메뉴 건너뛰기




Volumn 19, Issue 2, 1999, Pages 539-548

The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development

Author keywords

C. elegans; GABA; GAD; Glutamate decarboxylase; Neuromuscular junctions; amino butyric acid

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; DNA; GLUTAMATE DECARBOXYLASE;

EID: 0033556159     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-02-00539.1999     Document Type: Article
Times cited : (226)

References (58)
  • 1
  • 3
    • 0024319166 scopus 로고
    • The basal component of the nematode dense-body is vinculin
    • Barstead RJ, Waterston RH (1989) The basal component of the nematode dense-body is vinculin. J Biol Chem 264:10177-10185.
    • (1989) J Biol Chem , vol.264 , pp. 10177-10185
    • Barstead, R.J.1    Waterston, R.H.2
  • 5
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 6
    • 0030025958 scopus 로고    scopus 로고
    • A sperm-supplied factor required for embryogenesis in C. elegans
    • Browning H, Strome S (1996) A sperm-supplied factor required for embryogenesis in C. elegans. Development 122:391-404.
    • (1996) Development , vol.122 , pp. 391-404
    • Browning, H.1    Strome, S.2
  • 7
    • 0028341371 scopus 로고
    • The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD
    • Bu D, Tobin A (1994) The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD. Genomics 21:222-228.
    • (1994) Genomics , vol.21 , pp. 222-228
    • Bu, D.1    Tobin, A.2
  • 9
    • 0031282636 scopus 로고    scopus 로고
    • Translational attenuation mediated by an mRNA intron
    • Chapman RE, Walter P (1997) Translational attenuation mediated by an mRNA intron. Curr Biol 7:850-859.
    • (1997) Curr Biol , vol.7 , pp. 850-859
    • Chapman, R.E.1    Walter, P.2
  • 10
    • 0024307886 scopus 로고
    • The earliest-generated neurons of the cat cerebral cortex: Characterization by MAP2 and neurotransmitter immunohistochemistry during fetal life
    • Chun JJ, Shatz CJ (1989) The earliest-generated neurons of the cat cerebral cortex: characterization by MAP2 and neurotransmitter immunohistochemistry during fetal life. J Neurosci 9:1648-1667.
    • (1989) J Neurosci , vol.9 , pp. 1648-1667
    • Chun, J.J.1    Shatz, C.J.2
  • 11
    • 0027935308 scopus 로고
    • The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins
    • Clark SG, Lu X, Horvitz HR (1994) The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins. Genetics 137:987-997.
    • (1994) Genetics , vol.137 , pp. 987-997
    • Clark, S.G.1    Lu, X.2    Horvitz, H.R.3
  • 12
    • 0030875819 scopus 로고    scopus 로고
    • Cleft palate in mice with a targeted mutation in the gamma aminobutyric acid producing enzyme glutamic acid decarboxylase 67
    • Condie BG, Bain G, Gottlieb DI, Capecchi ER (1997) Cleft palate in mice with a targeted mutation in the gamma aminobutyric acid producing enzyme glutamic acid decarboxylase 67. Proc Natl Acad Sci USA 94:11451-11455.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 11451-11455
    • Condie, B.G.1    Bain, G.2    Gottlieb, D.I.3    Capecchi, E.R.4
  • 13
    • 0025948182 scopus 로고
    • The regulation of synaptogenesis during normal development and following activity blockade
    • Dahm LM, Landmesser LT (1991) The regulation of synaptogenesis during normal development and following activity blockade. J Neurosci 11:238-255.
    • (1991) J Neurosci , vol.11 , pp. 238-255
    • Dahm, L.M.1    Landmesser, L.T.2
  • 14
    • 0029760240 scopus 로고    scopus 로고
    • Dual function of the intron of the rat insulin I gene in regulation of gene expression
    • Damert A, Leibiger B, Leihiger IB (1996) Dual function of the intron of the rat insulin I gene in regulation of gene expression. Diabetologia 39:1165-1172.
    • (1996) Diabetologia , vol.39 , pp. 1165-1172
    • Damert, A.1    Leibiger, B.2    Leihiger, I.B.3
  • 17
    • 0025816520 scopus 로고
    • The structural and functional heterogeneity of glutamic acid decarboxylase: A review
    • Erlander MG, Tobin AJ (1991) The structural and functional heterogeneity of glutamic acid decarboxylase: a review. Neurochem Res 16:215-226.
    • (1991) Neurochem Res , vol.16 , pp. 215-226
    • Erlander, M.G.1    Tobin, A.J.2
  • 18
    • 0028324791 scopus 로고
    • Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms
    • Esclapez M, Tillakaratne NJ, Kaufman DL, Tobin AJ, Houser CR (1994) Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. J Neurosci 14:1834-1855.
    • (1994) J Neurosci , vol.14 , pp. 1834-1855
    • Esclapez, M.1    Tillakaratne, N.J.2    Kaufman, D.L.3    Tobin, A.J.4    Houser, C.R.5
  • 19
    • 0025002190 scopus 로고
    • A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans
    • Fire A, Harrison SW, Dixon D (1990) A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans. Gene 93:184-198.
    • (1990) Gene , vol.93 , pp. 184-198
    • Fire, A.1    Harrison, S.W.2    Dixon, D.3
  • 20
    • 0028535368 scopus 로고
    • The regulation of gene expression in transformed maize aleurone and endosperm protoplasts: Analysis of promoter activity, intron enhancement, and mRNA untranslated regions on expression
    • Gallie DR, Young TE (1994) The regulation of gene expression in transformed maize aleurone and endosperm protoplasts: analysis of promoter activity, intron enhancement, and mRNA untranslated regions on expression. Plant Physiol 106:929-939.
    • (1994) Plant Physiol , vol.106 , pp. 929-939
    • Gallie, D.R.1    Young, T.E.2
  • 21
    • 0025844789 scopus 로고
    • Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans
    • Hall DH, Hedgecock EM (1991) Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. Cell 65:837-847.
    • (1991) Cell , vol.65 , pp. 837-847
    • Hall, D.H.1    Hedgecock, E.M.2
  • 23
    • 0002118805 scopus 로고
    • Male phenotypes and mating efficiency in Caenorhab-ditis elegans
    • Hodgkin J (1983) Male phenotypes and mating efficiency in Caenorhab-ditis elegans. Genetics 103:43-64.
    • (1983) Genetics , vol.103 , pp. 43-64
    • Hodgkin, J.1
  • 24
    • 0028003843 scopus 로고
    • Localization of mRNAs encoding two forms of glutamic acid decarboxylase in the rat hippocampal formation
    • Houser CR, Esclapez M (1994) Localization of mRNAs encoding two forms of glutamic acid decarboxylase in the rat hippocampal formation. Hippocampus 4:530-545.
    • (1994) Hippocampus , vol.4 , pp. 530-545
    • Houser, C.R.1    Esclapez, M.2
  • 25
    • 0025237705 scopus 로고
    • Drosophila GABAergic systems: Sequence and expression of glutamic acid decarboxylase
    • Jackson FR, Newby LM, Kulkarni SJ (1990) Drosophila GABAergic systems: sequence and expression of glutamic acid decarboxylase. J Neurochem 54:1068-1078.
    • (1990) J Neurochem , vol.54 , pp. 1068-1078
    • Jackson, F.R.1    Newby, L.M.2    Kulkarni, S.J.3
  • 26
    • 0027934744 scopus 로고
    • Induction of human interleukin-1 gene expression by retinoic acid and its regulation at processing of precursor transcripts
    • Jarrous N, Kaempfer R (1994) Induction of human interleukin-1 gene expression by retinoic acid and its regulation at processing of precursor transcripts. J Biol Chem 269:23141-23149.
    • (1994) J Biol Chem , vol.269 , pp. 23141-23149
    • Jarrous, N.1    Kaempfer, R.2
  • 27
    • 0028212113 scopus 로고
    • Posttranscriptional regulation of thymidylate synthase gene expression
    • Johnson LF (1994) Posttranscriptional regulation of thymidylate synthase gene expression. J Cell Biochem 54:387-392.
    • (1994) J Cell Biochem , vol.54 , pp. 387-392
    • Johnson, L.F.1
  • 28
    • 0028828226 scopus 로고
    • Defective recycling of synaptic vesicles in synaptotagmin mutants of C. elegans
    • Jorgensen EM, Hartwieg E, Schuske K, Nonet M, Jin Y, Horvitz HR (1995) Defective recycling of synaptic vesicles in synaptotagmin mutants of C. elegans. Nature 378:196-199.
    • (1995) Nature , vol.378 , pp. 196-199
    • Jorgensen, E.M.1    Hartwieg, E.2    Schuske, K.3    Nonet, M.4    Jin, Y.5    Horvitz, H.R.6
  • 29
    • 0025274443 scopus 로고
    • The Caenorhabilitis elegans rol-6 gene, which interacts with the sqt-I collagen gene to determine organismal morphology, encodes a collagen
    • Kramer JM, French RP, Park E-C, Johnson JJ (1990) The Caenorhabilitis elegans rol-6 gene, which interacts with the sqt-I collagen gene to determine organismal morphology, encodes a collagen. Mol Cell Biol 10:2081-2089.
    • (1990) Mol Cell Biol , vol.10 , pp. 2081-2089
    • Kramer, J.M.1    French, R.P.2    Park, E.-C.3    Johnson, J.J.4
  • 30
    • 0028246945 scopus 로고
    • Drosophila GABAergic systems. II. Mutational analysis of chromosomal segment 64AB: A region containing the glutamic acid decarboxylase gene
    • Kulkarni SJ, Newby LM, Jackson FR (1994) Drosophila GABAergic systems. II. Mutational analysis of chromosomal segment 64AB: a region containing the glutamic acid decarboxylase gene. Mol Gen Genet 243:555-564.
    • (1994) Mol Gen Genet , vol.243 , pp. 555-564
    • Kulkarni, S.J.1    Newby, L.M.2    Jackson, F.R.3
  • 31
    • 0019774324 scopus 로고
    • Pathway selection by embryonic chick motoneurons in an experimentally altered environment
    • Lance-Jones C, Landmesser LT (1981) Pathway selection by embryonic chick motoneurons in an experimentally altered environment. Proc R Soc Lond B Biol Sci 214:19-52.
    • (1981) Proc R Soc Lond B Biol Sci , vol.214 , pp. 19-52
    • Lance-Jones, C.1    Landmesser, L.T.2
  • 32
    • 0024392837 scopus 로고
    • Neurotransmitter regulation of neuronal outgrowth, plasticity and survival
    • Lipton SA, Kater SB (1989) Neurotransmitter regulation of neuronal outgrowth, plasticity and survival. Trends Neurosci 12:265-270.
    • (1989) Trends Neurosci , vol.12 , pp. 265-270
    • Lipton, S.A.1    Kater, S.B.2
  • 33
    • 0029618270 scopus 로고
    • GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis
    • LoTurco JJ, Owens DF, Heath MJS, Davis MB, Kriegstein AR (1995) GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis. Neuron 15:1287-1289.
    • (1995) Neuron , vol.15 , pp. 1287-1289
    • LoTurco, J.J.1    Owens, D.F.2    Heath, M.J.S.3    Davis, M.B.4    Kriegstein, A.R.5
  • 34
    • 0027395911 scopus 로고
    • Regulation of γ-aminobutyric acid synthesis in the brain
    • Martin DL, Rimvall K (1993) Regulation of γ-aminobutyric acid synthesis in the brain. J Neurochem 60:395-407.
    • (1993) J Neurochem , vol.60 , pp. 395-407
    • Martin, D.L.1    Rimvall, K.2
  • 35
    • 0023988721 scopus 로고
    • Neurotransmitters in the regulation of neuronal cytoarchitecture
    • Mattson MP (1988) Neurotransmitters in the regulation of neuronal cytoarchitecture. Brain Res 472:179-212.
    • (1988) Brain Res , vol.472 , pp. 179-212
    • Mattson, M.P.1
  • 36
    • 0023931488 scopus 로고
    • Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons
    • Mattson MP, Dou P, Kater SB (1988) Outgrowth-regulating actions of glutamate in isolated hippocampal pyramidal neurons. J Neurosci 8:2087-2100.
    • (1988) J Neurosci , vol.8 , pp. 2087-2100
    • Mattson, M.P.1    Dou, P.2    Kater, S.B.3
  • 37
    • 0026521660 scopus 로고
    • Genes necessary for directed axonal elongation or fasciculation in Caenorhabditis elegans
    • McIntire SL, Garriga G, White J, Jacobson D, Horvitz H R (1992) Genes necessary for directed axonal elongation or fasciculation in Caenorhabditis elegans. Neuron 8:307-322.
    • (1992) Neuron , vol.8 , pp. 307-322
    • McIntire, S.L.1    Garriga, G.2    White, J.3    Jacobson, D.4    Horvitz, H.R.5
  • 38
    • 0027272707 scopus 로고
    • Genes required for GABA function in Caenorhabditis elegans
    • McIntire SL, Jorgensen E, Horvitz HR (1993a) Genes required for GABA function in Caenorhabditis elegans. Nature 364:334-337.
    • (1993) Nature , vol.364 , pp. 334-337
    • McIntire, S.L.1    Jorgensen, E.2    Horvitz, H.R.3
  • 39
    • 0027200882 scopus 로고
    • The GABAergic nervous system of Caenorhabditis elegans
    • McIntire SL, Jorgensen E, Kaplan J, Horvitz HR (1993b) The GABAergic nervous system of Caenorhabditis elegans. Nature 364:337-341.
    • (1993) Nature , vol.364 , pp. 337-341
    • McIntire, S.L.1    Jorgensen, E.2    Kaplan, J.3    Horvitz, H.R.4
  • 40
    • 0025942107 scopus 로고
    • Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences
    • Mello CC, Kramer JM, Stinchcomb D, Ambros V (1991) Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 10:3959-3970.
    • (1991) EMBO J , vol.10 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.3    Ambros, V.4
  • 41
    • 0027516820 scopus 로고
    • The role of GABA during development of the outer retina in the rabbit
    • Messersmith EK, Redburn DA (1993) The role of GABA during development of the outer retina in the rabbit. Neurochem Res 18:463-470.
    • (1993) Neurochem Res , vol.18 , pp. 463-470
    • Messersmith, E.K.1    Redburn, D.A.2
  • 42
    • 0030594985 scopus 로고    scopus 로고
    • GABA and GABA-A receptors are maximally expressed in association with cone synaptogenesis in neonatal rabbit retina
    • Mitchell CK, Redburn DA (1996) GABA and GABA-A receptors are maximally expressed in association with cone synaptogenesis in neonatal rabbit retina. Dev Brain Res 95:63-71.
    • (1996) Dev Brain Res , vol.95 , pp. 63-71
    • Mitchell, C.K.1    Redburn, D.A.2
  • 43
    • 0031038166 scopus 로고    scopus 로고
    • Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha
    • Namchuk M, Lindsay L, Turck CW, Kanaani J, Baekkeskov S (1997) Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha. J Biol Chem 272:1548 -15571.
    • (1997) J Biol Chem , vol.272 , pp. 1548-15571
    • Namchuk, M.1    Lindsay, L.2    Turck, C.W.3    Kanaani, J.4    Baekkeskov, S.5
  • 44
    • 0031975266 scopus 로고    scopus 로고
    • Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants
    • Nonet LM, Saifee O, Zhao H, Rand JB, Wei L (1998) Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants. J Neurosci 18:70-80.
    • (1998) J Neurosci , vol.18 , pp. 70-80
    • Nonet, L.M.1    Saifee, O.2    Zhao, H.3    Rand, J.B.4    Wei, L.5
  • 45
    • 0027930361 scopus 로고
    • The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle
    • Okkema PG, Fire A (1944) The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle. Development 120:2175-2186.
    • (1944) Development , vol.120 , pp. 2175-2186
    • Okkema, P.G.1    Fire, A.2
  • 47
    • 0027496687 scopus 로고
    • A neural gene from Drosophila melanogaster with homology to vertebrate and invertebrate glutamate decarboxylases
    • Phillips AM, Salkoff LB, Kelly LE (1993) A neural gene from Drosophila melanogaster with homology to vertebrate and invertebrate glutamate decarboxylases. J Neurochem 61:1291-1301.
    • (1993) J Neurochem , vol.61 , pp. 1291-1301
    • Phillips, A.M.1    Salkoff, L.B.2    Kelly, L.E.3
  • 48
    • 0029051065 scopus 로고
    • Reversal of a muscle response to GABA during c. elegans male development
    • Reiner DJ, Thomas JH (1995) Reversal of a muscle response to GABA during c. elegans male development. J. Neurosci. 15:6094-6102.
    • (1995) J. Neurosci. , vol.15 , pp. 6094-6102
    • Reiner, D.J.1    Thomas, J.H.2
  • 49
    • 0031259657 scopus 로고    scopus 로고
    • Intron-mediated enhancement of transgene expression in maize is a nuclear gene-dependent process
    • Rethmeier N, Seurinck J, Van Montagu M, Cornelissen M (1997) Intron-mediated enhancement of transgene expression in maize is a nuclear gene-dependent process. Plant J 12:895-899.
    • (1997) Plant J , vol.12 , pp. 895-899
    • Rethmeier, N.1    Seurinck, J.2    Van Montagu, M.3    Cornelissen, M.4
  • 54
    • 0025310659 scopus 로고
    • Pathfinding and synapse formation in a zebrafish mutant lacking functional acetylcholine receptors
    • Westerfield M, Liu DW, Kimmel CB, Walker C (1990) Pathfinding and synapse formation in a zebrafish mutant lacking functional acetylcholine receptors. Neuron 4:867-874.
    • (1990) Neuron , vol.4 , pp. 867-874
    • Westerfield, M.1    Liu, D.W.2    Kimmel, C.B.3    Walker, C.4
  • 56
    • 0028219210 scopus 로고
    • Turning of nerve growth cones induced by neurotransmitters
    • Zheng JQ, Felder M, Connor JA, Poo MM (1994) Turning of nerve growth cones induced by neurotransmitters. Nature 368:140-144.
    • (1994) Nature , vol.368 , pp. 140-144
    • Zheng, J.Q.1    Felder, M.2    Connor, J.A.3    Poo, M.M.4
  • 57
    • 0030319533 scopus 로고    scopus 로고
    • Calcium and chemotropic turning of nerve growth cones
    • Zheng JQ, Poo MM, Connor JA (1996a) Calcium and chemotropic turning of nerve growth cones. Perspect Dev Neurobiol 4:205-213.
    • (1996) Perspect Dev Neurobiol , vol.4 , pp. 205-213
    • Zheng, J.Q.1    Poo, M.M.2    Connor, J.A.3
  • 58
    • 0029985309 scopus 로고    scopus 로고
    • Essential role of filopodia in chemotropic turning of nerve growth cone induced by a glutamate gradient
    • Zheng JQ, Wan JJ, Poo MM (1996b) Essential role of filopodia in chemotropic turning of nerve growth cone induced by a glutamate gradient. J Neurosci 16:1140-1149.
    • (1996) J Neurosci , vol.16 , pp. 1140-1149
    • Zheng, J.Q.1    Wan, J.J.2    Poo, M.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.