Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu 1

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 18, 2013, Pages 5091-5096

  Manka, Jason T ^a   Rodriguez, Alice L ^a   Morrison, Ryan D ^a   Venable, Daryl F ^a   Cho, Hyekyung P ^a   Blobaum, Anna L ^a   Daniels, J Scott ^a   Niswender, Colleen M ^a   Conn, P Jeffrey ^a   Lindsley, Craig W ^a,b   Emmitte, Kyle A ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Allosteric modulator; CNS; Glutamate; GPCR mGlu1; Octahydropyrrolo 3,4 c pyrrole

Indexed keywords

A 582941; CYTOCHROME P450; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR ANTAGONIST; NICOTINIC RECEPTOR BLOCKING AGENT; OCTAHYDROPYRROLO[3,4 C]PYRROLE; PIPERAZINE; PIPERAZINE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; VU 0469650;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CELL ASSAY; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG METABOLISM; DRUG POTENCY; ENZYME INHIBITION; IC 50; LIPOPHILICITY; NONHUMAN; PROTEIN BINDING; RING OPENING; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC MODULATOR; CNS; GLUTAMATE; GPCR; MGLU(1); OCTAHYDROPYRROLO[3,4-C]PYRROLE;

ALLOSTERIC REGULATION; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; PYRROLES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882639949     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.07.029     Document Type: Article

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