Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 18, 2009, Pages 5464-5468

  Satoh, Atsushi ^a   Nagatomi, Yasushi ^a   Hirata, Yukari ^a   Ito, Satoru ^a   Suzuki, Gentaroh ^a   Kimura, Toshifumi ^a   Maehara, Shunsuke ^a   Hikichi, Hirohiko ^a   Satow, Akio ^a   Hata, Mikiko ^a   Ohta, Hisashi ^a   Kawamoto, Hiroshi ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antipsychotic; Biarylamide; mGluR1 antagonist

Indexed keywords

4 FLUORO N [4 [6 (ISOPROPYLAMINO)PYRIMIDIN 4 YL] 1,3 THIAZOL 2 YL] N METHYLBENZAMIDE; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR ANTAGONIST; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RECEPTOR BLOCKING;

ANIMALS; ANTIPSYCHOTIC AGENTS; BENZAMIDES; HUMANS; MICE; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; RATTUS;

EID: 68949136974     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.097     Document Type: Article

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