Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy

Journal of Molecular Medicine

Volumn 86, Issue 9, 2008, Pages 987-997

  Fechner, Henry ^a   Sipo, Isaac ^a   Westermann, Dirk ^a   Pinkert, Sandra ^a   Wang, Xiaomin ^a   Suckau, Lennart ^a   Kurreck, Jens ^b,d   Zeichhardt, Heinz ^a   Müller, Oliver ^c   Vetter, Roland ^a   Erdmann, Volker ^b   Tschope, Carsten ^a   Poller, Wolfgang ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d UNIVERSITY OF STUTTGART   (Germany)

Author keywords

Coxsackievirus; Gene silencing; Gene therapy; RNA interference; Virus infections

Indexed keywords

ADENOVIRUS VECTOR; RNA POLYMERASE; SHORT HAIRPIN RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CELL DEATH; CONTROLLED STUDY; COXSACKIE VIRUS B; DIASTOLE; EMBRYO; FEMALE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE RELAXATION; HEART PROTECTION; HUMAN; HUMAN CELL; NEWBORN; NONHUMAN; RAT; RNA INTERFERENCE; VIRUS CAPSID; VIRUS REPLICATION;

ADULT; ANIMALS; BASE SEQUENCE; CARDIOMYOPATHIES; CELL LINE; CHILD; COXSACKIEVIRUS INFECTIONS; DEPENDOVIRUS; ENTEROVIRUS B, HUMAN; GENETIC VECTORS; HEART; HEMODYNAMICS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MYOCARDIUM; RATS; RNA INTERFERENCE; RNA REPLICASE; RNA, VIRAL; VIRAL PROTEINS;

EID: 49749088323     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-008-0363-x     Document Type: Article

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