High doses of vitamin E improve mitochondrial dysfunction in rat hippocampus and frontal cortex upon aging

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 300, Issue 4, 2011, Pages

  Navarro, Ana ^a   Bandez, Manuel J ^a   Lopez Cepero, Jose M ^a   Gómez, Carmen ^a   Boveris, Alejandro D ^b   Cadenas, Enrique ^c   Boveris, Alberto ^b  

^a UNIVERSITY OF CÁDIZ   (Spain)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Antioxidant protection; Brain aging; Complex I syndrome; Frontal cortex aging; Hippocampus aging

Indexed keywords

ALPHA TOCOPHEROL; NITRIC OXIDE SYNTHASE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVITY; FRONTAL CORTEX; HIPPOCAMPUS; MALE; MITOCHONDRION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; SURVIVAL RATE;

AGING; ANIMALS; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX IV; FRONTAL LOBE; HIPPOCAMPUS; HYDROGEN PEROXIDE; MALE; MITOCHONDRIA; MODELS, ANIMAL; NITRIC OXIDE SYNTHASE; OXYGEN; RATS; RATS, WISTAR; VITAMIN E;

EID: 79954528153     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00525.2010     Document Type: Article

References (40)

1. Abramoff MD, Magelhaes PJ, Ram SJ. Image processing with ImageJ. In: Biophotonics International 11: 36-42, 2004.
2. Baloyannis SJ. Mitochondrial alterations in Alzheimer's disease. J Alzheimers Dis 9: 119-126, 2006.
3. Berlett BS, Stadtman ER. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272: 20313-20316, 1997.
4. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297: 842-857, 2007.
5. Boveris A. Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria. Methods Enzymol 105: 429-435, 1984.
6. Boveris A, Arnaiz SL, Bustamante J, Alvarez S, Valdez L, Boveris AD, Navarro A. Pharmacological regulation of mitochondrial nitric oxide synthase. Methods Enzymol 359: 328-339, 2002.
7. Boveris A, Costa LE, Cadenas E, Poderoso JJ. Regulation of mitochondrial respiration by adenosine diphosphate, oxygen, and nitric oxide. Methods Enzymol 301: 188-198, 1999.
8. Boveris A, Navarro A. Brain mitochondrial dysfunction in aging. IUBMB Life 60: 308-314, 2008.
9. Calabrese V, Scapagnini G, Ravagna A, Colombrita C, Spadaro F, Butterfield DA, Giuffrida Stella A. Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state. Mech Ageing Dev 125: 325-335, 2004.
10. Carreras MC, Converso DP, Lorenti AS, Barbich M, Levisman DM, Jaitovich A, Antico Arciuch VG, Galli S, Poderoso JJ. Mitochondrial nitric oxide synthase drives redox signals for proliferation and quiescence in rat liver development. Hepatology 40: 157-166, 2004.
11. Carreras MC, Franco MC, Peralta JG, Poderoso JJ. Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease. Mol Aspects Med 25: 125-139, 2004.
12. Clark JB, Nicklas WJ. The metabolism of rat brain mitochondria. Preparation and characterization. J Biol Chem 245: 4724-4731, 1970.
13. de Leon MJ, George AE, Golomb J, Tarshish C, Convit A, Kluger A, de SS, McRae T, Ferris SH, Reisberg B, Ince C, Rusinek H, Bobinski M, Quinn B, Miller DC, Wisniewski HM. Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiol Aging 18: 1-11, 1997.
14. Fjell AM, Westlye LT, Amlien I, Espeseth T, Reinvang I, Raz N, Agartz I, Salat DH, Greve DN, Fischl B, Dale AM, Walhovd KB. High consistency of regional cortical thinning in aging across multiple samples. Cereb Cortex 19: 2001-2012, 2009.
15. Fraga CG, Leibovitz BE, Tappel AL. Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: characterization and comparison with homogenates and microsomes. Free Radic Biol Med 4: 155-161, 1988.
16. Gonzalez-Flecha B, Cutrin JC, Boveris A. Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion. J Clin Invest 91: 456-464, 1993.
17. Hathcock JN, Azzi A, Blumberg J, Bray T, Dickinson A, Frei B, Jialal I, Johnston CS, Kelly FJ, Kraemer K, Packer L, Parthasarathy S, Sies H, Traber MG. Vitamins E and C are safe across a broad range of intakes. Am J Clin Nutr 81: 736-745, 2005.
18. Liu Q, Raina AK, Smith MA, Sayre LM, Perry G. Hydroxynonenal, toxic carbonyls, and Alzheimer disease. Mol Aspects Med 24: 305-313, 2003.
19. Lores-Arnaiz S, Perazzo JC, Prestifilippo JP, Lago N, D'Amico G, Czerniczyniec A, Bustamante J, Boveris A, Lemberg A. Hippocampal mitochondrial dysfunction with decreased mtNOS activity in prehepatic portal hypertensive rats. Neurochem Int 47: 362-368, 2005.
20. Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247: 3170-3175, 1972.
21. Navarro A, Boveris A. Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging. Am J Physiol Regul Integr Comp Physiol 287: R1244-R1249, 2004.
22. Navarro A, Boveris A, Bandez MJ, Sanchez-Pino MJ, Gomez C, Muntane G, Ferrer I. Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies. Free Radic Biol Med 46: 1574-1580, 2009.
23. Navarro A, Gomez C, Lopez-Cepero JM, Boveris A. Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer. Am J Physiol Regul Integr Comp Physiol 286: R505-R511, 2004.
24. Navarro A, Gomez C, Sanchez-Pino MJ, Gonzalez H, Bandez MJ, Boveris AD, Boveris A. Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice. Am J Physiol Regul Integr Comp Physiol 289: R1392-R1399, 2005.
25. Navarro A, Lopez-Cepero JM, Bandez MJ, Sanchez-Pino MJ, Gomez C, Cadenas E, Boveris A. Hippocampal mitochondrial dysfunction in rat aging. Am J Physiol Regul Integr Comp Physiol 294: R501-R509, 2008.
26. Navarro A, Sanchez Del Pino MJ, Gomez C, Peralta JL, Boveris A. Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice. Am J Physiol Regul Integr Comp Physiol 282: R985-R992, 2002.
27. Navarro A, Torrejon R, Bandez MJ, Lopez-Cepero JM, Boveris A. Mitochondrial function and mitochondria-induced apoptosis in an overstimulated rat ovarian cycle. Am J Physiol Endocrinol Metab 289: E1101-E1109, 2005.
28. Oliver CN, Ahn BW, Moerman EJ, Goldstein S, Stadtman ER. Age-related changes in oxidized proteins. J Biol Chem 262: 5488-5491, 1987.
29. Perkins GA, Ellisman MH. Mitochondrial architecture and heterogeneity. In: Hanbook of Neurochemistry and Molecular Neurobiology, edited by Lajtha A, Gibson GE, and Dienel GA. Heidelberg, Germany: Springer, 2007.
30. Sayre LM, Perry G, Smith MA. In situ methods for detection and localization of markers of oxidative stress: application in neurodegenerative disorders. Methods Enzymol 309: 133-152, 1999.
31. Sayre LM, Sha W, Xu G, Kaur K, Nadkarni D, Subbanagounder G, Salomon RG. Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal. Chem Res Toxicol 9: 1194-1201, 1996.
32. Scarpa A, Graziotti P. Mechanisms for intracellular calcium regulation in heart. I. Stopped-flow measurements of Ca++ uptake by cardiac mitochondria. J Gen Physiol 62: 756-772, 1973.
33. Schapira AH. Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol 7: 97-109, 2008.
34. Schapira AH, Cooper JM, Dexter D, Clark JB, Jenner P, Marsden CD. Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem 54: 823-827, 1990.
35. Schapira AH, Mann VM, Cooper JM, Dexter D, Daniel SE, Jenner P, Clark JB, Marsden CD. Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease. J Neurochem 55: 2142-2145, 1990.
36. Scopsi L, Larsson LI. Colloidal gold probes in immunocytochemistry. An optimization of their application in light microscopy by use of silver intensification procedures. Med Biol 64: 139-145, 1986.
37. Seligman AM, Karnovsky MJ, Wasserkrug HL, Hanker JS. Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent, diaminobenzidine (DAB). J Cell Biol 38: 1-14, 1968.
38. Valdez LB, Zaobornyj T, Boveris A. Functional activity of mitochondrial nitric oxide synthase. Methods Enzymol 396: 444-455, 2005.
39. White CR, Seymour RS. Mammalian basal metabolic rate is proportional to body mass2/3. Proc Natl Acad Sci USA 100: 4046-4049, 2003.
40. Zandi PP, Anthony JC, Khachaturian AS, Stone SV, Gustafson D, Tschanz JT, Norton MC, Welsh-Bohmer KA, Breitner JC. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol 61: 82-88, 2004.