Chronic Al 2O 3-nanoparticle exposure causes neurotoxic effects on locomotion behaviors by inducing severe ROS production and disruption of ROS defense mechanisms in nematode Caenorhabditis elegans

Journal of Hazardous Materials

Volumn 219-220, Issue , 2012, Pages 221-230

  Li, Yinxia ^a   Yu, Shunhui ^b   Wu, Quili ^a   Tang, Meng ^c   Pu, Yuepu ^c   Wang, Dayong ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b CHONGQING THREE GORGES UNIVERSITY   (China)

^c SOUTHEAST UNIVERSITY   (China)

Author keywords

Al 2O 3 nanoparticles; Caenorhabditis elegans; Chronic exposure; Locomotion behavior; Neurotoxicity; Oxidative stress

Indexed keywords

ADVERSE EFFECT; CAENORHABDITIS ELEGANS; CHRONIC EXPOSURE; DEFENSE MECHANISM; GENES ENCODING; LOCOMOTION BEHAVIOR; NEUROTOXIC EFFECTS; NEUROTOXICITY; OVER-EXPRESSION; STRESS RESPONSE; WILD TYPES;

GENE EXPRESSION; MANGANESE; NANOPARTICLES; OXIDATIVE STRESS; TOXICITY;

ALUMINUM;

ALUMINUM OXIDE; EXTRACELLULAR SUPEROXIDE DISMUTASE; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; METAL NANOPARTICLE; PRIMER DNA;

DEFENSE MECHANISM; GENE EXPRESSION; INHIBITION; NEMATODE; OXIDE; PARTICULATE MATTER; PHYSIOLOGICAL RESPONSE; POLLUTION EXPOSURE; TOXIC SUBSTANCE;

ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENE EXPRESSION; LOCOMOTION; LONG TERM EXPOSURE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; ANIMAL; DRUG EFFECT; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC ANIMAL;

CAENORHABDITIS ELEGANS; NEMATODA;

ALUMINUM OXIDE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; CAENORHABDITIS ELEGANS; DNA PRIMERS; LOCOMOTION; METAL NANOPARTICLES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84860759482     PISSN: 03043894     EISSN: 18733336     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2012.03.083     Document Type: Article

References (33)

1. Cho S.J., Maysinger D., Jain M., Röder B., Hackbarth S., Winnik F.M. Long-term exposure to CdTe quantum dots causes functional impairments in live cells. Langmuir 2007, 23:1974-1980.
2. Prasad B.R., Nikolskaya N., Connolly D., Smith T.J., Byrne S.J., Gérarad V.A., Guńko Y.K., Rochev Y. Long-term exposure of CdTe quantum dots on PC12 cellular activity and the determination of optimum non-toxic concentrations for biological use. J. Nanobiotechnol. 2010, 8:7.
3. 3-nanoparticle. Environ. Toxicol. Pharmacol. 2011, 32:233-241.
4. Baun A., Hartmann N.B., Grieger K., Kusk K.O. Ecotoxicity of engineered nanoparticles to aquatic invertebrates: a brief review and recommendations for future toxicity testing. Ecotoxicology 2008, 17:387-395.
5. Leung M.C.K., Williams P.L., Benedetto A., Au A., Helmcke K.J., Aschner M., Meyer J.N. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol. Sci. 2008, 106:5-28.
6. Xing X.-J., Guo Y.-L., Wang D.-Y. Using the larvae nematode Caenorhabditis elegans to evaluate neurobehavioral toxicity to metallic salts. Ecotoxicol. Environ. Safe. 2009, 72:1819-1823.
7. Shen L.-L., Xiao J., Ye H.-Y., Wang D.-Y. Toxicity evaluation in nematodes Caenorhabditis elegans after chronic metal exposure. Environ. Toxicol. Pharmacol. 2009, 28:125-132.
8. Wu Q.-L., Qu Y.-Y., Li X., Wang D.-Y. Chromium exhibits adverse effects at environmental relevant concentrations in chronic toxicity assay system of nematode Caenorhabditis elegans. Chemosphere 2012, 10.1016/j.chemosphere.2012.01.035.
9. Wagner A.J., Bleckmann C.A., Murdock R.C., Schrand A.M., Schlager J.J., Hussain S.M. Cellular interaction of different forms of aluminum nanoparticles in rat alveolar macrophages. J. Phys. Chem. B 2007, 111:7353-7359.
10. Jeng H.A., Swanson J. Toxicity of metal oxide nanoparticles in mammalian cells. J. Environ. Sci. Health A 2006, 41:2699-2711.
11. 2 to the nematode Caenorhabditis elegans. Environ. Pollut. 2009, 157:1171-1177.
12. Wu S., Lu J.-H., Rui Q., Yu S.-H., Cai T., Wang D.-Y. Aluminum nanoparticle exposure in L1 larvae results in more severe lethality toxicity than in L4 larvae or young adults by strengthening the formation of stress response and intestinal lipofuscin accumulation in nematodes. Environ. Toxicol. Pharmacol. 2011, 31:179-188.
13. Halatek T., Sinczuk-Walczak H., Rydzynski K. Prognostic significance of low serum levels of Clara cell phospholipid-binding protein in occupational aluminium neurotoxicity. J. Inorg. Biochem. 2005, 99:1904-1911.
14. Khanna N., Cressman C.P., Tatara C.P., Willimas P.L. Tolerance of the nematode Caenorhabditis elegans to pH, salinity, and hardness in aquatic media. Arch. Environ. Contam. Toxicol. 1997, 32:110-114.
15. Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974, 77:71-94.
16. Donkin S.G., Dusenbery D.B. A soil toxicity test using the nematode Caenorhabditis elegans and an effective method of recovery. Arch. Environ. Contam. Toxicol. 1993, 25:145-151.
17. Williams P.L., Dusenbery D.B. Aquatic toxicity testing using the nematode Caenorhabditis elegans. Environ. Toxicol. Chem. 1990, 9:1285-1290.
18. Gandhi S., Santelli J., Mitchell D.H., Stiles J.W., Sanadi D.R. A simple method for maintaining large, aging populations of Caenorhabditis elegans. Mech. Ageing Dev. 1980, 12:137-150.
19. Chu K.W., Chow K.L. Synergistic toxicity of multiple heavy metals is revealed by a biological assay using a nematode and its transgenic derivate. Aquat. Toxicol. 2002, 61:53-64.
20. Wang S., Zhao Y., Wu L., Tang M., Su C., Hei T.K., Yu Z. Induction of germline cell cycle arrest and apoptosis by sodium arsenite in Caenorhabditis elegans. Chem. Res. Toxicol. 2007, 20:181-186.
21. Huang J., Lemire B.D. Mutations in the C. elegans succinate dehydrogenase iron-sulfur subunit promote superoxide generation and premature aging. J. Mol. Biol. 2009, 387:559-569.
22. Mello C.C., Kramer J.M., Stinchcomb D., Ambros V. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequence. EMBO J. 1991, 10:3959-3970.
23. Wang D.-Y., Xing X.-J. Pre-treatment with mild UV irradiation suppresses reproductive toxicity induced by subsequent cadmium exposure in nematodes. Ecotoxicol. Environ. Saf. 2010, 73:423-429.
24. Balaban R.S., Nemoto S., Finkel T. Mitochondria, oxidants, and aging. Cell 2005, 120:483-495.
25. Hunter T., Bannister W.H., Hunter G.J. Cloning, expression, and characterization of two manganese superoxide dismutases from Caenorhabditis elegans. J. Biol. Chem. 1997, 272:28652-28659.
26. Van Raamsdonk J.M., Meng Y., Camp D., Yang W., Jia X., Benard C., Hekimi S. Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage. Genetics 2010, 185:559-571.
27. Honda Y., Tanaka M., Honda S. Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans. Exp. Gerontol. 2008, 43:520-529.
28. Hassellöv M., Readman J.W., Ranville J.F., Tiede K. Nanoparticle analysis and characterization methodologies in environmental risk assessment of engineered nanoparticles. Ecotoxicology 2008, 17:344-361.
29. 2 exhibits adverse effects at environmental relevant concentrations. Environ. Sci. Technol. 2011, 45:3725-3730.
30. Griffitt R.J., Feswick A., Weil R., Hyndman K., Carpinone P., Powers K., Denslow N.D., Barber D.S. Investigation of acute nanoparticulate aluminum toxicity in zebrafish. Environ. Toxicol. 2011, 26:541-551.
31. Zhu X., Zhu L., Duan Z., Qi R., Li Y., Lang Y. Comparative toxicity of several metal oxide nanoparticle aqueous suspensions to zebrafish (Danio rerio) early developmental stage. J. Environ. Sci. Health Part A 2008, 43:278-284.
32. 3 nanoparticles: a dynamic nano-toxicity assessment of energy budget distribution. J. Hazard. Mater. 2011, 187:502-508.
33. 2 nanoparticles to the yeast, Saccharomyces cerevisiae. J. Hazard. Mater. 2011, 192:1572-1579.