Model of the mass transport to the surface of animal cells cultured in a rotating bioreactor operated in micro gravity

Biotechnology and Bioengineering

Volumn 94, Issue 3, 2006, Pages 495-504

  Rivera Solorio, Ivan ^a   Kleis, Stanley J ^b  

^a SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

^b University of Houston   (United States)

Author keywords

Bioreactor; Dissolved oxygen; Mammalian cells; Mass transport; Microgravity

Indexed keywords

ANIMAL CELL CULTURE; CONCENTRATION (PROCESS); CORRELATION METHODS; DIFFUSION; DISSOLVED OXYGEN SENSORS; GRAVITATIONAL EFFECTS; MATHEMATICAL MODELS; REYNOLDS NUMBER; SURFACE PHENOMENA;

DISSOLVED OXYGEN; MAMMALIAN CELLS; MASS TRANSPORT; MICROGRAVITY; SHERWOOD NUMBER;

BIOREACTORS;

DISSOLVED OXYGEN;

ANIMAL CELL CULTURE; ARTICLE; BIOREACTOR; GRAVITY; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL;

ANIMALS; BIOLOGICAL TRANSPORT; BIOREACTORS; CELLS, CULTURED; DIFFUSION; MODELS, BIOLOGICAL; OXYGEN; OXYGEN CONSUMPTION; WEIGHTLESSNESS;

ANIMALIA;

EID: 33745200972     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.20864     Document Type: Article

References (17)

1. Barth TJ, Jespersen D. 1989. The design and application of upwind schemes on unstructured meshes. Technical Report AIAA-89-0366, AIAA 27th Aerospace Sciences Meeting, Reno, Nevada.
2. Begley CM. 1999. Fluid dynamics studies of the NASA/JSC RWPV bioreactor for cell culture in microgravity. Ph.D. Dissertation, University of Houston, Houston, TX.
3. Begley CM, Kleis SJ. 2000. The fluid dynamics and shear environment in the NASA JSC rotating-wall perfused vessel bioreactor. Biotechnol Bioeng 70:32-40.
4. Begley CM, Kleis SJ. 2002. RWPV Bioreactor mass transport: Earth-based and in microgravity. Biotechnol Bioeng 80(4):465-476.
5. Ferziger JH, Peric M. 1999. Computational methods for fluid dynamics, 2nd edition. New York: Springer.
6. Freed LE, Vunjak-Novakovic G. 1995. Cultivation of cell-polymer tissue construct in simulated microgravity. Biotechnol Bioeng 46:306-313.
7. Freed LE, Langer R, Martin I, Pellis NR, Vunjak-Novakovic G. 1997. Tissue engineering of cartilage in space. Proc Natl Acad Sci USA 94:13885-13890.
8. Goodwin TJ, Jessup JM, Wold DA. 1992. Morphologic differentiation of colon carcinoma cell lines HT-29 and HT-29KM in rotating-wall vessels. In Vitro Cell Dev Biol 28A:47-60.
9. Jorjani P, Ozturk SS. 1999. Effects of cell density and temperature on oxygen consumption rate of different mammalian cell lines. Biotechnol Bioeng 64(3):349-356.
10. Kargi F, Moo-Young M. 1985. Transport phenomena in bioprocesses. Compr Biotechnol: Prin Appl Regul Biotechnol Ind Agric Med 2:5-56.
11. Kleis SJ, Rivera-Solorio I. 2003. Time scales for unsteady mass transfer from a sphere at low finite Reynolds numbers. J Heat Transfer 125(4):716-723.
12. Miller WM, Wilke CR, Blanch HW. 1987. Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture. J Cell Physiol 132:524-530.
13. Riesle J, Hollander AP, Langer R, Freed LE, Vunjak-Novakovic G. 1998. Collagen in tissue-engineered cartilage: Types, structure and crosslink. J Cell Biochem 17:313-327.
14. Rivera-Solorio I. 2001. Local mass transfer for bioreactors in micro-gravity. Ph.D. Dissertation, University of Houston, Houston, TX.
15. Shuler ML, Kargi F. 1991. Bioprocess engineering: Basic concepts, 1st edition. New Jersey: Prentice Hall International Series in the Physical and Chemical Engineering Sciences.
16. Van Wezel AL. 1973. Microcarrier cultures of animal cells. Tissue culture: Methods and applications, Vol. II. New York: Academic Press.
17. Williams KA, Saini S, Wick TM. 2002. Computational fluid dynamics: Modeling of steady-state momentum and mass transport in a bioreactor for cartilage tissue engineering. Biotechnol Prog 18:951-963.