The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: Evidence from two-photon imaging

Cardiovascular Research

Volumn 83, Issue 2, 2009, Pages 335-344

  Kato, Masashi ^a   Akao, Masaharu ^a   Matsumoto Ida, Madoka ^a   Makiyama, Takeru ^a   Iguchi, Moritake ^a   Takeda, Toshihiro ^a   Shimizu, Shigeomi ^b   Kita, Toru ^a  

^a KYOTO UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Cardioprotection; Cyclophilin D; Ischaemia reperfusion; Mitochondrial permeability transition; Two photon imaging

Indexed keywords

CYCLOPHILIN D; CYCLOPHILIN D SHORT INTERFERING RNA; MESSENGER RNA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; OXIDIZING AGENT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG INHIBITION; DRUG TARGETING; GENE SILENCING; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; INJECTION; ISOLATED HEART; LASER MICROSCOPY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; REPERFUSION INJURY; RNA INTERFERENCE; RNA SYNTHESIS; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CYCLOPHILINS; CYTOPROTECTION; GENE THERAPY; GENETIC VECTORS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PERFUSION; RATS; RATS, WISTAR; RNA INTERFERENCE; TIME FACTORS; TRANSDUCTION, GENETIC;

EID: 67650248551     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp094     Document Type: Article

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