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Volumn 30, Issue 42, 2010, Pages 13932-13942

A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; CALRETICULIN; CHOLINERGIC RECEPTOR; IONOTROPIC RECEPTOR; MUTANT PROTEIN; RECEPTOR SUBUNIT;

EID: 77958615935     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1515-10.2010     Document Type: Article
Times cited : (33)

References (53)
  • 1
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 2
    • 0035974849 scopus 로고    scopus 로고
    • The C. elegans glutamate receptor subunit NMR-1 is required for slow NMDA-activated currents that regulate reversal frequency during locomotion
    • Brockie PJ, Mellem JE, Hills T, Madsen DM, Maricq AV (2001) The C. elegans glutamate receptor subunit NMR-1 is required for slow NMDA-activated currents that regulate reversal frequency during locomotion. Neuron 31:617-630.
    • (2001) Neuron , vol.31 , pp. 617-630
    • Brockie, P.J.1    Mellem, J.E.2    Hills, T.3    Madsen, D.M.4    Maricq, A.V.5
  • 3
    • 23444431611 scopus 로고
    • Green fluorescent protein as a marker for gene expression
    • Chalfie M, Tu Y, Euskirchen G, Ward WW, Prasher DC (1994) Green fluorescent protein as a marker for gene expression. Science 263:802-805. (Pubitemid 24093206)
    • (1994) Science , vol.263 , Issue.5148 , pp. 802-805
    • Chalfie, M.1    Tu, Y.2    Euskirchen, G.3    Ward, W.W.4    Prasher, D.C.5
  • 4
    • 13244300559 scopus 로고    scopus 로고
    • Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans
    • Chase DL, Pepper JS, Koelle MR (2004) Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans. Nat Neurosci 7:1096-1103.
    • (2004) Nat Neurosci , vol.7 , pp. 1096-1103
    • Chase, D.L.1    Pepper, J.S.2    Koelle, M.R.3
  • 5
    • 13944278450 scopus 로고    scopus 로고
    • Expression profiling of GABAergic motor neurons in Caenorhabditis elegans
    • Cinar H, Keles S, Jin Y (2005) Expression profiling of GABAergic motor neurons in Caenorhabditis elegans. Curr Biol 15:340-346.
    • (2005) Curr Biol , vol.15 , pp. 340-346
    • Cinar, H.1    Keles, S.2    Jin, Y.3
  • 7
    • 33847029091 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system
    • DOI 10.1146/annurev.pharmtox.47.120505.105214
    • Dani JA, Bertrand D (2007) Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu Rev Pharmacol Toxicol 47:699-729. (Pubitemid 46272144)
    • (2007) Annual Review of Pharmacology and Toxicology , vol.47 , pp. 699-729
    • Dani, J.A.1    Bertrand, D.2
  • 8
    • 0842281645 scopus 로고    scopus 로고
    • Cell Death: Critical Control Points
    • DOI 10.1016/S0092-8674(04)00046-7
    • Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205-219. (Pubitemid 38167313)
    • (2004) Cell , vol.116 , Issue.2 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 11
    • 0037373633 scopus 로고    scopus 로고
    • Dying for a cause: Invertebrate genetics takes on human neurodegeneration
    • DOI 10.1038/nrg1018
    • Driscoll M, Gerstbrein B (2003) Dying for a cause: invertebrate genetics takes on human neurodegeneration. Nat Rev Genet 4:181-194. (Pubitemid 36267889)
    • (2003) Nature Reviews Genetics , vol.4 , Issue.3 , pp. 181-194
    • Driscoll, M.1    Gerstbrein, B.2
  • 12
    • 35348894475 scopus 로고    scopus 로고
    • Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50
    • DOI 10.1038/sj.emboj.7601858, PII 7601858
    • Eimer S, Gottschalk A, Hengartner M, Horvitz HR, Richmond J, Schafer WR, Bessereau JL (2007) Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50. EMBO J 26:4313-4323. (Pubitemid 47587661)
    • (2007) EMBO Journal , vol.26 , Issue.20 , pp. 4313-4323
    • Eimer, S.1    Gottschalk, A.2    Hengartner, M.3    Horvitz, H.R.4    Richmond, J.5    Schafer, W.R.6    Bessereau, J.-L.7
  • 13
    • 2442629457 scopus 로고    scopus 로고
    • Calnexin, calreticulin, and ERp57: Teammates in glycoprotein folding
    • DOI 10.1385/CBB:39:3:223
    • Ellgaard L, Frickel EM (2003) Calnexin, calreticulin, and ERp57: teammates in glycoprotein folding. Cell Biochem Biophys 39:223-247. (Pubitemid 41270793)
    • (2003) Cell Biochemistry and Biophysics , vol.39 , Issue.3 , pp. 223-247
    • Ellgaard, L.1    Frickel, E.-M.2
  • 14
    • 0022497852 scopus 로고
    • Genetic control of programmed cell death in the nematode C. elegans
    • Ellis HM, Horvitz HR (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44:817-829.
    • (1986) Cell , vol.44 , pp. 817-829
    • Ellis, H.M.1    Horvitz, H.R.2
  • 15
    • 33749178260 scopus 로고    scopus 로고
    • Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response
    • DOI 10.1016/j.bbabio.2006.06.014, PII S000527280600212X, Mitochondria: from Molecular Insight to Physiology and Pathology
    • Festjens N, Vanden Berghe T, Vandenabeele P (2006) Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta 1757:1371-1387. (Pubitemid 44472550)
    • (2006) Biochimica et Biophysica Acta - Bioenergetics , vol.1757 , Issue.9-10 , pp. 1371-1387
    • Festjens, N.1    Vanden Berghe, T.2    Vandenabeele, P.3
  • 17
    • 20444417496 scopus 로고    scopus 로고
    • The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction
    • Francis MM, Evans SP, Jensen M, Madsen DM, Mancuso J, Norman KR, Maricq AV (2005) The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction. Neuron 46:581-594.
    • (2005) Neuron , vol.46 , pp. 581-594
    • Francis, M.M.1    Evans, S.P.2    Jensen, M.3    Madsen, D.M.4    Mancuso, J.5    Norman, K.R.6    Maricq, A.V.7
  • 18
    • 33846018602 scopus 로고    scopus 로고
    • Cell death by necrosis: Towards a molecular definition
    • DOI 10.1016/j.tibs.2006.11.001, PII S0968000406003185
    • Golstein P, Kroemer G (2007) Cell death by necrosis: towards a molecular definition. Trends Biochem Sci 32:37-43. (Pubitemid 46043552)
    • (2007) Trends in Biochemical Sciences , vol.32 , Issue.1 , pp. 37-43
    • Golstein, P.1    Kroemer, G.2
  • 19
    • 23044432697 scopus 로고    scopus 로고
    • Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans
    • Gottschalk A, Almedom RB, Schedletzky T, Anderson SD, Yates JR 3rd, Schafer WR (2005) Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. EMBO J 24:2566-2578.
    • (2005) EMBO J , vol.24 , pp. 2566-2578
    • Gottschalk, A.1    Almedom, R.B.2    Schedletzky, T.3    Anderson, S.D.4    Yates III, J.R.5    Schafer, W.R.6
  • 21
    • 77549088703 scopus 로고    scopus 로고
    • Calcium dysregulation in amyotrophic lateral sclerosis
    • Grosskreutz J, Van Den Bosch L, Keller BU (2010) Calcium dysregulation in amyotrophic lateral sclerosis. Cell Calcium 47:165-174.
    • (2010) Cell Calcium , vol.47 , pp. 165-174
    • Grosskreutz, J.1    Van Den Bosch, L.2    Keller, B.U.3
  • 22
    • 0033763794 scopus 로고    scopus 로고
    • The C. elegans NeuroD homolog cnd-1 functions in multiple aspects of motor neuron fate specification
    • Hallam S, Singer E, Waring D, Jin Y (2000) The C. elegans NeuroD homolog cnd-1 functions in multiple aspects of motor neuron fate specification. Development 127:4239-4252.
    • (2000) Development , vol.127 , pp. 4239-4252
    • Hallam, S.1    Singer, E.2    Waring, D.3    Jin, Y.4
  • 23
  • 24
    • 0033862578 scopus 로고    scopus 로고
    • Insights from mouse models into the molecular basis of neurodegeneration
    • DOI 10.1146/annurev.physiol.62.1.779
    • Heintz N, Zoghbi HY (2000) Insights from mouse models into the molecular basis of neurodegeneration. Annu Rev Physiol 62:779-802. (Pubitemid 30618282)
    • (2000) Annual Review of Physiology , vol.62 , pp. 779-802
    • Heintz, N.1    Zoghbi, H.Y.2
  • 25
    • 0026582702 scopus 로고
    • Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
    • Hengartner MO, Ellis RE, Horvitz HR (1992) Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356:494-499.
    • (1992) Nature , vol.356 , pp. 494-499
    • Hengartner, M.O.1    Ellis, R.E.2    Horvitz, H.R.3
  • 26
    • 35548993745 scopus 로고    scopus 로고
    • Cell-autonomous inhibition of alpha7-containing nicotinic acetylcholine receptors prevents death of parasympathetic neurons during development
    • DOI 10.1523/JNEUROSCI.3057-07.2007
    • Hruska M, Nishi R (2007) Cell-autonomous inhibition of alpha 7-containing nicotinic acetylcholine receptors prevents death of parasympathetic neurons during development. J Neurosci 27:11501-11509. (Pubitemid 350006897)
    • (2007) Journal of Neuroscience , vol.27 , Issue.43 , pp. 11501-11509
    • Hruska, M.1    Nishi, R.2
  • 27
    • 72449189587 scopus 로고    scopus 로고
    • Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons
    • Hruska M, Keefe J, Wert D, Tekinay AB, Hulce JJ, Ibañez-Tallon I, Nishi R (2009) Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons. J Neurosci 29:14847-14854.
    • (2009) J Neurosci , vol.29 , pp. 14847-14854
    • Hruska, M.1    Keefe, J.2    Wert, D.3    Tekinay, A.B.4    Hulce, J.J.5    Ibañez-Tallon, I.6    Nishi, R.7
  • 28
    • 34249813137 scopus 로고    scopus 로고
    • The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: An update on nomenclature
    • Jones AK, Davis P, Hodgkin J, Sattelle DB (2007) The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature. Invert Neurosci 7:129-131.
    • (2007) Invert Neurosci , vol.7 , pp. 129-131
    • Jones, A.K.1    Davis, P.2    Hodgkin, J.3    Sattelle, D.B.4
  • 31
    • 33745460795 scopus 로고    scopus 로고
    • Calcium-permeable AMPA channels in neurodegenerative disease and ischemia
    • DOI 10.1016/j.conb.2006.05.004, PII S0959438806000559
    • Kwak S, Weiss JH (2006) Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Curr Opin Neurobiol 16:281-287. (Pubitemid 43949226)
    • (2006) Current Opinion in Neurobiology , vol.16 , Issue.3 , pp. 281-287
    • Kwak, S.1    Weiss, J.H.2
  • 32
    • 0029163027 scopus 로고
    • Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
    • Labarca C, Nowak MW, Zhang H, Tang L, Deshpande P, Lester HA (1995) Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature 376:514-516.
    • (1995) Nature , vol.376 , pp. 514-516
    • Labarca, C.1    Nowak, M.W.2    Zhang, H.3    Tang, L.4    Deshpande, P.5    Lester, H.A.6
  • 34
    • 0034194089 scopus 로고    scopus 로고
    • Calcium signaling in the ER: Its role in neuronal plasticity and neurodegenerative disorders
    • DOI 10.1016/S0166-2236(00)01548-4, PII S0166223600015484
    • Mattson MP, LaFerla FM, Chan SL, Leissring MA, Shepel PN, Geiger JD (2000) Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci 23:222-229. (Pubitemid 30236182)
    • (2000) Trends in Neurosciences , vol.23 , Issue.5 , pp. 222-229
    • Mattson, M.P.1    LaFerla, F.M.2    Chan, S.L.3    Leissring, M.A.4    Shepel, P.N.5    Geiger, J.D.6
  • 37
    • 4844227016 scopus 로고    scopus 로고
    • Knockin mice with Leu9'Ser alpha4-nicotinic receptors: Substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally
    • DOI 10.1152/physiolgenomics.00012.2004
    • Orb S, Wieacker J, Labarca C, Fonck C, Lester HA, Schwarz J (2004) Knockin mice with Leu9'Ser alpha4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally. Physiol Genomics 18:299-307. (Pubitemid 39319513)
    • (2004) Physiological Genomics , vol.18 , pp. 299-307
    • Orb, S.1    Wieacker, J.2    Labarca, C.3    Fonck, C.4    Lester, H.A.5    Schwarz, J.6
  • 38
    • 0034101820 scopus 로고    scopus 로고
    • Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth
    • DOI 10.1046/j.1471-4159.2000.0742154.x
    • Orr-Urtreger A, Broide RS, Kasten MR, Dang H, Dani JA, Beaudet AL, Patrick JW (2000) Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth. J Neurochem 74:2154-2166. (Pubitemid 30217673)
    • (2000) Journal of Neurochemistry , vol.74 , Issue.5 , pp. 2154-2166
    • Orr-Urtreger, A.1    Broide, R.S.2    Kasten, M.R.3    Dang, H.4    Dani, J.A.5    Beaudet, A.L.6    Patrick, J.W.7
  • 39
    • 38449111281 scopus 로고    scopus 로고
    • Acetylcholine
    • Rand JB (2007) Acetylcholine. WormBook 1-21.
    • (2007) WormBook , pp. 1-21
    • Rand, J.B.1
  • 40
    • 1842843860 scopus 로고    scopus 로고
    • Coupling endoplasmic reticulum stress to the cell death program
    • DOI 10.1038/sj.cdd.4401378
    • Rao RV, Ellerby HM, Bredesen DE (2004) Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11:372-380. (Pubitemid 38489415)
    • (2004) Cell Death and Differentiation , vol.11 , Issue.4 , pp. 372-380
    • Rao, R.V.1    Ellerby, H.M.2    Bredesen, D.E.3
  • 42
    • 0033361969 scopus 로고    scopus 로고
    • One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction
    • Richmond JE, Jorgensen EM (1999) One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction. Nat Neurosci 2:791-797.
    • (1999) Nat Neurosci , vol.2 , pp. 791-797
    • Richmond, J.E.1    Jorgensen, E.M.2
  • 43
    • 33745590390 scopus 로고    scopus 로고
    • Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans
    • Ruaud AF, Bessereau JL (2006) Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans. Development 133:2211-2222.
    • (2006) Development , vol.133 , pp. 2211-2222
    • Ruaud, A.F.1    Bessereau, J.L.2
  • 44
    • 0028865136 scopus 로고
    • Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease
    • Sagot Y, Dubois-Dauphin M, Tan SA, de Bilbao F, Aebischer P, Martinou JC, Kato AC (1995) Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease. J Neurosci 15:7727-7733.
    • (1995) J Neurosci , vol.15 , pp. 7727-7733
    • Sagot, Y.1    Dubois-Dauphin, M.2    Tan, S.A.3    De Bilbao, F.4    Aebischer, P.5    Martinou, J.C.6    Kato, A.C.7
  • 45
    • 0035693680 scopus 로고    scopus 로고
    • Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death
    • DOI 10.1385/MN:24:1-3:107
    • Sattler R, Tymianski M (2001) Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol 24:107-129. (Pubitemid 34066681)
    • (2001) Molecular Neurobiology , vol.24 , Issue.1-3 , pp. 107-129
    • Sattler, R.1    Tymianski, M.2
  • 46
    • 0017618537 scopus 로고
    • Post-embryonic cell lineages of the nematode, Caenorhabditis elegans
    • Sulston JE, Horvitz HR (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 56:110-156.
    • (1977) Dev Biol , vol.56 , pp. 110-156
    • Sulston, J.E.1    Horvitz, H.R.2
  • 47
    • 0037206901 scopus 로고    scopus 로고
    • Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans
    • Syntichaki P, Xu K, Driscoll M, Tavernarakis N (2002) Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature 419:939-944.
    • (2002) Nature , vol.419 , pp. 939-944
    • Syntichaki, P.1    Xu, K.2    Driscoll, M.3    Tavernarakis, N.4
  • 48
    • 77549083577 scopus 로고    scopus 로고
    • Calcium, ischemia and excitotoxicity
    • Szydlowska K, Tymianski M (2010) Calcium, ischemia and excitotoxicity. Cell Calcium 47:122-129.
    • (2010) Cell Calcium , vol.47 , pp. 122-129
    • Szydlowska, K.1    Tymianski, M.2
  • 49
    • 22844452091 scopus 로고    scopus 로고
    • Acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction
    • Touroutine D, Fox RM, Von Stetina SE, Burdina A, Miller DM 3rd, Richmond JE (2005) acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction. J Biol Chem 280:27013-27021.
    • (2005) J Biol Chem , vol.280 , pp. 27013-27021
    • Touroutine, D.1    Fox, R.M.2    Von Stetina, S.E.3    Burdina, A.4    Miller III, D.M.5    Richmond, J.E.6
  • 50
    • 0028944389 scopus 로고
    • A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans
    • Treinin M, Chalfie M (1995) A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans. Neuron 14:871-877.
    • (1995) Neuron , vol.14 , pp. 871-877
    • Treinin, M.1    Chalfie, M.2
  • 51
    • 0034978075 scopus 로고    scopus 로고
    • Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map
    • Wicks SR, Yeh RT, Gish WR, Waterston RH, Plasterk RH (2001) Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Nat Genet 28:160-164.
    • (2001) Nat Genet , vol.28 , pp. 160-164
    • Wicks, S.R.1    Yeh, R.T.2    Gish, W.R.3    Waterston, R.H.4    Plasterk, R.H.5
  • 53
    • 0030800468 scopus 로고    scopus 로고
    • Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene
    • Zuo J, De Jager PL, Takahashi KA, Jiang W, Linden DJ, Heintz N (1997) Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene. Nature 388:769-773.
    • (1997) Nature , vol.388 , pp. 769-773
    • Zuo, J.1    De Jager, P.L.2    Takahashi, K.A.3    Jiang, W.4    Linden, D.J.5    Heintz, N.6


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