메뉴 건너뛰기




Volumn 113, Issue 5, 2013, Pages 588-602

Cardiovascular RNA interference therapy: The broadening tool and target spectrum

Author keywords

cardiovascular diseases; genetic therapy; immunity, innate; nanoparticles; RNA interference; RNA, long untranslated; RNA, short untranslated

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CYCLOPHILIN D; DOUBLE STRANDED RNA; LONG UNTRANSLATED RNA; MALATE DEHYDROGENASE (DECARBOXYLATING); MYELOID DIFFERENTIATION FACTOR 88; MYOCARDIN; PIWI INTERACTING RNA; RECOMBINANT SOMATOMEDIN C; RNA; RNA BINDING PROTEIN; RNA INDUCED SILENCING COMPLEX; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SMALL NUCLEAR RNA; TRANSCRIPTION FACTOR; TRANSCRIPTOME; UNTRANSLATED RNA; ZINC FINGER NUCLEASE;

EID: 84883313004     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.301056     Document Type: Review
Times cited : (34)

References (149)
  • 1
    • 72449129174 scopus 로고    scopus 로고
    • A global view of genomic information- moving beyond the gene and the master regulator
    • Mattick JS, Taft RJ, Faulkner GJ. A global view of genomic information- moving beyond the gene and the master regulator. Trends Genet. 2010;26:21-28
    • (2010) Trends Genet , Issue.26 , pp. 21-28
    • Mattick, J.S.1    Taft, R.J.2    Faulkner, G.J.3
  • 3
    • 63649117394 scopus 로고    scopus 로고
    • Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy
    • Suckau L, Fechner H, Chemaly E, et al. Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy. Circulation. 2009;119:1241-1252
    • (2009) Circulation , vol.119 , pp. 1241-1252
    • Suckau, L.1    Fechner, H.2    Chemaly, E.3
  • 4
    • 84878000143 scopus 로고    scopus 로고
    • Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice
    • Majmudar MD, Keliher EJ, Heidt T, et al. Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice. Circulation. 2013;127:2038-2046
    • (2013) Circulation , Issue.127 , pp. 2038-2046
    • Majmudar, M.D.1    Keliher, E.J.2    Heidt, T.3
  • 6
    • 84857582662 scopus 로고    scopus 로고
    • Differential expression of microRNAs in different disease states
    • Abdellatif M. Differential expression of microRNAs in different disease states. Circ Res. 2012;110:638-650
    • (2012) Circ Res , Issue.110 , pp. 638-650
    • Abdellatif, M.1
  • 7
    • 84856694355 scopus 로고    scopus 로고
    • MicroRNAs in vascular and metabolic disease
    • Zampetaki A, Mayr M. MicroRNAs in vascular and metabolic disease. Circ Res. 2012;110:508-522
    • (2012) Circ Res , Issue.110 , pp. 508-522
    • Zampetaki, A.1    Mayr, M.2
  • 8
    • 84859299160 scopus 로고    scopus 로고
    • A new level of complexity: The role of microRNAs in cardiovascular development
    • Boettger T, Braun T. A new level of complexity: The role of microRNAs in cardiovascular development. Circ Res. 2012;110:1000-1013
    • (2012) Circ Res , Issue.110 , pp. 1000-1013
    • Boettger, T.1    Braun, T.2
  • 11
    • 84870364819 scopus 로고    scopus 로고
    • Comparative genomic analysis reveals evolutionary characteristics and patterns of microRNA clusters in vertebrates
    • Sun J, Gao B, Zhou M, Wang ZZ, Zhang F, Deng JE, Li X. Comparative genomic analysis reveals evolutionary characteristics and patterns of microRNA clusters in vertebrates. Gene. 2013;512:383-391
    • (2013) Gene , Issue.512 , pp. 383-391
    • Sun, J.1    Gao, B.2    Zhou, M.3    Wang, Z.Z.4    Zhang, F.5    Deng, J.E.6    Li, X.7
  • 14
    • 84860708360 scopus 로고    scopus 로고
    • Students of the bioinformatics computer lab evolution of the let-7 microrna family
    • Hertel J, Bartschat S, Wintsche A, Otto C, Stadler PF; Students of the Bioinformatics Computer Lab. Evolution of the let-7 microRNA family. RNA Biol. 2012;9:231-241
    • (2012) RNA Biol , Issue.9 , pp. 231-241
    • Hertel, J.1    Bartschat, S.2    Wintsche, A.3    Otto, C.4    Stadler, P.F.5
  • 15
    • 80051941625 scopus 로고    scopus 로고
    • Phylogenetic comparison of small RNA-triggered transcriptional gene silencing
    • Zhang X, Rossi JJ. Phylogenetic comparison of small RNA-triggered transcriptional gene silencing. J Biol Chem. 2011;286:29443-29448
    • (2011) J Biol Chem , Issue.286 , pp. 29443-29448
    • Zhang, X.1    Rossi, J.J.2
  • 16
    • 84875237641 scopus 로고    scopus 로고
    • Systematic analysis of genomic organization and structure of long non-coding RNAs in the human genome
    • Sun J, Zhou M, Mao ZT, Hao DP, Wang ZZ, Li CX. Systematic analysis of genomic organization and structure of long non-coding RNAs in the human genome. FEBS Lett. 2013;587:976-982
    • (2013) FEBS Lett , Issue.587 , pp. 976-982
    • Sun, J.1    Zhou, M.2    Mao, Z.T.3    Hao, D.P.4    Wang, Z.Z.5    Li, C.X.6
  • 19
    • 84875589012 scopus 로고    scopus 로고
    • RNA in the loop
    • Kung JT, Lee JT. RNA in the loop. Dev Cell. 2013;24:565-567
    • (2013) Dev Cell , Issue.24 , pp. 565-567
    • Kung, J.T.1    Lee, J.T.2
  • 20
    • 79960911703 scopus 로고    scopus 로고
    • The reality of pervasive transcription
    • e1000625 discussion e1001102
    • Clark MB, Amaral PP, Schlesinger FJ, et al. The reality of pervasive transcription. PLoS Biol. 2011;9:e1000625; discussion e1001102
    • (2011) PLoS Biol , Issue.9
    • Clark, M.B.1    Amaral, P.P.2    Schlesinger, F.J.3
  • 21
    • 79961170994 scopus 로고    scopus 로고
    • A CeRNA Hypo thesis the Rosetta Stone of a hidden RNA language?
    • Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: The Rosetta Stone of a hidden RNA language? Cell. 2011;146:353-358
    • (2011) Cell , Issue.146 , pp. 353-358
    • Salmena, L.1    Poliseno, L.2    Tay, Y.3    Kats, L.4    Pandolfi, P.P.5
  • 23
    • 77953957633 scopus 로고    scopus 로고
    • A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
    • Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature. 2010;465:1033-1038
    • (2010) Nature , vol.465 , pp. 1033-1038
    • Poliseno, L.1    Salmena, L.2    Zhang, J.3    Carver, B.4    Haveman, W.J.5    Pandolfi, P.P.6
  • 25
    • 84876566914 scopus 로고    scopus 로고
    • ChIPBase: A database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data
    • Yang JH, Li JH, Jiang S, Zhou H, Qu LH. ChIPBase: A database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data. Nucleic Acids Res. 2013;41:D177-D187
    • (2013) Nucleic Acids Res , Issue.41
    • Yang, J.H.1    Li, J.H.2    Jiang, S.3    Zhou, H.4    Qu, L.H.5
  • 26
    • 80052960863 scopus 로고    scopus 로고
    • Next-generation transcriptome assembly
    • Martin JA, Wang Z. Next-generation transcriptome assembly. Nat Rev Genet. 2011;12:671-682
    • (2011) Nat Rev Genet , Issue.12 , pp. 671-682
    • Martin, J.A.1    Wang, Z.2
  • 27
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies - The next generation
    • Metzker ML. Sequencing technologies - the next generation. Nat Rev Genet. 2010;11:31-46
    • (2010) Nat Rev Genet , Issue.11 , pp. 31-46
    • Metzker, M.L.1
  • 28
    • 78751570979 scopus 로고    scopus 로고
    • RNA sequencing: Advances, challenges and opportunities
    • Ozsolak F, Milos PM. RNA sequencing: Advances, challenges and opportunities. Nat Rev Genet. 2011;12:87-98
    • (2011) Nat Rev Genet , Issue.12 , pp. 87-98
    • Ozsolak, F.1    Milos, P.M.2
  • 29
    • 84856083581 scopus 로고    scopus 로고
    • Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts
    • Lee JH, Gao C, Peng G, Greer C, Ren S, Wang Y, Xiao X. Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts. Circ Res. 2011;109:1332-1341
    • (2011) Circ Res , Issue.109 , pp. 1332-1341
    • Lee, J.H.1    Gao, C.2    Peng, G.3    Greer, C.4    Ren, S.5    Wang, Y.6    Xiao, X.7
  • 30
    • 84859879034 scopus 로고    scopus 로고
    • Deep RNA sequencing reveals novel cardiac transcriptomic signatures for physiological and pathological hypertrophy
    • Song HK, Hong SE, Kim T, Kim do H. Deep RNA sequencing reveals novel cardiac transcriptomic signatures for physiological and pathological hypertrophy. PLoS One. 2012;7:e35552
    • (2012) PLoS One , Issue.7
    • Song, H.K.1    Hong, S.E.2    Kim, T.3    Kim Do, H.4
  • 32
    • 56349113455 scopus 로고    scopus 로고
    • 3' end processing of a long nuclearretained noncoding RNA yields a tRNA-like cytoplasmic RNA
    • Wilusz JE, Freier SM, Spector DL. 3' end processing of a long nuclearretained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell. 2008;135:919-932
    • (2008) Cell , vol.135 , pp. 919-932
    • Wilusz, J.E.1    Freier, S.M.2    Spector, D.L.3
  • 33
    • 84867575580 scopus 로고    scopus 로고
    • Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles
    • Naganuma T, Nakagawa S, Tanigawa A, Sasaki YF, Goshima N, Hirose T. Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles. EMBO J. 2012;31:4020-4034
    • (2012) EMBO J. , Issue.31 , pp. 4020-4034
    • Naganuma, T.1    Nakagawa, S.2    Tanigawa, A.3    Sasaki, Y.F.4    Goshima, N.5    Hirose, T.6
  • 34
    • 84874965439 scopus 로고    scopus 로고
    • Paraspeckle formation during the biogenesis of lncRNAs
    • Naganuma T, Hirose T. Paraspeckle formation during the biogenesis of lncRNAs. RNA Biol. 2013;10:456-461
    • (2013) RNA Biol , Issue.10 , pp. 456-461
    • Naganuma, T.1    Hirose, T.2
  • 35
    • 54349104464 scopus 로고    scopus 로고
    • Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs
    • Babiarz JE, Ruby JG, Wang Y, Bartel DP, Blelloch R. Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev. 2008;22:2773-2785
    • (2008) Genes Dev , vol.22 , pp. 2773-2785
    • Babiarz, J.E.1    Ruby, J.G.2    Wang, Y.3    Bartel, D.P.4    Blelloch, R.5
  • 36
    • 84870038812 scopus 로고    scopus 로고
    • Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties
    • Wee LM, Flores-Jasso CF, Salomon WE, Zamore PD. Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell. 2012;151:1055-1067
    • (2012) Cell , Issue.151 , pp. 1055-1067
    • Wee, L.M.1    Flores-Jasso, C.F.2    Salomon, W.E.3    Zamore, P.D.4
  • 37
    • 84883410514 scopus 로고    scopus 로고
    • Highly complementary target RNAs promote release of guide RNAs from human Argonaute2
    • De N, Young L, Lau PW, Meisner NC, Morrissey DV, MacRae IJ. Highly complementary target RNAs promote release of guide RNAs from human Argonaute2. Mol Cell. 2013;50:344-355
    • (2013) Mol Cell , Issue.50 , pp. 344-355
    • De N Young, L.1    Lau, P.W.2    Meisner, N.C.3    Morrissey, D.V.4    MacRae, I.J.5
  • 38
    • 81055140863 scopus 로고    scopus 로고
    • NcRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs
    • Yang L, Lin C, Liu W, Zhang J, Ohgi KA, Grinstein JD, Dorrestein PC, Rosenfeld MG. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell. 2011;147:773-788
    • (2011) Cell , Issue.147 , pp. 773-788
    • Yang, L.1    Lin, C.2    Liu, W.3    Zhang, J.4    Ohgi, K.A.5    Grinstein, J.D.6    Dorrestein, P.C.7    Rosenfeld, M.G.8
  • 39
    • 78649637489 scopus 로고    scopus 로고
    • Highly ordered spatial organization of the structural long noncoding NEAT1 RNAs within paraspeckle nuclear bodies
    • Souquere S, Beauclair G, Harper F, Fox A, Pierron G. Highly ordered spatial organization of the structural long noncoding NEAT1 RNAs within paraspeckle nuclear bodies. Mol Biol Cell. 2010;21:4020-4027
    • (2010) Mol Biol Cell , Issue.21 , pp. 4020-4027
    • Souquere, S.1    Beauclair, G.2    Harper, F.3    Fox, A.4    Pierron, G.5
  • 40
    • 84861904178 scopus 로고    scopus 로고
    • Genome regulation by long noncoding RNAs
    • Rinn JL, Chang HY. Genome regulation by long noncoding RNAs. Annu Rev Biochem. 2012;81:145-166
    • (2012) Annu Rev Biochem , Issue.81 , pp. 145-166
    • Rinn, J.L.1    Chang, H.Y.2
  • 41
    • 84871069553 scopus 로고    scopus 로고
    • Epigenetic regulation by long noncoding RNAs
    • Lee JT. Epigenetic regulation by long noncoding RNAs. Science. 2012;338:1435-1439
    • (2012) Science , Issue.338 , pp. 1435-1439
    • Lee, J.T.1
  • 42
    • 84855956560 scopus 로고    scopus 로고
    • Long non-coding RNAs in nuclear bodies
    • Ip JY, Nakagawa S. Long non-coding RNAs in nuclear bodies. Dev Growth Differ. 2012;54:44-54
    • (2012) Dev Growth Differ , Issue.54 , pp. 44-54
    • Ip, J.Y.1    Nakagawa, S.2
  • 43
    • 79954650563 scopus 로고    scopus 로고
    • State-of-the-art gene-based therapies: The road ahead
    • Kay MA. State-of-the-art gene-based therapies: The road ahead. Nat Rev Genet. 2011;12:316-328
    • (2011) Nat Rev Genet , Issue.12 , pp. 316-328
    • Kay, M.A.1
  • 45
    • 79955597265 scopus 로고    scopus 로고
    • Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins
    • Nathwani AC, Rosales C, McIntosh J, et al. Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins. Mol Ther. 2011;19:876-885
    • (2011) Mol Ther , Issue.19 , pp. 876-885
    • Nathwani, A.C.1    Rosales, C.2    McIntosh, J.3
  • 49
    • 68249114791 scopus 로고    scopus 로고
    • Combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNAs exerts synergistic antiviral activity against coxsackievirus B3
    • Werk D, Pinkert S, Heim A, Zeichhardt H, Grunert HP, Poller W, Erdmann VA, Fechner H, Kurreck J. Combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNAs exerts synergistic antiviral activity against coxsackievirus B3. Antiviral Res. 2009;83:298-306
    • (2009) Antiviral Res , vol.83 , pp. 298-306
    • Werk, D.1    Pinkert, S.2    Heim, A.3    Zeichhardt, H.4    Grunert, H.P.5    Poller, W.6    Erdmann, V.A.7    Fechner, H.8    Kurreck, J.9
  • 51
    • 84873864178 scopus 로고    scopus 로고
    • Potential of gene therapy as a treatment for heart failure
    • Hajjar RJ. Potential of gene therapy as a treatment for heart failure. J Clin Invest. 2013;123:53-61
    • (2013) J Clin Invest , Issue.123 , pp. 53-61
    • Hajjar, R.J.1
  • 53
    • 79961032369 scopus 로고    scopus 로고
    • Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (cupid): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum ca2+-atpase in patients with advanced heart failure
    • Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID) Investigators
    • Jessup M, Greenberg B, Mancini D, Cappola T, Pauly DF, Jaski B, Yaroshinsky A, Zsebo KM, Dittrich H, Hajjar RJ; Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID) Investigators. Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): A phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation. 2011;124:304-313
    • (2011) Circulation , Issue.124 , pp. 304-313
    • Jessup, M.1    Greenberg, B.2    Mancini, D.3    Cappola, T.4    Pauly, D.F.5    Jaski, B.6    Yaroshinsky, A.7    Zsebo, K.M.8    Dittrich, H.9    Hajjar, R.J.10
  • 55
    • 77952349351 scopus 로고    scopus 로고
    • Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure
    • Poller W, Hajjar R, Schultheiss HP, Fechner H. Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure. Cardiovasc Res. 2010;86:353-364
    • (2010) Cardiovasc Res , Issue.86 , pp. 353-364
    • Poller, W.1    Hajjar, R.2    Schultheiss, H.P.3    Fechner, H.4
  • 56
    • 79954622209 scopus 로고    scopus 로고
    • Therapeutic in vivo gene transfer for genetic disease using AAV: Progress and challenges
    • Mingozzi F, High KA. Therapeutic in vivo gene transfer for genetic disease using AAV: Progress and challenges. Nat Rev Genet. 2011;12:341-355
    • (2011) Nat Rev Genet , Issue.12 , pp. 341-355
    • Mingozzi, F.1    High, K.A.2
  • 57
    • 73449090107 scopus 로고    scopus 로고
    • Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor
    • Pinkert S, Westermann D, Wang X, et al. Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor. Circulation. 2009;120:2358-2366
    • (2009) Circulation , vol.120 , pp. 2358-2366
    • Pinkert, S.1    Westermann, D.2    Wang, X.3
  • 58
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interferencebased therapeutics
    • Castanotto D, Rossi JJ. The promises and pitfalls of RNA- interferencebased therapeutics. Nature. 2009;457:426-433
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 59
    • 79960060795 scopus 로고    scopus 로고
    • Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia
    • Huang M, Wu JC. Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia. Methods Mol Biol. 2011;709:211-221
    • (2011) Methods Mol Biol , Issue.709 , pp. 211-221
    • Huang, M.1    Wu, J.C.2
  • 60
    • 84880843089 scopus 로고    scopus 로고
    • Phd2 silencing enhances the survival and paracrine function of transplanted adipose-derived stem cells in infarcted myocardium
    • doi: 10.1161/CIRCRESAHA.113.300929
    • Wang WE, Yang D, Li L, Wang W, Peng Y, Chen C, Peng C, Xia X, Wang H, Jiang J, Liao Q, Li Y, Xie G, Huang H, Guo Y, et al. Phd2 silencing enhances the survival and paracrine function of transplanted adipose-derived stem cells in infarcted myocardium. Circ Res. 2013;113:288-300. doi: 10.1161/CIRCRESAHA.113. 300929
    • (2013) Circ Res , Issue.113 , pp. 288-300
    • Wang, W.E.1    Yang, D.2    Li, L.3    Wang, W.4    Peng, Y.5    Chen, C.6    Peng, C.7    Xia, X.8    Wang, H.9    Jiang, J.10    Liao, Q.11    Li, Y.12    Xie, G.13    Huang, H.14    Guo, Y.15
  • 61
    • 84899514041 scopus 로고    scopus 로고
    • Allele-specific RNAi rescues the long-qt syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes
    • March 6, 2013 doi: 10.1093/eurheartj/eht067 Accessed August 2
    • Matsa E, Dixon JE, Medway C, Georgiou O, Patel MJ, Morgan K, Kemp PJ, Staniforth A, Mellor I, Denning C. Allele-specific RNAi rescues the long-qt syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. Eur Heart J. March 6, 2013. doi: 10.1093/eurheartj/eht067. http:// eurheartj.oxfordjournals.org/content/early/2013/03/06/eurheartj.eht067. long. Accessed August 2, 2013
    • (2013) Eur Heart J.
    • Matsa, E.1    Dixon, J.E.2    Medway, C.3    Georgiou, O.4    Patel, M.J.5    Morgan, K.6    Kemp, P.J.7    Staniforth, A.8    Mellor, I.9    Denning, C.10
  • 63
    • 84878581041 scopus 로고    scopus 로고
    • RNA interference - A silent but an efficient therapeutic tool
    • Ramachandran PV, Ignacimuthu S. RNA interference-a silent but an efficient therapeutic tool. Appl Biochem Biotechnol. 2013;169:1774-1789
    • (2013) Appl Biochem Biotechnol , Issue.169 , pp. 1774-1789
    • Ramachandran, P.V.1    Ignacimuthu, S.2
  • 64
    • 68049102296 scopus 로고    scopus 로고
    • Silencing the myotrophin gene by RNA interference leads to the regression of cardiac hypertrophy
    • Gupta S, Maitra R, Young D, Gupta A, Sen S. Silencing the myotrophin gene by RNA interference leads to the regression of cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2009;297:H627-H636
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Gupta, S.1    Maitra, R.2    Young, D.3    Gupta, A.4    Sen, S.5
  • 65
    • 80054775528 scopus 로고    scopus 로고
    • Targeted genesilencing reveals the functional significance of myocardin signaling in the failing heart
    • Torrado M, Iglesias R, Centeno A, López E, Mikhailov AT. Targeted genesilencing reveals the functional significance of myocardin signaling in the failing heart. PLoS One. 2011;6:e26392
    • (2011) PLoS One , Issue.6
    • Torrado, M.1    Iglesias, R.2    Centeno, A.3    López, E.4    Mikhailov, A.T.5
  • 66
    • 84875370416 scopus 로고    scopus 로고
    • Activator protein-2a mediates carbon monoxide-induced stromal cell-derived factor-1a expression and vascularization in ischemic heart
    • Lin HH, Chen YH, Chiang MT, Huang PL, Chau LY. Activator protein-2a mediates carbon monoxide-induced stromal cell-derived factor-1a expression and vascularization in ischemic heart. Arterioscler Thromb Vasc Biol. 2013;33:785-794
    • (2013) Arterioscler Thromb Vasc Biol , Issue.33 , pp. 785-794
    • Lin, H.H.1    Chen, Y.H.2    Chiang, M.T.3    Huang, P.L.4    Chau, L.Y.5
  • 67
    • 74949088039 scopus 로고    scopus 로고
    • Reduced expression of the Na+/Ca2+ exchanger in adult cardiomyocytes via adenovirally delivered shRNA results in resistance to simulated ischemic injury
    • Maddaford TG, Dibrov E, Hurtado C, Pierce GN. Reduced expression of the Na+/Ca2+ exchanger in adult cardiomyocytes via adenovirally delivered shRNA results in resistance to simulated ischemic injury. Am J Physiol Heart Circ Physiol. 2010;298:H360-H366
    • (2010) Am J Physiol Heart Circ Physiol , Issue.298
    • Maddaford, T.G.1    Dibrov, E.2    Hurtado, C.3    Pierce, G.N.4
  • 68
    • 84870230289 scopus 로고    scopus 로고
    • In vivo, cardiacspecific knockdown of a target protein, malic enzyme-1, in rat via adenoviral delivery of DNA for non-native miRNA
    • O'Donnell JM, Kalichira A, Bi J, Lewandowski ED. In vivo, cardiacspecific knockdown of a target protein, malic enzyme-1, in rat via adenoviral delivery of DNA for non-native miRNA. Curr Gene Ther. 2012;12:454-462
    • (2012) Curr Gene Ther , Issue.12 , pp. 454-462
    • O'Donnell, J.M.1    Kalichira, A.2    Bi, J.3    Lewandowski, E.D.4
  • 70
    • 84878904570 scopus 로고    scopus 로고
    • Lentivirusmediated RNAi of chymase increases the plaque stability in atherosclerosis in vivo [published online ahead of print May 24
    • doi: 10.1016/j.yexmp.2013.05.005
    • Guo T, Wang J, Yang J, Chen W, An G, Fan L, Peng Q. Lentivirusmediated RNAi of chymase increases the plaque stability in atherosclerosis in vivo [published online ahead of print May 24, 2013]. Exp Mol Pathol. 2013;95:51-56. doi: 10.1016/j.yexmp.2013.05.005
    • (2013) Exp Mol Pathol , vol.2013 , Issue.95 , pp. 51-56
    • Guo, T.1    Wang, J.2    Yang, J.3    Chen, W.4    An, G.5    Fan, L.6    Peng, Q.7
  • 71
    • 79958274671 scopus 로고    scopus 로고
    • An introduction to small non-coding RNAs: MiRNA and snoRNA
    • Holley CL, Topkara VK. An introduction to small non-coding RNAs: MiRNA and snoRNA. Cardiovasc Drugs Ther. 2011;25:151-159
    • (2011) Cardiovasc Drugs Ther , Issue.25 , pp. 151-159
    • Holley, C.L.1    Topkara, V.K.2
  • 72
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interferencebased therapies
    • Davidson BL, McCray PB Jr. Current prospects for RNA interferencebased therapies. Nat Rev Genet. 2011;12:329-340
    • (2011) Nat Rev Genet , Issue.12 , pp. 329-340
    • Davidson, B.L.1    McCray Jr., P.B.2
  • 73
    • 77955469975 scopus 로고    scopus 로고
    • A direct comparison of anti-microRNA oligonucleotide potency
    • Lennox KA, Behlke MA. A direct comparison of anti-microRNA oligonucleotide potency. Pharm Res. 2010;27:1788-1799
    • (2010) Pharm Res , Issue.27 , pp. 1788-1799
    • Lennox, K.A.1    Behlke, M.A.2
  • 77
    • 77955603961 scopus 로고    scopus 로고
    • Development of novel cardiovascular therapeutics from small regulatory RNA molecules-an outline of key requirements
    • Poller W, Fechner H. Development of novel cardiovascular therapeutics from small regulatory RNA molecules-an outline of key requirements. Curr Pharm Des. 2010;16:2252-2268
    • (2010) Curr Pharm Des , Issue.16 , pp. 2252-2268
    • Poller, W.1    Fechner, H.2
  • 78
    • 0036828203 scopus 로고    scopus 로고
    • A limited number of transducible hepatocytes restricts a wide-range linear vector dose response in recombinant adeno-associated virus-mediated liver transduction
    • Nakai H, Thomas CE, Storm TA, Fuess S, Powell S, Wright JF, Kay MA. A limited number of transducible hepatocytes restricts a wide-range linear vector dose response in recombinant adeno-associated virus-mediated liver transduction. J Virol. 2002;76:11343-11349
    • (2002) J Virol , vol.76 , pp. 11343-11349
    • Nakai, H.1    Thomas, C.E.2    Storm, T.A.3    Fuess, S.4    Powell, S.5    Wright, J.F.6    Kay, M.A.7
  • 80
    • 33744900338 scopus 로고    scopus 로고
    • Highlevel transgene expression in nonhuman primate liver with novel adenoassociated virus serotypes containing self-complementary genomes
    • Gao GP, Lu Y, Sun X, Johnston J, Calcedo R, Grant R, Wilson JM. Highlevel transgene expression in nonhuman primate liver with novel adenoassociated virus serotypes containing self-complementary genomes. J Virol. 2006;80:6192-6194
    • (2006) J Virol , vol.80 , pp. 6192-6194
    • Gao, G.P.1    Lu, Y.2    Sun, X.3    Johnston, J.4    Calcedo, R.5    Grant, R.6    Wilson, J.M.7
  • 81
    • 62649133817 scopus 로고    scopus 로고
    • Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In Cardiac Disease (CUPID) Trial Investigators Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-inhuman phase clinical trial
    • Jaski BE, Jessup ML, Mancini DM, Cappola TP, Pauly DF, Greenberg B, Borow K, Dittrich H, Zsebo KM, Hajjar RJ; Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In Cardiac Disease (CUPID) Trial Investigators. Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID Trial), a first-inhuman phase . clinical trial. J Card Fail. 2009;15:171-181
    • (2009) J Card Fail , vol.15 , pp. 171-181
    • Jaski, B.E.1    Jessup, M.L.2    Mancini, D.M.3    Cappola, T.P.4    Pauly, D.F.5    Greenberg, B.6    Borow, K.7    Dittrich, H.8    Zsebo, K.M.9    Hajjar, R.J.10
  • 82
    • 57749169283 scopus 로고    scopus 로고
    • Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat
    • Bish LT, Morine K, Sleeper MM, Sanmiguel J, Wu D, Gao G, Wilson JM, Sweeney HL. Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat. Hum Gene Ther. 2008;19:1359-1368
    • (2008) Hum Gene Ther , vol.19 , pp. 1359-1368
    • Bish, L.T.1    Morine, K.2    Sleeper, M.M.3    Sanmiguel, J.4    Wu, D.5    Gao, G.6    Wilson, J.M.7    Sweeney, H.L.8
  • 83
    • 33745143956 scopus 로고    scopus 로고
    • Robust systemic transduction with AAV9 vectors in mice: Efficient global cardiac gene transfer superior to that of AAV8
    • Inagaki K, Fuess S, Storm TA, Gibson GA, Mctiernan CF, Kay MA, Nakai H. Robust systemic transduction with AAV9 vectors in mice: Efficient global cardiac gene transfer superior to that of AAV8. Mol Ther. 2006;14:45-53
    • (2006) Mol Ther , vol.14 , pp. 45-53
    • Inagaki, K.1    Fuess, S.2    Storm, T.A.3    Gibson, G.A.4    Mctiernan, C.F.5    Kay, M.A.6    Nakai, H.7
  • 85
    • 79951510234 scopus 로고    scopus 로고
    • Microrna122-regulated transgene expression increases specificity of cardiac gene transfer upon intravenous delivery of AAV9 vectors
    • Geisler A, Jungmann A, Kurreck J, Poller W, Katus HA, Vetter R, Fechner H, Müller OJ. microRNA122-regulated transgene expression increases specificity of cardiac gene transfer upon intravenous delivery of AAV9 vectors. Gene Ther. 2011;18:199-209
    • (2011) Gene Ther , Issue.18 , pp. 199-209
    • Geisler, A.1    Jungmann, A.2    Kurreck, J.3    Poller, W.4    Katus, H.A.5    Vetter, R.6    Fechner, H.7    Müller, O.J.8
  • 90
    • 0036294527 scopus 로고    scopus 로고
    • Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
    • Zeng Y, Wagner EJ, Cullen BR. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol Cell. 2002;9:1327-1333
    • (2002) Mol Cell , vol.9 , pp. 1327-1333
    • Zeng, Y.1    Wagner, E.J.2    Cullen, B.R.3
  • 92
    • 84855464239 scopus 로고    scopus 로고
    • Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNAalbumin conjugation
    • Lau S, Graham B, Cao N, Boyd BJ, Pouton CW, White PJ. Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNAalbumin conjugation. Mol Pharm. 2012;9:71-80
    • (2012) Mol Pharm , Issue.9 , pp. 71-80
    • Lau, S.1    Graham, B.2    Cao, N.3    Boyd, B.J.4    Pouton, C.W.5    White, P.J.6
  • 93
    • 84866011910 scopus 로고    scopus 로고
    • Effect of GPE-AGT nanoparticle shRNA transfection system mediated RNAi on early atherosclerotic lesion
    • Lu P, Yuan L, Wang Y, Du Q, Sheng J. Effect of GPE-AGT nanoparticle shRNA transfection system mediated RNAi on early atherosclerotic lesion. Int J Clin Exp Pathol. 2012;5:698-706
    • (2012) Int J Clin Exp Pathol , Issue.5 , pp. 698-706
    • Lu, P.1    Yuan, L.2    Wang, Y.3    Du, Q.4    Sheng, J.5
  • 94
    • 77954362096 scopus 로고    scopus 로고
    • Aptamer-targeted cell-specific RNA interference
    • Zhou J, Rossi JJ. Aptamer-targeted cell-specific RNA interference. Silence. 2010;1:4
    • (2010) Silence , Issue.1 , pp. 4
    • Zhou, J.1    Rossi, J.J.2
  • 95
    • 82855164053 scopus 로고    scopus 로고
    • Small-interfering RNA-eluting surfaces as a novel concept for intravascular local gene silencing
    • Nolte A, Walker T, Schneider M, Kray O, Avci-Adali M, Ziemer G, Wendel HP. Small-interfering RNA-eluting surfaces as a novel concept for intravascular local gene silencing. Mol Med. 2011;17:1213-1222
    • (2011) Mol Med , Issue.17 , pp. 1213-1222
    • Nolte, A.1    Walker, T.2    Schneider, M.3    Kray, O.4    Avci-Adali, M.5    Ziemer, G.6    Wendel, H.P.7
  • 97
    • 77952955053 scopus 로고    scopus 로고
    • Recent advances in small interfering RNA sensing by the immune system
    • Sioud M. Recent advances in small interfering RNA sensing by the immune system. N Biotechnol. 2010;27:236-242
    • (2010) N Biotechnol , Issue.27 , pp. 236-242
    • Sioud, M.1
  • 98
    • 84866601880 scopus 로고    scopus 로고
    • Mechanistic characterization of the 5'-triphosphate-dependent activation of PKR: Lack of 5'-end nucleobase specificity, evidence for a distinct triphosphate binding site, and a critical role for the dsRBD
    • Toroney R, Hull CM, Sokoloski JE, Bevilacqua PC. Mechanistic characterization of the 5'-triphosphate-dependent activation of PKR: Lack of 5'-end nucleobase specificity, evidence for a distinct triphosphate binding site, and a critical role for the dsRBD. RNA. 2012;18:1862-1874
    • (2012) RNA , vol.18 , pp. 1862-1874
    • Toroney, R.1    Hull, C.M.2    Sokoloski, J.E.3    Bevilacqua, P.C.4
  • 99
    • 77952300185 scopus 로고    scopus 로고
    • Inhibitory RNA molecules in immunotherapy for cancer
    • Mao CP, Wu TC. Inhibitory RNA molecules in immunotherapy for cancer. Methods Mol Biol. 2010;623:325-339
    • (2010) Methods Mol Biol , Issue.623 , pp. 325-339
    • Mao, C.P.1    Wu, T.C.2
  • 100
    • 84871991715 scopus 로고    scopus 로고
    • Gene therapy enters the pharma market: The short story of a long journey
    • Büning H. Gene therapy enters the pharma market: The short story of a long journey. EMBO Mol Med. 2013;5:1-3
    • (2013) EMBO Mol Med , Issue.5 , pp. 1-3
    • Büning, H.1
  • 102
    • 84872533627 scopus 로고    scopus 로고
    • RNA interference in the nucleus: Roles for small RNAs in transcription, epigenetics and beyond
    • Castel SE, Martienssen RA. RNA interference in the nucleus: Roles for small RNAs in transcription, epigenetics and beyond. Nat Rev Genet. 2013;14:100-112
    • (2013) Nat Rev Genet , Issue.14 , pp. 100-112
    • Castel, S.E.1    Martienssen, R.A.2
  • 104
    • 77649239548 scopus 로고    scopus 로고
    • Six RNA viruses and fortyone hosts: Viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
    • Parameswaran P, Sklan E, Wilkins C, et al. Six RNA viruses and fortyone hosts: Viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog. 2010;6:e1000764
    • (2010) PLoS Pathog , Issue.6
    • Parameswaran, P.1    Sklan, E.2    Wilkins, C.3
  • 105
    • 81355123438 scopus 로고    scopus 로고
    • Evolution of microRNA diversity and regulation in animals
    • Berezikov E. Evolution of microRNA diversity and regulation in animals. Nat Rev Genet. 2011;12:846-860
    • (2011) Nat Rev Genet , Issue.12 , pp. 846-860
    • Berezikov, E.1
  • 106
    • 78751477191 scopus 로고    scopus 로고
    • Gene silencing by microRNAs: Contributions of translational repression and mRNA decay
    • Huntzinger E, Izaurralde E. Gene silencing by microRNAs: Contributions of translational repression and mRNA decay. Nat Rev Genet. 2011;12:99-110
    • (2011) Nat Rev Genet , Issue.12 , pp. 99-110
    • Huntzinger, E.1    Izaurralde, E.2
  • 108
    • 84871426033 scopus 로고    scopus 로고
    • Cardiovascular biology: A boost for heart regeneration
    • Mercola M. Cardiovascular biology: A boost for heart regeneration. Nature. 2012;492:360-362
    • (2012) Nature , Issue.492 , pp. 360-362
    • Mercola, M.1
  • 109
    • 84858446579 scopus 로고    scopus 로고
    • MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship
    • Pasquinelli AE. MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet. 2012;13:271-282
    • (2012) Nat Rev Genet , Issue.13 , pp. 271-282
    • Pasquinelli, A.E.1
  • 110
    • 84878527849 scopus 로고    scopus 로고
    • Vesicle trafficking and RNA transfer add complexity and connectivity to cell-cell communication
    • Roberts CT Jr, Kurre P. Vesicle trafficking and RNA transfer add complexity and connectivity to cell-cell communication. Cancer Res. 2013;73:3200-3205
    • (2013) Cancer Res , Issue.73 , pp. 3200-3205
    • Roberts Jr., C.T.1    Kurre, P.2
  • 111
    • 84874541064 scopus 로고    scopus 로고
    • A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance
    • Ohanian M, Humphreys DT, Anderson E, Preiss T, Fatkin D. A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance. BMC Genet. 2013;14:18
    • (2013) BMC Genet , Issue.14 , pp. 18
    • Ohanian, M.1    Humphreys, D.T.2    Anderson, E.3    Preiss, T.4    Fatkin, D.5
  • 112
    • 84880318171 scopus 로고    scopus 로고
    • Regulation of the mir155 host gene in physiological and pathological processes
    • Elton TS, Selemon H, Elton SM, Parinandi NL. Regulation of the mir155 host gene in physiological and pathological processes. Gene. 2012;112:01512-0
    • (2012) Gene , Issue.112 , pp. 01512-01520
    • Elton, T.S.1    Selemon, H.2    Elton, S.M.3    Parinandi, N.L.4
  • 113
    • 84869015900 scopus 로고    scopus 로고
    • Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci
    • Sati S, Ghosh S, Jain V, Scaria V, Sengupta S. Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci. Nucleic Acids Res. 2012;40:10018-10031
    • (2012) Nucleic Acids Res , Issue.40 , pp. 10018-10031
    • Sati, S.1    Ghosh, S.2    Jain, V.3    Scaria, V.4    Sengupta, S.5
  • 114
    • 79952137666 scopus 로고    scopus 로고
    • Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling
    • Peng X, Gralinski L, Armour CD, et al. Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling. MBio. 2010;1:e00206-e00210
    • (2010) MBio , Issue.1
    • Peng, X.1    Gralinski, L.2    Armour, C.D.3
  • 116
    • 80052869283 scopus 로고    scopus 로고
    • LincRNAs act in the circuitry controlling pluripotency and differentiation
    • Guttman M, Donaghey J, Carey BW, et al. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature. 2011;477:295-300
    • (2011) Nature , Issue.477 , pp. 295-300
    • Guttman, M.1    Donaghey, J.2    Carey, B.W.3
  • 117
    • 84868705910 scopus 로고    scopus 로고
    • Long noncoding RNAs in cardiac development and pathophysiology
    • Schonrock N, Harvey RP, Mattick JS. Long noncoding RNAs in cardiac development and pathophysiology. Circ Res. 2012;111:1349-1362
    • (2012) Circ Res , Issue.111 , pp. 1349-1362
    • Schonrock, N.1    Harvey, R.P.2    Mattick, J.S.3
  • 118
    • 79957506175 scopus 로고    scopus 로고
    • Strategic approaches to unraveling genetic causes of cardiovascular diseases
    • Marian AJ, Belmont J. Strategic approaches to unraveling genetic causes of cardiovascular diseases. Circ Res. 2011;108:1252-1269
    • (2011) Circ Res , Issue.108 , pp. 1252-1269
    • Marian, A.J.1    Belmont, J.2
  • 119
    • 84874115034 scopus 로고    scopus 로고
    • Resequencing and clinical associations of the 9p21.3 region: A comprehensive investigation in the Framingham heart study
    • Johnson AD, Hwang SJ, Voorman A, et al. Resequencing and clinical associations of the 9p21.3 region: A comprehensive investigation in the Framingham heart study. Circulation. 2013;127:799-810
    • (2013) Circulation , Issue.127 , pp. 799-810
    • Johnson, A.D.1    Hwang, S.J.2    Voorman, A.3
  • 120
    • 84855976300 scopus 로고    scopus 로고
    • Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B
    • Congrains A, Kamide K, Oguro R, et al. Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B. Atherosclerosis. 2012;220:449-455
    • (2012) Atherosclerosis , Issue.220 , pp. 449-455
    • Congrains, A.1    Kamide, K.2    Oguro, R.3
  • 121
    • 79551623370 scopus 로고    scopus 로고
    • ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS
    • Pasmant E, Sabbagh A, Vidaud M, Bièche I. ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS. FASEB J. 2011;25:444-448
    • (2011) FASEB J. , Issue.25 , pp. 444-448
    • Pasmant, E.1    Sabbagh, A.2    Vidaud, M.3    Bièche, I.4
  • 123
    • 84878646684 scopus 로고    scopus 로고
    • ANRIL: Molecular Mechanisms and Implications in Human Health
    • Congrains A, Kamide K, Ohishi M, Rakugi H. ANRIL: Molecular Mechanisms and Implications in Human Health. Int J Mol Sci. 2013;14:1278-1292
    • (2013) Int J Mol Sci , Issue.14 , pp. 1278-1292
    • Congrains, A.1    Kamide, K.2    Ohishi, M.3    Rakugi, H.4
  • 124
    • 84874969813 scopus 로고    scopus 로고
    • Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway
    • Wan G, Mathur R, Hu X, Liu Y, Zhang X, Peng G, Lu X. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway. Cell Signal. 2013;25:1086-1095
    • (2013) Cell Signal , Issue.25 , pp. 1086-1095
    • Wan, G.1    Mathur, R.2    Hu, X.3    Liu, Y.4    Zhang, X.5    Peng, G.6    Lu, X.7
  • 126
    • 79955103588 scopus 로고    scopus 로고
    • Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1
    • Tsuiji H, Yoshimoto R, Hasegawa Y, Furuno M, Yoshida M, Nakagawa S. Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1. Genes Cells. 2011;16:479-490
    • (2011) Genes Cells , Issue.16 , pp. 479-490
    • Tsuiji, H.1    Yoshimoto, R.2    Hasegawa, Y.3    Furuno, M.4    Yoshida, M.5    Nakagawa, S.6
  • 128
    • 67649671961 scopus 로고    scopus 로고
    • Long noncoding RNAs: Functional surprises from the RNA world
    • Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: Functional surprises from the RNA world. Genes Dev. 2009;23:1494-1504
    • (2009) Genes Dev , vol.23 , pp. 1494-1504
    • Wilusz, J.E.1    Sunwoo, H.2    Spector, D.L.3
  • 130
    • 80555157531 scopus 로고    scopus 로고
    • Noncoding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases
    • Gutschner T, Baas M, Diederichs S. Noncoding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases. Genome Res. 2011;21:1944-1954
    • (2011) Genome Res , vol.21 , pp. 1944-1954
    • Gutschner, T.1    Baas, M.2    Diederichs, S.3
  • 136
    • 84863115198 scopus 로고    scopus 로고
    • Intrinsic antiviral immunity
    • Yan N, Chen ZJ. Intrinsic antiviral immunity. Nat Immunol. 2012;13:214-222
    • (2012) Nat Immunol , Issue.13 , pp. 214-222
    • Yan, N.1    Chen, Z.J.2
  • 137
    • 78650511795 scopus 로고    scopus 로고
    • Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs
    • Mao YS, Sunwoo H, Zhang B, Spector DL. Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs. Nat Cell Biol. 2011;13:95-101
    • (2011) Nat Cell Biol , Issue.13 , pp. 95-101
    • Mao, Y.S.1    Sunwoo, H.2    Zhang, B.3    Spector, D.L.4
  • 138
    • 84874614275 scopus 로고    scopus 로고
    • NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression
    • Zhang Q, Chen CY, Yedavalli VS, Jeang KT. NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression. MBio. 2013;4:e00596-e00512
    • (2013) MBio , Issue.4
    • Zhang, Q.1    Chen, C.Y.2    Yedavalli, V.S.3    Jeang, K.T.4
  • 139
    • 5144222861 scopus 로고    scopus 로고
    • Inhibition of alloresponse by a human trophoblast non-coding RNA suppressing class II transactivator promoter III and major histocompatibility class II expression in murine B-lymphocytes
    • Geirsson A, Bothwell AL, Hammond GL. Inhibition of alloresponse by a human trophoblast non-coding RNA suppressing class II transactivator promoter III and major histocompatibility class II expression in murine B-lymphocytes. J Heart Lung Transplant. 2004;23:1077-1081
    • (2004) J Heart Lung Transplant , vol.23 , pp. 1077-1081
    • Geirsson, A.1    Bothwell, A.L.2    Hammond, G.L.3
  • 140
    • 0041766147 scopus 로고    scopus 로고
    • Class II transactivator promoter activity is suppressed through regulation by a trophoblast noncoding RNA
    • Geirsson A, Paliwal I, Lynch RJ, Bothwell AL, Hammond GL. Class II transactivator promoter activity is suppressed through regulation by a trophoblast noncoding RNA. Transplantation. 2003;76:387-394
    • (2003) Transplantation , vol.76 , pp. 387-394
    • Geirsson, A.1    Paliwal, I.2    Lynch, R.J.3    Bothwell, A.L.4    Hammond, G.L.5
  • 143
    • 84874760989 scopus 로고    scopus 로고
    • RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function
    • Blattmann P, Schuberth C, Pepperkok R, Runz H. RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function. PLoS Genet. 2013;9:e1003338
    • (2013) PLoS Genet , Issue.9
    • Blattmann, P.1    Schuberth, C.2    Pepperkok, R.3    Runz, H.4
  • 144
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A networkbased approach to human disease
    • Barabási AL, Gulbahce N, Loscalzo J. Network medicine: A networkbased approach to human disease. Nat Rev Genet. 2011;12:56-68
    • (2011) Nat Rev Genet , Issue.12 , pp. 56-68
    • Barabási, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 146
    • 84857138320 scopus 로고    scopus 로고
    • Wiley Interdiscip Rev RNA
    • Lehman N. RNA in evolution. Wiley Interdiscip Rev RNA. 2010;1:202-213
    • (2010) RNA in Evolution , Issue.1 , pp. 202-213
    • Lehman, N.1
  • 147
    • 51449085579 scopus 로고    scopus 로고
    • Origins and evolution of eukaryotic RNA interference
    • Shabalina SA, Koonin EV. Origins and evolution of eukaryotic RNA interference. Trends Ecol Evol. 2008;23:578-587
    • (2008) Trends Ecol Evol , vol.23 , pp. 578-587
    • Shabalina, S.A.1    Koonin, E.V.2
  • 149
    • 84873606896 scopus 로고    scopus 로고
    • Evolution of animal and plant dicers: Early parallel duplications and recurrent adaptation of antiviral RNA binding in plants
    • Mukherjee K, Campos H, Kolaczkowski B. Evolution of animal and plant dicers: Early parallel duplications and recurrent adaptation of antiviral RNA binding in plants. Mol Biol Evol. 2013;30:627-641
    • (2013) Mol Biol Evol , Issue.30 , pp. 627-641
    • Mukherjee, K.1    Campos, H.2    Kolaczkowski, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.