Combination of on-line pH and oxygen transfer rate measurement in shake flasks by fiber optical technique and Respiration Activity MOnitoring System (RAMOS)

Sensors

Volumn 7, Issue 12, 2007, Pages 3472-3480

  Scheidle, Marco ^a   Klinger, Johannes ^a   Büchs, Jochen ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

E. Coli; Fiber optical pH measurement; Oxygen transfer rate; Process development; RAMOS; Shaking flask

Indexed keywords

BOTTLES; ESCHERICHIA COLI; FIBERS; OPTICAL ENGINEERING; PH; POTENTIOMETRIC SENSORS;

E. COLI; OXYGEN TRANSFER RATE; PH MEASUREMENTS; PROCESS DEVELOPMENT; RAMOS; SHAKING FLASKS;

OXYGEN;

EID: 39749175542     PISSN: 14243210     EISSN: 14248220     Source Type: Journal    
DOI: 10.3390/s7123472     Document Type: Article

References (28)

1. Anderlei, T.; Buchs, J. Device for sterile online measurement of the oxygen transfer rate in shaking flasks. Biochemical Engineering Journal 2001, 7(2), 157-162.
2. Anderlei, T.; Zang, W.; Papaspyrou, M.; Buchs, J. Online respiration activity measurement (OTR, CTR, RQ) in shake flasks. Biochemical Engineering Journal 2004, 17(3), 187-194.
3. Buchs, J. Introduction to advantages and problems of shaken cultures. Biochemical Engineering Journal 2001, 7(2), 91-98.
4. Buchs, J. Biochemical Engineering Journal - Preface. Biochemical Engineering Journal 2004, 17(3), 153-153.
5. Christensen, M.L.; Eriksen, N.T. Growth and proton exchange in recombinant Escherichia coli BL21. Enzyme and Microbial Technology 2002, 31, 566-574.
6. Danielson, P.B.; Buchs, J.; Stockmann, C.; Fogleman, J.C. Maximizing cell densities in miniprepscale cultures with H15 medium and improved oxygen transfer. Biochemical Engineering Journal 2004, 17(3), 175-180.
7. st Ed.; Krieg N.R., Holt J.G., Eds.; Williams and Wilkins: Baltimore, 1984; 1, 267-278.
8. Freyer, S.A.; König, M.; Kunkel, A. Validating shaking flasks as representativ screening systems. Biochemical Engineering Journal 2004, 17, 169-173.
9. Hermann, R.; Walther, N.; Maier, U.; Buchs, J. Optical method for the determination of the oxygen-transfer capacity of small bioreactors based on sulfite oxidation. Biotechnology and Bioengineering 2001, 74(5), 355-363.
10. Huber, C.; Klimant, I.; Krause, C.; Werner, T.; Mayr, T.; Wolfbeis, O.S. Optical sensor for seawater salinity. Fresenius' Journal of Analytical Chemistry 2000, 368(2), 196-202.
11. Jeude, M.; Dittrich, B.; Niederschulte, H.; Anderlei, T.; Knocke, C.; Klee, D.; Buchs, J. Fedbatch mode in shake flasks by slow-release technique. Biotechnol Bioeng 2006, 95(3), 433-45.
12. John, G.T.; Goelling, D.; Klimant, I.; Schneider, H.; Heinzle, E. pH-sensing 96-well microtitre plates for the characterization of acid production by dairy starter cultures. J Dairy Res 2003, 70(3), 327-33.
13. Kensy, F.; John, G.T.; Hofmann, B.; Buchs, J. Characterisation of operation conditions and online monitoring of physiological culture parameters in shaken 24-well microtiter plates. Bioprocess and Biosystems Engineering 2005, 28(2), 75-81.
14. Levering, P.R.; Weenk, G.; Olijve, W.; Dijkhuizen, L.; Harder, W. Regulation of gluconate and ketogluconate production in Gluconobacter oxydans ATCC 621-H. Archives of Microbiology 1988, 149(6), 534-539.
15. Losen, M.; Frolich, B.; Pohl, M.; Buchs, J. Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures. Biotechnology Progress 2004, 20(4), 1062-1068.
16. Maier, U.; Losen, M.; Buchs, J. Advances in understanding and modeling the gas-liquid mass transfer in shake flasks. Biochemical Engineering Journal 2004, 17(3), 155-167.
17. Peter, C.P.; Lotter, S.; Maier, U.; Buchs, J. Impact of out-of-phase conditions on screening results in shaking flask experiments. Biochemical Engineering Journal 2004, 17(3), 205-215.
18. Puskeiler, R.; Kusterer, A.; John, G.T.; Weuster-Botz, D. Miniature bioreactors for automated high-throughput bioprocess design (HTBD): Reproducibility of parallel fed-batch cultivations with Escherichia coli. Biotechnol Appl Biochem 2005.
19. Qazi, G.N.; Parshad, R.; Verma, V.; Chopra, C.L.; Buse, R.; Trager, M.; Onken, U. Diketogluconate fermentation by Gluconobacter oxydans. Enzyme and Microbial Technology 1991, 13(6), 504-507.
20. Samorski, M.; Müller-Newen, G.; Buchs, J. Quasi-continuous combined scattered light and fluorescence measurements: a novel measurement technique for shaken microtiter plates. Biotechnol Bioeng 2005, 92(1), 61-8.
21. Seletzky, J.; Noack, U.; Fricke, J.; Hahn, S.; Buchs, J. Metabolic activity of Corynebacterium glutamicum grown on 1 -lactic acid under stress. Applied Microbiology and Biotechnology 2006, 72(6), 1297-1307.
22. Seletzky, J.M.; Noack, U.; Hahn, S.; Knoll, A.; Amoabediny, G.; Buchs, J. An experimental comparison of respiration measuring techniques in fermenters and shake flasks: exhaust gas analyzer vs. RAMOS device vs. respirometer. J Ind Microbiol Biotechnol 2007, 34(2), 123-30.
23. Siano, S.A. On the use of the pH control reagent addition rate for fermentation monitoring. Biotechnology and Bioengineering 1995, 47(6), 651-665.
24. Silberbach, M.; Maier, B.; Zimmermann, M.; Buchs, J. Glucose oxidation by Gluconobacter oxydans: characterization in shaking-flasks, scale-up and optimization of the pH profile. Applied Microbiology and Biotechnology 2003, 52(1), 92-98.
25. Stöckmann, C.; Losen, M.; Dahlems, U.; Knocke, C.; Gellissen, G.; Büchs, J. Effect of oxygen supply on passaging, stabilising and screening of recombinant Hansenula polymorpha production strains in test tube cultures. FEMS Yeast Res 2003, 4(2), 195-205.
26. Stöckmann, C.; Maier, U.; Anderlei, T.; Knocke, C.; Gellissen, G.; Buchs, J. The oxygen transfer rate as key parameter for the characterization of Hansenula polymorpha screening cultures. Journal of Industrial Microbiology & Biotechnology 2003, 30(10), 613-622.
27. Wilms, B.; Hauck, A.; Reuss, M.; Syldatk, C.; Mattes, R.; Siemann, M.; Altenbuchner, J. Highcell-density fermentation for production of L-N-carbamoylase using an expression system based on the Escherichia coli rhaBAD promoter. Biotechnology and Bioengineering 2001, 73(2), 95-103.
28. Zimmermann, H.F.; Anderlei, T.; Buchs, J.; Binder, M. Oxygen limitation is a pitfall during screening for industrial strains. Appl Microbiol Biotechnol 2006, 72(6), 1157-60.