Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences

Structure

Volumn 9, Issue 7, 2001, Pages 615-625

  Taylor, Alexander B ^a,b   Smith, Barbara S ^a,b   Kitada, Sakae ^c   Kojima, Katsuhiko ^c   Miyaura, Hideki ^c   Otwinowski, Zbyszek ^b   Ito, Akio ^c   Deisenhofer, Johann ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Crystal structure; Metallopeptidase; Mitochondrial signal sequence; Substrate complex; Zinc binding

Indexed keywords

ARGININE; CORE PROTEIN; MITOCHONDRIAL PROCESSING PEPTIDASE; MUTANT PROTEIN; PEPTIDE; PROTEIN SUBUNIT; RECOMBINANT ENZYME; SIGNAL PEPTIDASE; SYNTHETIC PEPTIDE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; MITOCHONDRION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; YEAST;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ELECTRON TRANSPORT COMPLEX III; ELECTRON TRANSPORT COMPLEX IV; MALATE DEHYDROGENASE; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PROTEIN CONFORMATION; PROTEIN SORTING SIGNALS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 0034940401     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00621-9     Document Type: Article

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