D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis

Apoptosis

Volumn 17, Issue 10, 2012, Pages 1079-1094

  Qiao, Shuxi ^a   Cabello, Christopher M ^a   Lamore, Sarah D ^a   Lesson, Jessica L ^a   Wondrak, Georg T ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Apoptosis; D Penicillamine; Mcl 1; Metastatic melanoma; Noxa (PMAIP1); Unfolded protein response (UPR)

Indexed keywords

ACETYLCYSTEINE; DITHIOTHREITOL; DOUBLE STRANDED RNA ACTIVATED PROTEIN KINASE LIKE ENDOPLASMIC RETICULUM KINASE; GLUCOSE REGULATED PROTEIN 78; GLUTATHIONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN 70; INITIATION FACTOR 2ALPHA; PENICILLAMINE; PHOSPHOTRANSFERASE; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN NOXA; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER MODEL; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MELANOCYTE; MELANOMA CELL; METASTATIC MELANOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; HUMANS; MELANOMA; MICE; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; OXIDATIVE STRESS; PENICILLAMINE; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSCRIPTOME; TRANSPLANTATION, HETEROLOGOUS; UNFOLDED PROTEIN RESPONSE;

MURINAE;

EID: 84868102038     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0746-x     Document Type: Article

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