Exposure to Mn/Zn ethylene-bis-dithiocarbamate and glyphosate pesticides leads to neurodegeneration in Caenorhabditis elegans

NeuroToxicology

Volumn 32, Issue 3, 2011, Pages 331-341

  Negga, Rekek ^a   Rudd, David A ^a   Davis, Nathan S ^a   Justice, Amanda N ^a   Hatfield, Holly E ^a   Valente, Ana L ^a   Fields, Anthony S ^a   Fitsanakis, Vanessa A ^a  

^a King College   (United States)

Author keywords

C. elegans; Glyphosate; Mancozeb; Neurodegeneration; NW1229; Pesticides

Indexed keywords

GLYPHOSATE; GREEN FLUORESCENT PROTEIN; MANEB; ZINEB;

ARTICLE; CAENORHABDITIS ELEGANS; CELL COUNT; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; LC 50; LONG TERM EXPOSURE; MICROPHOTOGRAPHY; NERVE DEGENERATION; PRIORITY JOURNAL; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FUNGICIDES, INDUSTRIAL; GLYCINE; GREEN FLUORESCENT PROTEINS; HERBICIDES; LETHAL DOSE 50; MANEB; MICROSCOPY, FLUORESCENCE; NERVE DEGENERATION; NEURONS; TIME FACTORS; ZINEB;

CAENORHABDITIS ELEGANS;

EID: 79953120967     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2011.02.002     Document Type: Article

References (59)

1. Ascherio A., Chen H., Weisskopf M.G., O'Reilly E., McCullough M.L., Calle E.E., et al. Pesticide exposure and risk for Parkinson's disease. Ann Neurol 2006, 60:197-203.
2. Astiz M., de Alaniz M.J., Marra C.A. Effect of pesticides on cell survival in liver and brain rat tissues. Ecotoxicol Environ Saf 2009, 72:2025-2032.
3. Bababunmi E.A., Olorunsogo O.O., Bassir O. The uncoupling effect of N-(phosphonomethyl)glycine on isolated rat liver mitochondria. Biochem Pharmacol 1979, 28:925-927.
4. Billingslea J.M. Notice of receipt of a request to voluntarily cancel pesticide registrations of certain products. United States Environmental Protection Agency 2009, Environmental Protection Agency (Ed.).
5. Bonide Moancozeb flowable with zinc concentrate. Oriskany 2010, Bonide Products Inc., NY. Bonide Products I (Ed.).
6. Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974, 77:71-94.
7. Buck E., Eyzaguirre A., Brown E., Petti F., McCormack S., Haley J.D., et al. Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non-small-cell lung, pancreatic, colon, and breast tumors. Mol Cancer Ther 2006, 5:2676-2684.
8. Calviello G., Piccioni E., Boninsegna A., Tedesco B., Maggiano N., Serini S., et al. DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: involvement of the oxidative mechanism. Toxicol Appl Pharmacol 2006, 211:87-96.
9. Chalfie M., White J. The nervous system. The Nematode Caeorhabditis elegans 1988, 337-392. Cold Spring Harbor Laboratory Press, Cold Spring Harbor. W.B. Wood (Ed.).
10. Weed Science Society of America Committee Herbicide Handbook of the Weed Science Society of America 1979, Weed Science Society of America, Champaign, IL. 4th ed.
11. Cornell University. Mancozeb (Dithane M-45, Manzate 200)-Chemical Profile 4/87. Pesticide Management Education Program (PMEP) at Cornell University Cooperative Extension; 1987.
12. Dewar A.M. Weed control in glyphosate-tolerant maize in Europe. Pest Manag Sci 2009, 65:1047-1058.
13. Domico L.M., Cooper K.R., Bernard L.P., Zeevalk G.D. Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology 2007, 28:1079-1091.
14. Domico L.M., Zeevalk G.D., Bernard L.P., Cooper K.R. Acute neurotoxic effects of mancozeb and maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction. Neurotoxicology 2006, 27:816-825.
15. Donaldson D., Kiely T., Grube A. Pesticides industry sales and usage: 2000 and 2001 market estimates. United States Environmental Protection Agency 2004, United States Environmental Protection Agency (Ed.).
16. Easton A., Guven K., de Pomerai D.I. Toxicity of the dithiocarbamate fungicide mancozeb to the nontarget soil nematode, Caenorhabditis elegans. J Biochem Mol Toxicol 2001, 15:15-25.
17. Elbaz A., Clavel J., Rathouz P.J., Moisan F., Galanaud J.P., Delemotte B., et al. Professional exposure to pesticides and Parkinson disease. Ann Neurol 2009, 66:494-504.
18. Ferraz H.B., Bertolucci P.H., Pereira J.S., Lima J.G., Andrade L.A. Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology 1988, 38:550-553.
19. Gardner J.G., Nelson G.C. Herbicides, glyphosate resistance and acute mammalian toxicity: simulating an environmental effect of glyphosate-resistant weeds in the USA. Pest Manag Sci 2008, 64:470-478.
20. Gatto N.M., Cockburn M., Bronstein J., Manthripragada A.D., Ritz B. Well-water consumption and Parkinson's disease in rural California. Environ Health Perspect 2009, 117:1912-1918.
21. Gianessi L., Reigner N. Pesticide use in U.S. crop production: 2002, with comparison to 1992 & 1997: fungicides & herbicides. pesticide use in US crop production 2006, CropLife Foundation, Washington, DC.
22. Giannesse L., Marcelli M. Pesticide use in US crop production: 1997. United States Department of Agriculture 2000, National Center for Food Agricultural Policy (Ed.).
23. Gorell J.M., Peterson E.L., Rybicki B.A., Johnson C.C. Multiple risk factors for Parkinson's disease. J Neurol Sci 2004, 217:169.
24. Hancock D.B., Martin E.R., Mayhew G.M., Stajich J.M., Jewett R., Stacy M.A., et al. Pesticide exposure and risk of Parkinson's disease: a family-based case-control study. BMC Neurol 2008, 8:6.
25. Hernandez E.H., Valentini M.C., Discalzi G. T1-weighted hyperintensity in basal ganglia at brain magnetic resonance imaging: are different pathologies sharing a common mechanism?. NeuroToxicology 2002, 23:669-674.
26. Israeli R., Sculsky M., Tiberin P. Acute central nervous system changes due to intoxication by Manzidan (a combined dithiocarbamate of maneb and zineb). Arch Toxicol Suppl 1983, 6:238-243.
27. Israeli R., Sculsky M., Tiberin P. Acute intoxication due to exposure to maneb and zineb. A case with behavioral and central nervous system changes. Scand J Work Environ Health 1983, 9:47-51.
28. Keeney P.M., Xie J., Capaldi R.A., Bennett J.P. Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J Neurosci 2006, 26:5256-5264.
29. Kiely T., Donaldson D., Grube A. Pesticides industry sales and usage: 2000 and 2001 market estimates. Office of Prevention and Toxic Substances 2004, Agency USEP (Ed.).
30. Leung M.C., Williams P.L., Benedetto A., Au C., Helmcke K.J., Aschner M., et al. Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci 2008, 106:5-28.
31. Liou H.H., Tsai M.C., Chen C.J., Jeng J.S., Chang Y.C., Chen S.Y., et al. Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology 1997, 48:1583-1588.
32. Manthripragada A.D., Costello S., Cockburn M.G., Bronstein J.M., Ritz B. Paraoxonase 1, agricultural organophosphate exposure, and Parkinson disease. Epidemiology 2010, 21:87-94.
33. Meco G., Bonifati V., Vanacore N., Fabrizio E. Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate). Scand J Work Environ Health 1994, 20:301-305.
34. Morais V.A., De Strooper B. Mitochondria dysfunction and neurodegenerative disorders: cause or consequence. J Alzheimers Dis 2010.
35. Morato G.S., Lemos T., Takahashi R.N. Acute exposure to maneb alters some behavioral functions in the mouse. Neurotoxicol Terat 1989, 11:421-425.
36. Olorunsogo O. Defective nicotinamide nucleotide transhydrogenase reaction in hepatic mitochondria of N-(phosphonomethyl)-glycine treated rats. Biochem Pharmacol 1982, 31:2191-2192.
37. Olorunsogo O.O. Modification of the transport of protons and Ca2+ ions across mitochondrial coupling membrane by N-(phosphonomethyl)-glycine. Toxicology 1990, 61:205-209.
38. Olorunsogo O.O., Bababunmi E.A. Inhibition of succinate-linking reduction of pyridine nucleotide in rat liver mitochondria 'in vivo' by N-(phosphonomethyl)-glycine. Toxicol Lett 1980, 7:149-152.
39. Olorunsogo O.O., Bababunmi E.A., Bassir O. Effect of glyphosate on rat liver mitochondria in vivo. Bull Environ Contam Toxicol 1979, 22:357-364.
40. Olorunsogo O.O., Bababunmi E.A., Bassir O. Interaction of N-(phosphonomethyl)-glycine with some respiratory chain enzymes of isolated corn-shoot mitochondria. Arch Environ Contam Toxicol 1980, 9:109-114.
41. Peixoto F. Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation. Chemosphere 2005, 61:1115.
42. Peterson R.T., Nass R., Boyd W.A., Freedman J.H., Dong K., Narahashi T. Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology 2008, 29:546-555.
43. Piccoli C., Sardanelli A., Scrima R., Ripoli M., Quarato G., D'Aprile A., et al. Mitochondrial respiratory dysfunction in familiar parkinsonism associated with PINK1 mutation. Neurochem Res 2008, 33:2565-2574.
44. Racette B.A., Tabbal S.D., Jennings D., Good L., Perlmutter J.S., Evanoff B. Prevalence of parkinsonism and relationship to exposure in a large sample of Alabama welders. Neurology 2005, 64:230-235.
45. Rand J.B., Nonet M.L. Appendix 2: neurotransmitter assignments for specific neurons. C elegans II. Plainview 1997, Cold Spring Harbor Laboratory Press, New York. D.L. Riddle, T. Blumenthal, B.J. Meyer, J.R. Priess (Eds.).
46. Rand J.B., Nonet M.L. Synaptic transmission. C. elegans II 1997, 611-644. Cold Springs Harbor Laboratory Press, New York. D.L. Riddle, T. Blumenthal, B.J. Meyer, J.R. Priess (Eds.).
47. Richardson J.R., Quan Y., Sherer T.B., Greenamyre J.T., Miller G.W. Paraquat neurotoxicity is distinct from that of MPTP and rotenone. Toxicol Sci 2005, 88:193-201.
48. Ruan Q.L., Ju J.J., Li Y.H., Liu R., Pu Y.P., Yin L.H., et al. Evaluation of pesticide toxicities with differing mechanisms using Caenorhabditis elegans. J Toxicol Environ Health A 2009, 72:746-751.
49. Saffih-Hdadi K., Bruckler L., Amichot M., Belzunces L. Modeling impact of parathion and its metabolite paraoxon on the nematode Caenorhabditis elegans in soil. Environ Toxicol Chem 2005, 24:1387-1394.
50. Saha S., Guillily M.D., Ferree A., Lanceta J., Chan D., Ghosh J., et al. LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci 2009, 29:9210-9218.
51. Soleo L., Defazio G., Scarselli R., Zefferino R., Livrea P., Foa V. Toxicity of fungicides containing ethylene-bis-dithiocarbamate in serumless dissociated mesencephalic-striatal primary coculture. Arch Toxicol 1996, 70:678-682.
52. Svendsen C., Siang P., Lister L.J., Rice A., Spurgeon D.J. Similarity, independence, or interaction for binary mixture effects of nerve toxicants for the nematode Caenorhabditis elegans. Environ Toxicol Chem 2010, 29:1182-1191.
53. Syngenta TouchDown Hi Tech. Product Label. Greensboro 2010, Syngenta Crop Protection, NC. Syngenta (Ed.).
54. Tanner C.M., Ottman R., Goldman S.M., Ellenberg J., Chan P., Mayeux R., et al. Parkinson disease in twins: an etiologic study. JAMA 1999, 281:341-346.
55. Testa C.M., Sherer T.B., Greenamyre J.T. Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures. Mol Brain Res 2005, 134:109.
56. Wood W.B. Introduction to C. elegans biology. The Nematode Caenorhabditis elegans 1988, 1-16. Cold Spring Harbor Laboratory Press, Cold Spring Harbor. W.B. Wood (Ed.).
57. Woodburn A.T. Glyphosate: production, pricing and use worldwide. Pest Manag Sci 2000, 56:309-312.
58. Worthington C. The Pesticide Manual: A World Compendium 1983, The British Crop Protection Council, Croydon, England. 7th ed.
59. Zhang J., Fitsanakis V.A., Gu G., Jing D., Ao M., Amarnath V., et al. Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction. J Neurochem 2003, 84:336-346.