro-Shelef, M.2
Iwakoshi, N.N.3
Lee, A.H.4
Qian, S.B.5
Zhao, H.6
-
59
-
-
0029903049
-
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
-
Shamu, C. E., and Walter, P. (1996). Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J. 15, 3028-3039.
-
(1996)
EMBO J.
, vol.15
, pp. 3028-3039
-
-
Shamu, C.E.1
Walter, P.2
-
60
-
-
0030954870
-
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
-
doi: 10.1016/S0092-8674(00)80369-4
-
Sidrauski, C., and Walter, P. (1997). The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90, 1031-1039. doi: 10.1016/S0092-8674(00)80369-4
-
(1997)
Cell
, vol.90
, pp. 1031-1039
-
-
Sidrauski, C.1
Walter, P.2
-
61
-
-
0036063247
-
BiP binding keeps ATF6 at bay
-
doi: 10.1016/S1534-5807(02)00210-1
-
Sommer, T., and Jarosch, E. (2002). BiP binding keeps ATF6 at bay. Dev. Cell 3, 1-2. doi: 10.1016/S1534-5807(02)00210-1
-
(2002)
Dev. Cell
, vol.3
, pp. 1-2
-
-
Sommer, T.1
Jarosch, E.2
-
62
-
-
0032525990
-
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
-
doi: 10.1101/gad.12.12.1812
-
Tirasophon, W., Welihinda, A. A., and Kaufman, R. J. (1998). A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12, 1812-1824. doi: 10.1101/gad.12.12.1812
-
(1998)
Genes Dev.
, vol.12
, pp. 1812-1824
-
-
Tirasophon, W.1
Welihinda, A.A.2
Kaufman, R.J.3
-
63
-
-
0032190546
-
Cloning of mammalian Ire1 reveals diversity in the ER stress responses
-
doi: 10.1093/emboj/17.19.5708
-
Wang, X. Z., Harding, H. P., Zhang, Y., Jolicoeur, E. M., Kuroda, M., and Ron, D. (1998). Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17, 5708-5717.doi: 10.1093/emboj/17.19.5708
-
(1998)
EMBO J.
, vol.17
, pp. 5708-5717
-
-
Wang, X.Z.1
Harding, H.P.2
Zhang, Y.3
Jolicoeur, E.M.4
Kuroda, M.5
Ron, D.6
-
64
-
-
35848935017
-
Translational control and the unfolded protein response
-
doi: 10.1089/ars.2007.1764
-
Wek, R. C., and Cavener, D. R. (2007). Translational control and the unfolded protein response. Antioxid. Redox Signal. 9, 2357-2371. doi: 10.1089/ars.2007.1764
-
(2007)
Antioxid. Redox Signal.
, vol.9
, pp. 2357-2371
-
-
Wek, R.C.1
Cavener, D.R.2
-
65
-
-
70350574128
-
The role of protein synthesis in cell cycling and cancer
-
doi: 10.1016/j.molonc.2009.05.003
-
White-Gilbertson, S., Kurtz, D. T., and Voelkel-Johnson, C. (2009). The role of protein synthesis in cell cycling and cancer. Mol. Oncol. 3, 402-408. doi: 10.1016/j.molonc.2009.05.003
-
(2009)
Mol. Oncol.
, vol.3
, pp. 402-408
-
-
White-Gilbertson, S.1
Kurtz, D.T.2
Voelkel-Johnson, C.3
-
66
-
-
79958033194
-
Modulating stress responses by the UPRosome: a matter of life and death
-
doi: 10.1016/j.tibs.2011.03.001
-
Woehlbier, U., and Hetz, C. (2011). Modulating stress responses by the UPRosome: a matter of life and death. Trends Biochem. Sci. 36, 329-337.doi: 10.1016/j.tibs.2011.03.001
-
(2011)
Trends Biochem. Sci.
, vol.36
, pp. 329-337
-
-
Woehlbier, U.1
Hetz, C.2
-
67
-
-
39749173737
-
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells
-
doi: 10.1158/1535-7163.MCT-07-2166
-
Yacoub, A., Park, M. A., Gupta, P., Rahmani, M., Zhang, G., Hamed, H., et al. (2008). Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Mol. Cancer Ther. 7, 297-313. doi: 10.1158/1535-7163.MCT-07-2166
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 297-313
-
-
Yacoub, A.1
Park, M.A.2
Gupta, P.3
Rahmani, M.4
Zhang, G.5
Hamed, H.6
-
68
-
-
77955698519
-
Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response
-
doi: 10.1186/1471-2407-10-445
-
Yan, Y., Gao, Y. Y., Liu, B. Q., Niu, X. F., Zhuang, Y., and Wang, H. Q. (2010). Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response. BMC Cancer 10, 445. doi: 10.1186/1471-2407-10-445
-
(2010)
BMC Cancer
, vol.10
, pp. 445
-
-
Yan, Y.1
Gao, Y.Y.2
Liu, B.Q.3
Niu, X.F.4
Zhuang, Y.5
Wang, H.Q.6
-
69
-
-
68349137570
-
ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis
-
doi: 10.2174/156652409788167096
-
Ye, J., and Koumenis, C. (2009). ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis. Curr. Mol. Med. 9, 411-416.doi: 10.2174/156652409788167096
-
(2009)
Curr. Mol. Med.
, vol.9
, pp. 411-416
-
-
Ye, J.1
Koumenis, C.2
-
70
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
doi: 10.1016/S0092-8674(01)00611-0
-
Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., and Mori, K. (2001). XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881-891. doi: 10.1016/S0092-8674(01)00611-0
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
71
-
-
0033815971
-
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
-
doi: 10.1128/MCB.20.18.6755-6767.2000
-
Yoshida, H., Okada, T., Haze, K., Yanagi, H., Yura, T., Negishi, M., et al. (2000). ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol. Cell. Biol. 20, 6755-6767.doi: 10.1128/MCB.20.18.6755-6767.2000
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6755-6767
-
-
Yoshida, H.1
Okada, T.2
Haze, K.3
Yanagi, H.4
Yura, T.5
Negishi, M.6
-
72
-
-
14944371187
-
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis
-
doi: 10.1172/JCI200521848
-
Zhang, K., Wong, H. N., Song, B., Miller, C. N., Scheuner, D., and Kaufman, R. J. (2005). The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J. Clin. Invest. 115, 268-281.doi: 10.1172/JCI200521848
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 268-281
-
-
Zhang, K.1
Wong, H.N.2
Song, B.3
Miller, C.N.4
Scheuner, D.5
Kaufman, R.J.6
|