Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction

Molecular and Cellular Endocrinology

Volumn 367, Issue 1-2, 2013, Pages 1-10

  Bugliani, Marco ^a   Liechti, Robin ^b   Cheon, Hwanju ^c   Suleiman, Mara ^a   Marselli, Lorella ^a   Kirkpatrick, Clare ^d   Filipponi, Franco ^a   Boggi, Ugo ^a   Xenarios, Ioannis ^b   Syed, Farooq ^a   Ladriere, Laurence ^e   Wollheim, Claes ^d   Lee, Myung Shik ^c   Marchetti, Piero ^a  

^a UNIVERSITY OF PISA   (Italy)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^c Samsung Advanced Institute of Technology (SAIT)   (South Korea)

^d UNIVERSITY OF GENEVA   (Switzerland)

^e UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Beta cells; Lipotoxicity; Microarray; Type 2 diabetes; Ubiquitin proteasome system

Indexed keywords

PROTEASOME; TRANSCRIPTOME; UBIQUITIN;

ADULT; AGED; ARTICLE; CELL REGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EXOCYTOSIS; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RELEASE; MALE; MICROARRAY ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION;

AGED; ANIMALS; CELL LINE; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PALMITATES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTOME; UBIQUITIN; UBIQUITINATED PROTEINS;

EID: 84873523692     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.12.001     Document Type: Article

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