메뉴 건너뛰기




Volumn 9, Issue 2, 2013, Pages

RNAi-Based Functional Profiling of Loci from Blood Lipid Genome-Wide Association Studies Identifies Genes with Cholesterol-Regulatory Function

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GREEN FLUORESCENT PROTEIN; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; STROMAL CELL DERIVED FACTOR 1; TRIACYLGLYCEROL;

EID: 84874760989     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003338     Document Type: Article
Times cited : (47)

References (49)
  • 1
    • 58149161560 scopus 로고    scopus 로고
    • Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    • Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, et al. (2009) Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 41: 47-55.
    • (2009) Nat Genet , vol.41 , pp. 47-55
    • Aulchenko, Y.S.1    Ripatti, S.2    Lindqvist, I.3    Boomsma, D.4    Heid, I.M.5
  • 2
    • 55449105227 scopus 로고    scopus 로고
    • Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13
    • Burkhardt R, Kenny EE, Lowe JK, Birkeland A, Josowitz R, et al. (2008) Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. Arterioscler Thromb Vasc Biol 28: 2078-2084.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2078-2084
    • Burkhardt, R.1    Kenny, E.E.2    Lowe, J.K.3    Birkeland, A.4    Josowitz, R.5
  • 3
    • 73649103089 scopus 로고    scopus 로고
    • Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis
    • doi:10.1371/journal.pgen.1000730
    • Chasman DI, Pare G, Mora S, Hopewell JC, Peloso G, et al. (2009) Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet 5: e1000730 doi:10.1371/journal.pgen.1000730.
    • (2009) PLoS Genet , vol.5
    • Chasman, D.I.1    Pare, G.2    Mora, S.3    Hopewell, J.C.4    Peloso, G.5
  • 4
  • 5
  • 6
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • Kathiresan S, Melander O, Guiducci C, Surti A, Burtt NP, et al. (2008) Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 40: 189-197.
    • (2008) Nat Genet , vol.40 , pp. 189-197
    • Kathiresan, S.1    Melander, O.2    Guiducci, C.3    Surti, A.4    Burtt, N.P.5
  • 8
    • 38649084407 scopus 로고    scopus 로고
    • Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    • Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, et al. (2008) Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet 40: 149-151.
    • (2008) Nat Genet , vol.40 , pp. 149-151
    • Kooner, J.S.1    Chambers, J.C.2    Aguilar-Salinas, C.A.3    Hinds, D.A.4    Hyde, C.L.5
  • 9
    • 34249996115 scopus 로고    scopus 로고
    • A common allele on chromosome 9 associated with coronary heart disease
    • McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, et al. (2007) A common allele on chromosome 9 associated with coronary heart disease. Science 316: 1488-1491.
    • (2007) Science , vol.316 , pp. 1488-1491
    • McPherson, R.1    Pertsemlidis, A.2    Kavaslar, N.3    Stewart, A.4    Roberts, R.5
  • 10
    • 70749096913 scopus 로고    scopus 로고
    • Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    • Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, et al. (2009) Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 41: 334-341.
    • (2009) Nat Genet , vol.41 , pp. 334-341
    • Kathiresan, S.1    Voight, B.F.2    Purcell, S.3    Musunuru, K.4    Ardissino, D.5
  • 11
    • 58149262866 scopus 로고    scopus 로고
    • A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
    • Pollin TI, Damcott CM, Shen H, Ott SH, Shelton J, et al. (2008) A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection. Science 322: 1702-1705.
    • (2008) Science , vol.322 , pp. 1702-1705
    • Pollin, T.I.1    Damcott, C.M.2    Shen, H.3    Ott, S.H.4    Shelton, J.5
  • 12
    • 67649367650 scopus 로고    scopus 로고
    • Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study
    • Ridker PM, Pare G, Parker AN, Zee RY, Miletich JP, et al. (2009) Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study. Circ Cardiovasc Genet 2: 26-33.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 26-33
    • Ridker, P.M.1    Pare, G.2    Parker, A.N.3    Zee, R.Y.4    Miletich, J.P.5
  • 13
    • 58149159573 scopus 로고    scopus 로고
    • Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
    • Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, et al. (2009) Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 41: 35-46.
    • (2009) Nat Genet , vol.41 , pp. 35-46
    • Sabatti, C.1    Service, S.K.2    Hartikainen, A.L.3    Pouta, A.4    Ripatti, S.5
  • 16
    • 79953204259 scopus 로고    scopus 로고
    • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
    • Schunkert H, Konig IR, Kathiresan S, Reilly MP, Assimes TL, et al. (2011) Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 43: 333-338.
    • (2011) Nat Genet , vol.43 , pp. 333-338
    • Schunkert, H.1    Konig, I.R.2    Kathiresan, S.3    Reilly, M.P.4    Assimes, T.L.5
  • 17
  • 18
    • 61349137526 scopus 로고    scopus 로고
    • Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
    • Tregouet DA, Konig IR, Erdmann J, Munteanu A, Braund PS, et al. (2009) Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet 41: 283-285.
    • (2009) Nat Genet , vol.41 , pp. 283-285
    • Tregouet, D.A.1    Konig, I.R.2    Erdmann, J.3    Munteanu, A.4    Braund, P.S.5
  • 19
    • 38749149611 scopus 로고    scopus 로고
    • Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
    • Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, et al. (2008) Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet 82: 139-149.
    • (2008) Am J Hum Genet , vol.82 , pp. 139-149
    • Wallace, C.1    Newhouse, S.J.2    Braund, P.3    Zhang, F.4    Tobin, M.5
  • 20
    • 38649125868 scopus 로고    scopus 로고
    • Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    • Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, et al. (2008) Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 40: 161-169.
    • (2008) Nat Genet , vol.40 , pp. 161-169
    • Willer, C.J.1    Sanna, S.2    Jackson, A.U.3    Scuteri, A.4    Bonnycastle, L.L.5
  • 21
    • 78149245489 scopus 로고    scopus 로고
    • Genetic variants influencing circulating lipid levels and risk of coronary artery disease
    • Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, et al. (2010) Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol 30: 2264-2276.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2264-2276
    • Waterworth, D.M.1    Ricketts, S.L.2    Song, K.3    Chen, L.4    Zhao, J.H.5
  • 22
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • The Wellcome Trust Case Control Consortium
    • The Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 23
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, et al. (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316: 1331-1336.
    • (2007) Science , vol.316 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3    Burtt, N.P.4    de Bakker, P.I.5
  • 24
    • 77955499945 scopus 로고    scopus 로고
    • From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
    • Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, et al. (2010) From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466: 714-719.
    • (2010) Nature , vol.466 , pp. 714-719
    • Musunuru, K.1    Strong, A.2    Frank-Kamenetsky, M.3    Lee, N.E.4    Ahfeldt, T.5
  • 25
    • 77954407332 scopus 로고    scopus 로고
    • Genomewide association studies and assessment of the risk of disease
    • Manolio TA, (2010) Genomewide association studies and assessment of the risk of disease. N Engl J Med 363: 166-176.
    • (2010) N Engl J Med , vol.363 , pp. 166-176
    • Manolio, T.A.1
  • 26
    • 79951481957 scopus 로고    scopus 로고
    • Initial impact of the sequencing of the human genome
    • Lander ES, (2011) Initial impact of the sequencing of the human genome. Nature 470: 187-197.
    • (2011) Nature , vol.470 , pp. 187-197
    • Lander, E.S.1
  • 27
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • Altshuler D, Daly MJ, Lander ES, (2008) Genetic mapping in human disease. Science 322: 881-888.
    • (2008) Science , vol.322 , pp. 881-888
    • Altshuler, D.1    Daly, M.J.2    Lander, E.S.3
  • 29
    • 77953626646 scopus 로고    scopus 로고
    • Genomic screening with RNAi: results and challenges
    • Mohr S, Bakal C, Perrimon N, (2010) Genomic screening with RNAi: results and challenges. Annu Rev Biochem 79: 37-64.
    • (2010) Annu Rev Biochem , vol.79 , pp. 37-64
    • Mohr, S.1    Bakal, C.2    Perrimon, N.3
  • 30
    • 67649424755 scopus 로고    scopus 로고
    • Identification of cholesterol-regulating genes by targeted RNAi screening
    • Bartz F, Kern L, Erz D, Zhu M, Gilbert D, et al. (2009) Identification of cholesterol-regulating genes by targeted RNAi screening. Cell Metab 10: 63-75.
    • (2009) Cell Metab , vol.10 , pp. 63-75
    • Bartz, F.1    Kern, L.2    Erz, D.3    Zhu, M.4    Gilbert, D.5
  • 31
    • 34347220153 scopus 로고    scopus 로고
    • Reverse transfection on cell arrays for high content screening microscopy
    • Erfle H, Neumann B, Liebel U, Rogers P, Held M, et al. (2007) Reverse transfection on cell arrays for high content screening microscopy. Nat Protoc 2: 392-399.
    • (2007) Nat Protoc , vol.2 , pp. 392-399
    • Erfle, H.1    Neumann, B.2    Liebel, U.3    Rogers, P.4    Held, M.5
  • 32
    • 77950387346 scopus 로고    scopus 로고
    • Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes
    • Neumann B, Walter T, Heriche JK, Bulkescher J, Erfle H, et al. (2010) Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 464: 721-727.
    • (2010) Nature , vol.464 , pp. 721-727
    • Neumann, B.1    Walter, T.2    Heriche, J.K.3    Bulkescher, J.4    Erfle, H.5
  • 33
    • 80051469646 scopus 로고    scopus 로고
    • Genome-Wide RNAi Screens Identify Genes Required for Ricin and PE Intoxications
    • Moreau D, Kumar P, Wang SC, Chaumet A, Chew SY, et al. (2011) Genome-Wide RNAi Screens Identify Genes Required for Ricin and PE Intoxications. Dev Cell 21: 231-244.
    • (2011) Dev Cell , vol.21 , pp. 231-244
    • Moreau, D.1    Kumar, P.2    Wang, S.C.3    Chaumet, A.4    Chew, S.Y.5
  • 34
    • 39349097864 scopus 로고    scopus 로고
    • Identification of host proteins required for HIV infection through a functional genomic screen
    • Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, et al. (2008) Identification of host proteins required for HIV infection through a functional genomic screen. Science 319: 921-926.
    • (2008) Science , vol.319 , pp. 921-926
    • Brass, A.L.1    Dykxhoorn, D.M.2    Benita, Y.3    Yan, N.4    Engelman, A.5
  • 35
    • 55249088255 scopus 로고    scopus 로고
    • Genome-scale RNAi screen for host factors required for HIV replication
    • Zhou H, Xu M, Huang Q, Gates AT, Zhang XD, et al. (2008) Genome-scale RNAi screen for host factors required for HIV replication. Cell Host Microbe 4: 495-504.
    • (2008) Cell Host Microbe , vol.4 , pp. 495-504
    • Zhou, H.1    Xu, M.2    Huang, Q.3    Gates, A.T.4    Zhang, X.D.5
  • 36
    • 52949130695 scopus 로고    scopus 로고
    • Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication
    • Konig R, Zhou Y, Elleder D, Diamond TL, Bonamy GM, et al. (2008) Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 135: 49-60.
    • (2008) Cell , vol.135 , pp. 49-60
    • Konig, R.1    Zhou, Y.2    Elleder, D.3    Diamond, T.L.4    Bonamy, G.M.5
  • 37
    • 79959895383 scopus 로고    scopus 로고
    • The phospholipase A2 enzyme complex PAFAH Ib mediates endosomal membrane tubule formation and trafficking
    • Bechler ME, Doody AM, Ha KD, Judson BL, Chen I, et al. (2011) The phospholipase A2 enzyme complex PAFAH Ib mediates endosomal membrane tubule formation and trafficking. Mol Biol Cell 22: 2348-2359.
    • (2011) Mol Biol Cell , vol.22 , pp. 2348-2359
    • Bechler, M.E.1    Doody, A.M.2    Ha, K.D.3    Judson, B.L.4    Chen, I.5
  • 40
    • 84863393589 scopus 로고    scopus 로고
    • The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals
    • Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, et al. (2012) The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab 15: 240-246.
    • (2012) Cell Metab , vol.15 , pp. 240-246
    • Moon, Y.A.1    Liang, G.2    Xie, X.3    Frank-Kamenetsky, M.4    Fitzgerald, K.5
  • 42
    • 80655144889 scopus 로고    scopus 로고
    • The bladder tumor suppressor protein TERE1 (UBIAD1) modulates cell cholesterol: implications for tumor progression
    • Fredericks WJ, McGarvey T, Wang H, Lal P, Puthiyaveettil R, et al. (2011) The bladder tumor suppressor protein TERE1 (UBIAD1) modulates cell cholesterol: implications for tumor progression. DNA Cell Biol 30: 851-864.
    • (2011) DNA Cell Biol , vol.30 , pp. 851-864
    • Fredericks, W.J.1    McGarvey, T.2    Wang, H.3    Lal, P.4    Puthiyaveettil, R.5
  • 43
    • 84861473712 scopus 로고    scopus 로고
    • Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice
    • doi:10.1371/journal.pone.0037803
    • Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, et al. (2012) Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice. PLoS ONE 7: e37803 doi:10.1371/journal.pone.0037803.
    • (2012) PLoS ONE , vol.7
    • Uebi, T.1    Itoh, Y.2    Hatano, O.3    Kumagai, A.4    Sanosaka, M.5
  • 44
    • 0037082099 scopus 로고    scopus 로고
    • Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis
    • Goldstein JL, Rawson RB, Brown MS, (2002) Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Archives of biochemistry and biophysics 397: 139-148.
    • (2002) Archives of Biochemistry and Biophysics , vol.397 , pp. 139-148
    • Goldstein, J.L.1    Rawson, R.B.2    Brown, M.S.3
  • 45
    • 77949424084 scopus 로고    scopus 로고
    • Systems survey of endocytosis by multiparametric image analysis
    • Collinet C, Stoter M, Bradshaw CR, Samusik N, Rink JC, et al. (2010) Systems survey of endocytosis by multiparametric image analysis. Nature 464: 243-249.
    • (2010) Nature , vol.464 , pp. 243-249
    • Collinet, C.1    Stoter, M.2    Bradshaw, C.R.3    Samusik, N.4    Rink, J.C.5
  • 46
    • 49249126411 scopus 로고    scopus 로고
    • Work flow for multiplexing siRNA assays by solid-phase reverse transfection in multiwell plates
    • Erfle H, Neumann B, Rogers P, Bulkescher J, Ellenberg J, et al. (2008) Work flow for multiplexing siRNA assays by solid-phase reverse transfection in multiwell plates. J Biomol Screen 13: 575-580.
    • (2008) J Biomol Screen , vol.13 , pp. 575-580
    • Erfle, H.1    Neumann, B.2    Rogers, P.3    Bulkescher, J.4    Ellenberg, J.5
  • 47
    • 33845792555 scopus 로고    scopus 로고
    • CellProfiler: image analysis software for identifying and quantifying cell phenotypes
    • Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, et al. (2006) CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol 7: R100.
    • (2006) Genome Biol , vol.7
    • Carpenter, A.E.1    Jones, T.R.2    Lamprecht, M.R.3    Clarke, C.4    Kang, I.H.5
  • 48
    • 79959224232 scopus 로고    scopus 로고
    • Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain
    • Arthur JR, Heinecke KA, Seyfried TN, (2011) Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain. J Lipid Res 52: 1345-1351.
    • (2011) J Lipid Res , vol.52 , pp. 1345-1351
    • Arthur, J.R.1    Heinecke, K.A.2    Seyfried, T.N.3
  • 49
    • 84863205689 scopus 로고    scopus 로고
    • Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway
    • Simpson JC, Joggerst B, Laketa V, Verissimo F, Cetin C, et al. (2012) Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway. Nature cell biology 14: 764-774.
    • (2012) Nature Cell Biology , vol.14 , pp. 764-774
    • Simpson, J.C.1    Joggerst, B.2    Laketa, V.3    Verissimo, F.4    Cetin, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.