Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 980-984

  Lachance, Nicolas ^a   Gareau, Yves ^a   Guiral, Sébastien ^a   Huang, Zheng ^a   Isabel, Elise ^a   Leclerc, Jean Philippe ^a   Léger, Serge ^a   Martins, Evelyn ^a   Nadeau, Christian ^a   Oballa, Renata M ^a   Ouellet, Stéphane G ^a   Powell, David A ^a   Ramtohul, Yeeman K ^a   Tranmer, Geoffrey K ^a   Trinh, Thao ^a   Wang, Hao ^a   Zhang, Lei ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Desaturation index; Liver targeted; MK 8245; SCD inhibitors; Stearoyl CoA desaturase inhibitors

Indexed keywords

ACYL COENZYME A DESATURASE; BISPYRROLIDINE DERIVATIVE; MK 8245; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER; LIVER MICROSOME; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEP G2 CELLS; HUMANS; LIVER; MOLECULAR STRUCTURE; PYRROLIDINES; RATS; STEAROYL-COA DESATURASE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RODENTIA;

EID: 84855689015     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.002     Document Type: Article

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