메뉴 건너뛰기




Volumn 5, Issue MAY, 2013, Pages

Metal-induced neurodegeneration in C. elegans

Author keywords

Behavior; C. elegans; Metals; Neurodegeneration; Neurotransmitters

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ALCOHOL; ALPHA TOCOPHEROL; ALUMINUM; CADMIUM; COPPER; DOPAMINE; GLUTAMATE RECEPTOR; GREEN FLUORESCENT PROTEIN; IRON; LEAD; MANGANESE; METAL; METHYLMERCURY; OCTOPAMINE; SEROTONIN; TYRAMINE; ZINC;

EID: 84883501192     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2013.00018     Document Type: Review
Times cited : (66)

References (154)
  • 1
    • 77149145212 scopus 로고    scopus 로고
    • Reverse Genetics
    • Wormbook, ed The C. elegans Research Community. 10.1895/wormbook.1.47.1. Available online at:
    • Ahringer, J. (2006). "Reverse Genetics," in Wormbook, ed The C. elegans Research Community, 10.1895/wormbook.1.47.1. Available online at: http://www.wormbook.org
    • (2006)
    • Ahringer, J.1
  • 2
    • 17444432931 scopus 로고    scopus 로고
    • Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system
    • Alkema, M. J., Hunter-Ensor, M., Ringstad, N., and Horvitz, H. R. (2005). Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system. Neuron, 46, 247-260.
    • (2005) Neuron , vol.46 , pp. 247-260
    • Alkema, M.J.1    Hunter-Ensor, M.2    Ringstad, N.3    Horvitz, H.R.4
  • 3
    • 34250697119 scopus 로고    scopus 로고
    • The versatile worm: genetic and genomic resources for Caenorhabditis elegans research
    • Antoshechkin, I., and Sternberg, P. W. (2007). The versatile worm: genetic and genomic resources for Caenorhabditis elegans research. Nat. Rev. Genet., 8, 518-532.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 518-532
    • Antoshechkin, I.1    Sternberg, P.W.2
  • 4
    • 24044498988 scopus 로고    scopus 로고
    • Iron and copper metabolism
    • Arredondo, M., and Nunez, M. T. (2005). Iron and copper metabolism. Mol. Aspects Med., 26, 313-327.
    • (2005) Mol. Aspects Med. , vol.26 , pp. 313-327
    • Arredondo, M.1    Nunez, M.T.2
  • 5
    • 70849094908 scopus 로고    scopus 로고
    • SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans
    • doi: 10.1371/journal.pone.0007792
    • Au, C., Benedetto, A., Anderson, J., Labrousse, A., Erikson, K., Ewbank, J. J., et al. (2009). SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans. PLoS ONE 4:e7792. doi: 10.1371/journal.pone.0007792
    • (2009) PLoS ONE , vol.4
    • Au, C.1    Benedetto, A.2    Anderson, J.3    Labrousse, A.4    Erikson, K.5    Ewbank, J.J.6
  • 7
    • 0042337002 scopus 로고    scopus 로고
    • Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior
    • Bany, I. A., Dong, M-Q, and Koelle, M. R. (2003). Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior. J. Neurosci., 23, 8060-8069.
    • (2003) J. Neurosci. , vol.23 , pp. 8060-8069
    • Bany, I.A.1    Dong, M.-Q.2    Koelle, M.R.3
  • 8
    • 77958615935 scopus 로고    scopus 로고
    • A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans
    • Barbagallo, B., Prescott, H. A., Boyle, P., Climer, J., and Francis, M. M. (2010). A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans. J. Neurosci., 30, 13932-13942.
    • (2010) J. Neurosci. , vol.30 , pp. 13932-13942
    • Barbagallo, B.1    Prescott, H.A.2    Boyle, P.3    Climer, J.4    Francis, M.M.5
  • 9
    • 70349983047 scopus 로고    scopus 로고
    • The NemaGENETAG initiative: large scale transposon insertion gene-tagging in Caenorhabditis elegans
    • Bazopoulou, D., and Tavernarakis, N. (2009). The NemaGENETAG initiative: large scale transposon insertion gene-tagging in Caenorhabditis elegans. Genetica, 137, 39-46.
    • (2009) Genetica , vol.137 , pp. 39-46
    • Bazopoulou, D.1    Tavernarakis, N.2
  • 10
    • 77957363643 scopus 로고    scopus 로고
    • Extracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans
    • doi: 10.1371/journal.pgen.1001084
    • Benedetto, A., Au, C., Avila, D. S., Milatovic, D., and Aschner, M. (2010). Extracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans. PLoS Genet., 6, e1001084. doi: 10.1371/journal.pgen.1001084
    • (2010) PLoS Genet. , vol.6
    • Benedetto, A.1    Au, C.2    Avila, D.S.3    Milatovic, D.4    Aschner, M.5
  • 12
    • 56049100463 scopus 로고    scopus 로고
    • A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau
    • Brandt, R., Gergou, A., Wacker, I., Fath, T., and Hutter, H. (2009). A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiol. Aging, 30, 22-33.
    • (2009) Neurobiol. Aging , vol.30 , pp. 22-33
    • Brandt, R.1    Gergou, A.2    Wacker, I.3    Fath, T.4    Hutter, H.5
  • 13
    • 0035282944 scopus 로고    scopus 로고
    • Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42
    • Brockie, P. J., Madsen, D. M., Zheng, Y., Mellem, J., and Maricq, A. V. (2001). Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. J. Neurosci., 21, 1510-1522.
    • (2001) J. Neurosci. , vol.21 , pp. 1510-1522
    • Brockie, P.J.1    Madsen, D.M.2    Zheng, Y.3    Mellem, J.4    Maricq, A.V.5
  • 14
    • 0028603405 scopus 로고
    • Effects of changing interstimulus interval during habituation in Caenorhabditis elegans
    • Broster, B. S., and Rankin, C. H. (1994). Effects of changing interstimulus interval during habituation in Caenorhabditis elegans. Behav. Neurosci., 108, 1019-1029.
    • (1994) Behav. Neurosci. , vol.108 , pp. 1019-1029
    • Broster, B.S.1    Rankin, C.H.2
  • 15
    • 0037096190 scopus 로고    scopus 로고
    • The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage
    • Cairo, G., Recalcati, S., Pietrangelo, A., and Minotti, G. (2002). The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage. Free Radic. Biol. Med., 32, 1237-1243.
    • (2002) Free Radic. Biol. Med. , vol.32 , pp. 1237-1243
    • Cairo, G.1    Recalcati, S.2    Pietrangelo, A.3    Minotti, G.4
  • 16
    • 56649117662 scopus 로고    scopus 로고
    • Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper
    • Calafato, S., Swain, S., Hughes, S., Kille, P., and Sturzenbaum, S. R. (2008). Knock down of Caenorhabditis elegans cutc-1 exacerbates the sensitivity toward high levels of copper. Toxicol. Sci., 106, 384-391.
    • (2008) Toxicol. Sci. , vol.106 , pp. 384-391
    • Calafato, S.1    Swain, S.2    Hughes, S.3    Kille, P.4    Sturzenbaum, S.R.5
  • 17
    • 0037319121 scopus 로고    scopus 로고
    • Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins
    • Caldwell, G. A., Cao, S., Sexton, E. G., Gelwix, C. C., Bevel, J. P., and Caldwell, K. A. (2003). Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins. Hum. Mol. Genet., 12, 307-319.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 307-319
    • Caldwell, G.A.1    Cao, S.2    Sexton, E.G.3    Gelwix, C.C.4    Bevel, J.P.5    Caldwell, K.A.6
  • 18
    • 17644392138 scopus 로고    scopus 로고
    • Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans
    • Cao, S., Gelwix, C. C., Caldwell, K. A., and Caldwell, G. A. (2005). Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans. J. Neurosci. 25, 3801-3812.
    • (2005) J. Neurosci. , vol.25 , pp. 3801-3812
    • Cao, S.1    Gelwix, C.C.2    Caldwell, K.A.3    Caldwell, G.A.4
  • 19
    • 9444271637 scopus 로고    scopus 로고
    • The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo
    • Cerpa, W. F., Barria, M. I., Chacon, M. A., Suazo, M., Gonzalez, M., Opazo, C., et al. (2004). The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo. FASEB J. 18, 1701-1703.
    • (2004) FASEB J. , vol.18 , pp. 1701-1703
    • Cerpa, W.F.1    Barria, M.I.2    Chacon, M.A.3    Suazo, M.4    Gonzalez, M.5    Opazo, C.6
  • 20
    • 32244434109 scopus 로고    scopus 로고
    • Acute manganese administration alters dopamine transporter levels in the non-human primate striatum
    • Chen, M. K., Lee, J. S., McGlothan, J. L., Furukawa, E., Adams, R. J., Alexander, M., et al. (2006). Acute manganese administration alters dopamine transporter levels in the non-human primate striatum. Neurotoxicology 27, 229-236.
    • (2006) Neurotoxicology , vol.27 , pp. 229-236
    • Chen, M.K.1    Lee, J.S.2    McGlothan, J.L.3    Furukawa, E.4    Adams, R.J.5    Alexander, M.6
  • 21
    • 77956113164 scopus 로고    scopus 로고
    • The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response
    • Chen, P., Burdette, A. J., Porter, J. C., Ricketts, J. C., Fox, S. A., Nery, F. C., et al. (2010). The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response. Hum. Mol. Genet. 19, 3502-3515.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 3502-3515
    • Chen, P.1    Burdette, A.J.2    Porter, J.C.3    Ricketts, J.C.4    Fox, S.A.5    Nery, F.C.6
  • 22
    • 12744273945 scopus 로고    scopus 로고
    • Caenorhabditis elegans PMR1, a P-type calcium ATPase, is important for calcium/manganese homeostasis and oxidative stress response
    • Cho, J. H., Ko, K. M., Singaravelu, G., and Ahnn, J. (2005). Caenorhabditis elegans PMR1, a P-type calcium ATPase, is important for calcium/manganese homeostasis and oxidative stress response. FEBS Lett. 579, 778-782.
    • (2005) FEBS Lett. , vol.579 , pp. 778-782
    • Cho, J.H.1    Ko, K.M.2    Singaravelu, G.3    Ahnn, J.4
  • 23
    • 13944278450 scopus 로고    scopus 로고
    • Expression profiling of GABAergic motor neurons in Caenorhabditis elegans
    • Cinar, H., Keles, S., and Jin, Y. (2005). Expression profiling of GABAergic motor neurons in Caenorhabditis elegans. Curr. Biol. 15, 340-346.
    • (2005) Curr. Biol. , vol.15 , pp. 340-346
    • Cinar, H.1    Keles, S.2    Jin, Y.3
  • 24
    • 0028931470 scopus 로고
    • Odorant-specific adaptation pathways generate olfactory plasticity in C
    • Colbert, H. A., and Bargmann, C. I. (1995). Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans. Neuron 14, 803-812.
    • (1995) elegans. Neuron , vol.14 , pp. 803-812
    • Colbert, H.A.1    Bargmann, C.I.2
  • 25
    • 47049090944 scopus 로고    scopus 로고
    • Copper neurotoxicity in rat substantia nigra and striatum is dependent on DTdiaphorase inhibition
    • Diaz-Veliz, G., Paris, I., Mora, S., Raisman-Vozari, R., and Segura-Aguilar, J. (2008). Copper neurotoxicity in rat substantia nigra and striatum is dependent on DTdiaphorase inhibition. Chem. Res. Toxicol. 21, 1180-1185.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 1180-1185
    • Diaz-Veliz, G.1    Paris, I.2    Mora, S.3    Raisman-Vozari, R.4    Segura-Aguilar, J.5
  • 26
    • 62949208694 scopus 로고    scopus 로고
    • The neurotoxic effects of heavy metal exposure on GABAergic nervous system in nematode Caenorhabditis elegans
    • Du, M., and Wang, D. (2009). The neurotoxic effects of heavy metal exposure on GABAergic nervous system in nematode Caenorhabditis elegans. Environ. Toxicol. Pharmacol. 27, 314-320.
    • (2009) Environ. Toxicol. Pharmacol. , vol.27 , pp. 314-320
    • Du, M.1    Wang, D.2
  • 27
    • 84858157347 scopus 로고    scopus 로고
    • Iron dysregulation in movement disorders
    • Dusek, P., Jankovic, J., and Le, W. (2012). Iron dysregulation in movement disorders. Neurobiol. Dis. 46, 1-18.
    • (2012) Neurobiol. Dis. , vol.46 , pp. 1-18
    • Dusek, P.1    Jankovic, J.2    Le, W.3
  • 28
    • 77956281072 scopus 로고    scopus 로고
    • Coenzyme Q protects Caenorhabditis elegans GABA neurons from calcium-dependent degeneration
    • Earls, L. R., Hacker, M. L., Watson, J. D., and Miller, D. M. (2010). Coenzyme Q protects Caenorhabditis elegans GABA neurons from calcium-dependent degeneration. Proc. Natl. Acad. Sci. U.S.A. 107, 14460-14465.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 14460-14465
    • Earls, L.R.1    Hacker, M.L.2    Watson, J.D.3    Miller, D.M.4
  • 29
    • 70350170830 scopus 로고    scopus 로고
    • Cadmium in food. Scientific opinion of the panel on contaminants in the food chain
    • EFSA
    • EFSA. (2009). Cadmium in food. Scientific opinion of the panel on contaminants in the food chain. EFSA J. 980, 1-139.
    • (2009) EFSA J. , vol.980 , pp. 1-139
  • 31
    • 0026324532 scopus 로고
    • Mercury and monomethylmercury: present and future concerns
    • Fitzgerald, W. F., and Clarkson, T. W. (1991). Mercury and monomethylmercury: present and future concerns. Environ. Health Perspect. 96, 159-166.
    • (1991) Environ. Health Perspect. , vol.96 , pp. 159-166
    • Fitzgerald, W.F.1    Clarkson, T.W.2
  • 33
    • 61349147706 scopus 로고    scopus 로고
    • Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
    • Gitler, A. D., Chesi, A., Geddie, M. L., Strathearn, K. E., Hamamichi, S., Hill, K. J.,et al. (2009). Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat. Genet. 41, 308-315.
    • (2009) Nat. Genet. , vol.41 , pp. 308-315
    • Gitler, A.D.1    Chesi, A.2    Geddie, M.L.3    Strathearn, K.E.4    Hamamichi, S.5    Hill, K.J.6
  • 34
    • 0037474331 scopus 로고    scopus 로고
    • Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans
    • Gourley, B. L., Parker, S. B., Jones, B. J., Zumbrennen, K. B., and Leibold, E. A. (2003). Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans. J. Biol. Chem. 278, 3227-3234.
    • (2003) J. Biol. Chem. , vol.278 , pp. 3227-3234
    • Gourley, B.L.1    Parker, S.B.2    Jones, B.J.3    Zumbrennen, K.B.4    Leibold, E.A.5
  • 35
    • 0014850966 scopus 로고
    • Habituation: a dual-process theory
    • Groves, P. M., and Thompson, R. F. (1970). Habituation: a dual-process theory. Psychol. Rev. 77, 419-450.
    • (1970) Psychol. Rev. , vol.77 , pp. 419-450
    • Groves, P.M.1    Thompson, R.F.2
  • 36
    • 67349206907 scopus 로고    scopus 로고
    • Induction of reproductive deficits in nematode Caenorhabditis elegans exposed to metals at different developmental stages
    • Guo, Y., Yang, Y., and Wang, D. (2009). Induction of reproductive deficits in nematode Caenorhabditis elegans exposed to metals at different developmental stages. Reprod. Toxicol. 28, 90-95.
    • (2009) Reprod. Toxicol. , vol.28 , pp. 90-95
    • Guo, Y.1    Yang, Y.2    Wang, D.3
  • 37
    • 0032604999 scopus 로고    scopus 로고
    • The toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain of Caenorhabditis elegans
    • Guven, K., Power, R. S., Avramides, S., Allender, R., and de Pomerai, D. I. (1999). The toxicity of dithiocarbamate fungicides to soil nematodes, assessed using a stress-inducible transgenic strain of Caenorhabditis elegans. J. Biochem. Mol. Toxicol. 13, 324-333.
    • (1999) J. Biochem. Mol. Toxicol. , vol.13 , pp. 324-333
    • Guven, K.1    Power, R.S.2    Avramides, S.3    Allender, R.4    de Pomerai, D.I.5
  • 38
    • 24344455164 scopus 로고    scopus 로고
    • Prognostic significance of low serum levels of Clara cell phospholipid-binding protein in occupational aluminium neurotoxicity
    • Halatek, T., Sinczuk-Walczak, H., and Rydzynski, K. (2005). Prognostic significance of low serum levels of Clara cell phospholipid-binding protein in occupational aluminium neurotoxicity. J. Inorg. Biochem. 99, 1904-1911.
    • (2005) J. Inorg. Biochem. , vol.99 , pp. 1904-1911
    • Halatek, T.1    Sinczuk-Walczak, H.2    Rydzynski, K.3
  • 40
    • 33846850428 scopus 로고    scopus 로고
    • Shortened lifespan of nematode Caenorhabditis elegans after prolonged exposure to heavy metals and detergents
    • Harada, H., Kurauchi, M., Hayashi, R., and Eki, T. (2007). Shortened lifespan of nematode Caenorhabditis elegans after prolonged exposure to heavy metals and detergents. Ecotoxicol. Environ. Saf. 66, 378-383.
    • (2007) Ecotoxicol. Environ. Saf. , vol.66 , pp. 378-383
    • Harada, H.1    Kurauchi, M.2    Hayashi, R.3    Eki, T.4
  • 41
    • 84857015288 scopus 로고    scopus 로고
    • Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease
    • Harrington, A. J., Yacoubian, T. A., Slone, S. R., Caldwell, K. A., and Caldwell, G. A. (2012). Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease. J. Neurosci. 32, 2142-2153.
    • (2012) J. Neurosci. , vol.32 , pp. 2142-2153
    • Harrington, A.J.1    Yacoubian, T.A.2    Slone, S.R.3    Caldwell, K.A.4    Caldwell, G.A.5
  • 43
    • 77956913105 scopus 로고    scopus 로고
    • Hormetic effect of methylmercury on Caenorhabditis elegans
    • Helmcke, K. J., and Aschner, M. (2010). Hormetic effect of methylmercury on Caenorhabditis elegans. Toxicol. Appl. Pharmacol. 248, 156-164.
    • (2010) Toxicol. Appl. Pharmacol. , vol.248 , pp. 156-164
    • Helmcke, K.J.1    Aschner, M.2
  • 44
    • 73649131652 scopus 로고    scopus 로고
    • Utility of Caenorhabditis elegans in high throughput neurotoxicological research
    • Helmcke, K. J., Avila, D. S., and Aschner, M. (2010). Utility of Caenorhabditis elegans in high throughput neurotoxicological research. Neurotoxicol. Teratol. 32, 62-67.
    • (2010) Neurotoxicol. Teratol. , vol.32 , pp. 62-67
    • Helmcke, K.J.1    Avila, D.S.2    Aschner, M.3
  • 45
    • 70349232753 scopus 로고    scopus 로고
    • Characterization of the effects of methylmercury on Caenorhabditis elegans
    • Helmcke, K. J., Syversen, T., Miller, D. M. 3rd., and Aschner, M. (2009). Characterization of the effects of methylmercury on Caenorhabditis elegans. Toxicol. Appl. Pharmacol. 240, 265-272.
    • (2009) Toxicol. Appl. Pharmacol. , vol.240 , pp. 265-272
    • Helmcke, K.J.1    Syversen, T.2    Miller, D.M.3    Aschner, M.4
  • 46
    • 0842281817 scopus 로고    scopus 로고
    • Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans
    • Hills, T., Brockie, P. J., and Maricq, A. V. (2004). Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans. J. Neurosci. 24, 1217-1225.
    • (2004) J. Neurosci. , vol.24 , pp. 1217-1225
    • Hills, T.1    Brockie, P.J.2    Maricq, A.V.3
  • 47
    • 0019977293 scopus 로고
    • Serotonin and octopamine in the nematode Caenorhabditis elegans
    • Horvitz, H. R., Chalfie, M., Trent, C., Sulston, J. E., and Evans, P. D. (1982). Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216, 1012-1014.
    • (1982) Science , vol.216 , pp. 1012-1014
    • Horvitz, H.R.1    Chalfie, M.2    Trent, C.3    Sulston, J.E.4    Evans, P.D.5
  • 48
    • 82355190954 scopus 로고    scopus 로고
    • Toxicity of ingested cadmium to the nematode Caenorhabditis elegans
    • Hoss, S., Schlottmann, K., and Traunspurger, W. (2011). Toxicity of ingested cadmium to the nematode Caenorhabditis elegans. Environ. Sci. Technol. 45, 10219-10225.
    • (2011) Environ. Sci. Technol. , vol.45 , pp. 10219-10225
    • Hoss, S.1    Schlottmann, K.2    Traunspurger, W.3
  • 49
    • 84866359926 scopus 로고    scopus 로고
    • Quantum dot nanoparticles affect the reproductive system of Caenorhabditis elegans
    • Hsu, P. C., O'Callaghan, M., Al-Salim, N., and Hurst, M. R. (2012). Quantum dot nanoparticles affect the reproductive system of Caenorhabditis elegans. Environ. Toxicol. Chem. 31, 2366-2374.
    • (2012) Environ. Toxicol. Chem. , vol.31 , pp. 2366-2374
    • Hsu, P.C.1    O'Callaghan, M.2    Al-Salim, N.3    Hurst, M.R.4
  • 50
    • 59849129910 scopus 로고    scopus 로고
    • Phenotypic and behavioral defects induced by iron exposure can be transferred to progeny in Caenorhabditis elegans
    • Hu, Y. O., Wang, Y., Ye, B. P., and Wang, D. Y. (2008). Phenotypic and behavioral defects induced by iron exposure can be transferred to progeny in Caenorhabditis elegans. Biomed. Environ. Sci. 21, 467-473.
    • (2008) Biomed. Environ. Sci. , vol.21 , pp. 467-473
    • Hu, Y.O.1    Wang, Y.2    Ye, B.P.3    Wang, D.Y.4
  • 51
    • 84883501460 scopus 로고
    • Cadmium and certain cadmium compounds
    • IARC. Beryllium Cadmium, Mercury and Exposures in the Glass Manufacturing Industry (Lyon: IARC)
    • IARC. (1993). "Cadmium and certain cadmium compounds," in IARC Monographs on the EValuation the Carcinogenic Risk of Chemicals to Humans. Beryllium Cadmium, Mercury and Exposures in the Glass Manufacturing Industry (Lyon: IARC), 119-146, 210-236.
    • (1993) IARC Monographs on the EValuation the Carcinogenic Risk of Chemicals to Humans , vol.119-146 , pp. 210-236
  • 52
    • 84870485773 scopus 로고    scopus 로고
    • Biolistic transformation of Caenorhabditis elegans
    • Isik, M., and Berezikov, E. (2013). Biolistic transformation of Caenorhabditis elegans. Methods Mol. Biol. 940, 77-86.
    • (2013) Methods Mol. Biol. , vol.940 , pp. 77-86
    • Isik, M.1    Berezikov, E.2
  • 53
    • 0031754719 scopus 로고    scopus 로고
    • The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant-and cocaine-sensitive dopamine transporter
    • Jayanthi, L. D., Apparsundaram, S., Malone, M. D., Ward, E., Miller, D. M., Eppler, M., et al. (1998). The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant-and cocaine-sensitive dopamine transporter. Mol. Pharmacol. 54, 601-609.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 601-609
    • Jayanthi, L.D.1    Apparsundaram, S.2    Malone, M.D.3    Ward, E.4    Miller, D.M.5    Eppler, M.6
  • 54
    • 0028568659 scopus 로고
    • Control of type-D GABAergic neuron differentiation by C elegans UNC-30 homeodomain protein.
    • Jin, Y., Hoskins, R., and Horvitz, H. R. (1994). Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein. Nature 372, 780-783.
    • (1994) Nature , vol.372 , pp. 780-783
    • Jin, Y.1    Hoskins, R.2    Horvitz, H.R.3
  • 55
    • 0033556159 scopus 로고    scopus 로고
    • The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development
    • Jin, Y., Jorgensen, E., Hartwieg, E., and Horvitz, H. R. (1999). The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development. J. Neurosci. 19, 539-548.
    • (1999) J. Neurosci. , vol.19 , pp. 539-548
    • Jin, Y.1    Jorgensen, E.2    Hartwieg, E.3    Horvitz, H.R.4
  • 56
    • 84855388524 scopus 로고    scopus 로고
    • Single/low-copy integration of transgenes in Caenorhabditis elegans using an ultraviolet trimethylpsoralen method
    • doi: 10.1186/1472-6750-12-1
    • Kage-Nakadai, E., Kobuna, H., Funatsu, O., Otori, M., Gengyo-Ando, K., Yoshina, S., et al. (2012). Single/low-copy integration of transgenes in Caenorhabditis elegans using an ultraviolet trimethylpsoralen method. BMC Biotechnol. 12:1. doi: 10.1186/1472-6750-12-1
    • (2012) BMC Biotechnol. , vol.12 , pp. 1
    • Kage-Nakadai, E.1    Kobuna, H.2    Funatsu, O.3    Otori, M.4    Gengyo-Ando, K.5    Yoshina, S.6
  • 57
    • 1342346710 scopus 로고    scopus 로고
    • A conserved siRNA-degrading RNase negatively regulates RNA interference in C
    • Kennedy, S., Wang, D., and Ruvkun, G. (2004). A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature 427, 645-649.
    • (2004) elegans. Nature , vol.427 , pp. 645-649
    • Kennedy, S.1    Wang, D.2    Ruvkun, G.3
  • 58
    • 4344666717 scopus 로고    scopus 로고
    • Transcriptional regulation and life-span modulation of cytosolic aconitase and ferritin genes in C.elegans
    • Kim, Y. I., Cho, J. H., Yoo, O. J., and Ahnn, J. (2004). Transcriptional regulation and life-span modulation of cytosolic aconitase and ferritin genes in C.elegans. J. Mol. Biol. 342, 421-433.
    • (2004) J. Mol. Biol. , vol.342 , pp. 421-433
    • Kim, Y.I.1    Cho, J.H.2    Yoo, O.J.3    Ahnn, J.4
  • 61
    • 0032959163 scopus 로고    scopus 로고
    • EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in Caenorhabditis elegans
    • Lee, R. Y. N., Sawin, E. R., Chalfie, M., Horvitz, H. R., and Avery, L. (1999). EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in Caenorhabditis elegans. J. Neurosci. 19, 159-167.
    • (1999) J. Neurosci. , vol.19 , pp. 159-167
    • Lee, R.Y.N.1    Sawin, E.R.2    Chalfie, M.3    Horvitz, H.R.4    Avery, L.5
  • 62
    • 78649881414 scopus 로고    scopus 로고
    • Tools for metal ion sorting: in vitro evidence for partitioning of zinc and cadmium in C elegans metallothionein isoforms
    • Leszczyszyn, O. I., Zeitoun-Ghandour, S., Sturzenbaum, S. R., and Blindauer, C. A. (2011). Tools for metal ion sorting: in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms. Chem. Commun. (Camb.) 47, 448-450.
    • (2011) Chem. Commun. (Camb.) , vol.47 , pp. 448-450
    • Leszczyszyn, O.I.1    Zeitoun-Ghandour, S.2    Sturzenbaum, S.R.3    Blindauer, C.A.4
  • 63
    • 84860759482 scopus 로고    scopus 로고
    • Chronic Al2O3-nanoparticle exposure causes neurotoxic effects on locomotion behaviors by inducing severe ROS production and disruption of ROS defense mechanisms in nematode Caenorhabditis elegans
    • Li, Y., Yu, S., Wu, Q., Tang, M., Pu, Y., and Wang, D. (2012). Chronic Al2O3-nanoparticle exposure causes neurotoxic effects on locomotion behaviors by inducing severe ROS production and disruption of ROS defense mechanisms in nematode Caenorhabditis elegans. J. Hazard. Mater. 219-220, 221-230.
    • (2012) J. Hazard. Mater. , vol.219-220 , pp. 221-230
    • Li, Y.1    Yu, S.2    Wu, Q.3    Tang, M.4    Pu, Y.5    Wang, D.6
  • 64
    • 33644898819 scopus 로고    scopus 로고
    • Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant
    • Lin, Y. T., Hoang, H., Hsieh, S. I., Rangel, N., Foster, A. L., Sampayo, J. N., et al. (2006). Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant. Free Radic. Biol. Med. 40, 1185-1193.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 1185-1193
    • Lin, Y.T.1    Hoang, H.2    Hsieh, S.I.3    Rangel, N.4    Foster, A.L.5    Sampayo, J.N.6
  • 65
    • 0028895406 scopus 로고
    • Sensory regulation of male mating behavior in caenorhabditis elegans
    • Liu, K. S., and Sternberg, P. W. (1995). Sensory regulation of male mating behavior in caenorhabditis elegans. Neuron 14, 79-89.
    • (1995) Neuron , vol.14 , pp. 79-89
    • Liu, K.S.1    Sternberg, P.W.2
  • 66
    • 0027131206 scopus 로고
    • Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans
    • Loer, C. M., and Kenyon, C. J. (1993). Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans. J. Neurosci. 13, 5407-5417.
    • (1993) J. Neurosci. , vol.13 , pp. 5407-5417
    • Loer, C.M.1    Kenyon, C.J.2
  • 67
    • 79959613455 scopus 로고    scopus 로고
    • Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease
    • Luo, Y., Zhang, J., Liu, N., and Zhao, B. (2011). Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease. Sci. China Life Sci. 54, 527-534.
    • (2011) Sci. China Life Sci. , vol.54 , pp. 527-534
    • Luo, Y.1    Zhang, J.2    Liu, N.3    Zhao, B.4
  • 68
    • 36349010335 scopus 로고    scopus 로고
    • Caenorhabditis elegans glutamate transporters influence synaptic function and behavior at sites distant from the synapse
    • Mano, I., Straud, S., and Driscoll, M. (2007). Caenorhabditis elegans glutamate transporters influence synaptic function and behavior at sites distant from the synapse. J. Biol. Chem. 282, 34412-34419.
    • (2007) J. Biol. Chem. , vol.282 , pp. 34412-34419
    • Mano, I.1    Straud, S.2    Driscoll, M.3
  • 69
    • 80053497782 scopus 로고    scopus 로고
    • Revelations from the nematode Caenorhabditis elegans on the complex interplay of metal toxicological mechanisms
    • doi: 10.1155/2011/895236
    • Martinez-Finley, E. J., and Aschner, M. (2011). Revelations from the nematode Caenorhabditis elegans on the complex interplay of metal toxicological mechanisms. J. Toxicol. 2011, 895236. doi: 10.1155/2011/895236
    • (2011) J. Toxicol. , vol.2011 , pp. 895236
    • Martinez-Finley, E.J.1    Aschner, M.2
  • 70
    • 84857828366 scopus 로고    scopus 로고
    • Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese
    • doi: 10.1371/journal.pone.0032685
    • McColl, G., James, S. A., Mayo, S., Howard, D. L., Ryan, C. G., Kirkham, R., et al. (2012). Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese. PLoS ONE 7, e32685. doi: 10.1371/journal.pone.0032685
    • (2012) PLoS ONE , vol.7
    • McColl, G.1    James, S.A.2    Mayo, S.3    Howard, D.L.4    Ryan, C.G.5    Kirkham, R.6
  • 71
    • 80054832564 scopus 로고    scopus 로고
    • Comparative toxicology of mercurials in Caenorhabditis elegans
    • McElwee, M. K., and Freedman, J. H. (2011). Comparative toxicology of mercurials in Caenorhabditis elegans. Environ. Toxicol. Chem. 30, 2135-2141.
    • (2011) Environ. Toxicol. Chem. , vol.30 , pp. 2135-2141
    • McElwee, M.K.1    Freedman, J.H.2
  • 72
    • 0030734546 scopus 로고    scopus 로고
    • Identification and characterization of the vesicular GABA transporter
    • McIntire, S. L., Reimer, R. J., Schuske, K., Edwards, R. H., and Jorgensen, E. M. (1997). Identification and characterization of the vesicular GABA transporter. Nature 389, 870-876.
    • (1997) Nature , vol.389 , pp. 870-876
    • McIntire, S.L.1    Reimer, R.J.2    Schuske, K.3    Edwards, R.H.4    Jorgensen, E.M.5
  • 73
    • 1642281181 scopus 로고    scopus 로고
    • eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx
    • McKay, J. P., Raizen, D. M., Gottschalk, A., Schafer, W. R., and Avery, L. (2004). eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx. Genetics 166, 161-169.
    • (2004) Genetics , vol.166 , pp. 161-169
    • McKay, J.P.1    Raizen, D.M.2    Gottschalk, A.3    Schafer, W.R.4    Avery, L.5
  • 74
    • 0027272707 scopus 로고
    • Genes required for GABA function in Caenorhabditis elegans
    • McLntire, S. L., Jorgensen, E., and Horvitz, H. R. (1993). Genes required for GABA function in Caenorhabditis elegans. Nature 364, 334-337.
    • (1993) Nature , vol.364 , pp. 334-337
    • McLntire, S.L.1    Jorgensen, E.2    Horvitz, H.R.3
  • 75
    • 0037028037 scopus 로고    scopus 로고
    • Decoding of polymodal sensory stimuli by postsynaptic glutamate receptors in C
    • Mellem, J. E., Brockie, P. J., Zheng, Y., Madsen, D. M., and Maricq, A. V. (2002). Decoding of polymodal sensory stimuli by postsynaptic glutamate receptors in C. elegans. Neuron 36, 933-944.
    • (2002) elegans. Neuron , vol.36 , pp. 933-944
    • Mellem, J.E.1    Brockie, P.J.2    Zheng, Y.3    Madsen, D.M.4    Maricq, A.V.5
  • 79
    • 77955847504 scopus 로고    scopus 로고
    • Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease
    • Mocko, J. B., Kern, A., Moosmann, B., Behl, C., and Hajieva, P. (2010). Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease. Neurobiol. Dis. 40, 120-129.
    • (2010) Neurobiol. Dis. , vol.40 , pp. 120-129
    • Mocko, J.B.1    Kern, A.2    Moosmann, B.3    Behl, C.4    Hajieva, P.5
  • 80
    • 35048872247 scopus 로고    scopus 로고
    • Choline transport and de novo choline synthesis support acetylcholine biosynthesis in Caenorhabditis elegans cholinergic neurons
    • Mullen, G. P., Mathews, E. A., Vu, M. H., Hunter, J. W., Frisby, D. L., Duke, A., et al. (2007). Choline transport and de novo choline synthesis support acetylcholine biosynthesis in Caenorhabditis elegans cholinergic neurons. Genetics 177, 195-204.
    • (2007) Genetics , vol.177 , pp. 195-204
    • Mullen, G.P.1    Mathews, E.A.2    Vu, M.H.3    Hunter, J.W.4    Frisby, D.L.5    Duke, A.6
  • 81
    • 79953766071 scopus 로고    scopus 로고
    • Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans
    • doi: 10.1371/journal.pgen.1002013
    • Murphy, J. T., Bruinsma, J. J., Schneider, D. L., Collier, S., Guthrie, J., Chinwalla, A., et al. (2011). Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans. PLoS Genet. 7, e1002013. doi: 10.1371/journal.pgen.1002013
    • (2011) PLoS Genet. , vol.7
    • Murphy, J.T.1    Bruinsma, J.J.2    Schneider, D.L.3    Collier, S.4    Guthrie, J.5    Chinwalla, A.6
  • 82
    • 0037022668 scopus 로고    scopus 로고
    • Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans
    • Nass, R., Hall, D. H., Miller, D. M., and Blakely, R. D. (2002). Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 99, 3264-3269.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 3264-3269
    • Nass, R.1    Hall, D.H.2    Miller, D.M.3    Blakely, R.D.4
  • 83
    • 78650993109 scopus 로고    scopus 로고
    • Molecular neurobiology of lead (Pb(2+)): effects on synaptic function
    • Neal, A. P., and Guilarte, T. R. (2010). Molecular neurobiology of lead (Pb(2+)): effects on synaptic function. Mol. Neurobiol. 42, 151-160.
    • (2010) Mol. Neurobiol. , vol.42 , pp. 151-160
    • Neal, A.P.1    Guilarte, T.R.2
  • 84
    • 79953120967 scopus 로고    scopus 로고
    • Exposure to Mn/Zn ethylene-bis-dithiocarbamate and glyphosate pesticides leads to neurodegeneration in Caenorhabditis elegans
    • Negga, R., Rudd, D. A., Davis, N. S., Justice, A. N., Hatfield, H. E., Valente, A. L., et al. (2011). Exposure to Mn/Zn ethylene-bis-dithiocarbamate and glyphosate pesticides leads to neurodegeneration in Caenorhabditis elegans. Neurotoxicology 32, 331-341.
    • (2011) Neurotoxicology , vol.32 , pp. 331-341
    • Negga, R.1    Rudd, D.A.2    Davis, N.S.3    Justice, A.N.4    Hatfield, H.E.5    Valente, A.L.6
  • 85
    • 84861458044 scopus 로고    scopus 로고
    • Exposure to glyphosate-and/or Mn/Zn-ethylene-bis-dithiocarbamatecontaining pesticides leads to degeneration of gamma-aminobutyric acid and dopamine neurons in Caenorhabditis elegans
    • Negga, R., Stuart, J. A., Machen, M. L., Salva, J., Lizek, A. J., Richardson, S. J., et al. (2012). Exposure to glyphosate-and/or Mn/Zn-ethylene-bis-dithiocarbamatecontaining pesticides leads to degeneration of gamma-aminobutyric acid and dopamine neurons in Caenorhabditis elegans. Neurotox. Res. 21, 281-290.
    • (2012) Neurotox. Res. , vol.21 , pp. 281-290
    • Negga, R.1    Stuart, J.A.2    Machen, M.L.3    Salva, J.4    Lizek, A.J.5    Richardson, S.J.6
  • 86
    • 0037255932 scopus 로고    scopus 로고
    • Serotonin regulates repolarization of the C elegans pharyngeal muscle
    • Niacaris, T., and Avery, L. (2003). Serotonin regulates repolarization of the C. elegans pharyngeal muscle. J. Exp. Biol. 206, 223-231.
    • (2003) J. Exp. Biol. , vol.206 , pp. 223-231
    • Niacaris, T.1    Avery, L.2
  • 87
    • 84860765276 scopus 로고    scopus 로고
    • Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans
    • Page, K. E., White, K. N., McCrohan, C. R., Killilea, D. W., and Lithgow, G. J. (2012). Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans. Metallomics 4, 512-522.
    • (2012) Metallomics , vol.4 , pp. 512-522
    • Page, K.E.1    White, K.N.2    McCrohan, C.R.3    Killilea, D.W.4    Lithgow, G.J.5
  • 88
    • 0035818590 scopus 로고    scopus 로고
    • Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death
    • Parker, J. A., Connolly, J. B., Wellington, C., Hayden, M., Dausset, J., and Neri, C. (2001). Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death. Proc. Natl. Acad. Sci. U.S.A. 98, 13318-13323.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 13318-13323
    • Parker, J.A.1    Connolly, J.B.2    Wellington, C.3    Hayden, M.4    Dausset, J.5    Neri, C.6
  • 89
    • 0018706654 scopus 로고
    • Cadmium toxicity in the free-living nematode, Caenorhabditis elegans
    • Popham, J. D., and Webster, J. M. (1979). Cadmium toxicity in the free-living nematode, Caenorhabditis elegans. Environ. Res. 20, 183-191.
    • (1979) Environ. Res. , vol.20 , pp. 183-191
    • Popham, J.D.1    Webster, J.M.2
  • 90
    • 0035099902 scopus 로고    scopus 로고
    • Creation of low-copy integrated transgenic lines in Caenorhabditis elegans
    • Praitis, V., Casey, E., Collar, D., and Austin, J. (2001). Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. Genetics 157, 1217-1226.
    • (2001) Genetics , vol.157 , pp. 1217-1226
    • Praitis, V.1    Casey, E.2    Collar, D.3    Austin, J.4
  • 92
    • 0034235274 scopus 로고    scopus 로고
    • Long-term functional consequences of malnutrition during brain development: copper
    • Prohaska, J. R. (2000). Long-term functional consequences of malnutrition during brain development: copper. Nutrition 16, 502-504.
    • (2000) Nutrition , vol.16 , pp. 502-504
    • Prohaska, J.R.1
  • 93
    • 51049120267 scopus 로고    scopus 로고
    • Dopamine neuron degeneration induced by MPP+ is independent of CED-4 pathway in Caenorhabditis elegans
    • Pu, P., and Weidong, L. (2008). Dopamine neuron degeneration induced by MPP+ is independent of CED-4 pathway in Caenorhabditis elegans. Cell Res. 18, 978-981.
    • (2008) Cell Res. , vol.18 , pp. 978-981
    • Pu, P.1    Weidong, L.2
  • 94
    • 79960434279 scopus 로고    scopus 로고
    • Copper reduces Abeta oligomeric species and ameliorates neuromuscular synaptic defects in a C elegans model of inclusion body myositis
    • Rebolledo, D. L., Aldunate, R., Kohn, R., Neira, I., Minniti, A. N., and Inestrosa, N. C. (2011). Copper reduces Abeta oligomeric species and ameliorates neuromuscular synaptic defects in a C. elegans model of inclusion body myositis. J. Neurosci. 31, 10149-10158.
    • (2011) J. Neurosci. , vol.31 , pp. 10149-10158
    • Rebolledo, D.L.1    Aldunate, R.2    Kohn, R.3    Neira, I.4    Minniti, A.N.5    Inestrosa, N.C.6
  • 95
    • 0035889640 scopus 로고    scopus 로고
    • Regulation of the pharynx of Caenorhabditis elegans by 5-HT, octopamine, and FMRFamide-like neuropeptides
    • Rogers, C. M., Franks, C. J., Walker, R. J., Burke, J. F., and Holden-Dye, L. (2001). Regulation of the pharynx of Caenorhabditis elegans by 5-HT, octopamine, and FMRFamide-like neuropeptides. J. Neurobiol. 49, 235-244.
    • (2001) J. Neurobiol. , vol.49 , pp. 235-244
    • Rogers, C.M.1    Franks, C.J.2    Walker, R.J.3    Burke, J.F.4    Holden-Dye, L.5
  • 96
    • 84855281325 scopus 로고    scopus 로고
    • HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage
    • doi: 10.1371/journal.pgen.1002394
    • Romney, S. J., Newman, B. S., Thacker, C., and Leibold, E. A. (2011). HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage. PLoS Genet. 7, e1002394. doi: 10.1371/journal.pgen.1002394
    • (2011) PLoS Genet. , vol.7
    • Romney, S.J.1    Newman, B.S.2    Thacker, C.3    Leibold, E.A.4
  • 97
    • 0142182057 scopus 로고    scopus 로고
    • GLR-1, a non-NMDA glutamate receptor homolog, is critical for long-term memory in Caenorhabditis elegans
    • Rose, J. K., Kaun, K. R., Chen, S. H., and Rankin, C. H. (2003). GLR-1, a non-NMDA glutamate receptor homolog, is critical for long-term memory in Caenorhabditis elegans. J. Neurosci. 23, 9595-9599.
    • (2003) J. Neurosci. , vol.23 , pp. 9595-9599
    • Rose, J.K.1    Kaun, K.R.2    Chen, S.H.3    Rankin, C.H.4
  • 98
    • 0035069462 scopus 로고    scopus 로고
    • Analyses of habituation in Caenorhabditis elegans
    • Rose, J. K., and Rankin, C. H. (2001). Analyses of habituation in Caenorhabditis elegans. Learn. Mem. 8, 63-69.
    • (2001) Learn. Mem. , vol.8 , pp. 63-69
    • Rose, J.K.1    Rankin, C.H.2
  • 99
    • 72749106042 scopus 로고    scopus 로고
    • VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease
    • Ruan, Q., Harrington, A. J., Caldwell, K. A., Caldwell, G. A., and Standaert, D. G. (2010). VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiol. Dis. 37, 330-338.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 330-338
    • Ruan, Q.1    Harrington, A.J.2    Caldwell, K.A.3    Caldwell, G.A.4    Standaert, D.G.5
  • 101
    • 75649104591 scopus 로고    scopus 로고
    • Risk assessment of an essential element: manganese
    • Santamaria, A. B., and Sulsky, S. I. (2010). Risk assessment of an essential element: manganese. J. Toxicol. Environ. Health A 73, 128-155.
    • (2010) J. Toxicol. Environ. Health A , vol.73 , pp. 128-155
    • Santamaria, A.B.1    Sulsky, S.I.2
  • 102
    • 10744233265 scopus 로고    scopus 로고
    • Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans
    • Sanyal, S., Wintle, R. F., Kindt, K. S., Nuttley, W. M., Arvan, R., Fitzmaurice, P., et al. (2004). Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans. EMBO J. 23, 473-482.
    • (2004) EMBO J. , vol.23 , pp. 473-482
    • Sanyal, S.1    Wintle, R.F.2    Kindt, K.S.3    Nuttley, W.M.4    Arvan, R.5    Fitzmaurice, P.6
  • 103
    • 0033714116 scopus 로고    scopus 로고
    • C elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
    • Sawin, E. R., Ranganathan, R., and Horvitz, H. R. (2000). C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 26, 619-631.
    • (2000) Neuron , vol.26 , pp. 619-631
    • Sawin, E.R.1    Ranganathan, R.2    Horvitz, H.R.3
  • 104
    • 0028947566 scopus 로고
    • Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans
    • Segalat, L., Elkes, D., and Kaplan, J. (1995). Modulation of serotonin-controlled behaviors by Go in Caenorhabditis elegans. Science 267, 1648-1651.
    • (1995) Science , vol.267 , pp. 1648-1651
    • Segalat, L.1    Elkes, D.2    Kaplan, J.3
  • 105
    • 72149086928 scopus 로고    scopus 로고
    • The divalent metal transporter homologues SMF-1/2 mediate dopamine neuron sensitivity in caenorhabditis elegans models of manganism and parkinson disease
    • Settivari, R., Levora, J., and Nass, R. (2009). The divalent metal transporter homologues SMF-1/2 mediate dopamine neuron sensitivity in caenorhabditis elegans models of manganism and parkinson disease. J. Biol. Chem. 284, 35758-35768.
    • (2009) J. Biol. Chem. , vol.284 , pp. 35758-35768
    • Settivari, R.1    Levora, J.2    Nass, R.3
  • 106
    • 79956193293 scopus 로고    scopus 로고
    • SID-1 is a dsRNA-selective dsRNA-gated channel
    • Shih, J. D., and Hunter, C. P. (2011). SID-1 is a dsRNA-selective dsRNA-gated channel. RNA 17, 1057-1065.
    • (2011) RNA , vol.17 , pp. 1057-1065
    • Shih, J.D.1    Hunter, C.P.2
  • 107
    • 79960955504 scopus 로고    scopus 로고
    • Zinc: new clues to diverse roles in brain ischemia
    • Shuttleworth, C. W., and Weiss, J. H. (2011). Zinc: new clues to diverse roles in brain ischemia. Trends Pharmacol. Sci. 32, 480-486.
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 480-486
    • Shuttleworth, C.W.1    Weiss, J.H.2
  • 108
    • 0037031152 scopus 로고    scopus 로고
    • Loss of the putative RNA-directed RNA polymerase RRF-3 makes C elegans hypersensitive to RNAi
    • Simmer, F., Tijsterman, M., Parrish, S., Koushika, S. P., Nonet, M. L., Fire, A., et al. (2002). Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr. Biol. 12, 1317-1319.
    • (2002) Curr. Biol. , vol.12 , pp. 1317-1319
    • Simmer, F.1    Tijsterman, M.2    Parrish, S.3    Koushika, S.P.4    Nonet, M.L.5    Fire, A.6
  • 109
    • 0016766336 scopus 로고
    • Dopaminergic neurons in the nematode Caenorhabditis elegans
    • Sulston, J., Dew, M., and Brenner, S. (1975). Dopaminergic neurons in the nematode Caenorhabditis elegans. J. Comp. Neurol. 163, 215-226.
    • (1975) J. Comp. Neurol. , vol.163 , pp. 215-226
    • Sulston, J.1    Dew, M.2    Brenner, S.3
  • 110
    • 0342680006 scopus 로고    scopus 로고
    • Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
    • Sze, J. Y., Victor, M., Loer, C., Shi, Y., and Ruvkun, G. (2000). Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant. Nature 403, 560-564.
    • (2000) Nature , vol.403 , pp. 560-564
    • Sze, J.Y.1    Victor, M.2    Loer, C.3    Shi, Y.4    Ruvkun, G.5
  • 111
  • 112
    • 0032538391 scopus 로고    scopus 로고
    • RNAi in C elegans: soaking in the genome sequence
    • Tabara, H., Grishok, A., and Mello, C. C. (1998). RNAi in C. elegans: soaking in the genome sequence. Science 282, 430-431.
    • (1998) Science , vol.282 , pp. 430-431
    • Tabara, H.1    Grishok, A.2    Mello, C.C.3
  • 114
    • 84867248012 scopus 로고    scopus 로고
    • Iron metabolism: current facts and future directions
    • Tandara, L., and Salamunic, I. (2012). Iron metabolism: current facts and future directions. Biochem. Med. (Zagreb) 22, 311-328.
    • (2012) Biochem. Med. (Zagreb) , vol.22 , pp. 311-328
    • Tandara, L.1    Salamunic, I.2
  • 115
    • 0025254082 scopus 로고
    • Genetic analysis of defecation in Caenorhabditis elegans
    • Thomas, J. H. (1990). Genetic analysis of defecation in Caenorhabditis elegans. Genetics 124, 855-872.
    • (1990) Genetics , vol.124 , pp. 855-872
    • Thomas, J.H.1
  • 116
    • 33745223646 scopus 로고    scopus 로고
    • Finding function in novel targets: C elegans as a model organism
    • Titus, K., and Michael, O. H. (2006). Finding function in novel targets: C. elegans as a model organism. Nat. Rev. Drug Discov. 5, 387-399.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 387-399
    • Titus, K.1    Michael, O.H.2
  • 117
    • 84862900160 scopus 로고    scopus 로고
    • Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system
    • Toth, M. L., Melentijevic, I., Shah, L., Bhatia, A., Lu, K., Talwar, A., et al. (2012). Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system. J. Neurosci. 32, 8778-8790.
    • (2012) J. Neurosci. , vol.32 , pp. 8778-8790
    • Toth, M.L.1    Melentijevic, I.2    Shah, L.3    Bhatia, A.4    Lu, K.5    Talwar, A.6
  • 118
    • 84857410364 scopus 로고    scopus 로고
    • Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C elegans
    • doi: 10.1371/journal.pone.0031321
    • Vaccaro, A., Tauffenberger, A., Aggad, D., Rouleau, G., Drapeau, P., and Parker, J. A. (2012). Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans. PLoS ONE 7, e31321. doi: 10.1371/journal.pone.0031321
    • (2012) PLoS ONE , vol.7
    • Vaccaro, A.1    Tauffenberger, A.2    Aggad, D.3    Rouleau, G.4    Drapeau, P.5    Parker, J.A.6
  • 119
    • 84861234650 scopus 로고    scopus 로고
    • Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C elegans
    • Valentini, S., Cabreiro, F., Ackerman, D., Alam, M. M., Kunze, M. B., Kay, C. W., et al. (2012). Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans. Mech. Ageing Dev. 133, 282-290.
    • (2012) Mech. Ageing Dev. , vol.133 , pp. 282-290
    • Valentini, S.1    Cabreiro, F.2    Ackerman, D.3    Alam, M.M.4    Kunze, M.B.5    Kay, C.W.6
  • 120
    • 84870932163 scopus 로고    scopus 로고
    • The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration
    • VanDuyn, N., Settivari, R., LeVora, J., Zhou, S., Unrine, J., and Nass, R. (2013). The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration. J. Neurochem. 124, 147-157.
    • (2013) J. Neurochem. , vol.124 , pp. 147-157
    • VanDuyn, N.1    Settivari, R.2    LeVora, J.3    Zhou, S.4    Unrine, J.5    Nass, R.6
  • 121
    • 78549234350 scopus 로고    scopus 로고
    • SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity
    • VanDuyn, N., Settivari, R., Wong, G., and Nass, R. (2010). SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity. Toxicol. Sci. 118, 613-624.
    • (2010) Toxicol. Sci. , vol.118 , pp. 613-624
    • VanDuyn, N.1    Settivari, R.2    Wong, G.3    Nass, R.4
  • 122
    • 30044434872 scopus 로고    scopus 로고
    • Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans
    • Ved, R., Saha, S., Westlund, B., Perier, C., Burnam, L., Sluder, A., et al. (2005). Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J. Biol. Chem. 280, 42655-42668.
    • (2005) J. Biol. Chem. , vol.280 , pp. 42655-42668
    • Ved, R.1    Saha, S.2    Westlund, B.3    Perier, C.4    Burnam, L.5    Sluder, A.6
  • 123
    • 57249103549 scopus 로고    scopus 로고
    • Aluminium and lead: molecular mechanisms of brain toxicity
    • Verstraeten, S. V., Aimo, L., and Oteiza, P. I. (2008). Aluminium and lead: molecular mechanisms of brain toxicity. Arch. Toxicol. 82, 789-802.
    • (2008) Arch. Toxicol. , vol.82 , pp. 789-802
    • Verstraeten, S.V.1    Aimo, L.2    Oteiza, P.I.3
  • 124
    • 0032125818 scopus 로고    scopus 로고
    • Control of alternative behavioral states by serotonin in Caenorhabditis elegans
    • Waggoner, L. E., Zhou, G. T., Schafer, R. W., and Schafer, W. R. (1998). Control of alternative behavioral states by serotonin in Caenorhabditis elegans. Neuron 21, 203-214.
    • (1998) Neuron , vol.21 , pp. 203-214
    • Waggoner, L.E.1    Zhou, G.T.2    Schafer, R.W.3    Schafer, W.R.4
  • 125
    • 78650685650 scopus 로고    scopus 로고
    • beta-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease
    • Wan, L., Nie, G., Zhang, J., Luo, Y., Zhang, P., Zhang, Z., et al. (2011). beta-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease. Free Radic. Biol. Med. 50, 122-129.
    • (2011) Free Radic. Biol. Med. , vol.50 , pp. 122-129
    • Wan, L.1    Nie, G.2    Zhang, J.3    Luo, Y.4    Zhang, P.5    Zhang, Z.6
  • 126
    • 23144462374 scopus 로고    scopus 로고
    • Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
    • Wang, D., Kennedy, S., Conte, D. Jr., Kim, J. K., Gabel, H. W., Kamath, R. S., et al. (2005). Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature 436, 593-597.
    • (2005) Nature , vol.436 , pp. 593-597
    • Wang, D.1    Kennedy, S.2    Conte Jr., D.3    Kim, J.K.4    Gabel, H.W.5    Kamath, R.S.6
  • 127
    • 77951975292 scopus 로고    scopus 로고
    • Pre-treatment with mild UV irradiation increases the resistance of nematode Caenorhabditis elegans to toxicity on locomotion behaviors from metal exposure
    • Wang, D., Liu, P., and Xing, X. (2010). Pre-treatment with mild UV irradiation increases the resistance of nematode Caenorhabditis elegans to toxicity on locomotion behaviors from metal exposure. Environ. Toxicol. Pharmacol. 29, 213-222.
    • (2010) Environ. Toxicol. Pharmacol. , vol.29 , pp. 213-222
    • Wang, D.1    Liu, P.2    Xing, X.3
  • 128
    • 34648831239 scopus 로고    scopus 로고
    • The phenotypic and behavioral defects can be transferred from zinc-exposed nematodes to their progeny
    • Wang, D., Shen, L., and Wang, Y. (2007). The phenotypic and behavioral defects can be transferred from zinc-exposed nematodes to their progeny. Environ. Toxicol. Pharmacol. 24, 223-230.
    • (2007) Environ. Toxicol. Pharmacol. , vol.24 , pp. 223-230
    • Wang, D.1    Shen, L.2    Wang, Y.3
  • 129
    • 70149121319 scopus 로고    scopus 로고
    • [Aluminium toxicosis causing transferable defects from exposed animals to their progeny in Caenorhabditis elegans]
    • Wang, D. Y., Yang, Y. C., and Wang, Y. (2009). [Aluminium toxicosis causing transferable defects from exposed animals to their progeny in Caenorhabditis elegans]. Zhonghua Yu Fang Yi Xue Za Zhi 43, 45-51.
    • (2009) Zhonghua Yu Fang Yi Xue Za Zhi , vol.43 , pp. 45-51
    • Wang, D.Y.1    Yang, Y.C.2    Wang, Y.3
  • 130
    • 0028835184 scopus 로고
    • Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C
    • Weinshenker, D., Garriga, G., and Thomas, J. (1995). Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C. elegans. J. Neurosci. 15, 6975-6985.
    • (1995) elegans. J. Neurosci. , vol.15 , pp. 6975-6985
    • Weinshenker, D.1    Garriga, G.2    Thomas, J.3
  • 131
    • 0037079991 scopus 로고    scopus 로고
    • Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein
    • White, A. R., Multhaup, G., Galatis, D., McKinstry, W. J., Parker, M. W., Pipkorn, R., et al. (2002). Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. J. Neurosci. 22, 365-376.
    • (2002) J. Neurosci. , vol.22 , pp. 365-376
    • White, A.R.1    Multhaup, G.2    Galatis, D.3    McKinstry, W.J.4    Parker, M.W.5    Pipkorn, R.6
  • 133
    • 0001263837 scopus 로고    scopus 로고
    • Guidelines for drinking-water quality
    • WHO, (Geneva: World Health Organization),2nd Edn.
    • WHO. (1996). "Guidelines for drinking-water quality, 2nd Edn.," in Health Criteria and Other Supporting Information, Vol. 2. (Geneva: World Health Organization).
    • (1996) Health Criteria and Other Supporting Information , vol.2
  • 134
    • 0032728062 scopus 로고    scopus 로고
    • UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans
    • Winnier, A. R., Meir, J. Y., Ross, J. M., Tavernarakis, N., Driscoll, M., Ishihara, T., et al. (1999). UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans. Genes Dev. 13, 2774-2786.
    • (1999) Genes Dev. , vol.13 , pp. 2774-2786
    • Winnier, A.R.1    Meir, J.Y.2    Ross, J.M.3    Tavernarakis, N.4    Driscoll, M.5    Ishihara, T.6
  • 135
    • 84883526117 scopus 로고    scopus 로고
    • WormAtlas, Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall Available online at
    • WormAtlas. (2002). eds. Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at: http://www.wormatlas.org
    • (2002)
  • 136
    • 84883540185 scopus 로고    scopus 로고
    • WormAtlas, Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall Available online at:
    • WormAtlas. (2003). eds. Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at: http://www.wormatlas.org
    • (2003)
  • 137
    • 84883519209 scopus 로고    scopus 로고
    • WormAtlas,Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at:
    • WormAtlas. (2004). eds. Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at: http://www.wormatlas.org
    • (2004)
  • 138
    • 84883547254 scopus 로고    scopus 로고
    • WormAtlas, Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at:
    • WormAtlas. (2005). eds. Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at: http://www.wormatlas.org
    • (2005)
  • 139
    • 84883521850 scopus 로고    scopus 로고
    • WormAtlas, Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at:
    • WormAtlas. (2006). eds. Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at: http://www.wormatlas.org
    • (2006)
  • 140
    • 84883547346 scopus 로고    scopus 로고
    • WormAtlas, Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at:
    • WormAtlas. (2007). eds. Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at: http://www.wormatlas.org
    • (2007)
  • 141
    • 84883516877 scopus 로고    scopus 로고
    • WormAtlas, Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at:
    • WormAtlas. (2008). eds. Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at: http://www.wormatlas.org
    • (2008)
  • 142
    • 84883528255 scopus 로고    scopus 로고
    • WormAtlas, Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at:
    • WormAtlas. (2009). eds. Z. F. Altun, L. A. Herndon, C. Crocker, R. Lints, and D. H. Hall. Available online at: http://www.wormatlas.org
    • (2009)
  • 143
    • 84883514055 scopus 로고    scopus 로고
    • WormBase, Available online at:
    • WormBase. (2013). release WS236. Available online at: http://www.wormbase.org
    • (2013) release WS236
  • 144
    • 84859816521 scopus 로고    scopus 로고
    • Inhibition of ROS elevation and damage to mitochondrial function prevents lead-induced neurotoxic effects on structures and functions of AFD neurons in Caenorhabditis elegans
    • Wu, Q., Liu, P., Li, Y., Du, M., Xing, X., and Wang, D. (2012). Inhibition of ROS elevation and damage to mitochondrial function prevents lead-induced neurotoxic effects on structures and functions of AFD neurons in Caenorhabditis elegans. J. Environ. Sci. (China) 24, 733-742.
    • (2012) J. Environ. Sci. (China) , vol.24 , pp. 733-742
    • Wu, Q.1    Liu, P.2    Li, Y.3    Du, M.4    Xing, X.5    Wang, D.6
  • 145
    • 66949120323 scopus 로고    scopus 로고
    • Prolonged manganese exposure induces severe deficits in lifespan, development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans
    • Xiao, J., Rui, Q., Guo, Y., Chang, X., and Wang, D. (2009). Prolonged manganese exposure induces severe deficits in lifespan, development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans. J. Environ. Sci. (China) 21, 842-848.
    • (2009) J. Environ. Sci. (China) , vol.21 , pp. 842-848
    • Xiao, J.1    Rui, Q.2    Guo, Y.3    Chang, X.4    Wang, D.5
  • 146
    • 69949171166 scopus 로고    scopus 로고
    • Lethality toxicities induced by metal exposure during development in nematode Caenorhabditis elegans
    • Xing, X., Rui, Q., and Wang, D. (2009a). Lethality toxicities induced by metal exposure during development in nematode Caenorhabditis elegans. Bull. Environ. Contam. Toxicol. 83, 530-536.
    • (2009) Bull. Environ. Contam. Toxicol. , vol.83 , pp. 530-536
    • Xing, X.1    Rui, Q.2    Wang, D.3
  • 147
    • 64549108027 scopus 로고    scopus 로고
    • Exposure to lead and mercury in young larvae induces more severe deficits in neuronal survival and synaptic function than in adult nematodes
    • Xing, X. J., Rui, Q., Du, M., and Wang, D. Y. (2009b). Exposure to lead and mercury in young larvae induces more severe deficits in neuronal survival and synaptic function than in adult nematodes. Arch. Environ. Contam. Toxicol. 56, 732-741.
    • (2009) Arch. Environ. Contam. Toxicol. , vol.56 , pp. 732-741
    • Xing, X.J.1    Rui, Q.2    Du, M.3    Wang, D.Y.4
  • 148
    • 0032573592 scopus 로고    scopus 로고
    • Determination of endogenous trace metal contents in various mouse brain regions after prolonged oral administration of aluminum chloride
    • Yang, M. S., Wong, H. F., and Yung, K. L. (1998). Determination of endogenous trace metal contents in various mouse brain regions after prolonged oral administration of aluminum chloride. J. Toxicol. Environ. Health A 55, 445-453.
    • (1998) J. Toxicol. Environ. Health A , vol.55 , pp. 445-453
    • Yang, M.S.1    Wong, H.F.2    Yung, K.L.3
  • 149
    • 78649513742 scopus 로고    scopus 로고
    • Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes
    • doi: 10.1371/journal.pone.0014052
    • Ye, B., Rui, Q., Wu, Q., and Wang, D. (2010). Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes. PLoS ONE 5, e14052. doi: 10.1371/journal.pone.0014052
    • (2010) PLoS ONE , vol.5
    • Ye, B.1    Rui, Q.2    Wu, Q.3    Wang, D.4
  • 150
    • 44649126312 scopus 로고    scopus 로고
    • Trace administration of vitamin E can retrieve and prevent UV-irradiation-and metal exposure-induced memory deficits in nematode Caenorhabditis elegans
    • Ye, H., Ye, B., and Wang, D. (2008). Trace administration of vitamin E can retrieve and prevent UV-irradiation-and metal exposure-induced memory deficits in nematode Caenorhabditis elegans. Neurobiol. Learn. Mem. 90, 10-18.
    • (2008) Neurobiol. Learn. Mem. , vol.90 , pp. 10-18
    • Ye, H.1    Ye, B.2    Wang, D.3
  • 151
    • 0842328578 scopus 로고    scopus 로고
    • Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase
    • Yoder, J. H., Chong, H., Guan, K. L., and Han, M. (2004). Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J. 23, 111-119.
    • (2004) EMBO J. , vol.23 , pp. 111-119
    • Yoder, J.H.1    Chong, H.2    Guan, K.L.3    Han, M.4
  • 152
    • 80051601557 scopus 로고    scopus 로고
    • Close association of intestinal autofluorescence with the formation of severe oxidative damage in intestine of nematodes chronically exposed to Al(2)O(3)-nanoparticle
    • Yu, S., Rui, Q., Cai, T., Wu, Q., Li, Y., and Wang, D. (2011). Close association of intestinal autofluorescence with the formation of severe oxidative damage in intestine of nematodes chronically exposed to Al(2)O(3)-nanoparticle. Environ. Toxicol. Pharmacol. 32, 233-241.
    • (2011) Environ. Toxicol. Pharmacol. , vol.32 , pp. 233-241
    • Yu, S.1    Rui, Q.2    Cai, T.3    Wu, Q.4    Li, Y.5    Wang, D.6
  • 153
    • 84871660435 scopus 로고    scopus 로고
    • Transgenerational effects of heavy metals on L3 larva of Caenorhabditis elegans with greater behavior and growth inhibitions in the progeny
    • Yu, Z., Chen, X., Zhang, J., Wang, R., and Yin, D. (2013). Transgenerational effects of heavy metals on L3 larva of Caenorhabditis elegans with greater behavior and growth inhibitions in the progeny. Ecotoxicol. Environ. Saf. 88, 178-184.
    • (2013) Ecotoxicol. Environ. Saf. , vol.88 , pp. 178-184
    • Yu, Z.1    Chen, X.2    Zhang, J.3    Wang, R.4    Yin, D.5
  • 154
    • 77955866449 scopus 로고    scopus 로고
    • Effects of metal exposure on associative learning behavior in nematode Caenorhabditis elegans
    • Zhang, Y., Ye, B., and Wang, D. (2010). Effects of metal exposure on associative learning behavior in nematode Caenorhabditis elegans. Arch. Environ. Contam. Toxicol. 59, 129-136.
    • (2010) Arch. Environ. Contam. Toxicol. , vol.59 , pp. 129-136
    • Zhang, Y.1    Ye, B.2    Wang, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.