Zinc: New clues to diverse roles in brain ischemia

Trends in Pharmacological Sciences

Volumn 32, Issue 8, 2011, Pages 480-486

  Shuttleworth, C William ^b   Weiss, John H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; CALCIUM ION; GLUTAMATE RECEPTOR 2; GLUTAMIC ACID; METALLOTHIONEIN; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; ZINC ION; ZINC TRANSPORTER;

BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CATION TRANSPORT; CELL METABOLISM; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; CRANIAL NERVE; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVATION; ENZYME ACTIVITY; EXCITOTOXICITY; EXTRACELLULAR SPACE; HUMAN; NERVE DEGENERATION; NERVE INJURY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; REVIEW; SYNAPTIC TRANSMISSION; TRANSCRIPTION REGULATION;

APOPTOSIS; BRAIN; BRAIN ISCHEMIA; CALCIUM; HUMANS; MITOCHONDRIA; MODELS, BIOLOGICAL; NERVE DEGENERATION; NEURONS; REACTIVE OXYGEN SPECIES; STROKE; ZINC;

EID: 79960955504     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2011.04.001     Document Type: Review

References (78)

1. T.B. Cole Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene Proc. Natl. Acad. Sci. U.S.A. 96 1999 1716 1721 (Pubitemid 29098517)
2. 2+ from brain tissue during activity Nature 308 1984 734 736 (Pubitemid 14127670)
3. G.A. Howell Stimulation-induced uptake and release of zinc in hippocampal slices Nature 308 1984 736 738 (Pubitemid 14127671)
4. S.L. Sensi Zinc in the physiology and pathology of the CNS Nat. Rev. Neurosci. 10 2009 780 791
5. J.H. Weiss Zn(2+): a novel ionic mediator of neural injury in brain disease Trends Pharmacol. Sci. 21 2000 395 401
6. C.J. Frederickson The neurobiology of zinc in health and disease Nat. Rev. Neurosci. 6 2005 449 462 (Pubitemid 40774861)
7. W. Maret Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc Exp. Gerontol. 43 2008 363 369 (Pubitemid 351522406)
8. C.J. Frederickson Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion Exp. Neurol. 198 2006 285 293
9. 2+ in a rat transient middle cerebral artery occlusion model Brain Res. Bull. 69 2006 622 625 (Pubitemid 43728745)
10. T.B. Cole Seizures and neuronal damage in mice lacking vesicular zinc Epilepsy Res. 39 2000 153 169 (Pubitemid 30089587)
11. J.Y. Lee Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin J. Neurosci. 20 2000 RC79
12. J.Y. Lee Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury Exp. Neurol. 184 2003 337 347
13. P. Lipton Ischemic cell death in brain neurons Physiol. Rev. 79 1999 1431 1568 (Pubitemid 29473320)
14. M. Lauritzen Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury J. Cereb. Blood Flow Metab. 31 2011 17 35
15. R.E. Carter Spreading depression and related events are significant sources of neuronal Zn(2+) release and accumulation J. Cereb. Blood Flow Metab. 31 2010 1073 1084
16. D.J. Rossi Glutamate release in severe brain ischaemia is mainly by reversed uptake Nature 403 2000 316 321 (Pubitemid 30062388)
17. 2+ accumulation and neuronal loss in hippocampal pyramidal neurons J. Neurosci. 22 2002 1273 1279 (Pubitemid 34163729)
18. 2+ currents are mediated by calcium-permeable AMPA/kainate channels in cultured murine hippocampal neurones J. Physiol. 543 2002 35 48 (Pubitemid 34947295)
19. A. Calderone Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death J. Neurosci. 24 2004 9903 9913 (Pubitemid 39463571)
20. A. Calderone Ischemic insults derepress the gene silencer REST in neurons destined to die J. Neurosci. 23 2003 2112 2121 (Pubitemid 36368899)
21. K.M. Noh Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death Proc. Natl. Acad. Sci. U.S.A. 102 2005 12230 12235
22. J. Qian Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration J. Neurosci. 31 2011 97 104
23. J.M. Lee Zinc translocation accelerates infarction after mild transient focal ischemia Neuroscience 115 2002 871 878
24. Y. Kitamura Protective effect of zinc against ischemic neuronal injury in a middle cerebral artery occlusion model J. Pharmacol. Sci. 100 2006 142 148 (Pubitemid 43276947)
25. P. Paoletti Zinc at glutamatergic synapses Neuroscience 158 2009 126 136
26. 2+-permeable acid-sensing ion channels Stroke 38 2007 670 673 (Pubitemid 46184238)
27. Z.G. Xiong Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels Cell 118 2004 687 698
28. E. Aizenman Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release J. Neurochem. 75 2000 1878 1888
29. S.L. Sensi Modulation of mitochondrial function by endogenous Zn2+ pools Proc. Natl. Acad. Sci. U.S.A. 100 2003 6157 6162 (Pubitemid 36576947)
30. C.J. Frederickson Zinc and excitotoxic brain injury: a new model Neuroscientist 10 2004 18 25 (Pubitemid 38112696)
31. S.J. Won EAAC1 gene deletion alters zinc homeostasis and exacerbates neuronal injury after transient cerebral ischemia J. Neurosci. 30 2010 15409 15418
32. L.M. Malaiyandi Divergent consequences arise from metallothionein overexpression in astrocytes: zinc buffering and oxidant-induced zinc release Glia 45 2004 346 353 (Pubitemid 38332435)
33. M.A. Aras Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning J. Neurochem. 110 2009 106 117
34. A. Koumura Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia Brain Res. 1292 2009 148 154
35. P.J. Dittmer Genetically encoded sensors to elucidate spatial distribution of cellular zinc J. Biol. Chem. 284 2009 16289 16297
36. J.P. Liuzzi, and R.J. Cousins Mammalian zinc transporters Annu. Rev. Nutr. 24 2004 151 172 (Pubitemid 38949814)
37. 2+ homeostasis in neuronal dendrites is a downstream consequence of metabolic compromise during extended NMDA exposures J. Neurosci. 28 2008 5029 5039
38. 2+ increases in apical dendrites of CA1 pyramidal neurons Neuroscience 159 2009 104 114
39. 2+ influx is critical for some forms of spreading depression in brain slices J. Neurosci. 28 2008 8014 8024
40. 2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia J. Neurosci. 29 2009 1105 1114
41. C. Cheng, and I.J. Reynolds Calcium-sensitive fluorescent dyes can report increases in intracellular free zinc concentration in cultured forebrain neurons J. Neurochem. 71 1998 2401 2410 (Pubitemid 28531250)
42. 2+ indicators with greatly improved fluorescence properties J. Biol. Chem. 260 1985 3440 3450 (Pubitemid 15114340)
43. C.J. Stork, and Y.V. Li Intracellular zinc elevation measured with a "calcium-specific" indicator during ischemia and reperfusion in rat hippocampus: a question on calcium overload J. Neurosci. 26 2006 10430 10437 (Pubitemid 44564593)
44. A.R. Kay Detecting and minimizing zinc contamination in physiological solutions BMC Physiol. 4 2004 4
45. A.R. Kay Imaging synaptic zinc: promises and perils Trends Neurosci. 29 2006 200 206
46. M.J. Devinney 2nd Simultaneous detection of intracellular free calcium and zinc using fura-2FF and FluoZin-3 Cell Calcium 37 2005 225 232
47. K.E. Dineley Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria Mitochondrion 5 2005 55 65 (Pubitemid 40197725)
48. D. Jiang Zn(2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria J. Biol. Chem. 276 2001 47524 47529
49. 2+-induced permeability transition Cell Calcium 45 2009 447 455
50. K.E. Dineley Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration J. Neurochem. 85 2003 563 570 (Pubitemid 36534479)
51. I.G. Gazaryan Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition J. Biol. Chem. 282 2007 24373 24380 (Pubitemid 47328020)
52. L. Bonanni Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain J. Neurosci. 26 2006 6851 6862 (Pubitemid 44315246)
53. Y.H. Kim, and J.Y. Koh The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical culture Exp. Neurol. 177 2002 407 418
54. K.M. Noh, and J.Y. Koh Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes J. Neurosci. 20 2000 RC111
55. M.J. Eliasson Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia Nat. Med. 3 1997 1089 1095 (Pubitemid 27444449)
56. S.W. Yu Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death Proc. Natl. Acad. Sci. U.S.A. 103 2006 18314 18319
57. S.A. Andrabi Poly(ADP-ribose) (PAR) polymer is a death signal Proc. Natl. Acad. Sci. U.S.A. 103 2006 18308 18313 (Pubitemid 44871654)
58. C.C. Alano NAD+ Depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death J. Neurosci. 30 2010 2967 2978
59. J.Y. Lee Protection by pyruvate against transient forebrain ischemia in rats J. Neurosci. 21 2001 RC171
60. C.T. Sheline Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis J. Neurosci. 20 2000 3139 3146 (Pubitemid 30263130)
61. A.L. Cai Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway Eur. J. Neurosci. 24 2006 2169 2176
62. J.Y. Lee Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection J. Neurosci. 28 2008 10919 10927
63. S.W. Suh Zinc inhibits astrocyte glutamate uptake by activation of poly(ADP-ribose) polymerase-1 Mol. Med. 13 2007 344 349
64. T.M. Kauppinen Zinc triggers microglial activation J. Neurosci. 28 2008 5827 5835
65. E.A. Irving, and M. Bamford Role of mitogen- and stress-activated kinases in ischemic injury J. Cereb. Blood Flow Metab. 22 2002 631 647 (Pubitemid 34596455)
66. E. Bossy-Wetzel Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K(+) channels Neuron 41 2004 351 365 (Pubitemid 38221040)
67. B. McLaughlin p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis J. Neurosci. 21 2001 3303 3311 (Pubitemid 32422795)
68. P.T. Redman Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling J. Physiol. 587 2009 4393 4404
69. C.T. Chu Oxidative neuronal injury. The dark side of ERK1/2 Eur. J. Biochem. 271 2004 2060 2066 (Pubitemid 38747975)
70. K. He, and E. Aizenman ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity J. Neurochem. 114 2010 452 461
71. J.A. Park, and J.Y. Koh Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: its role in zinc-induced neuronal death J. Neurochem. 73 1999 450 456 (Pubitemid 29339816)
72. S.B. Lee Link between mitochondria and NADPH oxidase 1 isozyme for the sustained production of reactive oxygen species and cell death J. Biol. Chem. 281 2006 36228 36235
73. R.P. Brandes Triggering mitochondrial radical release: a new function for NADPH oxidases Hypertension 45 2005 847 848 (Pubitemid 40628925)
74. L. Besser Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus J. Neurosci. 29 2009 2890 2901
75. Y.Z. Huang Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse Neuron 57 2008 546 558 (Pubitemid 351273988)
76. J.J. Hwang Activation of the Trk signaling pathway by extracellular zinc, Role of metalloproteinases J. Biol. Chem. 280 2005 11995 12001
77. M. Hershfinkel Intracellular zinc inhibits KCC2 transporter activity Nat. Neurosci. 12 2009 725 727
78. S.J. Lee, and J.Y. Koh Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes Mol. Brain 3 2010 30