Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain

Journal of Medicinal Chemistry

Volumn 50, Issue 23, 2007, Pages 5550-5553

  Wu, Wen Lian ^a   Burnett, Duane A ^a   Domalski, Martin ^a   Greenlee, William J ^a   Li, Cheng ^a   Bertorelli, Rosalia ^b   Fredduzzi, Silva ^b   Lozza, Gianluca ^b   Veltri, Alessio ^b   Reggiani, Angelo ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Schering Plough Research Institute   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

A 841720; GLUTAMATE RECEPTOR 1; GLUTAMIC ACID; HETEROCYCLIC COMPOUND; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; JNJ 16259685; LY 456066; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR ANTAGONIST; MORPHOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CHRONIC PAIN; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; NERVE LIGATION; NEUROPATHIC PAIN; NEUROPHARMACOLOGY; NEUROTRANSMISSION; NONHUMAN; PAIN; RAT; SPINAL NERVE;

ANALGESICS; ANIMALS; AREA UNDER CURVE; CHRONIC DISEASE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INDAZOLES; MORPHOLINES; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; PYRIDINES; PYRROLES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 36149000929     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070590c     Document Type: Article

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