Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

Nature Biotechnology

Volumn 30, Issue 6, 2012, Pages 543-548

  Whitehead, Timothy A ^a,e   Chevalier, Aaron ^a   Song, Yifan ^a   Dreyfus, Cyrille ^b   Fleishman, Sarel J ^a,f   De Mattos, Cecilia ^c   Myers, Chris A ^c   Kamisetty, Hetunandan ^a   Blair, Patrick ^c   Wilson, Ian A ^b   Baker, David ^a,d  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c NAVAL MEDICAL CENTER SAN DIEGO   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e Michigan State University   (United States)

^f WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY MATURATION; BINDING AFFINITIES; COMPREHENSIVE ENERGY; COMPUTATIONAL DESIGN; CONVENTIONAL APPROACH;

BINDING ENERGY; VIRUSES;

OPTIMIZATION;

INFLUENZA VIRUS HEMAGGLUTININ; MONOCLONAL ANTIBODY;

ARTICLE; BINDING AFFINITY; CROSS REACTION; INFLUENZA VIRUS A H1N1; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SEQUENCE ANALYSIS;

ANIMALS; ANTIVIRAL AGENTS; CELL SURVIVAL; COMPUTATIONAL BIOLOGY; DOGS; DRUG DISCOVERY; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; INFLUENZA A VIRUS, H1N1 SUBTYPE; MADIN DARBY CANINE KIDNEY CELLS; MODELS, MOLECULAR; NEUTRALIZATION TESTS; PROTEIN BINDING; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 84862025262     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2214     Document Type: Article

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