Utility of Caenorhabditis elegans in high throughput neurotoxicological research

Neurotoxicology and Teratology

Volumn 32, Issue 1, 2010, Pages 62-67

  Helmcke, Kirsten J ^a   Avila, Daiana Silva ^b   Aschner, Michael ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Caenorhabditis elegans; High throughput; Neurotoxicology

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; GREEN FLUORESCENT PROTEIN; POLYCHLORINATED BIPHENYL; ZINC;

ARTICLE; CAENORHABDITIS ELEGANS; CELL LINEAGE; EXPERIMENTAL MODEL; GENE EXPRESSION PROFILING; GENE SEQUENCE; GENETIC SCREENING; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; LIFE CYCLE; MEDICAL RESEARCH; MICROARRAY ANALYSIS; MUTAGENESIS; NEMATODE; NERVOUS SYSTEM; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; RNA INTERFERENCE; TOXICITY TESTING;

ANIMALS; CAENORHABDITIS ELEGANS; HIGH-THROUGHPUT SCREENING ASSAYS; NERVOUS SYSTEM; TOXICITY TESTS;

CAENORHABDITIS ELEGANS;

EID: 73649131652     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2008.11.005     Document Type: Article

References (73)

1. An J.H., and Blackwell T.K. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev. 17 (2003) 1882-1893
2. Avery L., and Horvitz H.R. Pharyngeal pumping continues after laser killing of the pharyngeal nervous system of C. elegans. Neuron 3 (1989) 473-485
3. Baek J.H., Cosman P., Feng Z., Silver J., and Schafer W.R. Using machine vision to analyze and classify Caenorhabditis elegans behavioral phenotypes quantitatively. J. Neurosci. Methods 118 (2002) 9-21
4. Bargmann C.I. Chemosensation in C. elegans. WormBook (2006) 1-29
5. Barr M.M., and Garcia L.R. Male mating behavior. WormBook (2006) 1-11
6. Bennett J.L., and Pax R.A. Micromotility meter: an instrument designed to evaluate the action of drugs on motility of larval and adult nematodes. Parasitology 93 Pt 2 (1986) 341-346
7. Bishop N.A., and Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447 (2007) 545-549
8. Bonifati V., Rizzu P., Squitieri F., Krieger E., Vanacore N., van Swieten J.C., Brice A., van Duijn C.M., Oostra B., Meco G., and Heutink P. DJ-1(PARK7), a novel gene for autosomal recessive, early onset parkinsonism. Neurol. Sci. 24 (2003) 159-160
9. Boyd W.A., Cole R.D., Anderson G.L., and Williams P.L. The effects of metals and food availability on the behavior of Caenorhabditis elegans. Environ. Toxicol. Chem. 22 (2003) 3049-3055
10. Boyd W.A., McBride S.J., and Freedman J.H. Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay. PLoS ONE 2 (2007) e1259
11. Braungart E., Gerlach M., Riederer P., Baumeister R., and Hoener M.C. Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings. Neurodegener. Dis. 1 (2004) 175-183
12. Brenner S. The genetics of Caenorhabditis elegans. Genetics 77 (1974) 71-94
13. Browne S.E., and Beal M.F. Oxidative damage in Huntington's disease pathogenesis. Antioxid. Redox Signal. 8 (2006) 2061-2073
14. Bruinsma J.J., Schneider D.L., Davis D.E., and Kornfeld K. Identification of mutations in Caenorhabditis elegans that cause resistance to high levels of dietary zinc and analysis using a genomewide map of single nucleotide polymorphisms scored by pyrosequencing. Genetics 179 (2008) 811-828
15. Burns A.R., Kwok T.C., Howard A., Houston E., Johanson K., Chan A., Cutler S.R., McCourt P., and Roy P.J. High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans. Natl. Protoc. 1 (2006) 1906-1914
16. Bus J.S., Aust S.D., and Gibson J.E. Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity. Biochem. Biophys. Res. Commun. 58 (1974) 749-755
17. Chen B.L., Hall D.H., and Chklovskii D.B. Wiring optimization can relate neuronal structure and function. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 4723-4728
18. Cole R.D., Anderson G.L., and Williams P.L. The nematode Caenorhabditis elegans as a model of organophosphate-induced mammalian neurotoxicity. Toxicol. Appl. Pharmacol. 194 (2004) 248-256
19. Drake J., Link C.D., and Butterfield D.A. Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model. Neurobiol. Aging 24 (2003) 415-420
20. Fewell G.D., and Schmitt K. Vector-based RNAi approaches for stable, inducible and genome-wide screens. Drug Discov. Today 11 (2006) 975-982
21. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., and Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
22. Fukui H., and Moraes C.T. The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?. Trends Neurosci. 31 (2008) 251-256
23. Harris T.W., Chen N., Cunningham F., Tello-Ruiz M., Antoshechkin I., Bastiani C., Bieri T., Blasiar D., Bradnam K., Chan J., Chen C.K., Chen W.J., Davis P., Kenny E., Kishore R., Lawson D., Lee R., Muller H.M., Nakamura C., Ozersky P., Petcherski A., Rogers A., Sabo A., Schwarz E.M., Van Auken K., Wang Q., Durbin R., Spieth J., Sternberg P.W., and Stein L.D. WormBase: a multi-species resource for nematode biology and genomics. Nucleic Acids Res. 32 (2004) D411-417
24. Hilliard M.A., Apicella A.J., Kerr R., Suzuki H., Bazzicalupo P., and Schafer W.R. In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents. Embo J. 24 (2005) 63-72
25. Hobert O. Specification of the nervous system. WormBook (2005) 1-19
26. Hodgkin J. Conventional genetics. In: Hope I.A. (Ed). C. elegans: A Practical Approach (1999), Oxford University Press, New York 245-270
27. Hope I.A. Background on Caenorhabditis elegans. In: Hope I.A. (Ed). C. elegans: A Practical Approach (1999), Oxford University Press, New York 1-15
28. Hulme S.E., Shevkoplyas S.S., Apfeld J., Fontana W., and Whitesides G.M. A microfabricated array of clamps for immobilizing and imaging C. elegans. Lab Chip 7 (2007) 1515-1523
29. Hulme S.E., Shevkoplyas S.S., and Samuel A. Microfluidics: streamlining discovery in worm biology. Nat. Methods 5 (2008) 589-590
30. Inoue H., Hisamoto N., An J.H., Oliveira R.P., Nishida E., Blackwell T.K., and Matsumoto K. The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev. 19 (2005) 2278-2283
31. Ishiguro H., Yasuda K., Ishii N., Ihara K., Ohkubo T., Hiyoshi M., Ono K., Senoo-Matsuda N., Shinohara O., Yosshii F., Murakami M., Hartman P.S., and Tsuda M. Enhancement of oxidative damage to cultured cells and Caenorhabditis elegans by mitochondrial electron transport inhibitors. IUBMB Life 51 (2001) 263-268
32. Jiang G.C., Tidwell K., McLaughlin B.A., Cai J., Gupta R.C., Milatovic D., Nass R., and Aschner M. Neurotoxic potential of depleted uranium effects in primary cortical neuron cultures and in Caenorhabditis elegans. Toxicol. Sci. 99 (2007) 553-565
33. Jiang M., Ryu J., Kiraly M., Duke K., Reinke V., and Kim S.K. Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 218-223
34. Jones D., and Candido E.P. Feeding is inhibited by sublethal concentrations of toxicants and by heat stress in the nematode Caenorhabditis elegans: relationship to the cellular stress response. J. Exp. Zool. 284 (1999) 147-157
35. Kaletta T., and Hengartner M.O. Finding function in novel targets: C. elegans as a model organism. Nat. Rev. Drug Discov. 5 (2006) 387-398
36. Kamath R.S., and Ahringer J. Genome-wide RNAi screening in Caenorhabditis elegans. Methods 30 (2003) 313-321
37. Kitagawa N., Shimohama S., Oeda T., Uemura K., Kohno R., Kuzuya A., Shibasaki H., and Ishii N. The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities. J. Biol. Chem. 278 (2003) 12130-12134
38. Kopin I.J., and Markey S.P. MPTP toxicity: implications for research in Parkinson's disease. Annu. Rev. Neurosci. 11 (1988) 81-96
39. Langston J.W., Langston E.B., and Irwin I. MPTP-induced parkinsonism in human and non-human primates-clinical and experimental aspects. Acta. Neurol. Scand. Suppl. 100 (1984) 49-54
40. Leung M.C., Williams P.L., Benedetto A., Au C., Helmcke K.J., Aschner M., and Meyer J.N. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol. Sci. 106 (2008) 5-28
41. Levitan D., and Greenwald I. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377 (1995) 351-354
42. Li S., Armstrong C.M., Bertin N., Ge H., Milstein S., Boxem M., Vidalain P.O., Han J.D., Chesneau A., Hao T., Goldberg D.S., Li N., Martinez M., Rual J.F., Lamesch P., Xu L., Tewari M., Wong S.L., Zhang L.V., Berriz G.F., Jacotot L., Vaglio P., Reboul J., Hirozane-Kishikawa T., Li Q., Gabel H.W., Elewa A., Baumgartner B., Rose D.J., Yu H., Bosak S., Sequerra R., Fraser A., Mango S.E., Saxton W.M., Strome S., Van Den Heuvel S., Piano F., Vandenhaute J., Sardet C., Gerstein M., Doucette-Stamm L., Gunsalus K.C., Harper J.W., Cusick M.E., Roth F.P., Hill D.E., and Vidal M. A map of the interactome network of the metazoan C. elegans. Science 303 (2004) 540-543
43. Link C.D. Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 9368-9372
44. Lund J., Tedesco P., Duke K., Wang J., Kim S.K., and Johnson T.E. Transcriptional profile of aging in C. elegans. Curr. Biol. 12 (2002) 1566-1573
45. Lynn S., Gurr J.R., Lai H.T., and Jan K.Y. NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells. Circ. Res. 86 (2000) 514-519
46. Menzel R., Yeo H.L., Rienau S., Li S., Steinberg C.E., and Sturzenbaum S.R. Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. J. Mol. Biol. 370 (2007) 1-13
47. Moreira P.I., Santos M.S., Oliveira C.R., Shenk J.C., Nunomura A., Smith M.A., Zhu X., and Perry G. Alzheimer disease and the role of free radicals in the pathogenesis of the disease. CNS Neurol. Disord. Drug Targets 7 (2008) 3-10
48. Murfitt R.R., Vogel K., and Sanadi D.R. Characterization of the mitochondria of the free-living nematode, Caenorhabditis elegans. Comp. Biochem. Physiol. B. 53 (1976) 423-430
49. Peterson R.T., Nass R., Boyd W.A., Freedman J.H., Dong K., and Narahashi T. Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology 29 (2008) 546-555
50. Pulak R. Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system. Methods Mol. Biol. 351 (2006) 275-286
51. Reichert K., and Menzel R. Expression profiling of five different xenobiotics using a Caenorhabditis elegans whole genome microarray. Chemosphere 61 (2005) 229-237
52. Riddle D.L., Blumenthal T., Meyer B.J., and Preiss J.R. C. elegans II, Cold Spring Harbor Laboratory Press (1997), Cold Spring Harbor, New York
53. Roh J.Y., Lee J., and Choi J. Assessment of stress-related gene expression in the heavy metal-exposed nematode Caenorhabditis elegans: a potential biomarker for metal-induced toxicity monitoring and environmental risk assessment. Environ. Toxicol. Chem. 25 (2006) 2946-2956
54. Rohde C.B., Zeng F., Gonzalez-Rubio R., Angel M., and Yanik M.F. Microfluidic system for on-chip high-throughput whole-animal sorting and screening at subcellular resolution. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 13891-13895
55. Sambongi Y., Nagae T., Liu Y., Yoshimizu T., Takeda K., Wada Y., and Futai M. Sensing of cadmium and copper ions by externally exposed ADL, ASE, and ASH neurons elicits avoidance response in Caenorhabditis elegans. Neuroreport 10 (1999) 753-757
56. Smith J.V., and Luo Y. Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761. J. Alzheimers Dis. 5 (2003) 287-300
57. Sulston J., Dew M., and Brenner S. Dopaminergic neurons in the nematode Caenorhabditis elegans. J. Comp. Neurol. 163 (1975) 215-226
58. Sulston J.E. Neuronal cell lineages in the nematode Caenorhabditis elegans. Cold Spring Harbor Symp. Quant. Biol. 48 Pt 2 (1983) 443-452
59. Sulston J.E., Schierenberg E., White J.G., and Thomson J.N. The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev. Biol. 100 (1983) 64-119
60. Szabados T., Dul C., Majtenyi K., Hargitai J., Penzes Z., and Urbanics R. A chronic Alzheimer's model evoked by mitochondrial poison sodium azide for pharmacological investigations. Behav. Brain Res. 154 (2004) 31-40
61. Timbrell J. Principles of Biochemical Toxicology (2000), Taylor & Francis, London
62. Tsibidis G.D., and Tavernarakis N. Nemo: a computational tool for analyzing nematode locomotion. BMC Neurosci. 8 (2007) 86
63. U.S. National Research Council. Scientific Frontiers in Developmental Toxicology and Risk Assessment (NRC, US) (2000), The National Academies Press, Washington, DC 296-308
64. Varadarajan S., Yatin S., Aksenova M., and Butterfield D.A. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J. Struct. Biol. 130 (2000) 184-208
65. Ved R., Saha S., Westlund B., Perier C., Burnam L., Sluder A., Hoener M., Rodrigues C.M., Alfonso A., Steer C., Liu L., Przedborski S., and Wolozin B. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J. Biol. Chem. 280 (2005) 42655-42668
66. Walker A.K., See R., Batchelder C., Kophengnavong T., Gronniger J.T., Shi Y., and Blackwell T.K. A conserved transcription motif suggesting functional parallels between Caenorhabditis elegans SKN-1 and Cap'n'Collar-related basic leucine zipper proteins. J. Biol. Chem. 275 (2000) 22166-22171
67. White J.G., Southgate E., Thompson J.N., and Brenner S. The structure of the nervous system of the nematode Caenorhabditis elegans. Philos. Trans. R. Soc. Lond., B (1986) 1-340
68. Wolters N.M., and MacKeigan J.P. From sequence to function: using RNAi to elucidate mechanisms of human disease. Cell Death Differ. 15 (2008) 809-819
69. Wu Z., Smith J.V., Paramasivam V., Butko P., Khan I., Cypser J.R., and Luo Y. Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans. Cell. Mol. Biol. (Noisy-le-grand) 48 (2002) 725-731
70. Yatin S.M., Varadarajan S., Link C.D., and Butterfield D.A. In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42). Neurobiol. Aging 20 (1999) 325-330 discussion 339-342
71. Ye H., Ye B., and Wang D. Trace administration of vitamin E can retrieve and prevent UV-irradiation- and metal exposure-induced memory deficits in nematode Caenorhabditis elegans. Neurobiol. Learn. Mem. 90 (2008) 10-18
72. Yuan H., Zheng J.C., Liu P., Zhang S.F., Xu J.Y., and Bai L.M. Pathogenesis of Parkinson's disease: oxidative stress, environmental impact factors and inflammatory processes. Neurosci. Bull. 23 (2007) 125-130
73. Zhong W., and Sternberg P.W. Genome-wide prediction of C. elegans genetic interactions. Science 311 (2006) 1481-1484